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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Unlocking Phenotypic Plasticity

Research Article

Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

Zhuxuan Li; Xueqian Zhuang; Chun-Hao Pan; Yan Yan; Rohit Thummalapalli; Jill Hallin; Stefan Torborg; Anupriya Singhal; Jason C. Chang; Eusebio Manchado; Lukas E. Dow; Rona Yaeger; James G. Christensen; Scott W. Lowe; Charles M. Rudin; Simon Joost; Tuomas Tammela

Doi: 10.1158/2159-8290.CD-23-0289

Research Article

Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer

Liwei Lang; Fanghui Chen; Yamin Li; Chloe Shay; Fan Yang; Hancai Dan; Zhuo G. Chen; Nabil F. Saba; Yong Teng

Doi: 10.1158/2767-9764.CRC-22-0289

Research Article

Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma

Priyanka Chaudhary; Xia Xu; Guangfang Wang; Jacob P. Hoj; Rishi R. Rampersad; Marie-Liesse Asselin-Labat; Stephanie Ting; William Kim; Pablo Tamayo; Ann Marie Pendergast; Mark W. Onaitis

Doi: 10.1158/2767-9764.CRC-22-0408

Translational Science

ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma

Ossia M. Eichhoff; Corinne I. Stoffel; Jan Käsler; Luzia Briker; Patrick Turko; Gergely Karsai; Nina Zila; Verena Paulitschke; Phil F. Cheng; Alexander Leitner; Andrea Bileck; Nicola Zamboni; Anja Irmisch; Zsolt Balazs; Aizhan Tastanova; Susana Pascoal; Pål Johansen; Rebekka Wegmann; Julien Mena; Alaa Othman; Vasanthi S. Viswanathan; Judith Wenzina; Andrea Aloia; Annalisa Saltari; Andreas Dzung; TuPro Consortium; Michael Krauthammer; Stuart L. Schreiber; Thorsten Hornemann; Martin Distel; Berend Snijder; Reinhard Dummer; Mitchell P. Levesque

Doi: 10.1158/0008-5472.CAN-22-1826

Cancer Landscapes

Mesenchymal-like Tumor Cells and Myofibroblastic Cancer-Associated Fibroblasts Are Associated with Progression and Immunotherapy Response of Clear Cell Renal Cell Carcinoma

Guillaume Davidson; Alexandra Helleux; Yann A. Vano; Véronique Lindner; Antonin Fattori; Marie Cerciat; Reza T. Elaidi; Virginie Verkarre; Cheng-Ming Sun; Christine Chevreau; Mostefa Bennamoun; Hervé Lang; Thibault Tricard; Wolf H. Fridman; Catherine Sautes-Fridman; Xiaoping Su; Damien Plassard; Celine Keime; Christelle Thibault-Carpentier; Philippe Barthelemy; Stéphane M. Oudard; Irwin Davidson; Gabriel G. Malouf

Doi: 10.1158/0008-5472.CAN-22-3034

Cancer Hallmarks Review

Lineage Plasticity: The New Cancer Hallmark on the Block

Arnav Mehta; Ben Z. Stanger

Doi: 10.1158/0008-5472.CAN-23-1067

Cancer Genes and Networks

Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer

Hannah Wollenzien; Yohannes Afeworki Tecleab; Robert Szczepaniak-Sloane; Anthony Restaino; Michael S. Kareta

Doi: 10.1158/1541-7786.MCR-22-0881

Cancer "-omics"

Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis

Jiahn Choi; Xusheng Zhang; Wenge Li; Michele Houston; Karina Peregrina; Robert Dubin; Kenny Ye; Leonard Augenlicht

Doi: 10.1158/1541-7786.MCR-22-1000

Research Article

Glioblastoma Vascular Plasticity Limits Effector T-cell Infiltration and Is Blocked by cAMP Activation

Zixi Qin; Youwei Huang; Zeying Li; Guopeng Pan; Liangying Zheng; Xiao Xiao; Fang Wang; Jiahong Chen; Xueqin Chen; Xi Lin; Kai Li; Guangmei Yan; Haipeng Zhang; Fan Xing

Doi: 10.1158/2326-6066.CIR-22-0872

Research Article

IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation

Niklas Landberg; Thomas Köhnke; Yang Feng; Yusuke Nakauchi; Amy C. Fan; Miles H. Linde; Daiki Karigane; Kelly Lim; Rahul Sinha; Luca Malcovati; Daniel Thomas; Ravindra Majeti

Doi: 10.1158/2643-3230.BCD-23-0195

Research Article

Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia

Andriana G. Kotini; Saul Carcamo; Nataly Cruz-Rodriguez; Malgorzata Olszewska; Tiansu Wang; Deniz Demircioglu; Chan-Jung Chang; Elsa Bernard; Mark P. Chao; Ravindra Majeti; Hanzhi Luo; Michael G. Kharas; Dan Hasson; Eirini P. Papapetrou

Doi: 10.1158/2643-3230.BCD-22-0167

Review

Significance of RB Loss in Unlocking Phenotypic Plasticity in Advanced Cancers

Varadha Balaji Venkadakrishnan; Yasutaka Yamada; Kenny Weng; Osasenaga Idahor; Himisha Beltran

Doi: 10.1158/1541-7786.MCR-23-0045

Mini Review

Mapping Phenotypic Plasticity upon the Cancer Cell State Landscape Using Manifold Learning

Daniel B. Burkhardt; Beatriz P. San Juan; John G. Lock; Smita Krishnaswamy; Christine L. Chaffer

Doi: 10.1158/2159-8290.CD-21-0282

Review

The Origins of Phenotypic Heterogeneity in Cancer

Guido Lenz; Giovana R. Onzi; Luana S. Lenz; Julieti H. Buss; Jephesson A. dos Santos; Karine R. Begnini

Doi: 10.1158/0008-5472.CAN-21-1940

Research Article

Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity

Hannah L. Williams; Andressa Dias Costa; Jinming Zhang; Srivatsan Raghavan; Peter S. Winter; Kevin S. Kapner; Scott P. Ginebaugh; Sara A. Väyrynen; Juha P. Väyrynen; Chen Yuan; Andrew W. Navia; Junning Wang; Annan Yang; Timothy L. Bosse; Radha L. Kalekar; Kristen E. Lowder; Mai Chan Lau; Dalia Elganainy; Vicente Morales-Oyarvide; Douglas A. Rubinson; Harshabad Singh; Kimberly Perez; James M. Cleary; Thomas E. Clancy; Jiping Wang; Joseph D. Mancias; Lauren K. Brais; Emma R. Hill; Margaret M. Kozak; David C. Linehan; Richard F. Dunne; Daniel T. Chang; Albert C. Koong; Aram F. Hezel; William C. Hahn; Alex K. Shalek; Andrew J. Aguirre; Jonathan A. Nowak; Brian M. Wolpin

Doi: 10.1158/0008-5472.CAN-22-3050

Research Article

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes

Lőrinc Sándor Pongor; Christopher W. Schultz; Lorenzo Rinaldi; Darawalee Wangsa; Christophe E. Redon; Nobuyuki Takahashi; Gavriel Fialkoff; Parth Desai; Yang Zhang; Sandra Burkett; Nadav Hermoni; Noa Vilk; Jenia Gutin; Rona Gergely; Yongmei Zhao; Samantha Nichols; Rasa Vilimas; Linda Sciuto; Chante Graham; Juan Manuel Caravaca; Sevilay Turan; Shen Tsai-wei; Vinodh N. Rajapakse; Rajesh Kumar; Deep Upadhyay; Suresh Kumar; Yoo Sun Kim; Nitin Roper; Bao Tran; Stephen M. Hewitt; David E. Kleiner; Mirit I. Aladjem; Nir Friedman; Gordon L. Hager; Yves Pommier; Thomas Ried; Anish Thomas

Doi: 10.1158/2159-8290.CD-22-0796

Research Article

Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer

Ellen Langille; Khalid N. Al-Zahrani; Zhibo Ma; Minggao Liang; Liis Uuskula-Reimand; Roderic Espin; Katie Teng; Ahmad Malik; Helga Bergholtz; Samah El Ghamrasni; Somaieh Afiuni-Zadeh; Ricky Tsai; Sana Alvi; Andrew Elia; YiQing Lü; Robin H. Oh; Katelyn J. Kozma; Daniel Trcka; Masahiro Narimatsu; Jeff C. Liu; Thomas Nguyen; Seda Barutcu; Sampath K. Loganathan; Rod Bremner; Gary D. Bader; Sean E. Egan; David W. Cescon; Therese Sørlie; Jeffrey L. Wrana; Hartland W. Jackson; Michael D. Wilson; Agnieszka K. Witkiewicz; Erik S. Knudsen; Miguel Angel Pujana; Geoffrey M. Wahl; Daniel Schramek

Doi: 10.1158/2159-8290.CD-21-0865

Research Article

Progenitor Hierarchy of Chronic Myelomonocytic Leukemia Identifies Inflammatory Monocytic-Biased Trajectory Linked to Worse Outcomes

Meghan C. Ferrall-Fairbanks; Abhishek Dhawan; Brian Johnson; Hannah Newman; Virginia Volpe; Christopher Letson; Markus Ball; Anthony M. Hunter; Maria E. Balasis; Traci Kruer; Nana Adjoa Ben-Crentsil; Jodi L. Kroeger; Robert Balderas; Rami S. Komrokji; David A. Sallman; Jing Zhang; Rafael Bejar; Philipp M. Altrock; Eric Padron

Doi: 10.1158/2643-3230.BCD-21-0217

Research Article

STAG2 Expression is Associated with Adverse Survival Outcomes and Regulates Cell Phenotype in Muscle-invasive Bladder Cancer

Sarah R. Athans; Nithya Krishnan; Swathi Ramakrishnan; Eduardo Cortes Gomez; Sofía Lage-Vickers; Monika Rak; Zara I. Kazmierczak; Joyce Ellen Ohm; Kristopher Attwood; Jianmin Wang; Anna Woloszynska

Doi: 10.1158/2767-9764.CRC-22-0155

Research Article

Transcriptional Plasticity Drives Leukemia Immune Escape

Kenneth Eagle; Taku Harada; Jérémie Kalfon; Monika W. Perez; Yaser Heshmati; Jazmin Ewers; Jošt Vrabič Koren; Joshua M. Dempster; Guillaume Kugener; Vikram R. Paralkar; Charles Y. Lin; Neekesh V. Dharia; Kimberly Stegmaier; Stuart H. Orkin; Maxim Pimkin

Doi: 10.1158/2643-3230.BCD-21-0207

Research Article

ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia

Kirsten M. Dickerson; Chunxu Qu; Qingsong Gao; Ilaria Iacobucci; Zhaohui Gu; Hiroki Yoshihara; Emily A. Backhaus; Yunchao Chang; Laura J. Janke; Beisi Xu; Gang Wu; Evangelia K. Papachristou; Clive S. D'Santos; Kathryn G. Roberts; Charles G. Mullighan

Doi: 10.1158/2643-3230.BCD-21-0163

Research Article

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Maria C. Heinz; Niek A. Peters; Koen C. Oost; Rik G.H. Lindeboom; Lisa van Voorthuijsen; Arianna Fumagalli; Mirjam C. van der Net; Gustavo de Medeiros; Joris H. Hageman; Ingrid Verlaan-Klink; Inne H.M. Borel Rinkes; Prisca Liberali; Martijn Gloerich; Jacco van Rheenen; Michiel Vermeulen; Onno Kranenburg; Hugo J.G. Snippert

Doi: 10.1158/0008-5472.CAN-21-0933

Research Article

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Adriana M. Mujal; Alexis J. Combes; Arjun A. Rao; Mikhail Binnewies; Bushra Samad; Jessica Tsui; Alexandre Boissonnas; Joshua L. Pollack; Rafael J. Argüello; Maxwell V. Meng; Sima P. Porten; Megan K. Ruhland; Kevin C. Barry; Vincent Chan; Matthew F. Krummel

Doi: 10.1158/2326-6066.CIR-21-0588

Research Article

Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer

Deli Hong; Erik H. Knelson; Yixiang Li; Yavuz T. Durmaz; Wenhua Gao; Emily Walton; Amir Vajdi; Tran Thai; Maura Sticco-Ivins; Amin H. Sabet; Kristen L. Jones; Anna C. Schinzel; Rod T. Bronson; Quang-De Nguyen; Michael Y. Tolstorukov; Marina Vivero; Sabina Signoretti; David A. Barbie; Matthew G. Oser

Doi: 10.1158/0008-5472.CAN-21-1991

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