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AACR Virtual Journal Club:
Cancer Research Communications With Drs. Stephen W. Clark and Lucas A. Salas

Moderated by: Lucas Brand, PhD
Associate Editor, Cancer Research Communications
Recorded: 08/12/2022

Watch the recording of the AACR Journal Club session featuring Drs. Stephen W. Clark and Lucas A. Salas discuss their article recently published in Cancer Research Communications, "Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma." Many gliomas have aberrantly low methylation of key tumorigenic genes, whose increased expression has historically been linked with aggressive disease and poor outcomes. This trial reports the first successful modulation of methylation states in a solid tumor in humans.

Stay tuned for the Q&A session at the end of the recording.


About the Featured Speakers:

Stephen W. Clark, MD, PhD, is an Assistant Professor of Neurology at the Vanderbilt University Ingram Cancer Center, where he serves as an attending physician for general neurology and neuro-oncology. His research program in the Translational Research and Interventional Oncology Research Program centers on improving outcomes for patients with neurological cancers through the development of new treatment and detection methods.

Lucas A. Salas, MD, MPH, PhD, is an Assistant Professor of Epidemiology in the Dartmouth College Cancer Population Sciences Research Program. His research focuses on how various endogenous and exogenous factors influence the human epigenome and cell plasticity, and by extension, patient outcomes.


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