Blood Cancer Discovery

METTL3-Mediated m⁶A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL
Yiming Wu, et al.
Blood Cancer Discovery May 2023

Cancer Discovery

Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047
Meredith S. Shiels, et al.
Cancer Discov May 2023

Cancer Epidemiology, Biomarkers & Prevention

Risk and Protective Factors for Cancer Mortality among United States Service Members and Veterans (2001–2018)
Neika Sharifian, et al.
Cancer Epidemiol Bio Prev May 2023

Cancer Immunology Research

Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes
Zachary L.Z. Hay, et al.
Cancer Immunol Res May 2023

Cancer Prevention Research

Stressful Life Events, Social Support, and Incident Breast Cancer by Estrogen Receptor Status
Wayne R. Lawrence, et al.
Cancer Prev Res May 2023

Cancer Research

Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Sammy Ferri-Borgogno, et al.
Cancer Res May 2023

Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell–Derived Cytokines
Simon Schwörer, et al.
Cancer Res May 2023

Clinical Cancer Research

Genomic Complexity Predicts Resistance to Endocrine Therapy and CDK4/6 Inhibition in Hormone Receptor–Positive (HR+)/HER2-Negative Metastatic Breast Cancer
Andrew A. Davis, et al.
Clin Cancer Res May 2023

Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis
Chong Kin Liam, et al.
Clin Cancer Res May 2023

Molecular Cancer Research

The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma
Sebastiaan M. Schieven, et al.
Mol Cancer Res May 2023

Molecular Cancer Therapeutics

Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
Gregor Rossmueller, et al.
Mol Cancer Ther May 2023

Cancer Research Communications

IOA-244 is a Non–ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance
Zoë Johnson, et al.
Cancer Res Commun May 2023

Blood Cancer Discovery

Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy
Alfred L. Garfall, et al.
Blood Cancer Discovery April 2023

Cancer Discovery

Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma
Zengpanpan Ye, et al.
Cancer Discov April 2023

Cancer Epidemiology, Biomarkers & Prevention

The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Shama D. Karanth, et al.
Cancer Epidemiol Bio Prev April 2023

Cancer Immunology Research

IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model
Veronika Lutz, et al.
Cancer Immunol Res April 2023

Cancer Prevention Research

Safety Run-in of Intramuscular pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN Protein Vaccination as Treatment for HPV16+ ASC-US, ASC-H, or LSIL/CIN1
Mark H. Einstein, et al.
Cancer Prev Res April 2023

Cancer Research

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Erika Y. Faraoni, et al.
Cancer Res April 2023

Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
Matthia A. Karreman, et al.
Cancer Res April 2023

Clinical Cancer Research

Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma
James Nguyen, et al.
Clin Cancer Res April 2023

The Oral PI3Kδ Inhibitor Linperlisib for the Treatment of Relapsed and/or Refractory Follicular Lymphoma: A Phase II, Single-Arm, Open-Label Clinical Trial
Tingyu Wang, et al.
Clin Cancer Res April 2023

Molecular Cancer Research

Multi-substrate Metabolic Tracing Reveals Marked Heterogeneity and Dependency on Fatty Acid Metabolism in Human Prostate Cancer
Gio Fidelito, et al.
Mol Cancer Res April 2023

Molecular Cancer Therapeutics

SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
Rebecca Mazahreh, et al.
Mol Cancer Ther April 2023

Cancer Research Communications

Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Jason Garcia, et al.
Cancer Res Commun April 2023

Blood Cancer Discovery

Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis
Rathana Kim, et al.
Blood Cancer Discovery March 2023

Cancer Discovery

Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal Cancer
Andreana N. Holowatyj, et al.
Cancer Discov March 2023

Cancer Epidemiology, Biomarkers & Prevention

Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study
Shannon S. Cigan, et al.
Cancer Epidemiol Bio Prev March 2023

Cancer Immunology Research

Syntaphilin Regulates Neutrophil Migration in Cancer
Shuyu Fu, et al.
Cancer Immunol Res March 2023

Cancer Prevention Research

Benign Breast Disease, NSAIDs, and Postmenopausal Breast Cancer Risk in the CPS-II Cohort
Mark E. Sherman, et al.
Cancer Prev Res March 2023

Cancer Research

Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors
Takahiko Akiyama, et al.
Cancer Res March 2023

Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss–Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities
Ravinder Verma, et al.
Cancer Res March 2023

Clinical Cancer Research

Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial
Andrés Elía, et al.
Clin Cancer Res March 2023

A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study
Lavinia Tan, et al.
Clin Cancer Res March 2023

Molecular Cancer Research

ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Thomas E. Bass; Donald E. Fleenor; Paige E. Burrell; Michael B. Kastan
Mol Cancer Res March 2023

Molecular Cancer Therapeutics

Interplay Between Extracellular Matrix Remodeling and Angiogenesis in Tumor Ecosystem
Rohit Siddhartha; Minal Garg
Mol Cancer Ther March 2023

Cancer Research Communications

Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer
Channing J. Paller, et al.
Cancer Res Commun March 2023

Blood Cancer Discovery

Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies
Ruth Flümann, et al.
Blood Cancer Discovery January 2023

Cancer Discovery

Efficacy of a Small-Molecule Inhibitor of Kras^G12D in Immunocompetent Models of Pancreatic Cancer
Samantha B. Kemp, et al.
Cancer Discov February 2023

Cancer Epidemiology, Biomarkers & Prevention

Race Differences in Patient-Reported Symptoms during Chemotherapy among Women with Early-Stage Hormone Receptor–Positive Breast Cancer
Xin Hu, et al.
Cancer Epidemiol Bio Prev February 2023

Cancer Immunology Research

Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR
Ximin Chen, et al.
Cancer Immunol Res February 2023

Cancer Prevention Research

Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes
Stina Bodén, et al.
Cancer Prev Res February 2023

Cancer Research

Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Tracey W. Chan, et al.
Cancer Res February 2023

The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer
Weisi Liu, et al.
Cancer Res February 2023

Clinical Cancer Research

Clinical Features Associated with Outcomes and Biomarker Analysis of Dabrafenib plus Trametinib Treatment in Patients with BRAF-Mutant Melanoma Brain Metastases
James S. Wilmott, et al.
Clin Cancer Res February 2023

Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non–Small Cell Lung Cancer
Samuel Rosner, et al.
Clin Cancer Res February 2023

Molecular Cancer Research

BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation
Haobin Chen, et al.
Mol Cancer Res February 2023

Molecular Cancer Therapeutics

Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers
Xiaofan Li, et al.
Mol Cancer Ther February 2023

Cancer Research Communications

Incorporating RNA-based Risk Scores for Genomic Instability to Predict Breast Cancer Recurrence and Immunogenicity in a Diverse Population
Alina M. Hamilton, et al.
Cancer Res Commun January 2023

Blood Cancer Discovery

Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
Ernesto Gargiulo, et al.
Blood Cancer Discovery January 2023

Cancer Discovery

Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy
Takamitsu Hattori, et al.
Cancer Discov January 2023

Cancer Epidemiology, Biomarkers & Prevention

Impact and Recovery from COVID-19–Related Disruptions in Colorectal Cancer Screening and Care in the US: A Scenario Analysis
Rosita van den Puttelaar, et al.
Cancer Epidemiol Bio Prev January 2023

Cancer Immunology Research

The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain
Jay A. Bowman-Kirigin, et al.
Cancer Immunol Res January 2023

Cancer Prevention Research

Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer
Parijatham S. Thomas, et al.
Cancer Prev Res January 2023

Cancer Research

Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast Cancer
Rania Bassiouni, et al.
Cancer Res January 2023

Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma
Haowen Jiang, et al.
Cancer Res January 2023

Clinical Cancer Research

Pilot Study of ONCOS-102 and Pembrolizumab: Remodeling of the Tumor Microenvironment and Clinical Outcomes in Anti–PD-1–Resistant Advanced Melanoma
Alexander N. Shoushtari, et al.
Clin Cancer Res January 2023

Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
Daniel S. Green, et al.
Clin Cancer Res January 2023

Molecular Cancer Research

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
Shideh Mirhadi, et al.
Mol Cancer Res January 2023

Molecular Cancer Therapeutics

Antibody–Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release
Anna Kopp, et al.
Mol Cancer Ther January 2023

Cancer Research Communications

Complex Patterns of Genomic Heterogeneity Identified in 42 Tumor Samples and ctDNA of a Pulmonary Atypical Carcinoid Patient
Tamsin J. Robb, et al.
Cancer Res Commun January 2023