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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Inducing or Accessing Vasculature

Research Article

Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression

Wen-Hao Hsu; Kyle A. LaBella; Yiyun Lin; Ping Xu; Rumi Lee; Cheng-En Hsieh; Lei Yang; Ashley Zhou; Jonathan M. Blecher; Chang-Jiun Wu; Kangyu Lin; Xiaoying Shang; Shan Jiang; Denise J. Spring; Yan Xia; Peiwen Chen; John Paul Shen; Scott Kopetz; Ronald A. DePinho

Doi: 10.1158/2159-8290.CD-22-1467

Research Article

Cancer-associated Fibroblast–specific Expression of the Matricellular Protein CCN1 Coordinates Neovascularization and Stroma Deposition in Melanoma Metastasis

James Hutchenreuther; John Nguyen; Katherine Quesnel; Krista M. Vincent; Louis Petitjean; Sophia Bourgeois; Mark Boyd; George Bou-Gharios; Lynne-Marie Postovit; Andrew Leask

Doi: 10.1158/2767-9764.CRC-23-0571

Research Article

A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors

Michael A. Carducci; Ding Wang; Christina Habermehl; Matthias Bödding; Felix Rohdich; Floriane Lignet; Klaus Duecker; Oleksandr Karpenko; Linda Pudelko; Claude Gimmi; Patricia LoRusso

Doi: 10.1158/2767-9764.CRC-23-0048

Tumor Biology and Immunology

Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization

Matthia A. Karreman; Alexander T. Bauer; Gergely Solecki; Anna S. Berghoff; Chanté D. Mayer; Katharina Frey; Nils Hebach; Manuel J. Feinauer; Nicole L. Schieber; Cedric Tehranian; Luc Mercier; Mahak Singhal; Varun Venkataramani; Marc C. Schubert; Daniel Hinze; Michael Hölzel; Iris Helfrich; Dirk Schadendorf; Stefan W. Schneider; Dana Westphal; Hellmut G. Augustin; Jacky G. Goetz; Yannick Schwab; Wolfgang Wick; Frank Winkler

Doi: 10.1158/0008-5472.CAN-22-3964

Cancer Biology

Angiopoietin-2–Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma

Ha-Ram Park; Anahita Shiva; Portia Cummings; Seoyeon Kim; Sungsoo Kim; Eunhyeong Lee; Alessandra Leong; Subrata Chowdhury; Carrie Shawber; Richard Carvajal; Gavin Thurston; Joon-Yong An; Amanda W. Lund; Hee Won Yang; Minah Kim

Doi: 10.1158/0008-5472.CAN-22-2838

Tumor Microenvironment and Immunobiology

Low- and High-Grade Glioma-Associated Vascular Cells Differentially Regulate Tumor Growth

Sree Deepthi Muthukrishnan; Haocheng Qi; David Wang; Lubayna Elahi; Amy Pham; Alvaro G. Alvarado; Tie Li; Fuying Gao; Riki Kawaguchi; Albert Lai; Harley I. Kornblum

Doi: 10.1158/1541-7786.MCR-23-1069

Research Article

Vasorin exocytosed from glioma cells facilitates angiogenesis via VEGFR2/AKT signaling pathway

Ying Zhong; Hui Kang; Ziqing Ma; Jiayu Li; Zixi Qin; Zixuan Zhang; Peiwen Li; Ying Zhong; Lihui Wang

Doi: 10.1158/1541-7786.MCR-23-0469

Research Article

Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer

Benedetta Donati; Francesca Reggiani; Federica Torricelli; Giacomo Santandrea; Teresa Rossi; Alessandra Bisagni; Elisa Gasparini; Antonino Neri; Laura Cortesi; Guglielmo Ferrari; Giancarlo Bisagni; Moira Ragazzi; Alessia Ciarrocchi

Doi: 10.1158/2326-6066.CIR-23-0076

Targeting Drug Resistance

Enhanced Antipediatric Sarcoma Effect of Everolimus with Secukinumab by Targeting IL17A

Dan Huang; Zhipeng Wu; Zhengyi Wu; Nuoya Li; Liang Hao; Kuangfan Li; Junquan Zeng; Bingbing Qiu; Shouhua Zhang; Jinlong Yan

Doi: 10.1158/1535-7163.MCT-23-0342

Research Article

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models

Manja Friese-Hamim; Maria J. Ortiz Ruiz; Olga Bogatyrova; Marina Keil; Felix Rohdich; Beatrix Blume; Birgitta Leuthner; Frank Czauderna; Diane Hahn; Julia Jabs; Frank Jaehrling; Timo Heinrich; Roland Kellner; Katherine Chan; Amy H.Y. Tong; Dirk Wienke; Jason Moffat; Andree Blaukat; Frank T. Zenke

Doi: 10.1158/1535-7163.MCT-23-0102

Companion Diagnostic, Pharmacogenomic, and Cancer Biomarkers

Amelioration of Tumor-promoting Microenvironment via Vascular Remodeling and CAF Suppression Using E7130: Biomarker Analysis by Multimodal Imaging Modalities

Ken Ito; Masayuki Yamaguchi; Taro Semba; Kimiyo Tabata; Moe Tamura; Muneo Aoyama; Takanori Abe; Osamu Asano; Yasuhiko Terada; Yasuhiro Funahashi; Hirofumi Fujii

Doi: 10.1158/1535-7163.MCT-23-0158

Research Article

Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study

Clara L. Lindley; Biljana Gigic; Anita R. Peoples; Claire J. Han; Tengda Lin; Caroline Himbert; Christy A. Warby; Juergen Boehm; Sheetal Hardikar; Anjelica Ashworth; Martin Schneider; Alexis Ulrich; Petra Schrotz-King; Jane C. Figueiredo; Christopher I. Li; David Shibata; Erin M. Siegel; Adetunji T. Toriola; Cornelia M. Ulrich; Karen L. Syrjala; Jennifer Ose

Doi: 10.1158/1055-9965.EPI-22-0882

Review

Immune Potential Untapped: Leveraging the Lymphatic System for Cancer Immunotherapy

Amanda W. Lund

Doi: 10.1158/2326-6066.CIR-22-0266

Research Article

Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages

Elisenda Alsina-Sanchis; Ronja Mülfarth; Iris Moll; Sarah Böhn; Lena Wiedmann; Lorea Jordana-Urriza; Tara Ziegelbauer; Eleni Zimmer; Jacqueline Taylor; Francesca De Angelis Rigotti; Adrian Stögbauer; Benedetto Daniele Giaimo; Adelheid Cerwenka; Tilman Borggrefe; Andreas Fischer; Juan Rodriguez-Vita

Doi: 10.1158/0008-5472.CAN-22-0076

Research Article

Three-dimensional Imaging Reveals Immune-driven Tumor-associated High Endothelial Venules as a Key Correlate of Tumor Rejection Following Depletion of Regulatory T Cells

Stefan Milutinovic; Jun Abe; Emma Jones; Inken Kelch; Kathryn Smart; Sarah N. Lauder; Michelle Somerville; Carl Ware; Andrew Godkin; Jens V. Stein; Gib Bogle; Awen Gallimore

Doi: 10.1158/2767-9764.CRC-21-0123

Research Article

Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis

Christopher J. Benwell; Robert T. Johnson; James A.G.E. Taylor; Christopher A. Price; Stephen D. Robinson

Doi: 10.1158/2767-9764.CRC-22-0250

Research Article

CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer

Chia-Lun Hong; I-Shing Yu; Chen-Hsueh Pai; Jin-Shing Chen; Min-Shu Hsieh; Hua-Lin Wu; Shu-Wha Lin; Hsiang-Po Huang

Doi: 10.1158/0008-5472.CAN-22-1695

Research Article

A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Namrata Bora-Singhal; Biswarup Saha; Durairaj Mohankumar; Jaya Padmanabhan; Domenico Coppola; Srikumar Chellappan

Doi: 10.1158/2767-9764.CRC-21-0084

Research Article

Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS

Moeez Rathore; Wei Zhang; Michel'le Wright; Rajat Bhattacharya; Fan Fan; Ali Vaziri-Gohar; Jordan Winter; Zhenghe Wang; Sanford D. Markowitz; Joseph Willis; Lee M. Ellis; Rui Wang

Doi: 10.1158/1541-7786.MCR-21-0633

Research Article

δ-Tocotrienol is the Most Potent Vitamin E Form in Inhibiting Prostate Cancer Cell Growth and Inhibits Prostate Carcinogenesis in Ptenp−/− Mice

Hong Wang; William Yan; Yuhai Sun; Chung S. Yang

Doi: 10.1158/1940-6207.CAPR-21-0508

Research Article

Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival

Junko Sawada; Nobuyoshi Hiraoka; Rongsu Qi; Lu Jiang; Ashley E. Fournier-Goss; Masayuki Yoshida; Hiroto Kawashima; Masanobu Komatsu

Doi: 10.1158/2326-6066.CIR-21-0369

Cancer Research Landmark

Antiangiogenesis: Vessel Regression, Vessel Normalization, or Both?

Hellmut G. Augustin; Gou Young Koh

Doi: 10.1158/0008-5472.CAN-21-3515

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