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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Sustaining Proliferative Signaling

Research Article

INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors

Catherine Dietrich; Alec Trub; Antonio Ahn; Michael Taylor; Krutika Ambani; Keefe T. Chan; Kun-Hui Lu; Christabella A. Mahendra; Catherine Blyth; Rhiannon Coulson; Susanne Ramm; April C. Watt; Sunil Kumar Matsa; John Bisi; Jay Strum; Patrick Roberts; Shom Goel

Doi: 10.1158/2159-8290.CD-23-0954

Research Article

Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia

Andreas Varkaris; Ermira Pazolli; Hakan Gunaydin; Qi Wang; Levi Pierce; Alessandro A. Boezio; Artemisa Bulku; Lucian DiPietro; Cary Fridrich; Adam Frost; Fabrizio Giordanetto; Erika P. Hamilton; Katherine Harris; Michael Holliday; Tamieka L. Hunter; Amanda Iskandar; Yongli Ji; Alexandre Larivée; Jonathan R. LaRochelle; André Lescarbeau; Fabien Llambi; Brenda Lormil; Mary M. Mader; Brenton G. Mar; Iain Martin; Thomas H. McLean; Klaus Michelsen; Yakov Pechersky; Erika Puente-Poushnejad; Kevin Raynor; Dipali Rogala; Ramin Samadani; Alison M. Schram; Kelley Shortsleeves; Sweta Swaminathan; Shahein Tajmir; Gege Tan; Yong Tang; Roberto Valverde; Bryan Wehrenberg; Jeremy Wilbur; Bret R. Williams; Hongtao Zeng; Hanmo Zhang; W. Patrick Walters; Beni B. Wolf; David E. Shaw; Donald A. Bergstrom; James Watters; James S. Fraser; Pascal D. Fortin; D. Randal Kipp

Doi: 10.1158/2159-8290.CD-23-0944

Research Brief

Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations

Andreas Varkaris; Ferran Fece de la Cruz; Elizabeth E. Martin; Bryanna L. Norden; Nicholas Chevalier; Allison M. Kehlmann; Ignaty Leshchiner; Haley Barnes; Sara Ehnstrom; Anastasia-Maria Stavridi; Xin Yuan; Janice S. Kim; Haley Ellis; Alkistis Papatheodoridi; Hakan Gunaydin; Brian P. Danysh; Laxmi Parida; Ioannis Sanidas; Yongli Ji; Kayao Lau; Gerburg M. Wulf; Aditya Bardia; Laura M. Spring; Steven J. Isakoff; Jochen K. Lennerz; Kathryn Del Vecchio; Levi Pierce; Ermira Pazolli; Gad Getz; Ryan B. Corcoran; Dejan Juric

Doi: 10.1158/2159-8290.CD-23-0704

Research Article

Signaling Pathway Alterations Driven by BRCA1 and BRCA2 Germline Mutations are Sufficient to Initiate Breast Tumorigenesis by the PIK3CAH1047R Oncogene

Poornima Bhat-Nakshatri; Aditi S. Khatpe; Duojiao Chen; Katie Batic; Henry Mang; Christopher Herodotou; Patrick C. McGuire; Xiaoling Xuei; Cihat Erdogan; Hongyu Gao; Yunlong Liu; George Sandusky; Anna Maria Storniolo; Harikrishna Nakshatri

Doi: 10.1158/2767-9764.CRC-23-0330

Research Article

A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer

M. Dorso; Payal T. Patel; Aleksandr Pankov; Jacob A. Boyer; Rajesh K. Soni; Isabella S. Del Priore; Omar Hayatt; Amanda Kulick; Connor J. Hagen; Elisa de Stanchina; Melissa R. Junttila; Anneleen Daemen; Lori S. Friedman; Ronald C. Hendrickson; Sarat Chandarlapaty

Doi: 10.1158/2767-9764.CRC-23-0310

Tumor Microenvironment and Immunobiology

Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma

Karen J. Dunbar; Tatiana A. Karakasheva; Qiaosi Tang; Gizem Efe; Eric W. Lin; Michael Harris; Varun Sahu; Uma M. Sachdeva; Jianhua Hu; Andres J. Klein-Szanto; Brian Henick; J. Alan Diehl; Hiroshi Nakagawa; Anil K. Rustgi

Doi: 10.1158/1541-7786.MCR-22-0872

Cancer Genes and Networks

TBX3 Promotes Cervical Cancer Proliferation and Migration via HPV E6 and E7 Signaling

Saif F. Khan; Carly A. Burmeister; David J. Scott; Musalula Sinkala; Amsha Ramburan; Hue-Tsi Wu; Georgia Schäfer; Arieh A. Katz; Sharon Prince

Doi: 10.1158/1541-7786.MCR-22-0598

Research Article

TITLE

Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells

Doi: 10.1158/1535-7163.MCT-23-0135

Research Article

MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells

Kazuya Fukasawa; Jiajun Lyu; Takuya Kubo; Yuki Tanaka; Akane Suzuki; Tetsuhiro Horie; Akane Tomizawa; Ryoma Osumi; Sayuki Iwahashi; Kazuya Tokumura; Misato Murata; Masaki Kobayashi; Tomoki Todo; Atsushi Hirao; Eiichi Hinoi

Doi: 10.1158/2767-9764.CRC-22-0243

Research Article

Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer

Mariana Cooke; Xuyao Zhang; Suli Zhang; Evgeniy Eruslanov; Priti Lal; Reba E. Daniel; Michael D. Feldman; Martin C. Abba; Marcelo G. Kazanietz

Doi: 10.1158/2767-9764.CRC-22-0170

Research Article

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer

Owen J. Chen; Ester Castellsagué; Mohamed Moustafa-Kamal; Javad Nadaf; Barbara Rivera; Somayyeh Fahiminiya; Yilin Wang; Isabelle Gamache; Caterina Pacifico; Lai Jiang; Jian Carrot-Zhang; Leora Witkowski; Albert M. Berghuis; Stefan Schönberger; Dominik Schneider; Morten Hillmer; Susanne Bens; Reiner Siebert; Colin J.R. Stewart; Ziguo Zhang; William C.H. Chao; Celia M.T. Greenwood; David Barford; Marc Tischkowitz; Jacek Majewski; William D. Foulkes; Jose G. Teodoro

Doi: 10.1158/0008-5472.CAN-21-3956

Research Article

Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia

June Takeda; Kenichi Yoshida; Masahiro M. Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M. Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa

Doi: 10.1158/2643-3230.BCD-21-0192

Research Article

MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling

Madison Furnish; Dillon P. Boulton; Victoria Genther; Denisa Grofova; Mitchell Lee Ellinwood; Lina Romero; M. Scott Lucia; Scott D. Cramer; M. Cecilia Caino

Doi: 10.1158/1541-7786.MCR-21-0374

Research Article

RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy

Kyung W. Song; Kyle A. Edgar; Emily J. Hanan; Marc Hafner; Jason Oeh; Mark Merchant; Deepak Sampath; Michelle A. Nannini; Rebecca Hong; Lilian Phu; William F. Forrest; Eric Stawiski; Stephen Schmidt; Nicholas Endres; Jane Guan; Jeffrey J. Wallin; Jonathan Cheong; Emile G. Plise; Gail D. Lewis Phillips; Laurent Salphati; Timothy P. Heffron; Alan G. Olivero; Shiva Malek; Steven T. Staben; Donald S. Kirkpatrick; Anwesha Dey; Lori S. Friedman

Doi: 10.1158/2159-8290.CD-21-0072

Research Article

GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer

Marieke Burleson; Janice J. Deng; Tai Qin; Thu Minh Duong; Yuqian Yan; Xiang Gu; Debodipta Das; Acarizia Easley; Michael A. Liss; P. Renee Yew; Roble Bedolla; Addanki Pratap Kumar; Tim Hui-Ming Huang; Yi Zou; Yidong Chen; Chun-Liang Chen; Haojie Huang; Lu-Zhe Sun; Thomas G. Boyer

Doi: 10.1158/1541-7786.MCR-21-0108

Research Article

An Unbiased Functional Genetics Screen Identifies Rare Activating ERBB4 Mutations

Deepankar Chakroborty; Veera K. Ojala; Anna M. Knittle; Jasmin Drexler; Mahlet Z. Tamirat; Regina Ruzicka; Karin Bosch; Johanna Woertl; Susanne Schmittner; Laura L. Elo; Mark S. Johnson; Kari J. Kurppa; Flavio Solca; Klaus Elenius

Doi: 10.1158/2767-9764.CRC-21-0021

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