Cancer Hallmarks

Research Article

Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma

Zhang'E Choo; Xiaoying Koh; Megan Rui En Wong; Ruth Minothini Ashokan; Nurul Suhana Binte Ali Ahamed; CongBao Kang; Chik Hong Kuick; Kenneth Tou En Chang; Sarit Larisch; Amos Hong Pheng Loh; Zhi Xiong Chen

Doi: 10.1158/2767-9764.CRC-23-0082

Research Article

Identification and Characterization of a Small Molecule Bcl-2 Functional Converter

Prasad R. Kopparapu; Martin C. Pearce; Christiane V. Löhr; Cathy Duong; Hyo Sang Jang; Shanthakumar Tyavanagimatt; Edmond F. O'Donnell, 3rd; Harikrishna Nakshatri; Siva K. Kolluri

Doi: 10.1158/2767-9764.CRC-22-0526

Molecular Cell Biology

HBx-Induced HSPA8 Stimulates HBV Replication and Suppresses Ferroptosis to Support Liver Cancer Progression

Yufei Wang; Man Zhao; Lina Zhao; Yu Geng; Guanghao Li; Lin Chen; Jingxuan Yu; Hongfeng Yuan; Huihui Zhang; Haolin Yun; Ying Yuan; Guowen Wang; Jinyan Feng; Liang Xu; Shuai Wang; Chunyu Hou; Guang Yang; Ningning Zhang; Wei Lu; Xiaodong Zhang

Doi: 10.1158/0008-5472.CAN-22-3169

In Focus

Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities

Guang Lei; Boyi Gan

Doi: 10.1158/0008-5472.CAN-23-4042

Cancer Genes and Networks

Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia

Seemana Bhattacharya; Sujan Piya; Huaxian Ma; Priyanka Sharma; Qi Zhang; Natalia Baran; Vivian R. Ruvolo; Teresa McQueen; R. Eric Davis; Rasoul Pourebrahim; Marina Konopleva; Hagop Kantarjian; Nicholas D. P. Cosford; Michael Andreeff; Gautam Borthakur

Doi: 10.1158/1541-7786.MCR-22-0343

Genome Maintenance

USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma

Halle J. Mallard; Shibiao Wan; Prakriti Nidhi; Yvan D. Hanscom-Trofy; Bhopal Mohapatra; Nicholas T. Woods; Jose Antonio Lopez-Guerrero; Antonio Llombart-Bosch; Isidro Machado; Katia Scotlandi; Natasha F. Kreiling; Megan C. Perry; Sameer Mirza; Donald W. Coulter; Vimla Band; Hamid Band; Gargi Ghosal

Doi: 10.1158/1541-7786.MCR-23-0323

Research Article

Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts

Elyse A. Olesinski; Karanpreet Singh Bhatia; Chuqi Wang; Marissa S. Pioso; Xiao Xian Lin; Ahmed M. Mamdouh; Shu Xuan Ng; Vedant Sandhu; Shaista Shabbir Jasdanwala; Binyam Yilma; Stephan Bohl; Jeremy A. Ryan; Disha Malani; Marlise R. Luskin; Olli Kallioniemi; Kimmo Porkka; Sophia Adamia; Wee Joo Chng; Motomi Osato; David M. Weinstock; Jacqueline S. Garcia; Anthony Letai; Shruti Bhatt

Doi: 10.1158/2643-3230.BCD-24-0001

First Disclosure

The novel ATR inhibitor M1774 induces replication protein overexpression and broad synergy with DNA-targeted anticancer drugs

Ukhyun Jo; Yashuhiro Arakawa; Astrid Zimmermann; Daiki Taniyama; Makito Mizunuma; Lisa M. Jenkins; Tapan Maity; Suresh Kumar; Frank T. Zenke; Naoko Takebe; Yves Pommier

Doi: 10.1158/1535-7163.MCT-23-0402

Small Model Therapeutics

Genetic Silencing of AKT Induces Melanoma Cell Death via mTOR Suppression

Gennie L. Parkman; Tursun Turapov; David A. Kircher; William J. Burnett; Christopher M. Stehn; Kayla O'Toole; Katie M. Culver; Ashley T. Chadwick; Riley C. Elmer; Ryan Flaherty; Karly A. Stanley; Mona Foth; David H. Lum; Robert L. Judson-Torres; John E. Friend; Matthew W. VanBrocklin; Martin McMahon; Sheri L. Holmen

Doi: 10.1158/1535-7163.MCT-23-0474

Review

Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics

Joan Montero; Rizwan Haq

Doi: 10.1158/2159-8290.CD-21-1334

Research Article

Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies

Ruth Flümann; Julia Hansen; Benedikt W. Pelzer; Pascal Nieper; Tim Lohmann; Ilmars Kisis; Tobias Riet; Viktoria Kohlhas; Phuong-Hien Nguyen; Martin Peifer; Nima Abedpour; Graziella Bosco; Roman K. Thomas; Moritz Kochanek; Jacqueline Knüfer; Lorenz Jonigkeit; Filippo Beleggia; Alessandra Holzem; Reinhard Büttner; Philipp Lohneis; Jörn Meinel; Monika Ortmann; Thorsten Persigehl; Michael Hallek; Dinis Pedro Calado; Markus Chmielewski; Sebastian Klein; Joachim R. Göthert; Bjoern Chapuy; Branko Zevnik; F. Thomas Wunderlich; Bastian von Tresckow; Ron D. Jachimowicz; Ari M. Melnick; Hans Christian Reinhardt; Gero Knittel

Doi: 10.1158/2643-3230.BCD-22-0007

Research Article

A Recurrent ADPRHL1 Germline Mutation Activates PARP1 and Confers Prostate Cancer Risk in African American Families

Guanyi Zhang; Zemin Wang; Jasmin Bavarva; Katherine J. Kuhns; Jianhui Guo; Elisa M. Ledet; Chiping Qian; Yuan Lin; Zhide Fang; Jovanny Zabaleta; Luis Del Valle; Jennifer J. Hu; Diptasri Mandal; Wanguo Liu

Doi: 10.1158/1541-7786.MCR-21-0874

Research Article

Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T-cell Immunotherapy against Cancer

Yong Gu Lee; Puneeth Guruprasad; Guido Ghilardi; Raymone Pajarillo; Christopher Tor Sauter; Ruchi Patel; Hatcher J. Ballard; Seok Jae Hong; Inkook Chun; Nicholas Yang; Kimberly V. Amelsberg; Katherine D. Cummins; Jakub Svoboda; Saar Gill; Elise A. Chong; Khrystyna North; Sarah E. Church; Joseph A. Fraietta; Wan-Jung Chang; Simon F. Lacey; Xueqing Maggie Lu; Yunlin Zhang; Kanupriya Whig; David C. Schultz; Sara Cherry; James Gerson; Stephen J. Schuster; Patrizia Porazzi; Marco Ruella

Doi: 10.1158/2159-8290.CD-21-1026

Research Article

GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma

Sawako Suzuki; Divya Venkatesh; Hiroaki Kanda; Akitoshi Nakayama; Hiroyuki Hosokawa; Eunyoung Lee; Takashi Miki; Brent R. Stockwell; Koutaro Yokote; Tomoaki Tanaka; Carol Prives

Doi: 10.1158/0008-5472.CAN-21-3914

Research Article

NetrinG1⁺ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress

Kristopher S. Raghavan; Ralph Francescone; Janusz Franco-Barraza; Jaye C. Gardiner; Débora B. Vendramini-Costa; Tiffany Luong; Narges Pourmandi; Anthony Andren; Alison Kurimchak; Charline Ogier; Paul M. Campbell; James S. Duncan; Costas A. Lyssiotis; Lucia R. Languino; Edna Cukierman

Doi: 10.1158/2767-9764.CRC-21-0147

Research Article

Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor–Induced Synthetic Lethality

Anand V.R. Kornepati; Jacob T. Boyd; Clare E. Murray; Julia Saifetiarova; Bárbara de la Peña Avalos; Cody M. Rogers; Haiyan Bai; Alvaro S. Padron; Yiji Liao; Carlos Ontiveros; Robert S. Svatek; Robert Hromas; Rong Li; Yanfen Hu; Jose R. Conejo-Garcia; Ratna K. Vadlamudi; Weixing Zhao; Eloïse Dray; Patrick Sung; Tyler J. Curiel

Doi: 10.1158/0008-5472.CAN-21-2076

Research Article

Pharmacologic Reduction of Mitochondrial Iron Triggers a Noncanonical BAX/BAK-Dependent Cell Death

Sylvain Garciaz; Andrew A. Guirguis; Sebastian Müller; Fiona C. Brown; Yih-Chih Chan; Ali Motazedian; Caitlin L. Rowe; James A. Kuzich; Kah Lok Chan; Kevin Tran; Lorey Smith; Laura MacPherson; Brian Liddicoat; Enid Y.N. Lam; Tatiana Cañeque; Marian L. Burr; Véronique Litalien; Giovanna Pomilio; Mathilde Poplineau; Estelle Duprez; Sarah-Jane Dawson; Georg Ramm; Andrew G. Cox; Kristin K. Brown; David C.S. Huang; Andrew H. Wei; Kate McArthur; Raphaël Rodriguez; Mark A. Dawson

Doi: 10.1158/2159-8290.CD-21-0522