Skip to Main Content

Advertisement

Skip Nav Destination

Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Deregulating Cellular Metabolism

Cancer Hallmarks Review

Metabolic Signaling in Cancer Metastasis

Sarah Krieg; Sara Isabel Fernandes; Constantinos Kolliopoulos; Ming Liu; Sarah-Maria Fendt

Doi: 10.1158/2159-8290.CD-24-0174

Research Article

Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

Jared H. Rowe; Ilaria Elia; Osmaan Shahid; Emily F. Gaudiano; Natalia E. Sifnugel; Sheila Johnson; Amy G. Reynolds; Megan E. Fung; Shakchhi Joshi; Martin W. LaFleur; Joon Seok Park; Kristen E. Pauken; Joshua D. Rabinowitz; Gordon J. Freeman; Marcia C. Haigis; Arlene H. Sharpe

Doi: 10.1158/2159-8290.CD-22-1301

Research Article

FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer

Blake R. Wilde; Nishma Chakraborty; Nedas Matulionis; Stephanie Hernandez; Daiki Ueno; Michayla E. Gee; Edward D. Esplin; Karen Ouyang; Keith Nykamp; Brian Shuch; Heather R. Christofk

Doi: 10.1158/2159-8290.CD-22-0874

Research Article

Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

Omer Goldman; Lital N. Adler; Emma Hajaj; Tommaso Croese; Naama Darzi; Sivan Galai; Hila Tishler; Yarden Ariav; Dor Lavie; Liat Fellus-Alyagor; Roni Oren; Yuri Kuznetsov; Eyal David; Rami Jaschek; Chani Stossel; Oded Singer; Sergey Malitsky; Renana Barak; Rony Seger; Neta Erez; Ido Amit; Amos Tanay; Ann Saada; Talia Golan; Tamar Rubinek; Joo Sang Lee; Shay Ben-Shachar; Ido Wolf; Ayelet Erez

Doi: 10.1158/2159-8290.CD-22-1062

Research Article

Vitamin B6 Competition in the Tumor Microenvironment Hampers Antitumor Functions of NK Cells

Chunbo He; Dezhen Wang; Surendra K. Shukla; Tuo Hu; Ravi Thakur; Xiao Fu; Ryan J. King; Sai Sundeep Kollala; Kuldeep S. Attri; Divya Murthy; Nina V. Chaika; Yuki Fujii; Daisy Gonzalez; Camila G. Pacheco; Yudong Qiu; Pankaj K. Singh; Jason W. Locasale; Kamiya Mehla

Doi: 10.1158/2159-8290.CD-23-0334

Research Article

Mitochondria Transfer from Mesenchymal Stem Cells Confers Chemoresistance to Glioblastoma Stem Cells through Metabolic Rewiring

Jean Nakhle; Khattar Khattar; Tülin Özkan; Adel Boughlita; Daouda Abba Moussa; Amélie Darlix; Frédérique Lorcy; Valérie Rigau; Luc Bauchet; Sabine Gerbal-Chaloin; Martine Daujat-Chavanieu; Floriant Bellvert; Laurent Turchi; Thierry Virolle; Jean-Philippe Hugnot; Nicolas Buisine; Mireille Galloni; Valérie Dardalhon; Anne-Marie Rodriguez; Marie-Luce Vignais

Doi: 10.1158/2767-9764.CRC-23-0144

Research Article

WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers

Joseph L. Sottnik; Madeleine T. Shackleford; Sydney K. Robinson; Fabian R. Villagomez; Shaymaa Bahnassy; Steffi Oesterreich; Junxiao Hu; Zeynep Madak-Erdogan; Rebecca B. Riggins; Bradley R. Corr; Linda S. Cook; Lindsey S. Treviño; Benjamin G. Bitler; Matthew J. Sikora

Doi: 10.1158/2767-9764.CRC-23-0275

Metabolism and Chemical Biology

Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer

Seung Joon Park; Hee Chan Yoo; Eunyong Ahn; Enzhi Luo; Yeabeen Kim; Yulseung Sung; Ya Chun Yu; Kibum Kim; Do Sik Min; Hee Seung Lee; Geum-Sook Hwang; TaeJin Ahn; Junjeong Choi; Seungmin Bang; Jung Min Han

Doi: 10.1158/0008-5472.CAN-22-2045

Cancer Metabolism and Molecular Mechanisms

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity

Dominik Awad; Pham Hong Anh Cao; Thomas L. Pulliam; Meredith Spradlin; Elavarasan Subramani; Tristen V. Tellman; Caroline F. Ribeiro; Riccardo Muzzioli; Brittany E. Jewell; Hubert Pakula; Jeffrey J. Ackroyd; Mollianne M. Murray; Jenny J. Han; Mei Leng; Antrix Jain; Badrajee Piyarathna; Jingjing Liu; Xingzhi Song; Jianhua Zhang; Albert R. Klekers; Justin M. Drake; Michael M. Ittmann; Cristian Coarfa; David Piwnica-Worms; Mary C. Farach-Carson; Massimo Loda; Livia S. Eberlin; Daniel E. Frigo

Doi: 10.1158/0008-5472.CAN-23-0555

Metabolism

An Endosomal Acid-Regulatory Feedback System Rewires Cytosolic cAMP Metabolism and Drives Tumor Progression

Hari Prasad; Susmita Mandal; John Kandam Kulathu Mathew; Aparna Cherukunnath; Atchuta Srinivas Duddu; Mallar Banerjee; Harini Ramani; Ramray Bhat; Mohit Kumar Jolly; Sandhya S. Visweswariah

Doi: 10.1158/1541-7786.MCR-23-0606

Metabolism

FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma

Diyala Shihadih; Xue Wang; Peter-James H. Zushin; Pavlo Khodakivskyi; Hyo Min Park; Emily Tso; Jena Shiblak; Angela Misic; Sharon M. Louie; Catherine Ward; Marc Hellerstein; Daniel K. Nomura; Elena Goun; Francesco Urigo; Diego F. Calvisi; Xin Chen; Andreas Stahl

Doi: 10.1158/1541-7786.MCR-23-0389

Research Article

A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer

Sotiria Pinioti; Himal Sharma; Nina C. Flerin; Qian Yu; Amalia Tzoumpa; Sarah Trusso Cafarello; Elien De Bousser; Nico Callewaert; Guillaume Oldenhove; Susan Schlenner; Bernard Thienpont; Abhishek D. Garg; Mario Di Matteo; Massimiliano Mazzone

Doi: 10.1158/2326-6066.CIR-22-0606

Research Article

A Metabolic Axis of Immune Intractability

Dominique C. Hinshaw; Meet Patel; Lalita A. Shevde

Doi: 10.1158/2326-6066.CIR-23-0433

Research Article

The Polyamine–Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma

Shima Nakanishi; Jiannong Li; Anders E. Berglund; Youngchul Kim; Yonghong Zhang; Ling Zhang; Chunying Yang; Jinming Song; Raghavendra G. Mirmira; John L. Cleveland

Doi: 10.1158/2643-3230.BCD-22-0162

Research Article

HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion

Kosuke Toyoda; Jun-ichirou Yasunaga; Takafumi Shichijo; Yuichiro Arima; Kenichi Tsujita; Azusa Tanaka; Tarig Salah; Wenyi Zhang; Osama Hussein; Miyu Sonoda; Miho Watanabe; Daisuke Kurita; Kazutaka Nakashima; Kyohei Yamada; Hiroaki Miyoshi; Koichi Ohshima; Masao Matsuoka

Doi: 10.1158/2643-3230.BCD-22-0139

Small Model Therapeutics

Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

Adrianne Wallace-Povirk; Carrie O'Connor; Aamod S. Dekhne; Xun Bao; Md. Junayed Nayeen; Mathew Schneider; Jade M. Katinas; Jennifer Wong-Roushar; Seongho Kim; Lisa Polin; Jing Li; Jessica B. Back; Charles E. Dann, 3rd; Aleem Gangjee; Zhanjun Hou; Larry H. Matherly

Doi: 10.1158/1535-7163.MCT-23-0550

Research Article

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

Takuma Uo; Kayode K. Ojo; Cynthia C. T. Sprenger; Kathryn Soriano Epilepsia; B. Gayani K. Perera; Mamatha Damodarasamy; Shihua Sun; Soojin Kim; Hannah H. Hogan; Matthew A. Hulverson; Ryan Choi; Grant R. Whitman; Lynn K. Barrett; Samantha A. Michaels; Linda H. Xu; Vicky L. Sun; Samuel L.M. Arnold; Haley J. Pang; Matthew M. Nguyen; Anna-Lena B.G. Vigil; Varun Kamat; Lucas B. Sullivan; Ian R. Sweet; Ram Vidadala; Dustin J. Maly; Wesley C. Van Voorhis; Stephen R. Plymate

Doi: 10.1158/1535-7163.MCT-23-0540

Small Model Therapeutics

Bromo- and Extra-Terminal Domain Inhibitors Induce Mitochondrial Stress in Pancreatic Ductal Adenocarcinoma

Manjul Rana; Rita G. Kansal; Bijay Bisunke; Jie Fang; David Shibata; Amandeep Bajwa; Jun Yang; Evan S. Glazer

Doi: 10.1158/1535-7163.MCT-23-0149

Research Article

The Associations between Intakes of One-Carbon Metabolism–Related Vitamins and Breast Density among Young Women

Eunyoung Han; Linda Van Horn; Linda Snetselaar; John A. Shepherd; Yoon Jung Park; Hyesook Kim; Seungyoun Jung; Joanne F. Dorgan

Doi: 10.1158/1055-9965.EPI-23-1279

Review

Monounsaturated Fatty Acids: Key Regulators of Cell Viability and Intracellular Signaling in Cancer

Julia S. Scott; Zeyad D. Nassar; Johannes V. Swinnen; Lisa M. Butler

Doi: 10.1158/1541-7786.MCR-21-1069

Review

Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer

Léa Montégut; Rafael de Cabo; Laurence Zitvogel; Guido Kroemer

Doi: 10.1158/2159-8290.CD-22-0504

Perspective

Diet and Exercise in Cancer Metabolism

Jason W. Locasale

Doi: 10.1158/2159-8290.CD-22-0096

Research Article

Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability

Daniel Thomas; Manhong Wu; Yusuke Nakauchi; Ming Zheng; Chloe A.L. Thompson-Peach; Kelly Lim; Niklas Landberg; Thomas Köhnke; Nirmal Robinson; Satinder Kaur; Monika Kutyna; Melissa Stafford; Devendra Hiwase; Andreas Reinisch; Gary Peltz; Ravindra Majeti

Doi: 10.1158/2159-8290.CD-21-0218

Research Article

Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy–driven Metabolic Reprogramming

Marni B. McClure; Yasunori Kogure; Naser Ansari-Pour; Yuki Saito; Hann-Hsiang Chao; Jonathan Shepherd; Mariko Tabata; Olufunmilayo I. Olopade; David C. Wedge; Katherine A. Hoadley; Charles M. Perou; Keisuke Kataoka

Doi: 10.1158/2767-9764.CRC-22-0073

Research Article

Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors

Jeroen Slaats; Esther Wagena; Daan Smits; Annemarie A. Berends; Ella Peters; Gert-Jan Bakker; Merijn van Erp; Bettina Weigelin; Gosse J. Adema; Peter Friedl

Doi: 10.1158/2326-6066.CIR-22-0113

Research Article

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers

Chengheng Liao; Cherise Ryan Glodowski; Cheng Fan; Juan Liu; Kevin R. Mott; Akash Kaushik; Hieu Vu; Jason W. Locasale; Samuel K. McBrayer; Ralph J. DeBerardinis; Charles M. Perou; Qing Zhang

Doi: 10.1158/0008-5472.CAN-21-2745

Research Article

Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer

Juho Pirhonen; Ábel Szkalisity; Jaana Hagström; Yonghyo Kim; Ede Migh; Mária Kovács; Maarit Hölttä; Johan Peränen; Hanna Seppänen; Caj Haglund; Jeovanis Gil; Melinda Rezeli; Johan Malm; Peter Horvath; György Markó-Varga; Pauli Puolakkainen; Elina Ikonen

Doi: 10.1158/0008-5472.CAN-22-0396

Research Article

DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1

Allison V. Mitchell; Jason Wu; Fanyan Meng; Lun Dong; C. James Block; Won-min Song; Bin Zhang; Jing Li; Guojun Wu

Doi: 10.1158/2767-9764.CRC-22-0013

Research Article

TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate

Rebecca S. Hesterberg; Min Liu; Aya G. Elmarsafawi; John M. Koomen; Eric A. Welsh; Stephen G. Hesterberg; Sujeewa Ranatunga; Chunying Yang; Weimin Li; Harshani R. Lawrence; Paulo C. Rodriguez; Anders E. Berglund; John L. Cleveland

Doi: 10.1158/2326-6066.CIR-21-0813

Research Article

Ceramide Kinase Inhibition Drives Ferroptosis and Sensitivity to Cisplatin in Mutant KRAS Lung Cancer by Dysregulating VDAC-Mediated Mitochondria Function

Ngoc T. Vu; Minjung Kim; Daniel J. Stephenson; H. Patrick MacKnight; Charles E. Chalfant

Doi: 10.1158/1541-7786.MCR-22-0085

Research Article

IFNα Potentiates Anti–PD-1 Efficacy by Remodeling Glucose Metabolism in the Hepatocellular Carcinoma Microenvironment

Bo Hu; Mincheng Yu; Xiaolu Ma; Jialei Sun; Chenglong Liu; Chunyan Wang; Suiyi Wu; Peiyao Fu; Zhen Yang; Yungang He; Yuanyuan Zhu; Cheng Huang; Xinrong Yang; Yinghong Shi; Shuangjian Qiu; Huichuan Sun; Andrew X. Zhu; Jian Zhou; Yang Xu; Di Zhu; Jia Fan

Doi: 10.1158/2159-8290.CD-21-1022

Research Article

Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy

Verra M. Ngwa; Deanna N. Edwards; Yoonha Hwang; Breelyn Karno; Xiaoyong Wang; Chi Yan; Ann Richmond; Dana M. Brantley-Sieders; Jin Chen

Doi: 10.1158/2767-9764.CRC-22-0048

Research Article

Targeting Metabolic Adaptations in the Breast Cancer–Liver Metastatic Niche Using Dietary Approaches to Improve Endocrine Therapy Efficacy

Qianying Zuo; Ayca Nazli Mogol; Yu-Jeh Liu; Ashlie Santaliz Casiano; Christine Chien; Jenny Drnevich; Ozan Berk Imir; Eylem Kulkoyluoglu-Cotul; Nicole Hwajin Park; David J. Shapiro; Ben Ho Park; Yvonne Ziegler; Benita S. Katzenellenbogen; Evelyn Aranda; John D. O'Neill; Akshara Singareeka Raghavendra; Debu Tripathy; Zeynep Madak Erdogan

Doi: 10.1158/1541-7786.MCR-21-0781

Research Article

Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer

Yogev Sela; Jinyang Li; Shivahamy Maheswaran; Robert Norgard; Salina Yuan; Maimon Hubbi; Miriam Doepner; Jimmy P. Xu; Elaine S. Ho; Clementina Mesaros; Colin Sheehan; Grace Croley; Alexander Muir; Ian A. Blair; Ophir Shalem; Chi V. Dang; Ben Z. Stanger

Doi: 10.1158/0008-5472.CAN-22-0431

Research Article

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Ruozheng Wei; Yuning Zhou; Chang Li; Piotr Rychahou; Shulin Zhang; William B. Titlow; Greg Bauman; Yuanyuan Wu; Jinpeng Liu; Chi Wang; Heidi L. Weiss; B. Mark Evers; Qingding Wang

Doi: 10.1158/0008-5472.CAN-21-2778

Research Article

Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia

Marissa Rashkovan; Robert Albero; Francesca Gianni; Pablo Perez-Duran; Hannah I. Miller; Adam L. Mackey; Elisabeth M. Paietta; Martin S. Tallman; Jacob M. Rowe; Mark R. Litzow; Peter H. Wiernik; Selina Luger; Maria Luisa Sulis; Rajesh K. Soni; Adolfo A. Ferrando

Doi: 10.1158/2159-8290.CD-21-0551

Research Article

Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer

Claudio Vernieri; Giovanni Fucà; Francesca Ligorio; Veronica Huber; Andrea Vingiani; Fabio Iannelli; Alessandra Raimondi; Darawan Rinchai; Gianmaria Frigè; Antonino Belfiore; Luca Lalli; Claudia Chiodoni; Valeria Cancila; Federica Zanardi; Arta Ajazi; Salvatore Cortellino; Viviana Vallacchi; Paola Squarcina; Agata Cova; Samantha Pesce; Paola Frati; Raghvendra Mall; Paola Antonia Corsetto; Angela Maria Rizzo; Cristina Ferraris; Secondo Folli; Marina Chiara Garassino; Giuseppe Capri; Giulia Bianchi; Mario Paolo Colombo; Saverio Minucci; Marco Foiani; Valter Daniel Longo; Giovanni Apolone; Valter Torri; Giancarlo Pruneri; Davide Bedognetti; Licia Rivoltini; Filippo de Braud

Doi: 10.1158/2159-8290.CD-21-0030

Research Article

Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

Meng Li; Matthew R. Teater; Jun Young Hong; Noel R. Park; Cihangir Duy; Hao Shen; Ling Wang; Zhengming Chen; Leandro Cerchietti; Shawn M. Davidson; Hening Lin; Ari M. Melnick

Doi: 10.1158/2643-3230.BCD-20-0183

Research Article

Anastrozole Regulates Fatty Acid Synthase in Breast Cancer

Junmei Cairns; James N. Ingle; Krishna R. Kalari; Matthew P. Goetz; Richard M. Weinshilboum; Huanyao Gao; Hu Li; Mehrab Ghanat Bari; Liewei Wang

Doi: 10.1158/1535-7163.MCT-21-0509

Close Modal

or Create an Account

Close Modal
Close Modal