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Cancer Hallmarks

Presented by the AACR journals

 

 

 

Avoiding Immune Destruction

Research Article

BCL2 Inhibition Reveals a Dendritic Cell–Specific Immune Checkpoint That Controls Tumor Immunosurveillance

Liwei Zhao; Peng Liu; Misha Mao; Shuai Zhang; Camille Bigenwald; Charles-Antoine Dutertre; Christian H.K. Lehmann; Hui Pan; Nicolas Paulhan; Lukas Amon; Aitziber Buqué; Takahiro Yamazaki; Lorenzo Galluzzi; Benoit Kloeckner; Aymeric Silvin; Yuhong Pan; Hui Chen; Ai-Ling Tian; Pierre Ly; Diana Dudziak; Laurence Zitvogel; Oliver Kepp; Guido Kroemer

Doi: 10.1158/2159-8290.CD-22-1338

Research Article

Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma

Juyeun Lee; Michael Nicosia; Ellen S. Hong; Daniel J. Silver; Cathy Li; Defne Bayik; Dionysios C. Watson; Adam Lauko; Kristen E. Kay; Sabrina Z. Wang; Sadie Johnson; Mary McGraw; Matthew M. Grabowski; Danielle D. Kish; Amar B. Desai; Wendy A. Goodman; Scott J. Cameron; Hideho Okada; Anna Valujskikh; Robert L. Fairchild; Manmeet S. Ahluwalia; Justin D. Lathia

Doi: 10.1158/2159-8290.CD-22-0869

Research Article

Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer

Wenhua Sang; Yiduo Zhou; Haiyan Chen; Chengxuan Yu; Lisi Dai; Zhongkun Liu; Lang Chen; Yimin Fang; Panpan Ma; Xiangji Wu; Hao Kong; Wenting Liao; Hong Jiang; Junbin Qian; Da Wang; Yun-Hua Liu

Doi: 10.1158/2159-8290.CD-23-0584

Research Article

Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary

Ido Yofe; Tamar Shami; Noam Cohen; Tomer Landsberger; Fadi Sheban; Liat Stoler-Barak; Adam Yalin; Truong San Phan; Baoguo Li; Lea Monteran; Ye'ela Scharff; Amir Giladi; Miriam Elbaz; Eyal David; Anna Gurevich-Shapiro; Chamutal Gur; Ziv Shulman; Neta Erez; Ido Amit

Doi: 10.1158/2159-8290.CD-23-0299

Research Article

Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

Lindy L. Visser; Margit Bleijs; Thanasis Margaritis; Marc van de Wetering; Frank C. P. Holstege; Hans Clevers

Doi: 10.1158/2767-9764.CRC-23-0027

Research Article

Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Jesus Amo-Aparicio; Adrian Dominguez; Shaikh M. Atif; Alberto Dinarello; Tania Azam; Kibrom M. Alula; Miles Piper; Christopher H. Lieu; Robert W. Lentz; Alexis D. Leal; Stacey M. Bagby; Wells A. Messersmith; Sana D. Karam; Charles A. Dinarello; Todd M. Pitts; Carlo Marchetti

Doi: 10.1158/2767-9764.CRC-23-0065

Tumor Biology and Immunology

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer

Erika Y. Faraoni; Kanchan Singh; Vidhi Chandra; Olivereen Le Roux; Yulin Dai; Ismet Sahin; Baylee J. O'Brien; Lincoln N. Strickland; Le Li; Emily Vucic; Amanda N. Warner; Melissa Pruski; Trent Clark; George Van Buren; Nirav C. Thosani; John S. Bynon; Curtis J. Wray; Dafna Bar-Sagi; Kyle L. Poulsen; Lana A. Vornik; Michelle I. Savage; Shizuko Sei; Altaf Mohammed; Zhongming Zhao; Powel H. Brown; Tingting Mills; Holger K. Eltzschig; Florencia McAllister; Jennifer M. Bailey-Lundberg

Doi: 10.1158/0008-5472.CAN-22-2553

Cancer Immunology

Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells

Ziwen Zhong; Hao Zhang; Ke Nan; Jing Zhong; Qichao Wu; Lihong Lu; Ying Yue; Zhenyu Zhang; Miaomiao Guo; Zhiqiang Wang; Jie Xia; Yun Xing; Ying Fu; Baichao Yu; Wenchang Zhou; Xingfeng Sun; Yang Shen; Wankun Chen; Jie Zhang; Jin Zhang; Duan Ma; Yiwei Chu; Ronghua Liu

Doi: 10.1158/0008-5472.CAN-23-0323

Cancer Hallmarks Review

Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells

Linheng Li; Roy A. Jensen

Doi: 10.1158/0008-5472.CAN-23-0230

Tumor Microenvironment and Immunobiology

Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Carcinogenesis

Benjamin L. Green; Lauren A. Gamble; Laurence P. Diggs; Darryl Nousome; Jesse C. Patterson; Brian A. Joughin; Billel Gasmi; Stephanie C. Lux; Sarah G. Samaranayake; Markku Miettinen; Martha Quezado; Jonathan M. Hernandez; Michael B. Yaffe; Jeremy L. Davis

Doi: 10.1158/1541-7786.MCR-23-0122

Tumor Microenvironment and Immunobiology

MDM2 Inhibition Enhances Immune Checkpoint Inhibitor Efficacy by Increasing IL15 and MHC Class II Production

Marlene Langenbach; Sophie Giesler; Stefan Richtsfeld; Sara Costa-Pereira; Lukas Rindlisbacher; Tobias Wertheimer; Lukas M. Braun; Geoffroy Andrieux; Sandra Duquesne; Dietmar Pfeifer; Nadine M. Woessner; Hans D. Menssen; Sanaz Taromi; Justus Duyster; Melanie Börries; Tilman Brummer; Bruce R. Blazar; Susana Minguet; Patrick Turko; Mitchell P. Levesque; Burkhard Becher; Robert Zeiser

Doi: 10.1158/1541-7786.MCR-22-0898

Research Article

FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment

David A. Knorr; Lucas Blanchard; Rom S. Leidner; Shawn M. Jensen; Ryan Meng; Andrew Jones; Carmen Ballesteros-Merino; Richard B. Bell; Maria Baez; Alessandra Marino; David Sprott; Carlo B. Bifulco; Brian Piening; Rony Dahan; Juan C. Osorio; Bernard A. Fox; Jeffrey V. Ravetch

Doi: 10.1158/2326-6066.CIR-23-0389

Research Article

LILRB3 Supports Immunosuppressive Activity of Myeloid Cells and Tumor Development

Ryan Huang; Xiaoye Liu; Jaehyup Kim; Hui Deng; Mi Deng; Xun Gui; Heyu Chen; Guojin Wu; Wei Xiong; Jingjing Xie; Cheryl Lewis; Jade Homsi; Xing Yang; Chengcheng Zhang; Yubo He; Qi Lou; Caroline Smith; Samuel John; Ningyan Zhang; Zhiqiang An; Cheng Cheng Zhang

Doi: 10.1158/2326-6066.CIR-23-0496

Cancer Hallmarks Perspective

A Metabolic Axis of Immune Intractability

Dominique C. Hinshaw; Meet Patel; Lalita A. Shevde

Doi: 10.1158/2326-6066.CIR-23-0433

Research Article

Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells

Annika Nelde; Heiko Schuster; Jonas S. Heitmann; Jens Bauer; Yacine Maringer; Melissa Zwick; Jens-Peter Volkmer; James Y. Chen; Anna M. Paczulla Stanger; Ariane Lehmann; Bismark Appiah; Melanie Märklin; Elke Rücker-Braun; Helmut R. Salih; Malte Roerden; Sarah M. Schroeder; Max-Felix Häring; Andreas Schlosser; Johannes Schetelig; Marc Schmitz; Melanie Boerries; Natalie Köhler; Claudia Lengerke; Ravindra Majeti; Irving L. Weissman; Hans-Georg Rammensee; Juliane S. Walz

Doi: 10.1158/2643-3230.BCD-23-0020

Small Molecule Therapeutics

Radiation Synergizes with IL2/IL15 Stimulation to Enhance Innate Immune Activation and Antitumor Immunity

Xuefeng Li; Kristin Huntoon; Yifan Wang; DaeYong Lee; Shiyan Dong; Abin Antony; Carl Walkey; Betty Y.S. Kim; Wen Jiang

Doi: 10.1158/1535-7163.MCT-23-0236

Small Molecule Therapeutics

Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes

Subhayan Sur; Pradeep Bhartiya; Robert Steele; Michelle Brennan; Richard J. DiPaolo; Ratna B. Ray

Doi: 10.1158/1535-7163.MCT-23-0718

Research Article

Genome-Scale Methylation Analysis Identifies Immune Profiles and Age Acceleration Associations with Bladder Cancer Outcomes

Ji-Qing Chen; Lucas A. Salas; John K. Wiencke; Devin C. Koestler; Annette M. Molinaro; Angeline S. Andrew; John D. Seigne; Margaret R. Karagas; Karl T. Kelsey; Brock C. Christensen

Doi: 10.1158/1055-9965.EPI-23-0331

Research Article

Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies

Ilona Argirion; Ruth M. Pfeiffer; Carla Proietti; Anna E. Coghill; Kelly J. Yu; Jaap M. Middeldorp; Yomani D. Sarathkumara; Wan-Lun Hsu; Yin-Chu Chien; Pei-Jen Lou; Cheng-Ping Wang; Nathaniel Rothman; Qing Lan; Chien-Jen Chen; Sam M. Mbulaiteye; Ruth F. Jarrett; Ingrid Glimelius; Karin E. Smedby; Henrik Hjalgrim; Allan Hildesheim; Denise L. Doolan; Zhiwei Liu

Doi: 10.1158/1055-9965.EPI-22-0452

Research Article

Methylation Signature Implicated in Immuno-Suppressive Activities in Tubo-Ovarian High-Grade Serous Carcinoma

Chen Wang; Matthew S. Block; Julie M. Cunningham; Mark E. Sherman; Bryan M. McCauley; Sebastian M. Armasu; Robert A. Vierkant; Nadia Traficante; for the Australian Ovarian Cancer Study Group; Aline Talhouk; Susan J. Ramus; Nadja Pejovic; Martin Köbel; Brooke D. Jorgensen; Dale W. Garsed; Sian Fereday; Jennifer A. Doherty; Dinuka Ariyaratne; Michael S. Anglesio; Martin Widschwendter; Tanja Pejovic; Jesus Gonzalez Bosquet; David D. Bowtell; Stacey J. Winham; Ellen L. Goode

Doi: 10.1158/1055-9965.EPI-22-0941

Review

Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells

Linheng Li; Roy A. Jensen

Doi: 10.1158/0008-5472.CAN-23-0230

Review

The Great Immune Escape: Understanding the Divergent Immune Response in Breast Cancer Subtypes

Sayali S. Onkar; Neil M. Carleton; Peter C. Lucas; Tullia C. Bruno; Adrian V. Lee; Dario A.A. Vignali; Steffi Oesterreich

Doi: 10.1158/2159-8290.CD-22-0475

Review

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

Chiara Falcomatà; Stefanie Bärthel; Günter Schneider; Roland Rad; Marc Schmidt-Supprian; Dieter Saur

Doi: 10.1158/2159-8290.CD-22-0876

Review

Epithelial–Mesenchymal Plasticity in Tumor Immune Evasion

Riley D.Z. Mullins; Ananya Pal; Thomas F. Barrett; Molly E. Heft Neal; Sidharth V. Puram

Doi: 10.1158/0008-5472.CAN-21-4370

Review

Hallmarks of Resistance to Immune-Checkpoint Inhibitors

Maria Karasarides; Alexandria P. Cogdill; Paul B. Robbins; Michaela Bowden; Elizabeth M. Burton; Lisa H. Butterfield; Alessandra Cesano; Christian Hammer; Cara L. Haymaker; Christine E. Horak; Heather M. McGee; Anne Monette; Nils-Petter Rudqvist; Christine N. Spencer; Randy F. Sweis; Benjamin G. Vincent; Erik Wennerberg; Jianda Yuan; Roberta Zappasodi; Vanessa M. Hubbard Lucey; Daniel K. Wells; Theresa LaVallee

Doi: 10.1158/2326-6066.CIR-20-0586

Cancer Immunology at the Crossroads

Coming of Age: Human Genomics and the Cancer–Immune Set Point

Christian Hammer; Ira Mellman

Doi: 10.1158/2326-6066.CIR-21-1017

Review

Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity

Matthew R. Strickland; Christopher Alvarez-Breckenridge; Justin F. Gainor; Priscilla K. Brastianos

Doi: 10.1158/2159-8290.CD-21-0976

Research Article

Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling

Israel Matos; Maunish Barvalia; Manreet K. Chehal; A. Gordon Robertson; Iva Kulic; Jessica A.F.D. Silva; Abhinandan Ranganathan; Amy Short; Yu-Hsuan Huang; Erin Long; John J. Priatel; Salim Dhanji; Brad H. Nelson; Danielle L. Krebs; Kenneth W. Harder

Doi: 10.1158/2767-9764.CRC-22-0278

Research Article

Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration

Cassandra A. Hathaway; Tianyi Wang; Mary K. Townsend; Christine Vinci; Danielle E. Jake-Schoffman; Daryoush Saeed-Vafa; Carlos Moran Segura; Jonathan V. Nguyen; Jose R. Conejo-Garcia; Brooke L. Fridley; Shelley S. Tworoger

Doi: 10.1158/1055-9965.EPI-22-0877

Research Article

Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses

Ernesto Gargiulo; Elodie Viry; Pablo Elías Morande; Anne Largeot; Susanne Gonder; Feng Xian; Nikolaos Ioannou; Mohaned Benzarti; Felix Bruno Kleine Borgmann; Michel Mittelbronn; Gunnar Dittmar; Petr V. Nazarov; Johannes Meiser; Basile Stamatopoulos; Alan G. Ramsay; Etienne Moussay; Jérôme Paggetti

Doi: 10.1158/2643-3230.BCD-22-0029

Research Article

Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer

Hao Chen; Gregory M. Cresswell; Sarah Libring; Mitchell G. Ayers; Jinmin Miao; Zhong-Yin Zhang; Luis Solorio; Timothy L. Ratliff; Michael K. Wendt

Doi: 10.1158/2767-9764.CRC-22-0117

Research Article

Transcriptional Plasticity Drives Leukemia Immune Escape

Kenneth Eagle; Taku Harada; Jérémie Kalfon; Monika W. Perez; Yaser Heshmati; Jazmin Ewers; Jošt Vrabič Koren; Joshua M. Dempster; Guillaume Kugener; Vikram R. Paralkar; Charles Y. Lin; Neekesh V. Dharia; Kimberly Stegmaier; Stuart H. Orkin; Maxim Pimkin

Doi: 10.1158/2643-3230.BCD-21-0207

Research Article

Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

Liam Jenkins; Ute Jungwirth; Alexandra Avgustinova; Marjan Iravani; Adam Mills; Syed Haider; James Harper; Clare M. Isacke

Doi: 10.1158/0008-5472.CAN-21-4141

Research Article

Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment

Jamila Kacher; Olivier Manches; Caroline Aspord; Hervé Sartelet; Laurence Chaperot

Doi: 10.1158/2767-9764.CRC-21-0134

Research Brief

Integrated Multiomic Profiling Identifies the Epigenetic Regulator PRC2 as a Therapeutic Target to Counteract Leukemia Immune Escape and Relapse

Valentina Gambacorta; Stefano Beretta; Martina Ciccimarra; Laura Zito; Kety Giannetti; Angela Andrisani; Daniela Gnani; Lucia Zanotti; Giacomo Oliveira; Matteo Giovanni Carrabba; Davide Cittaro; Ivan Merelli; Fabio Ciceri; Raffaella Di Micco; Luca Vago

Doi: 10.1158/2159-8290.CD-21-0980

Research Article

Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice

Akito Tsuruta; Yuki Shiiba; Naoya Matsunaga; Marina Fujimoto; Yuya Yoshida; Satoru Koyanagi; Shigehiro Ohdo

Doi: 10.1158/1541-7786.MCR-21-0786

Research Article

Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

Carlos R. Gil Del Alcazar; Anne Trinh; Maša Alečković; Ernesto Rojas Jimenez; Nicholas W. Harper; Michael U.J. Oliphant; Shanshan Xie; Ethan D. Krop; Bethlehem Lulseged; Katherine C. Murphy; Tanya E. Keenan; Eliezer M. Van Allen; Sara M. Tolaney; Gordon J. Freeman; Deborah A. Dillon; Senthil K. Muthuswamy; Kornelia Polyak

Doi: 10.1158/2326-6066.CIR-21-0804

Research Article

Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma

Wenjing Xuan; Wen-Hao Hsu; Fatima Khan; Madeline Dunterman; Lizhi Pang; Derek A. Wainwright; Atique U. Ahmed; Amy B. Heimberger; Maciej S. Lesniak; Peiwen Chen

Doi: 10.1158/2326-6066.CIR-21-0559

Research Article

JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA

Zegui Ni; Pengli Sun; Jin Zheng; Mingqing Wu; Congcong Yang; Maosheng Cheng; Mingwei Yin; Chengying Cui; Guangxian Wang; Lin Yuan; Qian Gao; Yang Li

Doi: 10.1158/0008-5472.CAN-21-1323

Research Article

Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma

Meng-Ju Wu; Lei Shi; Juan Dubrot; Joshua Merritt; Vindhya Vijay; Ting-Yu Wei; Emily Kessler; Kira E. Olander; Ramzi Adil; Amaya Pankaj; Krishna Seshu Tummala; Vajira Weeresekara; Yuanli Zhen; Qibiao Wu; Meiqi Luo; William Shen; María García-Beccaria; Mirian Fernández-Vaquero; Christine Hudson; Sebastien Ronseaux; Yi Sun; Rodrigo Saad-Berreta; Russell W. Jenkins; Tong Wang; Mathias Heikenwälder; Cristina R. Ferrone; Lipika Goyal; Brandon Nicolay; Vikram Deshpande; Rahul M. Kohli; Hongwu Zheng; Robert T. Manguso; Nabeel Bardeesy

Doi: 10.1158/2159-8290.CD-21-1077

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