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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Polymorphic Microbiomes

Research Article

Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma

Vinay Jain; Divyashri Baraniya; Doaa E. El-Hadedy; Tsute Chen; Michael Slifker; Fadhl Alakwaa; Kathy Q. Cai; Kumaraswamy N. Chitrala; Christopher Fundakowski; Nezar N. Al-Hebshi

Doi: 10.1158/2767-9764.CRC-22-0349

Research Article

Fusobacterium nucleatum Load Correlates with KRAS Mutation and Sessile Serrated Pathogenesis in Colorectal Adenocarcinoma

Koki Takeda; Minoru Koi; Yoshiki Okita; Sija Sajibu; Temitope O. Keku; John M. Carethers

Doi: 10.1158/2767-9764.CRC-23-0179

Translational Cancer Mechanisms and Therapy

Modulating Gut Microbiota Prevents Anastomotic Leak to Reduce Local Implantation and Dissemination of Colorectal Cancer Cells after Surgery

Roy Hajjar; Manon Oliero; Gabriela Fragoso; Ayodeji Samuel Ajayi; Ahmed Amine Alaoui; Hervé Vennin Rendos; Annie Calvé; Thibault Cuisiniere; Claire Gerkins; Sophie Thérien; Nassima Taleb; François Dagbert; Herawaty Sebajang; Rasmy Loungnarath; Frank Schwenter; Richard Ratelle; Ramses Wassef; Eric De Broux; Carole Richard; Manuela M. Santos

Doi: 10.1158/1078-0432.CCR-23-1601

Translational Cancer Mechanisms and Therapy

Short-Chain Fatty Acid Production by Gut Microbiota Predicts Treatment Response in Multiple Myeloma

Alba Rodríguez-García; Andrés Arroyo; Roberto García-Vicente; María Luz Morales; Rubén Gómez-Gordo; Pablo Justo; Clara Cuéllar; José Sánchez-Pina; Nieves López; Rafael Alonso; Noemí Puig; María-Victoria Mateos; Rosa Ayala; Dulcenombre Gómez-Garre; Joaquín Martínez-López; María Linares

Doi: 10.1158/1078-0432.CCR-23-0195

Translational Cancer Biology

Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Hong Wu; Xuefeng Leng; Qianshi Liu; Tianqin Mao; Tao Jiang; Yiqiang Liu; Feifei Li; Chenhui Cao; Jun Fan; Liang Chen; Yaqi Chen; Quan Yao; Shun Lu; Renchuan Liang; Lanlin Hu; Mingxin Liu; Yejian Wan; Zhaoshen Li; Jun Peng; Qiyu Luo; Hang Zhou; Jun Yin; Ke Xu; Mei Lan; Xinhao Peng; Haitao Lan; Gang Li; Yongtao Han; Xia Zhang; Zhi-Xiong Jim Xiao; Jinyi Lang; Guihua Wang; Chuan Xu

Doi: 10.1158/0008-5472.CAN-22-2593

Convergence Science

Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression

Qiuhua Cao; Mingrui Zhao; Yali Su; Siliang Liu; Yanting Lin; Huijuan Da; Chongxiu Yue; Yiming Liu; Dongquan Jing; Qixiang Zhao; Ning Liu; Juan Du; Zhanjie Zuo; Yao Fu; Anqi Chen; Lutz Birnbaumer; Yong Yang; Beiying Dai; Xinghua Gao

Doi: 10.1158/0008-5472.CAN-22-3705

Cancer Hallmarks Review

The Role of the Gut Microbiome in Hematological Cancers

Najihah Hussein; Reena Rajasuriar; Asif M. Khan; Yvonne Ai-Lian Lim; Gin Gin Gan

Doi: 10.1158/1541-7786.MCR-23-0080

Research Article

Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy

Natalia Szóstak; Luiza Handschuh; Anna Samelak-Czajka; Katarzyna Tomela; Bernadeta Pietrzak; Marcin Schmidt; Łukasz Galus; Jacek Mackiewicz; Andrzej Mackiewicz; Piotr Kozlowski; Anna Philips

Doi: 10.1158/2326-6066.CIR-23-0592

Research Article

The Salivary Microbiome and Predicted Metabolite Production Are Associated with Barrett's Esophagus and High-Grade Dysplasia or Adenocarcinoma

Quinn S. Solfisburg; Federico Baldini; Brittany Baldwin-Hunter; George I. Austin; Harry H. Lee; Heekuk Park; Daniel E. Freedberg; Charles J. Lightdale; Tal Korem; Julian A. Abrams

Doi: 10.1158/1055-9965.EPI-23-0652

Minireview

The Breast Microbiome in Breast Cancer Risk and Progression: A Narrative Review

Brandilyn A. Peters; Libusha Kelly; Tao Wang; Olivier Loudig; Thomas E. Rohan

Doi: 10.1158/1055-9965.EPI-23-0965

Research Article

Early-onset Colon Cancer Shows a Distinct Intestinal Microbiome and a Host–Microbe Interaction

Darbaz Adnan; Jonathan Q. Trinh; Deepak Sharma; Muhammad Alsayid; Faraz Bishehsari

Doi: 10.1158/1940-6207.CAPR-23-0091

Review

TIME for Bugs: The Immune Microenvironment and Microbes in Precancer

Mikayla Borthwick Bowen; Beth A. Helmink; Jennifer A. Wargo; Melinda S. Yates

Doi: 10.1158/1940-6207.CAPR-23-0087

Review

Oral Bacterial Contributions to Gingival Carcinogenesis and Progression

Kohei Okuyama; Souichi Yanamoto

Doi: 10.1158/1940-6207.CAPR-22-0511

Minireview

Vaccination and Microbiota Manipulation Approaches for Colon Cancer Prevention in Rodent Models

Elena Tosti; Nityanand Srivastava; Winfried Edelmann

Doi: 10.1158/1940-6207.CAPR-23-0015

Review

Microbiota Influences on Hematopoiesis and Blood Cancers: New Horizons?

Jessica R. Galloway-Pena; Christian Jobin

Doi: 10.1158/2643-3230.BCD-22-0172

Review

Oral bacterial contributions to gingival carcinogenesis and progression

Kohei Okuyama; Souichi Yanamoto

Doi: 10.1158/1940-6207.CAPR-22-0511

Review

Harnessing Microbiota to Improve Immunotherapy for Gastrointestinal Cancers

Jeremy Goc; Gregory F. Sonnenberg

Doi: 10.1158/2326-6066.CIR-22-0164

Controversy & Consensus

Fusobacterium and Colorectal Cancer: Important Association or Random Coincidence?

Blake E. Sanders; Guanxi Qiao; Matthew Meyerson

Doi: 10.1158/0008-5472.CAN-22-0099

Research Article

Microbes Contribute to Chemopreventive Efficacy, Intestinal Tumorigenesis, and the Metabolome

Carmen R. Ferrara; Ji Dong K. Bai; Erin M. McNally; Gregory G. Putzel; Xi Kathy Zhou; Hanhan Wang; Alan Lang; Deborah Nagle; Paula Denoya; Jan Krumsiek; Andrew J. Dannenberg; David C. Montrose

Doi: 10.1158/1940-6207.CAPR-22-0244

Research Article

Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer

Laura M. Chambers; Emily L. Esakov Rhoades; Rashmi Bharti; Chad Braley; Surabhi Tewari; Lexie Trestan; Zahraa Alali; Defne Bayik; Justin D. Lathia; Naseer Sangwan; Peter Bazeley; Amy S. Joehlin-Price; Zeneng Wang; Sumita Dutta; Mohammed Dwidar; Adeline Hajjar; Philip P. Ahern; Jan Claesen; Peter Rose; Roberto Vargas; J. Mark Brown; Chad M. Michener; Ofer Reizes

Doi: 10.1158/0008-5472.CAN-22-0455

Research Article

Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR+ Breast Tumors

Tzu-Yu Feng; Francesca N. Azar; Sally A. Dreger; Claire Buchta Rosean; Mitchell T. McGinty; Audrey M. Putelo; Sree H. Kolli; Maureen A. Carey; Stephanie Greenfield; Wesley J. Fowler; Stephen D. Robinson; Melanie R. Rutkowski

Doi: 10.1158/2326-6066.CIR-21-1120

Research Article

Pan-Cancer Analysis of Microbiome Quantitative Trait Loci

Can Chen; Yimin Cai; Yizhuo Liu; Shuoni Chen; Yanmin Li; Fuwei Zhang; Ming Zhang; Zequn Lu; Pingting Ying; Jinyu Huang; Linyun Fan; Xiaomin Cai; Caibo Ning; Wenzhuo Wang; Yuan Jiang; Heng Zhang; Shuhui Yang; Zhihua Wang; Xiaoyang Wang; Shaokai Zhang; Chaoqun Huang; Bin Xu; Zhenming Fu; Qibin Song; Mingjuan Jin; Kun Chen; Hongda Chen; Min Dai; Xiaoping Miao; Xiaojun Yang; Ying Zhu; Jianbo Tian

Doi: 10.1158/0008-5472.CAN-22-1854

Research Brief

Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice

Julia L. Drewes; Jie Chen; Nicholas O. Markham; Reece J. Knippel; Jada C. Domingue; Ada J. Tam; June L. Chan; Lana Kim; Madison McMann; Courtney Stevens; Christine M. Dejea; Sarah Tomkovich; John Michel; James R. White; Fuad Mohammad; Victoria L. Campodónico; Cody N. Heiser; Xinqun Wu; Shaoguang Wu; Hua Ding; Patricia Simner; Karen Carroll; Martha J. Shrubsole; Robert A. Anders; Seth T. Walk; Christian Jobin; Fengyi Wan; Robert J. Coffey; Franck Housseau; Ken S. Lau; Cynthia L. Sears

Doi: 10.1158/2159-8290.CD-21-1273

Research Article

Periodontal and Other Oral Bacteria and Risk of Lung Cancer in the Atherosclerosis Risk in Communities (ARIC) Study

Baijun Zhou; Jiayun Lu; James D. Beck; Kevin L. Moss; Anna E. Prizment; Ryan T. Demmer; Kori A. Porosnicu Rodriguez; Corinne E. Joshu; Dominique S. Michaud; Elizabeth A. Platz

Doi: 10.1158/1055-9965.EPI-22-0601

Research Article

The Vaginal Microbiome is Associated with Endometrial Cancer Grade and Histology

Hesamedin Hakimjavadi; Sophia H. George; Michael Taub; Leah V. Dodds; Alex P. Sanchez-Covarrubias; Marilyn Huang; J. Matt Pearson; Brian M. Slomovitz; Erin N. Kobetz; Raad Gharaibeh; Ramlogan Sowamber; Andre Pinto; Srikar Chamala; Matthew P. Schlumbrecht

Doi: 10.1158/2767-9764.CRC-22-0075

Research Article

Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy

Hirotaka Kawanabe-Matsuda; Kazuyoshi Takeda; Marie Nakamura; Seiya Makino; Takahiro Karasaki; Kazuhiro Kakimi; Megumi Nishimukai; Tatsukuni Ohno; Jumpei Omi; Kuniyuki Kano; Akiharu Uwamizu; Hideo Yagita; Ivo Gomperts Boneca; Gérard Eberl; Junken Aoki; Mark J. Smyth; Ko Okumura

Doi: 10.1158/2159-8290.CD-21-0929

Research Article

Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis that Contributes to Carcinogenesis

Satoru Yonekura; Safae Terrisse; Carolina Alves Costa Silva; Antoine Lafarge; Valerio Iebba; Gladys Ferrere; Anne-Gaëlle Goubet; Jean-Eudes Fahrner; Imran Lahmar; Kousuke Ueda; Gibrail Mansouri; Eugénie Pizzato; Pierre Ly; Marine Mazzenga; Cassandra Thelemaque; Marine Fidelle; Fanny Jaulin; Jérôme Cartry; Marc Deloger; Marine Aglave; Nathalie Droin; Paule Opolon; Angélique Puget; Fanny Mann; Michel Neunlist; Anne Bessard; Laetitia Aymeric; Tamara Matysiak-Budnik; Jacques Bosq; Paul Hofman; Connie P.M. Duong; Sophie Ugolini; Valentin Quiniou; Sylvie Berrard; Bernhard Ryffel; Oliver Kepp; Guido Kroemer; Bertrand Routy; Leonardo Lordello; Mohamed-Amine Bani; Nicola Segata; Fjodor Yousef Yengej; Hans Clevers; Jean-Yves Scoazec; Edoardo Pasolli; Lisa Derosa; Laurence Zitvogel

Doi: 10.1158/2159-8290.CD-21-0999

Research Article

A Natural Polyphenol Exerts Antitumor Activity and Circumvents Anti–PD-1 Resistance through Effects on the Gut Microbiota

Meriem Messaoudene; Reilly Pidgeon; Corentin Richard; Mayra Ponce; Khoudia Diop; Myriam Benlaifaoui; Alexis Nolin-Lapalme; Florent Cauchois; Julie Malo; Wiam Belkaid; Stephane Isnard; Yves Fradet; Lharbi Dridi; Dominique Velin; Paul Oster; Didier Raoult; François Ghiringhelli; Romain Boidot; Sandy Chevrier; David T. Kysela; Yves V. Brun; Emilia Liana Falcone; Geneviève Pilon; Florian Plaza Oñate; Oscar Gitton-Quent; Emmanuelle Le Chatelier; Sylvere Durand; Guido Kroemer; Arielle Elkrief; André Marette; Bastien Castagner; Bertrand Routy

Doi: 10.1158/2159-8290.CD-21-0808

Research Article

Tumor Necrosis Factor-α–Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer

Yunwei Lou; Miaomiao Song; Meijuan Han; Jiateng Zhong; Xueqin Tian; Yahan Ren; Yaru Song; Liangwei Duan; Peiqing Zhao; Xiangfeng Song; Wen Zhang; Youhai H. Chen; Hui Wang

Doi: 10.1158/2326-6066.CIR-21-0666

Research Article

Gut Microbiome–Dependent Metabolic Pathways and Risk of Lethal Prostate Cancer: Prospective Analysis of a PLCO Cancer Screening Trial Cohort

Chad A. Reichard; Bryan D. Naelitz; Zeneng Wang; Xun Jia; Jianbo Li; Meir J. Stampfer; Eric A. Klein; Stanley L. Hazen; Nima Sharifi

Doi: 10.1158/1055-9965.EPI-21-0766

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