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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Tumor-Promoting Inflammation

Research Article

An Inflammatory Checkpoint Generated by IL1RN Splicing Offers Therapeutic Opportunity for KRAS-Mutant Intrahepatic Cholangiocarcinoma

Mao Zhang; Yingying Huang; Jiaomeng Pan; Chen Sang; Youpei Lin; Liangqing Dong; Xia Shen; Yingcheng Wu; Guohe Song; Shuyi Ji; Fen Liu; Mengcheng Wang; Yuyan Zheng; Sirui Zhang; Zefeng Wang; Jianke Ren; Daming Gao; Jian Zhou; Jia Fan; Wu Wei; Jian Lin; Qiang Gao

Doi: 10.1158/2159-8290.CD-23-0282

Research Article

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer

Ledong Wan; Kuan-Ting Lin; Mohammad Alinoor Rahman; Yuma Ishigami; Zhikai Wang; Mads A. Jensen; John E. Wilkinson; Youngkyu Park; David A. Tuveson; Adrian R. Krainer

Doi: 10.1158/2159-8290.CD-22-1013

Research Article

EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth

Alexandra Kuhlmann-Hogan; Thekla Cordes; Ziyan Xu; Ramya S. Kuna; Kacie A. Traina; Camila Robles-Oteíza; Deborah Ayeni; Elizabeth M. Kwong; Stellar Levy; Anna-Maria Globig; Matthew M. Nobari; George Z. Cheng; Sandra L. Leibel; Robert J. Homer; Reuben J. Shaw; Christian M. Metallo; Katerina Politi; Susan M. Kaech

Doi: 10.1158/2159-8290.CD-23-0434

Research Article

Single-cell Profiling Uncovers a Muc4-Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori-driven Inflammation

Valerie P. O'Brien; Yuqi Kang; Meera K. Shenoy; Greg Finak; William C. Young; Julien Dubrulle; Lisa Koch; Armando E. Rodriguez Martinez; Jeffery Williams; Elizabeth Donato; Surinder K. Batra; Cecilia C.S. Yeung; William M. Grady; Meghan A. Koch; Raphael Gottardo; Nina R. Salama

Doi: 10.1158/2767-9764.CRC-23-0142

Research Article

p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis

Denada Dibra; Mihai Gagea; Yuan Qi; Gilda P. Chau; Xiaoping Su; Guillermina Lozano

Doi: 10.1158/2767-9764.CRC-23-0218

Cancer Immunology

Spatial Positioning of Immune Hotspots Reflects the Interplay between B and T Cells in Lung Squamous Cell Carcinoma

Hanyun Zhang; Khalid AbdulJabbar; David A. Moore; Ayse Akarca; Katey S.S. Enfield; Mariam Jamal-Hanjani; Shan E. Ahmed Raza; Selvaraju Veeriah; Roberto Salgado; Nicholas McGranahan; John Le Quesne; Charles Swanton; Teresa Marafioti; Yinyin Yuan

Doi: 10.1158/0008-5472.CAN-22-2589

Molecular Cell Biology

NFE2L2 Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells

Li Guan; Dhanya K. Nambiar; Hongbin Cao; Vignesh Viswanathan; Shirley Kwok; Angela B. Hui; Yuan Hou; Rachel Hildebrand; Rie von Eyben; Brittany J. Holmes; Junfei Zhao; Christina S. Kong; Nathan Wamsley; Weiruo Zhang; Michael B. Major; Seung W. Seol; John B. Sunwoo; D. Neil Hayes; Maximilian Diehn; Quynh-Thu Le

Doi: 10.1158/0008-5472.CAN-22-1903

Cell Fate Decisions

Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

Sabira Mohammed; Nidheesh Thadathil; Phoebe Ohene-Marfo; Albert L. Tran; Michael Van Der Veldt; Constantin Georgescu; Sangphil Oh; Evan H. Nicklas; Dawei Wang; Nair Hariprasad Haritha; Wenyi Luo; Ralf Janknecht; Benjamin F. Miller; Jonathan D. Wren; Willard M. Freeman; Sathyaseelan S. Deepa

Doi: 10.1158/1541-7786.MCR-22-0820

Research Article

Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory

Ayesha B. Alvero; Alexandra Fox; Bhaskara Reddy Madina; Marie M. Krady; Radhika Gogoi; Hussein Chehade; Valerian Nakaar; Bijan Almassian; Timur O. Yarovinsky; Thomas Rutherford; Gil Mor

Doi: 10.1158/2326-6066.CIR-23-0127

Priority Briefs

Bexmarilimab Activates Human Tumor-Associated Macrophages to Support Adaptive Immune Responses in Interferon-Poor Immune Microenvironments

Jenna H. Rannikko; Petri Bono; Johanna Hynninen; Maija Hollmén

Doi: 10.1158/2326-6066.CIR-23-0350

Research Article

A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML

Lanpeng Chen; Eline Pronk; Claire van Dijk; Yujie Bian; Jacqueline Feyen; Tim van Tienhoven; Meltem Yildirim; Paola Pisterzi; Madelon M.E. de Jong; Alejandro Bastidas; Remco M. Hoogenboezem; Chiel Wevers; Eric M. Bindels; Bob Löwenberg; Tom Cupedo; Mathijs A. Sanders; Marc H.G.P. Raaijmakers

Doi: 10.1158/2643-3230.BCD-23-0043

Targeting Drug Resistance

PUMA/RIP3 Mediates Chemotherapy Response via Necroptosis and Local Immune Activation in Colorectal Cancer

Dongshi Chen; Kaylee Ermine; Yi-Jun Wang; Xiaojun Chen; Xinyan Lu; Peng Wang; Donna Beer-Stolz; Jian Yu; Lin Zhang

Doi: 10.1158/1535-7163.MCT-23-0162

Research Article

The Association of Kidney Function and Inflammatory Biomarkers with Epithelial Ovarian Cancer Risk

Cassandra A. Hathaway; Mary K. Townsend; Elliot M. Sklar; Kamilah B. Thomas-Purcell; Kathryn L. Terry; Britton Trabert; Shelley S. Tworoger

Doi: 10.1158/1055-9965.EPI-23-0543

Review

Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Christopher T.V. Swain; Ann E. Drummond; Roger L. Milne; Dallas R. English; Kristy A. Brown; Makayla W.C. Lou; Leonessa Boing; Amy Bageley; Tina L. Skinner; Eline H. van Roekel; Melissa M. Moore; Tom R. Gaunt; Richard M. Martin; Sarah J. Lewis; Brigid M. Lynch

Doi: 10.1158/1055-9965.EPI-22-0928

Review

Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Makayla W.C. Lou; Ann E. Drummond; Christopher T.V. Swain; Roger L. Milne; Dallas R. English; Kristy A. Brown; Eline H. van Roekel; Tina L. Skinner; Melissa M. Moore; Tom R. Gaunt; Richard M. Martin; Sarah J. Lewis; Brigid M. Lynch

Doi: 10.1158/1055-9965.EPI-22-0929

Research Article

Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response

Robert Carreras-Torres; Andre E. Kim; Yi Lin; Virginia Díez-Obrero; Stephanie A. Bien; Conghui Qu; Jun Wang; Niki Dimou; Elom K. Aglago; Demetrius Albanes; Volker Arndt; James W. Baurley; Sonja I. Berndt; Stéphane Bézieau; D. Timothy Bishop; Emmanouil Bouras; Hermann Brenner; Arif Budiarto; Peter T. Campbell; Graham Casey; Andrew T. Chan; Jenny Chang-Claude; Xuechen Chen; David V. Conti; Christopher H. Dampier; Matthew A.M. Devall; David A. Drew; Jane C. Figueiredo; Steven Gallinger; Graham G. Giles; Stephen B. Gruber; Andrea Gsur; Marc J. Gunter; Tabitha A. Harrison; Akihisa Hidaka; Michael Hoffmeister; Jeroen R. Huyghe; Mark A. Jenkins; Kristina M. Jordahl; Eric Kawaguchi; Temitope O. Keku; Anshul Kundaje; Loic Le Marchand; Juan Pablo Lewinger; Li Li; Bharuno Mahesworo; John L. Morrison; Neil Murphy; Hongmei Nan; Rami Nassir; Polly A. Newcomb; Mireia Obón-Santacana; Shuji Ogino; Jennifer Ose; Rish K. Pai; Julie R. Palmer; Nikos Papadimitriou; Bens Pardamean; Anita R. Peoples; Paul D.P. Pharoah; Elizabeth A. Platz; Gad Rennert; Edward Ruiz-Narvaez; Lori C. Sakoda; Peter C. Scacheri; Stephanie L. Schmit; Robert E. Schoen; Anna Shcherbina; Martha L. Slattery; Mariana C. Stern; Yu-Ru Su; Catherine M. Tangen; Duncan C. Thomas; Yu Tian; Konstantinos K. Tsilidis; Cornelia M. Ulrich; Fränzel J.B. van Duijnhoven; Bethany Van Guelpen; Kala Visvanathan; Pavel Vodicka; Tjeng Wawan Cenggoro; Stephanie J. Weinstein; Emily White; Alicja Wolk; Michael O. Woods; Li Hsu; Ulrike Peters; Victor Moreno; W. James Gauderman

Doi: 10.1158/1055-9965.EPI-22-0763

Cancer Hallmarks Review

The Past and Future of Inflammation as a Target to Cancer Prevention

Laura Antonucci; Michael Karin

Doi: 10.1158/1940-6207.CAPR-23-0423

Review

The Role of Inflammation in the Initiation and Progression of Myeloid Neoplasms

Juan Balandran; Audrey Lasry; Iannis Aifantis

Doi: 10.1158/2643-3230.BCD-22-0176

Review

Myeloid Cell–Derived Oxidized Lipids and Regulation of the Tumor Microenvironment

Kristin C. Hicks; Yulia Y. Tyurina; Valerian E. Kagan; Dmitry I. Gabrilovich

Doi: 10.1158/0008-5472.CAN-21-3054

Research Article

Progenitor Hierarchy of Chronic Myelomonocytic Leukemia Identifies Inflammatory Monocytic-Biased Trajectory Linked to Worse Outcomes

Meghan C. Ferrall-Fairbanks; Abhishek Dhawan; Brian Johnson; Hannah Newman; Virginia Volpe; Christopher Letson; Markus Ball; Anthony M. Hunter; Maria E. Balasis; Traci Kruer; Nana Adjoa Ben-Crentsil; Jodi L. Kroeger; Robert Balderas; Rami S. Komrokji; David A. Sallman; Jing Zhang; Rafael Bejar; Philipp M. Altrock; Eric Padron

Doi: 10.1158/2643-3230.BCD-21-0217

Research Article

A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma

Phillip M. Rappold; Lynda Vuong; Josef Leibold; Nicholas H. Chakiryan; Michael Curry; Fengshen Kuo; Erich Sabio; Hui Jiang; Briana G. Nixon; Ming Liu; Anders E. Berglund; Andrew W. Silagy; Eduardo A. Mascareno; Mahdi Golkaram; Mahtab Marker; Albert Reising; Alexander Savchenko; John Millholland; Ying-Bei Chen; Paul Russo; Jonathan Coleman; Ed Reznik; Brandon J. Manley; Irina Ostrovnaya; Vladimir Makarov; Renzo G. DiNatale; Kyle A. Blum; Xiaoxiao Ma; Diego Chowell; Ming O. Li; David B. Solit; Scott W. Lowe; Timothy A. Chan; Robert J. Motzer; Martin H. Voss; A. Ari Hakimi

Doi: 10.1158/2159-8290.CD-21-0925

Research Article

The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation

Anna Yeaton; Geraldine Cayanan; Sanam Loghavi; Igor Dolgalev; Emmett M. Leddin; Christian E. Loo; Hedieh Torabifard; Deedra Nicolet; Jingjing Wang; Kate Corrigan; Varvara Paraskevopoulou; Daniel T Starczynowski; Eric Wang; Omar Abdel-Wahab; Aaron D Viny; Richard M. Stone; John C. Byrd; Olga A. Guryanova; Rahul M. Kohli; G. Andrés Cisneros; Aristotelis Tsirigos; Ann-Kathrin Eisfeld; Iannis Aifantis; Maria Guillamot

Doi: 10.1158/2159-8290.CD-21-1146

Research Article

Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis

Mijung Kwon; Genesaret Rubio; Haitao Wang; Gregory Riedlinger; Asha Adem; Hua Zhong; Daniel Slegowski; Louisa Post-Zwicker; Anshruta Chidananda; David S. Schrump; Sharon R. Pine; Steven K. Libutti

Doi: 10.1158/2767-9764.CRC-22-0233

Research Article

Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer

Chang-Suk Chae; Tito A. Sandoval; Sung-Min Hwang; Eun Sil Park; Paolo Giovanelli; Deepika Awasthi; Camilla Salvagno; Alexander Emmanuelli; Chen Tan; Vidyanath Chaudhary; Julia Casado; Andrew V. Kossenkov; Minkyung Song; Franck J. Barrat; Kevin Holcomb; E. Alfonso Romero-Sandoval; Dmitriy Zamarin; David Pépin; Alan D. D'Andrea; Anniina Färkkilä; Juan R. Cubillos-Ruiz

Doi: 10.1158/2159-8290.CD-21-1181

Research Article

IL6 and CCL18 Mediate Cross-talk between VHL-Deficient Kidney Cells and Macrophages during Development of Renal Cell Carcinoma

Thi-Ngoc Nguyen; Hieu-Huy Nguyen-Tran; Chen-Yun Chen; Tien Hsu

Doi: 10.1158/0008-5472.CAN-21-3749

Research Article

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts

Jana M. Ellegast; Gabriela Alexe; Amanda Hamze; Shan Lin; Hannah J. Uckelmann; Philipp J. Rauch; Maxim Pimkin; Linda S. Ross; Neekesh V. Dharia; Amanda L. Robichaud; Amy Saur Conway; Delan Khalid; Jennifer A. Perry; Mark Wunderlich; Lina Benajiba; Yana Pikman; Behnam Nabet; Nathanael S. Gray; Stuart H. Orkin; Kimberly Stegmaier

Doi: 10.1158/2159-8290.CD-21-0956

Research Article

The COX-2–PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas

Jie Wei; Jinyu Zhang; Dingzhi Wang; Bo Cen; Jessica D. Lang; Raymond N. DuBois

Doi: 10.1158/1940-6207.CAPR-21-0572

Research Article

Aberrant Extrafollicular B Cells, Immune Dysfunction, Myeloid Inflammation, and MyD88-Mutant Progenitors Precede Waldenstrom Macroglobulinemia

Akhilesh Kaushal; Ajay K. Nooka; Allison R. Carr; Katherine E. Pendleton; Benjamin G. Barwick; Julia Manalo; Samuel S. McCachren; Vikas A. Gupta; Nisha S. Joseph; Craig C. Hofmeister; Jonathan L. Kaufman; Leonard T. Heffner; Stephen M. Ansell; Lawrence H. Boise; Sagar Lonial; Kavita M. Dhodapkar; Madhav V. Dhodapkar

Doi: 10.1158/2643-3230.BCD-21-0043

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