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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Nonmutational Epigenetic Reprogramming

Research Article

Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer

Giacomo Grillo; Tina Keshavarzian; Simon Linder; Christopher Arlidge; Lisanne Mout; Ankita Nand; Mona Teng; Aditi Qamra; Stanley Zhou; Ken J. Kron; Alex Murison; James R. Hawley; Michael Fraser; Theodorus H. van der Kwast; Ganesh V. Raj; Housheng Hansen He; Wilbert Zwart; Mathieu Lupien

Doi: 10.1158/2159-8290.CD-23-0331

Research Article

Long-term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells

Dalia Rosano; Emre Sofyali; Heena Dhiman; Chiara Ghirardi; Diana Ivanoiu; Timon Heide; Andrea Vingiani; Alessia Bertolotti; Giancarlo Pruneri; Eleonora Canale; Hannah F. Dewhurst; Debjani Saha; Neil Slaven; Iros Barozzi; Tong Li; Grigory Zemlyanskiy; Henry Phillips; Chela James; Balázs Győrffy; Claire Lynn; George D. Cresswell; Farah Rehman; Roberta Noberini; Tiziana Bonaldi; Andrea Sottoriva; Luca Magnani

Doi: 10.1158/2159-8290.CD-23-1161

Research Article

Single-Cell Chromatin Accessibility Analysis Reveals the Epigenetic Basis and Signature Transcription Factors for the Molecular Subtypes of Colorectal Cancers

Zhenyu Liu; Yuqiong Hu; Haoling Xie; Kexuan Chen; Lu Wen; Wei Fu; Xin Zhou; Fuchou Tang

Doi: 10.1158/2159-8290.CD-23-1445

Research Article

Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Anne-Sophie Sertier; Anthony Ferrari; Roxane M. Pommier; Isabelle Treilleux; Sandrine Boyault; Mojgan Devouassoux-Shisheboran; Janice Kielbassa; Emilie Thomas; Laurie Tonon; Vincent Le Texier; Amandine Charreton; Anne-Pierre Morel; Anne Floquet; Florence Joly; Dominique Berton-Rigaud; Gwenaël Ferron; Laurent Arnould; Sabrina Croce; Guillaume Bataillon; Pierre Saintigny; Eliane Mery-Lamarche; Christine Sagan; Aruni P. Senaratne; Ivo G. Gut; Fabien Calvo; Alain Viari; Maria Ouzounova; Isabelle Ray-Coquard; Alain Puisieux

Doi: 10.1158/2767-9764.CRC-22-0520

Research Article

Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557–558 Deletion Mutations

Keiichi Ohshima; Takeshi Nagashima; Keiichi Fujiya; Keiichi Hatakeyama; Yuko Watanabe; Kimiko Morimoto; Fukumi Kamada; Yuji Shimoda; Sumiko Ohnami; Akane Naruoka; Masakuni Serizawa; Shumpei Ohnami; Hirotsugu Kenmotsu; Akio Shiomi; Yasuhiro Tsubosa; Etsuro Bando; Teiichi Sugiura; Takashi Sugino; Masanori Terashima; Katsuhiko Uesaka; Kenichi Urakami; Yasuto Akiyama; Ken Yamaguchi

Doi: 10.1158/2767-9764.CRC-22-0364

Translational Cancer Biology

LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer

Muqing Li; Mingyu Liu; Wanting Han; Zifeng Wang; Dong Han; Susan Patalano; Jill A. Macoska; Steven P. Balk; Housheng Hansen He; Eva Corey; Shuai Gao; Changmeng Cai

Doi: 10.1158/0008-5472.CAN-22-2433

Genome and Epigenome

KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Hong Qiu; Vladimir Makarov; Jennifer K. Bolzenius; Angela Halstead; Yvonne Parker; Allen Wang; Gopakumar V. Iyer; Hannah Wise; Daniel Kim; Varna Thayaparan; Daniel J. Lindner; Georges-Pascal Haber; Angela H. Ting; Bing Ren; Timothy A. Chan; Vivek Arora; David B. Solit; Byron H. Lee

Doi: 10.1158/0008-5472.CAN-22-1444

Cancer Hallmarks Review

Chromatin Remodelers Are Regulators of the Tumor Immune Microenvironment

Apoorvi Chaudhri; Gregory Lizee; Patrick Hwu; Kunal Rai

Doi: 10.1158/0008-5472.CAN-23-2244

Cancer Genes and Networks

Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma

Xin Wang; Ana P. Kutschat; Joana Aggrey-Fynn; Feda H. Hamdan; Rondell P. Graham; Alexander Q. Wixom; Yara Souto; Swetlana Ladigan-Badura; Jennifer A. Yonkus; Amro M. Abdelrahman; Roberto Alva-Ruiz; Jochen Gaedcke; Philipp Ströbel; Robyn Laura Kosinsky; Florian Wegwitz; Patrick Hermann; Mark J. Truty; Jens T. Siveke; Stephan A. Hahn; Elisabeth Hessmann; Steven A. Johnsen; Zeynab Najafova

Doi: 10.1158/1541-7786.MCR-22-0916

New Horizons in Cancer Biology

FOXA1 Reprogramming Dictates Retinoid X Receptor Response in ESR1-Mutant Breast Cancer

Yang Wu; Zheqi Li; Abdalla M. Wedn; Allison N. Casey; Daniel Brown; Shalini V. Rao; Soleilmane Omarjee; Jagmohan Hooda; Jason S. Carroll; Jason Gertz; Jennifer M. Atkinson; Adrian V. Lee; Steffi Oesterreich

Doi: 10.1158/1541-7786.MCR-22-0516

Research Article

Antigen Priming Induces Functional Reprogramming in iNKT Cells via Metabolic and Epigenetic Regulation: An Insight into iNKT Cell-Based Antitumor Immunotherapy

Huimin Zhang; Sanwei Chen; Yuwei Zhang; Chenxi Tian; Jun Pan; Yu Wang; Shiyu Bai; Qielan Wu; Miya Su; Di Xie; Sicheng Fu; Shuhang Li; Jing Zhang; Yusheng Chen; Shasha Zhu; Yeben Qian; Li Bai

Doi: 10.1158/2326-6066.CIR-23-0448

Research Article

Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma

Seth J. Welsh; Benjamin G. Barwick; Erin W. Meermeier; Daniel L. Riggs; Chang-Xin Shi; Yuan Xiao Zhu; Meaghen E. Sharik; Megan T. Du; Leslie D. Abrego Rocha; Victoria M. Garbitt; Caleb K. Stein; Joachim L. Petit; Nathalie Meurice; Yuliza Tafoya Alvarado; Rodrigo Fonseca; Kennedi T. Todd; Sochilt Brown; Zachery J. Hammond; Nicklus H. Cuc; Courtney Wittenberg; Camille Herzog; Anna V. Roschke; Yulia N. Demchenko; Wei-dong D. Chen; Peng Li; Wei Liao; Warren J. Leonard; Sagar Lonial; Nizar J. Bahlis; Paola Neri; Lawrence H. Boise; Marta Chesi; P. Leif Bergsagel

Doi: 10.1158/2643-3230.BCD-23-0062

Research Article

ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma

Paola Neri; Benjamin G. Barwick; David Jung; Jonathan C. Patton; Ranjan Maity; Ines Tagoug; Caleb K. Stein; Remi Tilmont; Noemie Leblay; Sungwoo Ahn; Holly Lee; Seth J. Welsh; Daniel L. Riggs; Nicholas Stong; Erin Flynt; Anjan Thakurta; Jonathan J. Keats; Sagar Lonial; P. Leif Bergsagel; Lawrence H. Boise; Nizar J. Bahlis

Doi: 10.1158/2643-3230.BCD-23-0061

Research Article

Human ASXL1-mutant hematopoiesis is driven by a truncated protein associated with aberrant de-ubiquitination of H2AK119

Thomas Kohnke; Kevin A. Nuno; Catherine C. Alder; Eric J. Gars; Paul Phan; Amy C. Fan; Ravindra Majeti

Doi: 10.1158/2643-3230.BCD-23-0235

Small Molecule Therapeutics

Microtubule-Targeting Combined with HDAC Inhibition Is a Novel Therapeutic Strategy for Diffuse Intrinsic Pontine Gliomas

Anahid Ehteda; Aaminah Khan; Gayathiri Rajakumar; Anne S. Vanniasinghe; Anjana Gopalakrishnan; Jie Liu; Maria Tsoli; David S. Ziegler

Doi: 10.1158/1535-7163.MCT-23-0179

Research Article

Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors

Meghan E. Muse; Connolly D. Carroll; Lucas A. Salas; Margaret R. Karagas; Brock C. Christensen

Doi: 10.1158/1055-9965.EPI-22-0405

Research Article

The Impact of Inherited Genetic Variation on DNA Methylation in Prostate Cancer and Benign Tissues of African American and European American Men

Dayana Delgado; Marc Gillard; Lin Tong; Kathryn Demanelis; Meritxell Oliva; Kevin J. Gleason; Meytal Chernoff; Lin Chen; Gladell P. Paner; Donald Vander Griend; Brandon L. Pierce

Doi: 10.1158/1055-9965.EPI-23-0849

Research Article

Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells

Pochung Jordan Chou; Md Shahid Sarwar; Lujing Wang; Renyi Wu; Shanyi Li; Rasika R. Hudlikar; Yujue Wang; Xiaoyang Su; Ah-Ng Kong

Doi: 10.1158/1940-6207.CAPR-22-0384

Review

Small non-coding RNAs in Soft Tissue Sarcomas: State of the Art and Future Directions

Alessandro La Ferlita; Nipin Sp; Marina Goryunova; Giovanni Nigita; Raphael E. Pollock; Carlo M. Croce; Joal D. Beane

Doi: 10.1158/1541-7786.MCR-22-1008

Review

The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy

Goran Micevic; Marcus W. Bosenberg; Qin Yan

Doi: 10.1158/1078-0432.CCR-22-0784

CR Landmarks

Early Insights into Cancer Epigenetics: Gene Promoter Hypermethylation Emerges as a Potential Biomarker for Cancer Detection

Susan J. Clark; Peter L. Molloy

Doi: 10.1158/0008-5472.CAN-22-0657

Review

B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers

Tabitha McLachlan; William C. Matthews; Evangeline R. Jackson; Dilana E. Staudt; Alicia M. Douglas; Izac J. Findlay; Mika L. Persson; Ryan J. Duchatel; Abdul Mannan; Zacary P. Germon; Matthew D. Dun

Doi: 10.1158/1541-7786.MCR-22-0567

Research Article

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma

Eshini Panditharatna; Joana G. Marques; Tingjian Wang; Maria C. Trissal; Ilon Liu; Li Jiang; Alexander Beck; Andrew Groves; Neekesh V. Dharia; Deyao Li; Samantha E. Hoffman; Guillaume Kugener; McKenzie L. Shaw; Hafsa M. Mire; Olivia A. Hack; Joshua M. Dempster; Caleb Lareau; Lingling Dai; Logan H. Sigua; Michael A. Quezada; Ann-Catherine J. Stanton; Meghan Wyatt; Zohra Kalani; Amy Goodale; Francisca Vazquez; Federica Piccioni; John G. Doench; David E. Root; Jamie N. Anastas; Kristen L. Jones; Amy Saur Conway; Sylwia Stopka; Michael S. Regan; Yu Liang; Hyuk-Soo Seo; Kijun Song; Puspalata Bashyal; William P. Jerome; Nathan D. Mathewson; Sirano Dhe-Paganon; Mario L. Suvà; Angel M. Carcaboso; Cinzia Lavarino; Jaume Mora; Quang-De Nguyen; Keith L. Ligon; Yang Shi; Sameer Agnihotri; Nathalie Y.R. Agar; Kimberly Stegmaier; Charles D. Stiles; Michelle Monje; Todd R. Golub; Jun Qi; Mariella G. Filbin

Doi: 10.1158/2159-8290.CD-21-1491

Research Article

Epigenome Programming by H3.3K27M Mutation Creates a Dependence of Pediatric Glioma on SMARCA4

Yan Mo; Shoufu Duan; Xu Zhang; Xu Hua; Hui Zhou; Hong-Jian Wei; Jun Watanabe; Nicholas McQuillan; Zhenyi Su; Wei Gu; Cheng-Chia Wu; Christopher R. Vakoc; Rintaro Hashizume; Kenneth Chang; Zhiguo Zhang

Doi: 10.1158/2159-8290.CD-21-1492

Research Article

Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 Stabilization and Chromatin Condensation

Laure Maneix; Polina Iakova; Shannon E. Moree; Joanne I. Hsu; Ragini M. Mistry; Fabio Stossi; Premal Lulla; Zheng Sun; Ergun Sahin; Sarvari V. Yellapragada; André Catic

Doi: 10.1158/2767-9764.CRC-22-0255

Research Article

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Martin Sjöström; Shuang G. Zhao; Samuel Levy; Meng Zhang; Yuhong Ning; Raunak Shrestha; Arian Lundberg; Cameron Herberts; Adam Foye; Rahul Aggarwal; Junjie T. Hua; Haolong Li; Anna Bergamaschi; Corinne Maurice-Dror; Ashutosh Maheshwari; Sujun Chen; Sarah W.S. Ng; Wenbin Ye; Jessica Petricca; Michael Fraser; Lisa Chesner; Marc D. Perry; Thaidy Moreno-Rodriguez; William S. Chen; Joshi J. Alumkal; Jonathan Chou; Alicia K. Morgans; Tomasz M. Beer; George V. Thomas; Martin Gleave; Paul Lloyd; Tierney Phillips; Erin McCarthy; Michael C. Haffner; Amina Zoubeidi; Matti Annala; Robert E. Reiter; Matthew B. Rettig; Owen N. Witte; Lawrence Fong; Rohit Bose; Franklin W. Huang; Jianhua Luo; Anders Bjartell; Joshua M. Lang; Nupam P. Mahajan; Primo N. Lara; Christopher P. Evans; Phuoc T. Tran; Edwin M. Posadas; Chuan He; Xiao-Long Cui; Jiaoti Huang; Wilbert Zwart; Luke A. Gilbert; Christopher A. Maher; Paul C. Boutros; Kim N. Chi; Alan Ashworth; Eric J. Small; Housheng H. He; Alexander W. Wyatt; David A. Quigley; Felix Y. Feng

Doi: 10.1158/0008-5472.CAN-22-1123

Research Article

Association Study between Polymorphisms in DNA Methylation–Related Genes and Testicular Germ Cell Tumor Risk

Chiara Grasso; Maja Popovic; Elena Isaevska; Fulvio Lazzarato; Valentina Fiano; Daniela Zugna; John Pluta; Benita Weathers; Kurt D'Andrea; Kristian Almstrup; Lynn Anson-Cartwright; D. Timothy Bishop; Stephen J. Chanock; Chu Chen; Victoria K. Cortessis; Marlene D. Dalgaard; Siamak Daneshmand; Alberto Ferlin; Carlo Foresta; Megan N. Frone; Marija Gamulin; Jourik A. Gietema; Mark H. Greene; Tom Grotmol; Robert J. Hamilton; Trine B. Haugen; Russ Hauser; Robert Karlsson; Lambertus A. Kiemeney; Davor Lessel; Patrizia Lista; Ragnhild A. Lothe; Chey Loveday; Coby Meijer; Kevin T. Nead; Jérémie Nsengimana; Rolf I. Skotheim; Clare Turnbull; David J. Vaughn; Fredrik Wiklund; Tongzhang Zheng; Andrea Zitella; Stephen M. Schwartz; Katherine A. McGlynn; Peter A. Kanetsky; Katherine L. Nathanson; Lorenzo Richiardi; the Testicular Cancer Consortium

Doi: 10.1158/1055-9965.EPI-22-0123

Research Article

Reversing the Genomic, Epigenetic, and Triple-Negative Breast Cancer–Enhancing Effects of Obesity

Laura W. Bowers; Steven S. Doerstling; Meghana G. Shamsunder; Claire G. Lineberger; Emily L. Rossi; Stephanie A. Montgomery; Michael F. Coleman; Weida Gong; Joel S. Parker; Anthony Howell; Michelle Harvie; Stephen D. Hursting

Doi: 10.1158/1940-6207.CAPR-22-0113

Research Article

Developmental Pathways Are Epigenetically Reprogrammed during Lung Cancer Brain Metastasis

Jennifer A. Karlow; Siddhartha Devarakonda; Xiaoyun Xing; Hyo Sik Jang; Ramaswamy Govindan; Mark Watson; Ting Wang

Doi: 10.1158/0008-5472.CAN-21-4160

Research Article

KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer

Heng Liu; Jianhuang Lin; Wei Zhou; Renyta Moses; Zhongping Dai; Andrew V. Kossenkov; Ronny Drapkin; Benjamin G. Bitler; Sergey Karakashev; Rugang Zhang

Doi: 10.1158/2326-6066.CIR-22-0088

Research Article

MOZ and Menin–MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

Matthew L. Hemming; Morgan R. Benson; Michael A. Loycano; Justin A. Anderson; Jessica L. Andersen; Madeleine L. Taddei; Andrei V. Krivtsov; Brandon J. Aubrey; Jevon A. Cutler; Charlie Hatton; Ewa Sicinska; Scott A. Armstrong

Doi: 10.1158/2159-8290.CD-21-0646

Research Article

Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer

Kyung-min Lee; Chang-Ching Lin; Alberto Servetto; Joonbeom Bae; Vishal Kandagatla; Dan Ye; GunMin Kim; Dhivya R. Sudhan; Saurabh Mendiratta; Paula I. González Ericsson; Justin M. Balko; Jeon Lee; Spencer Barnes; Venkat S. Malladi; Siamak Tabrizi; Sangeetha M. Reddy; Seoyun Yum; Ching-Wei Chang; Katherine E. Hutchinson; Susan E. Yost; Yuan Yuan; Zhijian J. Chen; Yang-Xin Fu; Ariella B. Hanker; Carlos L. Arteaga

Doi: 10.1158/2326-6066.CIR-21-0826

Research Article

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M. Salmon; Izabela Todorovski; Kym L. Stanley; Claudia Bruedigam; Conor J. Kearney; Luciano G. Martelotto; Fernando Rossello; Timothy Semple; Gisela Mir Arnau; Magnus Zethoven; Michael Bots; Stefan Bjelosevic; Leonie A. Cluse; Peter J. Fraser; Veronique Litalien; Eva Vidacs; Kate McArthur; Antony Y. Matthews; Elise Gressier; Nicole A. de Weerd; Jens Lichte; Madison J. Kelly; Simon J. Hogg; Paul J. Hertzog; Lev M. Kats; Stephin J. Vervoort; Daniel D. De Carvalho; Stefanie Scheu; Sammy Bedoui; Benjamin T. Kile; Steven W. Lane; Andrew C. Perkins; Andrew H. Wei; Pilar M. Dominguez; Ricky W. Johnstone

Doi: 10.1158/2159-8290.CD-20-1145

Research Article

MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

Atrayee Bhattacharya; Atsushi Fushimi; Nami Yamashita; Masayuki Hagiwara; Yoshihiro Morimoto; Hasan Rajabi; Mark D. Long; Maha Abdulla; Rehan Ahmad; Kelly Street; Song Liu; Tao Liu; Donald Kufe

Doi: 10.1158/1541-7786.MCR-21-0672

Research Article

Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer

Luigi Ippolito; Giuseppina Comito; Matteo Parri; Marta Iozzo; Assia Duatti; Francesca Virgilio; Nicla Lorito; Marina Bacci; Elisa Pardella; Giada Sandrini; Francesca Bianchini; Roberta Damiano; Lavinia Ferrone; Giancarlo la Marca; Sergio Serni; Pietro Spatafora; Carlo V. Catapano; Andrea Morandi; Elisa Giannoni; Paola Chiarugi

Doi: 10.1158/0008-5472.CAN-21-0914

Research Article

BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes

Eva J. Schaefer; Helen C. Wang; Hannah Q. Karp; Clifford A. Meyer; Paloma Cejas; Micah D. Gearhart; Emmalee R. Adelman; Iman Fares; Annie Apffel; Klothilda Lim; Yingtian Xie; Christopher J. Gibson; Monica Schenone; H. Moses Murdock; Eunice S. Wang; Lukasz P. Gondek; Martin P. Carroll; Rahul S. Vedula; Eric S. Winer; Jacqueline S. Garcia; Richard M. Stone; Marlise R. Luskin; Steven A. Carr; Henry W. Long; Vivian J. Bardwell; Maria E. Figueroa; R. Coleman Lindsley

Doi: 10.1158/2643-3230.BCD-21-0115

Research Article

Identification and Targeting of the Developmental Blockade in Extranodal Natural Killer/T-cell Lymphoma

Bethany L. Mundy-Bosse; Christoph Weigel; Yue-Zhong Wu; Salma Abdelbaky; Youssef Youssef; Susana Beceiro Casas; Nicholas Polley; Gabrielle Ernst; Karen A. Young; Kathleen K. McConnell; Ansel P. Nalin; Kevin G. Wu; Megan Broughton; Matthew R. Lordo; Ekaterina Altynova; Everardo Hegewisch-Solloa; Daniel Y. Enriquez-Vera; Daniela Dueñas; Carlos Barrionuevo; Shan-Chi Yu; Atif Saleem; Carlos J. Suarez; Edward L. Briercheck; Hernan Molina-Kirsch; Thomas P. Loughran; Dieter Weichenhan; Christoph Plass; John C. Reneau; Emily M. Mace; Fabiola Valvert Gamboa; David M. Weinstock; Yasodha Natkunam; Michael A. Caligiuri; Anjali Mishra; Pierluigi Porcu; Robert A. Baiocchi; Jonathan E. Brammer; Aharon G. Freud; Christopher C. Oakes

Doi: 10.1158/2643-3230.BCD-21-0098

Priority Brief

PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner

Mi Zhou; Janet Y. Leung; Kathryn H. Gessner; Austin J. Hepperla; Jeremy M. Simon; Ian J. Davis; William Y. Kim

Doi: 10.1158/2326-6066.CIR-21-0480

Research Article

DNA Methylation Profiles of Ovarian Clear Cell Carcinoma

Julie M. Cunningham; Stacey J. Winham; Chen Wang; Britta Weiglt; Zhuxuan Fu; Sebastian M. Armasu; Bryan M. McCauley; Alison H. Brand; Yoke-Eng Chiew; Esther Elishaev; Charlie Gourley; Catherine J. Kennedy; Angela Laslavic; Jenny Lester; Anna Piskorz; Magdalena Sekowska; James D. Brenton; Michael Churchman; Anna DeFazio; Ronny Drapkin; Kevin M. Elias; David G. Huntsman; Beth Y. Karlan; Martin Köbel; Jason Konner; Kate Lawrenson; Elli Papaemmanuil; Kelly L. Bolton; Francesmary Modugno; Ellen L. Goode

Doi: 10.1158/1055-9965.EPI-21-0677

Research Article

BET Inhibition Enhances TNF-Mediated Antitumor Immunity

Lisa C. Wellinger; Simon J. Hogg; Dane M. Newman; Thomas Friess; Daniela Geiss; Jessica Michie; Kelly M. Ramsbottom; Marina Bacac; Tanja Fauti; Daniel Marbach; Laura Jarassier; Phillip Thienger; Axel Paehler; Leonie A. Cluse; Conor J. Kearney; Stephin J. Vervoort; Joseph A. Trapani; Jane Oliaro; Jake Shortt; Astrid Ruefli-Brasse; Daniel Rohle; Ricky W. Johnstone

Doi: 10.1158/2326-6066.CIR-21-0224

Research Article

Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma

Lucas A. Salas; Thomas G. Stewart; Bret C. Mobley; Chengwei Peng; Jing Liu; Sudan N. Loganathan; Jialiang Wang; Yanjun Ma; Mitchel S. Berger; Devin Absher; Yang Hu; Paul L. Moots; Brock C. Christensen; Stephen W. Clark

Doi: 10.1158/2767-9764.CRC-21-0088

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