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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Evading Growth Suppressors

Research Article

Loss-of-Function but Not Gain-of-Function Properties of Mutant TP53 Are Critical for the Proliferation, Survival, and Metastasis of a Broad Range of Cancer Cells

Zilu Wang; Matteo Burigotto; Sabrina Ghetti; François Vaillant; Tao Tan; Bianca D. Capaldo; Michelle Palmieri; Yumiko Hirokawa; Lin Tai; Daniel S. Simpson; Catherine Chang; Allan Shuai Huang; Elizabeth Lieschke; Sarah T. Diepstraten; Deeksha Kaloni; Chris Riffkin; David C.S. Huang; Connie S.N. Li Wai Suen; Alexandra L. Garnham; Peter Gibbs; Jane E. Visvader; Oliver M. Sieber; Marco J. Herold; Luca L. Fava; Gemma L. Kelly; Andreas Strasser

Doi: 10.1158/2159-8290.CD-23-0402

Research Article

GABA Regulates Electrical Activity and Tumor Initiation in Melanoma

Mohita Tagore; Emiliano Hergenreder; Sarah C. Perlee; Nelly M. Cruz; Laura Menocal; Shruthy Suresh; Eric Chan; Maayan Baron; Stephanie Melendez; Asim Dave; Walid K. Chatila; Jeremie Nsengimana; Richard P. Koche; Travis J. Hollmann; Trey Ideker; Lorenz Studer; Andrea Schietinger; Richard M. White

Doi: 10.1158/2159-8290.CD-23-0389

Research Article

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

Alexandra Indeglia; Jessica C. Leung; Sven A. Miller; Julia I-Ju Leu; James F. Dougherty; Nicole L. Clarke; Nicole A. Kirven; Chunlei Shao; Lei Ke; Scott Lovell; Thibaut Barnoud; David Y. Lu; Cindy Lin; Toshitha Kannan; Kevin P. Battaile; Tyler Hong Loong Yang; Isabela Batista Oliva; Daniel T. Claiborne; Peter Vogel; Lijun Liu; Qin Liu; Yulia Nefedova; Joel Cassel; Noam Auslander; Andrew V. Kossenkov; John Karanicolas; Maureen E. Murphy

Doi: 10.1158/2159-8290.CD-22-1315

Research Article

Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress

Emma E. Croushore; Stacia L. Koppenhafer; Kelli L. Goss; Elizabeth L. Geary; David J. Gordon

Doi: 10.1158/2767-9764.CRC-23-0268

Research Article

Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models

Frederick Nguele Meke; Yunpeng Bai; Diego Ruiz-Avila; Colin Carlock; Jinan Ayub; Jinmin Miao; Yanyang Hu; Qinglin Li; Zhong-Yin Zhang

Doi: 10.1158/2767-9764.CRC-23-0308

Cell Fate Decisions

Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress

Sara Sannino; Allison M. Manuel; Chaowei Shang; Stacy G. Wendell; Peter Wipf; Jeffrey L. Brodsky

Doi: 10.1158/1541-7786.MCR-22-0843

Cancer Genes and Networks

ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity

XiaoPeng Wang; Mo Zhu; Hao Zuo; Guowei Hou; Rui Xie

Doi: 10.1158/1541-7786.MCR-22-0384

Research Article

In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities

Elisa ten Hacken; Tomasz Sewastianik; Shanye Yin; Gabriela Brunsting Hoffmann; Michaela Gruber; Kendell Clement; Livius Penter; Robert A. Redd; Neil Ruthen; Sébastien Hergalant; Alanna Sholokhova; Geoffrey Fell; Erin M. Parry; Julien Broséus; Romain Guieze; Fabienne Lucas; María Hernández-Sánchez; Kaitlyn Baranowski; Jackson Southard; Heather Joyal; Leah Billington; Fara Faye D. Regis; Elizabeth Witten; Mohamed Uduman; Binyamin A. Knisbacher; Shuqiang Li; Haoxiang Lyu; Tiziana Vaisitti; Silvia Deaglio; Giorgio Inghirami; Pierre Feugier; Stephan Stilgenbauer; Eugen Tausch; Matthew S. Davids; Gad Getz; Kenneth J. Livak; Ivana Bozic; Donna S. Neuberg; Ruben D. Carrasco; Catherine J. Wu

Doi: 10.1158/2643-3230.BCD-22-0082

First Disclosure

Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth

Kyle Begovich; Angela Schoolmeesters; Navin Rajapakse; Elena Martinez-Terroba; Maneesh Kumar; Arvind Shakya; Chon Lai; Steven Greene; Brandon Whitefield; Akinori Okano; Venkat Mali; Shenlin Huang; Aparajita H. Chourasia; Leah Fung

Doi: 10.1158/1535-7163.MCT-23-0513

Research Article

MEX3A Mediates p53 Degradation to Suppress Ferroptosis and Facilitate Ovarian Cancer Tumorigenesis

Cheng-Kai Wang; Tzu-Jou Chen; Grace Y.T. Tan; Fang-Pei Chang; Samyuktha Sridharan; Chen-Hsin Albert Yu; Yen-Hou Chang; Yi-Jen Chen; Li-Tzu Cheng; Wendy W. Hwang-Verslues

Doi: 10.1158/0008-5472.CAN-22-1159

Research Article

SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression

Mariafausta Fischietti; Frank Eckerdt; Ricardo E. Perez; Jamie N. Guillen Magaña; Candice Mazewski; Sang Ho; Christopher Gonzalez; Lukas D. Streich; Elspeth M. Beauchamp; Amy B. Heimberger; Aneta H. Baran; Feng Yue; C. David James; Leonidas C. Platanias

Doi: 10.1158/2767-9764.CRC-22-0192

Research Article

Constitutive β-Catenin Overexpression Represses Lncrna MIR100HG Transcription via HDAC6-Mediated Histone Modification in Colorectal Cancer

Jian Peng; Yiming Ma; Xinhua Zhao; Xu Yang; Hongying Wang

Doi: https://doi.org/10.1158/1541-7786.MCR-21-0923

Research Article

Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities

Maryam Yousefi; Gábor Boross; Carly Weiss; Christopher W. Murray; Jess D. Hebert; Hongchen Cai; Emily L. Ashkin; Saswati Karmakar; Laura Andrejka; Leo Chen; Minwei Wang; Min K. Tsai; Wen-Yang Lin; Chuan Li; Pegah Yakhchalian; Caterina I. Colón; Su-Kit Chew; Pauline Chu; Charles Swanton; Christian A. Kunder; Dmitri A. Petrov; Monte M. Winslow

Doi: 10.1158/0008-5472.CAN-22-0059

Research Article

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Qing Li; Baishan Jiang; Jiaye Guo; Hong Shao; Isabella S. Del Priore; Qing Chang; Rei Kudo; Zhiqiang Li; Pedram Razavi; Bo Liu; Andrew S. Boghossian; Matthew G. Rees; Melissa M. Ronan; Jennifer A. Roth; Katherine A. Donovan; Marta Palafox; Jorge S. Reis-Filho; Elisa de Stanchina; Eric S. Fischer; Neal Rosen; Violeta Serra; Andrew Koff; John D. Chodera; Nathanael S. Gray; Sarat Chandarlapaty

Doi: 10.1158/2159-8290.CD-20-1726

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