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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Genome Instability and Mutation

Research Article

GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress

Weihua Zhou; Zitong Zhao; Angelica Lin; John Z. Yang; Jie Xu; Kari Wilder-Romans; Annabel Yang; Jing Li; Sumeet Solanki; Jennifer M. Speth; Natalie Walker; Andrew J. Scott; Lu Wang; Bo Wen; Anthony Andren; Li Zhang; Ayesha U. Kothari; Yangyang Yao; Erik R. Peterson; Navyateja Korimerla; Christian K. Werner; Alexander Ullrich; Jessica Liang; Janna Jacobson; Sravya Palavalasa; Alexandra M. O’Brien; Ameer L. Elaimy; Sean P. Ferris; Shuang G. Zhao; Jann N. Sarkaria; Balázs Győrffy; Shuqun Zhang; Wajd N. Al-Holou; Yoshie Umemura; Meredith A. Morgan; Theodore S. Lawrence; Costas A. Lyssiotis; Marc Peters-Golden; Yatrik M. Shah; Daniel R. Wahl

Doi: 10.1158/2159-8290.CD-23-0437

Research Article

Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting

Chani Stossel; Maria Raitses-Gurevich; Dikla Atias; Tamar Beller; Yulia Glick Gorman; Sharon Halperin; Eyal Peer; Robert E. Denroche; Amy Zhang; Faiyaz Notta; Julie M. Wilson; Grainne M. O'Kane; Elina Haimov Talmoud; Nora Amison; Michael Schvimer; Seth J. Salpeter; Vered Bar; Adi Zundelevich; Itay Tirosh; Rotem Tal; Gal Dinstag; Yaron Kinar; Yonatan Eliezer; Uri Ben-David; Nancy S. Gavert; Ravid Straussman; Steven J. Gallinger; Raanan Berger; Talia Golan

Doi: 10.1158/2159-8290.CD-22-0412

Research Article

Cancer Mutations Converge on a Collection of Protein Assemblies to Predict Resistance to Replication Stress

Xiaoyu Zhao; Akshat Singhal; Sungjoon Park; JungHo Kong; Robin Bachelder; Trey Ideker

Doi: 10.1158/2159-8290.CD-23-0641

Research Article

Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs

Shreoshi Pal Choudhuri; Luc Girard; Jun Yi Stanley Lim; Jillian F. Wise; Braeden Freitas; Di Yang; Edmond Wong; Seth Hamilton; Victor D. Chien; Yoon Jung Kim; Collin Gilbreath; Jun Zhong; Sarah Phat; David T. Myers; Camilla L. Christensen; Hanieh Mazloom-Farsibaf; Marcello Stanzione; Kwok-Kin Wong; Yin P. Hung; Anna F. Farago; Catherine B. Meador; Nicholas J. Dyson; Michael S. Lawrence; Sihan Wu; Benjamin J. Drapkin

Doi: 10.1158/2159-8290.CD-23-0656

Cancer Hallmarks Review

The DNA Damage Response and Inflammation in Cancer

Vanessa Klapp; Beatriz Álvarez-Abril; Giuseppe Leuzzi; Guido Kroemer; Alberto Ciccia; Lorenzo Galluzzi

Doi: 10.1158/2159-8290.CD-22-1220

Cancer Hallmarks Review

Micronuclei and Cancer

Melody Di Bona; Samuel F. Bakhoum

Doi: 10.1158/2159-8290.CD-23-1073

Research Article

Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer

John B. Tucker; Sarah C. Bonema; Rebeca García-Varela; Ryan A. Denu; Yang Hu; Stephanie M. McGregor; Mark E. Burkard; Beth A. Weaver

Doi: 10.1158/2767-9764.CRC-22-0302

Research Article

Natural History of Germline BRCA1 Mutated and BRCA Wild-type Triple-negative Breast Cancer

Nilesh Gardi; Rohan Chaubal; Pallavi Parab; Sunil Pachakar; Suyash Kulkarni; Tanuja Shet; Shalaka Joshi; Yogesh Kembhavi; Pratik Chandrani; Jelmar Quist; Pradnya Kowtal; Anita Grigoriadis; Rajiv Sarin; Raman Govindarajan; Sudeep Gupta

Doi: 10.1158/2767-9764.CRC-23-0277

Convergence Science

BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance

Xiaodong Shu; Jianjie Li; Un In Chan; Sek Man Su; Changxiang Shi; Xin Zhang; Tingting An; Jun Xu; Lihua Mo; Jianlin Liu; Yuqing Wang; Xiaoling Li; Min Deng; Josh Haipeng Lei; Chunfei Wang; Hao Tian; Sun Heng; Joong Sup Shim; Xuanjun Zhang; Yunlu Dai; Zhicheng Yao; Xiaying Kuang; Ying Lin; Chu-Xia Deng; Xiaoling Xu

Doi: 10.1158/0008-5472.CAN-22-3398

Cancer Genes and Networks

Integrating Clinical Cancer and PTM Proteomics Data Identifies a Mechanism of ACK1 Kinase Activation

Eranga R. Balasooriya; Deshan Madhusanka; Tania P. López-Palacios; Riley J. Eastmond; Dasun Jayatunge; Jake J. Owen; Jack S. Gashler; Christina M. Egbert; Chanaka Bulathsinghalage; Lu Liu; Stephen R. Piccolo; Joshua L. Andersen

Doi: 10.1158/1541-7786.MCR-23-0153

Cancer Genes and Networks

Spatial Transcriptomics Suggests That Alterations Occur in the Preneoplastic Breast Microenvironment of BRCA1/2 Mutation Carriers

Anthony Caputo; Kavya Vipparthi; Peter Bazeley; Erinn Downs-Kelly; Patrick McIntire; Lauren A. Duckworth; Ying Ni; Bo Hu; Ruth A. Keri; Mihriban Karaayvaz

Doi: 10.1158/1541-7786.MCR-23-0489

Research Article

Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis

Caner Saygin; Pu Zhang; Jacob Stauber; Ibrahim Aldoss; Adam S. Sperling; Lachelle D. Weeks; Marlise R. Luskin; Todd C. Knepper; Pankhuri Wanjari; Peng Wang; Angela M. Lager; Carrie Fitzpatrick; Jeremy P. Segal; Mehdi Gharghabi; Sandeep Gurbuxani; Girish Venkataraman; Jason X. Cheng; Bart J. Eisfelder; Oliver Bohorquez; Anand A. Patel; Sheethal Umesh Nagalakshmi; Savita Jayaram; Olatoyosi M. Odenike; Richard A. Larson; Lucy A. Godley; Daniel A. Arber; Christopher J. Gibson; Nikhil C. Munshi; Guido Marcucci; Benjamin L. Ebert; John M. Greally; Ulrich Steidl; Rosa Lapalombella; Bijal D. Shah; Wendy Stock

Doi: 10.1158/2643-3230.BCD-23-0106

Research Article

Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells

Francesco Maura; Bachisio Ziccheddu; Jenny Z. Xiang; Bhavneet Bhinder; Joel Rosiene; Federico Abascal; Kylee H. Maclachlan; Kenneth Wha Eng; Manik Uppal; Feng He; Wei Zhang; Qi Gao; Venkata D. Yellapantula; Vicenta Trujillo-Alonso; Sunita I. Park; Matthew J. Oberley; Elizabeth Ruckdeschel; Megan S. Lim; Gerald B. Wertheim; Matthew J. Barth; Terzah M. Horton; Andriy Derkach; Alexandra E. Kovach; Christopher J. Forlenza; Yanming Zhang; Ola Landgren; Craig H. Moskowitz; Ethel Cesarman; Marcin Imielinski; Olivier Elemento; Mikhail Roshal; Lisa Giulino-Roth

Doi: 10.1158/2643-3230.BCD-22-0128

Small Molecule Therapeutics

Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma

Mason McCrury; Kennith Swafford; Sydnye L. Shuttleworth; Syed Hassan Mehdi; Baku Acharya; Debasmita Saha; Kevin Naceanceno; Stephanie D. Byrum; Aaron J. Storey; Ying-Zhi Xu; Claire Doshier; Vijay Patel; Ginell R. Post; Annick De Loose; Analiz Rodriguez; Leonard D. Shultz; Fenghuang Zhan; Donghoon Yoon; Brendan Frett; Samantha Kendrick

Doi: 10.1158/1535-7163.MCT-23-0299

Research Article

Large-Scale Cancer Genomic Analysis Reveals Significant Disparities between Microsatellite Instability and Tumor Mutational Burden

Jungyoon Choi; Kyong Hwa Park; Yeul Hong Kim; Jason K. Sa; Hwa Jung Sung; Yu-Wei Chen; Zhishan Chen; Chao Li; Wanqing Wen; Qingrun Zhang; Xiao-ou Shu; Wei Zheng; Jung Sun Kim; Xingyi Guo

Doi: 10.1158/1055-9965.EPI-23-1466

Research Article

Diffsig: Associating Risk Factors with Mutational Signatures

Ji-Eun Park; Markia A. Smith; Sarah C. Van Alsten; Andrea Walens; Di Wu; Katherine A. Hoadley; Melissa A. Troester; Michael I. Love

Doi: 10.1158/1055-9965.EPI-23-0728

Research Article

Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature

Claire E. Thomas; Peter Georgeson; Conghui Qu; Robert S. Steinfelder; Daniel D. Buchanan; Mingyang Song; Tabitha A. Harrison; Caroline Y. Um; Meredith A. Hullar; Mark A. Jenkins; Bethany Van Guelpen; Brigid M. Lynch; Yohannes Adama Melaku; Jeroen R. Huyghe; Elom K. Aglago; Sonja I. Berndt; Lisa A. Boardman; Peter T. Campbell; Yin Cao; Andrew T. Chan; David A. Drew; Jane C. Figueiredo; Amy J. French; Marios Giannakis; Ellen L. Goode; Stephen B. Gruber; Andrea Gsur; Marc J. Gunter; Michael Hoffmeister; Li Hsu; Wen-Yi Huang; Victor Moreno; Neil Murphy; Polly A. Newcomb; Christina C. Newton; Jonathan A. Nowak; Mireia Obón-Santacana; Shuji Ogino; Wei Sun; Amanda E. Toland; Quang M. Trinh; Tomotaka Ugai; Syed H. Zaidi; Ulrike Peters; Amanda I. Phipps

Doi: 10.1158/1055-9965.EPI-23-0600

Research Article

Inference on the Genetic Architecture of Breast Cancer Risk

Yutaka Yasui; William Letsou; Fan Wang; Cindy Im; Yadav Sapkota; Zhaoming Wang; Sedigheh Mirzaei Salehabadi; Jessica L. Baedke; Won Jong Moon; Qi Liu; Leslie L. Robison; Jose Miguel Martinez

Doi: 10.1158/1055-9965.EPI-22-1073

Research Article

Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors

Nicole Gonzalez; Nina Rao; Michael Dean; Donghyuk Lee; Amber N. Hurson; Dalsu Baris; Molly Schwenn; Alison Johnson; Ludmila Prokunina-Olsson; Melissa C. Friesen; Bin Zhu; Nathaniel Rothman; Debra T. Silverman; Stella Koutros

Doi: 10.1158/1055-9965.EPI-22-1208

Research Article

Polymorphisms in the Nonhomologous End-joining DNA Repair Pathway are Associated with HPV Integration in Cervical Dysplasia

Jennifer M. Geris; E. Susan Amirian; Deborah A. Marquez-Do; Martial Guillaud; Laura M. Dillon; Michele Follen; Michael E. Scheurer

Doi: 10.1158/1940-6207.CAPR-23-0051

Review

Somatic Mutation: What Shapes the Mutational Landscape of Normal Epithelia?

Joanna C. Fowler; Philip H. Jones

Doi: 10.1158/2159-8290.CD-22-0145

Review

Tissue-Agnostic Activity of BRAF plus MEK Inhibitor in BRAF V600–Mutant Tumors

Jacob J. Adashek; Arjun K. Menta; Neha K. Reddy; Aakash P. Desai; Jason Roszik; Vivek Subbiah

Doi: 10.1158/1535-7163.MCT-21-0950

Research Article

Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis

Rathana Kim; Hugo Bergugnat; Lise Larcher; Matthieu Duchmann; Marie Passet; Stéphanie Gachet; Wendy Cuccuini; Marina Lafage-Pochitaloff; Cédric Pastoret; Nathalie Grardel; Vahid Asnafi; Beat W. Schäfer; Eric Delabesse; Raphaël Itzykson; Lionel Adès; Yosr Hicheri; Yves Chalandon; Carlos Graux; Patrice Chevallier; Mathilde Hunault; Thibaut Leguay; Françoise Huguet; Véronique Lhéritier; Hervé Dombret; Jean Soulier; Philippe Rousselot; Nicolas Boissel; Emmanuelle Clappier

Doi: 10.1158/2643-3230.BCD-22-0154

Research Article

Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma

Prashanthi Dharanipragada; Xiao Zhang; Sixue Liu; Shirley H. Lomeli; Aayoung Hong; Yan Wang; Zhentao Yang; Kara Z. Lo; Agustin Vega-Crespo; Antoni Ribas; Stergios J. Moschos; Gatien Moriceau; Roger S. Lo

Doi: 10.1158/2159-8290.CD-22-0787

Research Article

Misaligned Chromosomes are a Major Source of Chromosomal Instability in Breast Cancer

John B. Tucker; Sarah C. Bonema; Rebeca García-Varela; Ryan A. Denu; Yang Hu; Stephanie M. McGregor; Mark E. Burkard; Beth A. Weaver

Doi: 10.1158/2767-9764.CRC-22-0302

Research Article

ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia

Rohan Kodgule; Joshua W. Goldman; Alexander C. Monovich; Travis Saari; Athalee R. Aguilar; Cody N. Hall; Niharika Rajesh; Juhi Gupta; Shih-Chun A. Chu; Li Ye; Aishwarya Gurumurthy; Ashwin Iyer; Noah A. Brown; Mark Y. Chiang; Marcin P. Cieslik; Russell J.H. Ryan

Doi: 10.1158/2643-3230.BCD-21-0224

Research Article

Uterine Lavage Identifies Cancer Mutations and Increased TP53 Somatic Mutation Burden in Individuals with Ovarian Cancer

Talayeh S. Ghezelayagh; Brendan F. Kohrn; Jeanne Fredrickson; Enna Manhardt; Marc R. Radke; Ronit Katz; Heidi J. Gray; Renata R. Urban; Kathryn P. Pennington; John B. Liao; Kemi M. Doll; Elise J. Simons; Jennifer K. Burzawa; Barbara A. Goff; Paul Speiser; Elizabeth M. Swisher; Barbara M. Norquist; Rosa Ana Risques

Doi: 10.1158/2767-9764.CRC-22-0314

Research Article

Human Papillomavirus Integration Strictly Correlates with Global Genome Instability in Head and Neck Cancer

Brandon Labarge; Max Hennessy; Lijun Zhang; David Goldrich; Scott Chartrand; Carson Purnell; Sage Wright; David Goldenberg; James R. Broach

Doi: 10.1158/1541-7786.MCR-21-0831

Research Article

Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts

Jonathan M. Downie; Moeen Riaz; Jing Xie; Minyi Lee; Andrew T. Chan; Peter Gibbs; Suzanne G. Orchard; Suzanne E. Mahady; Robert P. Sebra; Anne M. Murray; Finlay Macrae; Eric Schadt; Robyn L. Woods; John J. McNeil; Paul Lacaze; Manish Gala

Doi: 10.1158/1940-6207.CAPR-22-0080

Research Article

Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients

Giovanni Crisafulli; Andrea Sartore-Bianchi; Luca Lazzari; Filippo Pietrantonio; Alessio Amatu; Marco Macagno; Ludovic Barault; Andrea Cassingena; Alice Bartolini; Paolo Luraghi; Gianluca Mauri; Paolo Battuello; Nicola Personeni; Maria Giulia Zampino; Valeria Pessei; Pietro Paolo Vitiello; Federica Tosi; Laura Idotta; Federica Morano; Emanuele Valtorta; Emanuela Bonoldi; Giovanni Germano; Federica Di Nicolantonio; Silvia Marsoni; Salvatore Siena; Alberto Bardelli

Doi: 10.1158/2159-8290.CD-21-1434

Research Article

Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

Andrew J. Menssen; Ajay Khanna; Christopher A. Miller; Sridhar Nonavinkere Srivatsan; Gue Su Chang; Jin Shao; Joshua Robinson; Michele O'Laughlin; Catrina C. Fronick; Robert S. Fulton; Kimberly Brendel; Sharon E. Heath; Raya Saba; John S. Welch; David H. Spencer; Jacqueline E. Payton; Peter Westervelt; John F. DiPersio; Daniel C. Link; Matthew J. Schuelke; Meagan A. Jacoby; Eric J. Duncavage; Timothy J. Ley; Matthew J. Walter

Doi: 10.1158/2643-3230.BCD-21-0155

Research Article

Distinct Patterns of Clonal Evolution Drive Myelodysplastic Syndrome Progression to Secondary Acute Myeloid Leukemia

Tiffany Guess; Chad R. Potts; Pawan Bhat; Justin A. Cartailler; Austin Brooks; Clinton Holt; Ashwini Yenamandra; Ferrin C. Wheeler; Michael R. Savona; Jean-Philippe Cartailler; P. Brent Ferrell, Jr

Doi: 10.1158/2643-3230.BCD-21-0128

Research Article

PD-1 Blockade in Solid Tumors with Defects in Polymerase Epsilon

Benoit Rousseau; Ivan Bieche; Eric Pasmant; Nadim Hamzaoui; Nicolas Leulliot; Lucas Michon; Aurelien de Reynies; Valerie Attignon; Michael B. Foote; Julien Masliah-Planchon; Magali Svrcek; Romain Cohen; Victor Simmet; Paule Augereau; David Malka; Antoine Hollebecque; Damien Pouessel; Carlos Gomez-Roca; Rosine Guimbaud; Amandine Bruyas; Marielle Guillet; Jean-Jacques Grob; Muriel Duluc; Sophie Cousin; Christelle de la Fouchardiere; Aude Flechon; Frederic Rolland; Sandrine Hiret; Esma Saada-Bouzid; Olivier Bouche; Thierry Andre; Diane Pannier; Farid El Hajbi; Stephane Oudard; Christophe Tournigand; Jean-Charles Soria; Stephane Champiat; Drew G. Gerber; Dennis Stephens; Michelle F. Lamendola-Essel; Steven B. Maron; Bill H. Diplas; Guillem Argiles; Asha R. Krishnan; Severine Tabone-Eglinger; Anthony Ferrari; Neil H. Segal; Andrea Cercek; Natalie Hoog-Labouret; Frederic Legrand; Clotilde Simon; Assia Lamrani-Ghaouti; Luis A. Diaz, Jr; Pierre Saintigny; Sylvie Chevret; Aurelien Marabelle

Doi: 10.1158/2159-8290.CD-21-0521

Research Article

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers

Kavya Prasad; Mathew Bloomfield; Hagai Levi; Kristina Keuper; Sara V. Bernhard; Nicolaas C. Baudoin; Gil Leor; Yonatan Eliezer; Maybelline Giam; Cheng Kit Wong; Giulia Rancati; Zuzana Storchová; Daniela Cimini; Uri Ben-David

Doi: 10.1158/0008-5472.CAN-21-2065

Research Article

Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk

Rick A.C.M. Boonen; Wouter W. Wiegant; Nandi Celosse; Bas Vroling; Stephan Heijl; Zsofia Kote-Jarai; Martina Mijuskovic; Simona Cristea; Nienke Solleveld-Westerink; Tom van Wezel; Niko Beerenwinkel; Rosalind Eeles; Peter Devilee; Maaike P.G. Vreeswijk; Giancarlo Marra; Haico van Attikum

Doi: 10.1158/0008-5472.CAN-21-1845

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