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Cancer Hallmarks

Presented by the AACR Journals

 

 

 

Activating Invasion and Metastasis

Cancer Hallmarks Review

Metabolic Signaling in Cancer Metastasis

Sarah Krieg; Sara Isabel Fernandes; Constantinos Kolliopoulos; Ming Liu; Sarah-Maria Fendt

Doi: 10.1158/2159-8290.CD-24-0174

Research Article

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression

Gizem Efe; Karen J. Dunbar; Kensuke Sugiura; Katherine Cunningham; Saul Carcamo; Spyros Karaiskos; Qiaosi Tang; Ricardo Cruz-Acuña; Lois Resnick-Silverman; Jessica Peura; Chao Lu; Dan Hasson; Andres J. Klein-Szanto; Alison M. Taylor; James J. Manfredi; Carol Prives; Anil K. Rustgi

Doi: 10.1158/2159-8290.CD-23-0601

Research Article

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer

Nurmaa K. Dashzeveg; Yuzhi Jia; Youbin Zhang; Lorenzo Gerratana; Priyam Patel; Asif Shajahan; Tsogbadrakh Dandar; Erika K. Ramos; Hannah F. Almubarak; Valery Adorno-Cruz; Rokana Taftaf; Emma J. Schuster; David Scholten; Michael T. Sokolowski; Carolina Reduzzi; Lamiaa El-Shennawy; Andrew D. Hoffmann; Maroua Manai; Qiang Zhang; Paolo D'Amico; Parastoo Azadi; Karen J. Colley; Leonidas C. Platanias; Ami N. Shah; William J. Gradishar; Massimo Cristofanilli; William A. Muller; Brian A. Cobb; Huiping Liu

Doi: 10.1158/2159-8290.CD-22-0644

Research Article

Combining TIGIT blockage with MDSC inhibition hinders breast cancer bone metastasis by activating anti-tumor immunity

Lea Monteran; Nour Ershaid; Ye'ela Scharff; Yazeed Zoabi; Tamer Sanalla; Yunfeng Ding; Anna Pavlovsky; Yael Zait; Marva Langer; Tal Caller; Anat Eldar-Boock; Camila Avivi; Amir Sonnenblick; Ronit Satchi-Fainaro; Iris Barshack; Noam Shomron; Xiang H.-F. Zhang; Neta Erez

Doi: 10.1158/2159-8290.CD-23-0762

Research Article

Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer

Xuemei Xie; Gaurav B. Chauhan; Ramakrishna Edupuganti; Takahiro Kogawa; Jihyun Park; Moises Tacam; Alex W. Tan; Mohd Mughees; Fnu Vidhu; Diane D. Liu; Juliana M. Taliaferro; Mary Kathryn Pitner; Luke S. Browning; Ju-Hyeon Lee; François Bertucci; Yu Shen; Jian Wang; Naoto T. Ueno; Savitri Krishnamurthy; Gabriel N. Hortobagyi; Debu Tripathy; Steven J. Van Laere; Geoffrey Bartholomeusz; Kevin N. Dalby; Chandra Bartholomeusz

Doi: 10.1158/2767-9764.CRC-22-0330

Research Article

Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung Adenocarcinoma

Nelson F. Freeburg; Nia Peterson; Dain A. Ruiz; Amy C. Gladstein; David M. Feldser

Doi: 10.1158/2767-9764.CRC-23-0172

Cancer Biology

Small Cell Lung Cancer Plasticity Enables NFIB-Independent Metastasis

Julie H. Ko; Kyle E. Lambert; Debadrita Bhattacharya; Myung Chang Lee; Caterina I. Colón; Haley Hauser; Julien Sage

Doi: 10.1158/0008-5472.CAN-23-1079

Cancer Biology

Breast Cancer–Secreted Factors Promote Lung Metastasis by Signaling Systemically to Induce a Fibrotic Premetastatic Niche

Noam Cohen; Dhanashree Mundhe; Sarah K. Deasy; Omer Adler; Nour Ershaid; Tamar Shami; Oshrat Levi-Galibov; Rina Wassermann; Ruth Scherz-Shouval; Neta Erez

Doi: 10.1158/0008-5472.CAN-22-3707

Tumor Microenvironment and Immunobiology

Triple-Negative Breast Cancer-Derived Extracellular Vesicles Promote a Hepatic Premetastatic Niche via a Cascade of Microenvironment Remodeling

Woohang Heo; Woochan Lee; Jong Ho Cheun; Eun-Shin Lee; Songbin Li; Hoe suk Kim; Hye-Youn Son; Ju Hee Kim; Yeon Duk Woo; Doo Hyun Chung; Jihui Yun; Ji Gwang Jung; Han-Byoel Lee; Wonshik Han; Hong-Kyu Kim; Jong-Il Kim; Hyeong-Gon Moon

Doi: 10.1158/1541-7786.MCR-22-0673

Metabolism

FGFR1 Signaling Facilitates Obesity-Driven Pulmonary Outgrowth in Metastatic Breast Cancer

Eylem Kulkoyluoglu Cotul; Muhammad Hassan Safdar; Sebastian Juan Paez; Aneesha Kulkarni; Mitchell G. Ayers; Hang Lin; Zilin Xianyu; Dorothy Teegarden; Stephen D. Hursting; Michael K. Wendt

Doi: 10.1158/1541-7786.MCR-23-0955

Research Article

ANXA3-Rich Exosomes Derived from Tumor-Associated Macrophages Regulate Ferroptosis and Lymphatic Metastasis of Laryngeal Squamous Cell Carcinoma

Licheng Xu; Wenjing Li; Danxi Liu; Jing Cao; Jingchun Ge; Xinyu Liu; Yue Wang; Yujian Teng; Pengyan Liu; Xinyue Guo; Chen He; Ming Liu; Linli Tian

Doi: 10.1158/2326-6066.CIR-23-0595

Small Model Therapeutics

Neutrophil Elastase Remodels Mammary Tumors to Facilitate Lung Metastasis

Amriti R. Lulla; Said Akli; Cansu Karakas; Joseph A. Caruso; Lucas D. Warma; Natalie W. Fowlkes; Xiayu Rao; Jing Wang; Kelly K. Hunt; Stephanie S. Watowich; Khandan Keyomarsi

Doi: 10.1158/1535-7163.MCT-23-0414

Small Model Therapeutics

Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts

Jianxiang Ji; Sonja Dragojevic; Cameron M. Callaghan; Emily J. Smith; Surabhi Talele; Wenjuan Zhang; Margaret A. Connors; Ann C. Mladek; Zeng Hu; Katrina K. Bakken; Paige P. Sarkaria; Brett L. Carlson; Danielle M. Burgenske; Paul A. Decker; Mohammad Abdur Rashid; Mi-hyeon Jang; Shiv K. Gupta; Jeanette E. Eckel-Passow; William F. Elmquist; Jann N. Sarkaria

Doi: 10.1158/1535-7163.MCT-23-0552

Review

The Genetic Evolution of Metastasis

Aljosja Rogiers; Irene Lobon; Lavinia Spain; Samra Turajlic

Doi: 10.1158/0008-5472.CAN-21-3863

Research Article

Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2+ Cells

Weijie Zhang; Zhan Xu; Xiaoxin Hao; Tiancheng He; Jiasong Li; Yichao Shen; Kai Liu; Yang Gao; Jun Liu; David G. Edwards; Aaron M. Muscarella; Ling Wu; Liqun Yu; Longyong Xu; Xi Chen; Yi-Hsuan Wu; Igor L. Bado; Yunfeng Ding; Sergio Aguirre; Hai Wang; Zbigniew Gugala; Robert L. Satcher; Stephen T.C. Wong; Xiang H.-F. Zhang

Doi: 10.1158/2159-8290.CD-22-0220

Research Article

Extracellular Vesicle–Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis

Fang Wang; Yuequn Niu; Kelie Chen; Xiaoyu Yuan; Yuheng Qin; Fang Zheng; Zhenyan Cui; Weiguo Lu; Yihua Wu; Dajing Xia

Doi: 10.1158/2326-6066.CIR-22-0410

Research Article

Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

Boris Shorning; Neil Trent; David F. Griffiths; Thomas Worzfeld; Stefan Offermanns; Matthew J. Smalley; Magali Williamson

Doi: 10.1158/2767-9764.CRC-22-0480

Research Article

An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression

Manuel C. Scheidmann; Francesc Castro-Giner; Karin Strittmatter; Ilona Krol; Aino Paasinen-Sohns; Ramona Scherrer; Cinzia Donato; Sofia Gkountela; Barbara M. Szczerba; Zoi Diamantopoulou; Simone Muenst; Tatjana Vlajnic; Leo Kunz; Marcus Vetter; Christoph Rochlitz; Verdon Taylor; Claudio Giachino; Timm Schroeder; Randall J. Platt; Nicola Aceto

Doi: 10.1158/0008-5472.CAN-21-3908

Research Article

Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh; Roy Rabbie; Manik Garg; Dianne Lumaquin; Ting-Hsiang Huang; Emily Montal; Yilun Ma; Nelly M Cruz; Xinran Tang; Jérémie Nsengimana; Julia Newton-Bishop; Miranda V. Hunter; Yuxin Zhu; Kevin Chen; Elisa de Stanchina; David J. Adams; Richard M. White

Doi: 10.1158/2159-8290.CD-22-0427

Research Article

The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer

Priyanka S. Rana; Wei Wang; Vesna Markovic; Justin Szpendyk; Ernest Ricky Chan; Khalid Sossey-Alaoui

Doi: 10.1158/2767-9764.CRC-22-0249

Research Article

DKK1 Promotes Tumor Immune Evasion and Impedes Anti–PD-1 Treatment by Inducing Immunosuppressive Macrophages in Gastric Cancer

Tao Shi; Yipeng Zhang; Yue Wang; Xueru Song; Hanbing Wang; Xiaoyu Zhou; Kaijie Liang; Yuting Luo; Keying Che; Xuan Wang; Yunfeng Pan; Fangcen Liu; Ju Yang; Qin Liu; Lixia Yu; Baorui Liu; Jia Wei

Doi: 10.1158/2326-6066.CIR-22-0218

Research Article

Loss of Dok-3 in Non-tumor Cells Induces Malignant Transformation of Benign Epithelial Tumor Cells of the Intestine

Sumimasa Arimura; Akane Inoue-Yamauchi; Kotoe Katayama; Tatsuo Kanno; Hiroki Jozawa; Seiya Imoto; Yuji Yamanashi

Doi: 10.1158/2767-9764.CRC-22-0347

Research Article

IL1β Expression Driven by Androgen Receptor Absence or Inactivation Promotes Prostate Cancer Bone Metastasis

Anthony DiNatale; Asurayya Worrede; Waleed Iqbal; Michael Marchioli; Allison Toth; Martin Sjöström; Xiaolin Zhu; Eva Corey; Felix Y. Feng; Wanding Zhou; Alessandro Fatatis

Doi: 10.1158/2767-9764.CRC-22-0262

Research Article

Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion

Sylvie Deborde; Laxmi Gusain; Ann Powers; Andrea Marcadis; Yasong Yu; Chun-Hao Chen; Anna Frants; Elizabeth Kao; Laura H. Tang; Efsevia Vakiani; Masataka Amisaki; Vinod P. Balachandran; Annalisa Calo; Tatiana Omelchenko; Kristjan R. Jessen; Boris Reva; Richard J. Wong

Doi: 10.1158/2159-8290.CD-21-1690

Research Article

Treatment Represents a Key Driver of Metastatic Cancer Evolution

Ditte S. Christensen; Johanne Ahrenfeldt; Mateo Sokač; Judit Kisistók; Martin K. Thomsen; Lasse Maretty; Nicholas McGranahan; Nicolai J. Birkbak

Doi: 10.1158/0008-5472.CAN-22-0562

Research Article

Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition

Christopher Alvarez-Breckenridge; Samuel C. Markson; Jackson H. Stocking; Naema Nayyar; Matt Lastrapes; Matthew R. Strickland; Albert E. Kim; Magali de Sauvage; Ashish Dahal; Juliana M. Larson; Joana L. Mora; Andrew W. Navia; Robert H. Klein; Benjamin M. Kuter; Corey M. Gill; Mia Bertalan; Brian Shaw; Alexander Kaplan; Megha Subramanian; Aarushi Jain; Swaminathan Kumar; Husain Danish; Michael White; Osmaan Shahid; Kristen E. Pauken; Brian C. Miller; Dennie T. Frederick; Christine Hebert; McKenzie Shaw; Maria Martinez-Lage; Matthew Frosch; Nancy Wang; Elizabeth Gerstner; Brian V. Nahed; William T. Curry; Bob Carter; Daniel P. Cahill; Genevieve Marie Boland; Benjamin Izar; Michael A. Davies; Arlene H. Sharpe; Mario L. Suvà; Ryan J. Sullivan; Priscilla K. Brastianos; Scott L. Carter

Doi: 10.1158/2326-6066.CIR-21-0870

Research Article

Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

Kevin Kleffman; Grace Levinson; Indigo V.L. Rose; Lili M. Blumenberg; Sorin A.A. Shadaloey; Avantika Dhabaria; Eitan Wong; Francisco Galán-Echevarría; Alcida Karz; Diana Argibay; Richard Von Itter; Alfredo Floristán; Gillian Baptiste; Nicole M. Eskow; James A. Tranos; Jenny Chen; Eleazar C. Vega y Saenz de Miera; Melissa Call; Robert Rogers; George Jour; Youssef Zaim Wadghiri; Iman Osman; Yue-Ming Li; Paul Mathews; Ronald B. DeMattos; Beatrix Ueberheide; Kelly V. Ruggles; Shane A. Liddelow; Robert J. Schneider; Eva Hernando

Doi: 10.1158/2159-8290.CD-21-1006

Research Article

Uveal Melanoma Exosomes Induce a Prometastatic Microenvironment through Macrophage Migration Inhibitory Factor

Grazia Ambrosini; Alex J. Rai; Richard D. Carvajal; Gary K. Schwartz

Doi: 10.1158/1541-7786.MCR-21-0526

Research Article

Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma

Angela Riedel; Moutaz Helal; Luisa Pedro; Jonathan J. Swietlik; David Shorthouse; Werner Schmitz; Lisa Haas; Timothy Young; Ana S.H. da Costa; Sarah Davidson; Pranjali Bhandare; Elmar Wolf; Benjamin A. Hall; Christian Frezza; Thordur Oskarsson; Jacqueline D. Shields

Doi: 10.1158/2326-6066.CIR-21-0778

Research Article

Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II

Maria Kalli; Ruxuan Li; Gordon B. Mills; Triantafyllos Stylianopoulos; Ioannis K. Zervantonakis

Doi: 10.1158/1541-7786.MCR-21-0266

Research Article

Disruption of β-Catenin–Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion

George T. Chen; Delia F. Tifrea; Rabi Murad; Amber N. Habowski; Yung Lyou; Madeleine R. Duong; Linzi Hosohama; Ali Mortazavi; Robert A. Edwards; Marian L. Waterman

Doi: 10.1158/1541-7786.MCR-21-0349

Research Article

Multiomic Profiling of Central Nervous System Leukemia Identifies mRNA Translation as a Therapeutic Target

Robert J. Vanner; Stephanie M. Dobson; Olga I. Gan; Jessica McLeod; Erwin M. Schoof; Ildiko Grandal; Jeff A. Wintersinger; Laura Garcia-Prat; Mohsen Hosseini; Stephanie Z. Xie; Liqing Jin; Nathan Mbong; Veronique Voisin; Michelle Chan-Seng-Yue; James A. Kennedy; Esmé Waanders; Quaid Morris; Bo Porse; Steven M. Chan; Cynthia J. Guidos; Jayne S. Danska; Mark D. Minden; Charles G. Mullighan; John E. Dick

Doi: 10.1158/2643-3230.BCD-20-0216

Research Article

T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy

Jozafina Haj-Shomaly; Avital Vorontsova; Tamar Barenholz-Cohen; Oshrat Levi-Galibov; Mahesh Devarasetty; Michael Timaner; Ziv Raviv; Tim J. Cooper; Shay Soker; Peleg Hasson; Daphne Weihs; Ruth Scherz-Shouval; Yuval Shaked

Doi: 10.1158/0008-5472.CAN-21-1012

Research Article

AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer

Yuqing Zhang; Emily N. Arner; Ali Rizvi; Jason E. Toombs; Huocong Huang; Steven L. Warner; Jason M. Foulks; Rolf A. Brekken

Doi: 10.1158/1535-7163.MCT-21-0293

Research Article

Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation

Lauren E. Milling; Daniel Garafola; Yash Agarwal; Shengwei Wu; Ayush Thomas; Nathan Donahue; Josetta Adams; Nikki Thai; Heikyung Suh; Darrell J. Irvine

Doi: 10.1158/2326-6066.CIR-21-0247

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