Journal Club:
Cancer Research with Dr. Sarah-Maria Fendt

Moderated by: Harmony Turk, PhD
Cancer Research Executive Editor
Recorded: 4/20/2021

Watch the recording of the AACR Journal Club session featuring Sarah-Maria Fendt, Ph.D., discussing her article published in Cancer Research, "Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis." Characterization of metabolic rewiring elicited by high-fat diet prior to disease development revealed that fat induces increased glucose metabolism in normal livers, resembling the metabolic state of hepatocellular carcinoma. This study identified metabolic alterations associated with dietary fat that may foster cancer progression and showed that fat can increase metabolic hallmarks of liver cancers in non-transformed livers.

Stay tuned for the Q&A session at the end of the recording.

About the Featured Speaker:

Sarah-Maria Fendt, Ph.D., is a Principal Investigator at the VIB Center for Cancer Biology and Assistant Professor of Oncology at KU Leuven, Belgium. Her lab investigates how the microenvironment and the cellular phenotype define the in vivo metabolism of cancers, and her group is specifically interested in elucidating general regulatory principles in metabolism and understanding cancer metabolism during metastasis formation as well as during altered whole-body physiology.