2024
AACR offers monthly "Editors' Picks" from our journals. We highlight one article from each issue that has been determined a "must read" by the Editors. Be sure to bookmark this page, as it will be updated on a monthly basis.
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September
Blood Cancer Discovery
Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma
Blood Cancer Discovery September 2024
Cancer Discovery
MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer
Cancer Discov September 2024
Cancer Epidemiology, Biomarkers & Prevention
Use of Nonsteroidal Anti-Inflammatory Drugs and Pancreatic Cancer Risk in the Women’s Health Initiative
Cancer Epidemiol Bio Prev September 2024
Cancer Immunology Research
Nivolumab Reaches Brain Lesions in Patients with Recurrent Glioblastoma and Induces T-cell Activity and Upregulation of Checkpoint Pathways
Cancer Immunol Res September 2024
Cancer Prevention Research
Effect of Clonal Hematopoiesis Mutations and Canakinumab Treatment on Incidence of Solid Tumors in the CANTOS Randomized Clinical Trial
Cancer Prev Res September 2024
Cancer Research
Multistate Gene Cluster Switches Determine the Adaptive Mitochondrial and Metabolic Landscape of Breast Cancer
Cancer Res September 2024
Physical Activity Decreases Inflammation and Delays the Development of Obesity-Associated Pancreatic Ductal Adenocarcinoma
Cancer Res September 2024
Clinical Cancer Research
Safety, Efficacy, and Biological Data of T-Cell–Enabling Oncolytic Adenovirus TILT-123 in Advanced Solid Cancers from the TUNIMO Monotherapy Phase I Trial
Clin Cancer Res September 2024
Tumor-Localized Interleukin-2 and Interleukin-12 Combine with Radiation Therapy to Safely Potentiate Regression of Advanced Malignant Melanoma in Pet Dogs
Clin Cancer Res September 2024
Molecular Cancer Research
Clinically Relevant Humanized Mouse Models of Metastatic Prostate Cancer Facilitate Therapeutic Evaluation
Mol Cancer Res September 2024
Molecular Cancer Therapeutics
Pretargeted Radioimmunotherapy with the Novel Anti-oxMIF/HSG Bispecific Antibody ON105 Results in Significant Tumor Regression in Murine Models of Cancer
Mol Cancer Ther September 2024
Cancer Research Communications
Development and Application of Genetic Ancestry Reconstruction Methods to Study Diversity of Patient-Derived Models in the NCI PDXNet Consortium
Cancer Res Commun August 2024
August
Blood Cancer Discovery
Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC–Alarmin Axis
Blood Cancer Discovery July 2024
Cancer Discovery
Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Cancer Discov August 2024
Cancer Epidemiology, Biomarkers & Prevention
Joint Associations of Diet and Device-Measured Physical Activity with Mortality and Incident CVD and Cancer: A Prospective Analysis of the UK Biobank Study
Cancer Epidemiol Bio Prev August 2024
Cancer Immunology Research
T-Cell Expression of CXCL13 is Associated with Immunotherapy Response in a Sex-Dependent Manner in Patients with Lung Cancer
Cancer Immunol Res August 2024
Cancer Prevention Research
Colon Age: A Metric for Whether and How to Screen Male Veterans for Early-Onset Colorectal Cancer
Cancer Prev Res August 2024
Cancer Research
Human 3D Ovarian Cancer Models Reveal Malignant Cell–Intrinsic and –Extrinsic Factors That Influence CAR T-cell Activity
Cancer Res August 2024
Serine Depletion Promotes Anti-Tumor Immunity by Activating Mitochondrial DNA-mediated cGAS-STING Signaling
Cancer Res August 2024
Clinical Cancer Research
Plasma versus Tissue Tumor Mutational Burden as Biomarkers of Durvalumab plus Tremelimumab Response in Patients with Metastatic Colorectal Cancer in the CO.26 Trial
Clin Cancer Res August 2024
Nivolumab with or without Ipilimumab Combined with Stereotactic Body Radiotherapy in Patients with Metastatic Biliary Tract Cancer: A Randomized Phase 2 Study
Clin Cancer Res August 2024
Molecular Cancer Research
DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Mol Cancer Res August 2024
Molecular Cancer Therapeutics
Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab–Auristatin Conjugate with a Wide Therapeutic Window
Mol Cancer Ther August 2024
Cancer Research Communications
The Effect of Exposure to Neighborhood Violence on Glucocorticoid Receptor Signaling in Lung Tumors
Cancer Res Commun July 2024
July
Blood Cancer Discovery
The Fate(s) of CAR T-Cell Therapy: Navigating the Risks of CAR+ T-Cell Malignancy
Blood Cancer Discovery July 2024
Cancer Discovery
Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy
Cancer Discov July 2024
Cancer Epidemiology, Biomarkers & Prevention
Optimization and Local Cost-Effectiveness of Nasopharyngeal Carcinoma Screening Strategies in Southern China: Secondary Analysis of the Guangdong Randomized Trial
Cancer Epidemiol Bio Prev July 2024
Cancer Immunology Research
IL3-Driven T Cell–Basophil Crosstalk Enhances Antitumor Immunity
Cancer Immunol Res July 2024
Cancer Prevention Research
Evaluating the Reach of a Patient Navigation Program for Follow-up Colonoscopy in a Large Federally Qualified Health Center
Cancer Prev Res July 2024
Cancer Research
Comprehensive Genetic Profiling Reveals Frequent Alterations of Driver Genes on the X Chromosome in Extranodal NK/T-cell Lymphoma
Cancer Res July 2024
Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal Metaplasia
Cancer Res July 2024
Clinical Cancer Research
Safety and Efficacy of the Combination Lurbinectedin plus Doxorubicin from a Phase 1b Trial in Patients with Advanced/Metastatic Soft-Tissue Sarcoma
Clin Cancer Res July 2024
Phase II Clinical Trial of Intravenous Levothyroxine to Mitigate Pharyngocutaneous Fistula in Euthyroid Patients Undergoing Salvage Laryngectomy
Clin Cancer Res July 2024
Molecular Cancer Research
ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3
Mol Cancer Res July 2024
Molecular Cancer Therapeutics
Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations
Mol Cancer Ther July 2024
Cancer Research Communications
Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody–Drug Conjugate Targeting Fibroblast Activation Protein
Cancer Res Commun July 2024
June
Blood Cancer Discovery
Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis
Blood Cancer Discovery June 2024
Cancer Discovery
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Cancer Discov June 2024
Cancer Epidemiology, Biomarkers & Prevention
Reproductive Factors Related to Childbearing and a Novel Automated Mammographic Measure, V
Cancer Epidemiol Bio Prev June 2024
Cancer Immunology Research
Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects
Cancer Immunol Res June 2024
Cancer Prevention Research
Low-Carbohydrate Diet Score and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study
Cancer Prev Res June 2024
Cancer Research
Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
Cancer Res June 2024
Deuterium Metabolic Imaging Differentiates Glioblastoma Metabolic Subtypes and Detects Early Response to Chemoradiotherapy
Cancer Res June 2024
Clinical Cancer Research
A Signal-Finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration–Resistant Prostate Cancer: Results from CYCLONE 1
Clin Cancer Res June 2024
A Phase I Trial of Nab-Paclitaxel/Bevacizumab (AB160) Nano-Immunoconjugate Therapy for Gynecologic Malignancies
Clin Cancer Res June 2024
Molecular Cancer Research
FATP5 Is Indispensable for the Growth of Intrahepatic Cholangiocarcinoma
Mol Cancer Res June 2024
Molecular Cancer Therapeutics
A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors
Mol Cancer Ther June 2024
Cancer Research Communications
Exercise-induced β2-adrenergic Receptor Activation Enhances the Antileukemic Activity of Expanded γδ T-Cells via DNAM-1 Upregulation and PVR/Nectin-2 Recognition
Cancer Res Commun June 2024
May
Blood Cancer Discovery
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Blood Cancer Discovery May 2024
Cancer Discovery
Sotorasib Is a Pan-RASG12C Inhibitor Capable of Driving Clinical Response in NRASG12C Cancers
Cancer Discov May 2024
Cancer Epidemiology, Biomarkers & Prevention
Disparities in OncotypeDx Testing and Subsequent Chemotherapy Receipt by Geography and Socioeconomic Status
Cancer Epidemiol Bio Prev May 2024
Cancer Immunology Research
Machine Learning Links T-cell Function and Spatial Localization to Neoadjuvant Immunotherapy and Clinical Outcome in Pancreatic Cancer
Cancer Immunol Res May 2024
Cancer Prevention Research
Examining the Association between Abstinence from Smoking and Healthcare Costs among Patients with Cancer
Cancer Prev Res May 2024
Cancer Research
Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
Cancer Res May 2024
Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity
Cancer Res May 2024
Clinical Cancer Research
Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors
Clin Cancer Res May 2024
Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study
Clin Cancer Res May 2024
Molecular Cancer Research
Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts
Mol Cancer Res May 2024
Molecular Cancer Therapeutics
Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates
Mol Cancer Ther May 2024
Cancer Research Communications
Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent “NoGlow” Mice
Cancer Res Commun May 2024
April
Blood Cancer Discovery
IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation
Blood Cancer Discovery April 2024
Cancer Discovery
Cancer Hallmarks: Piecing the Puzzle Together
Cancer Discov April 2024
Cancer Epidemiology, Biomarkers & Prevention
Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study
Cancer Epidemiol Bio Prev April 2024
Cancer Immunology Research
Neutrophils Mediate Protection Against Colitis and Carcinogenesis by Controlling Bacterial Invasion and IL22 Production by γδ T Cells
Cancer Immunol Res April 2024
Cancer Prevention Research
Differences in Serum miRNA Profiles by Race, Ethnicity, and Socioeconomic Status: Implications for Developing an Equitable Ovarian Cancer Screening Test
Cancer Prev Res April 2024
Cancer Research
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia
Cancer Res April 2024
Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression
Cancer Res April 2024
Clinical Cancer Research
Phase II DORA Study of Olaparib with or without Durvalumab as a Chemotherapy-Free Maintenance Strategy in Platinum-Pretreated Advanced Triple-Negative Breast Cancer
Clin Cancer Res April 2024
Clinical Activity of TGF-β Inhibitor Vactosertib in Combination with Imatinib in Desmoid Tumors: A Multicenter Phase Ib/II Study
Clin Cancer Res April 2024
Molecular Cancer Research
Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA Sequencing
Mol Cancer Res April 2024
Molecular Cancer Therapeutics
Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth
Mol Cancer Ther April 2024
Cancer Research Communications
A Pilot Study on Patient-specific Computational Forecasting of Prostate Cancer Growth during Active Surveillance Using an Imaging-informed Biomechanistic Model
Cancer Res Commun April 2024
March
Blood Cancer Discovery
Synergistic Drug Combinations Promote the Development of Resistance in Acute Myeloid Leukemia
Blood Cancer Discovery March 2024
Cancer Discovery
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation
Cancer Discov March 2024
Cancer Epidemiology, Biomarkers & Prevention
Maternal Prenatal Use of Alcohol, Tobacco, and Illicit Drugs and Associations with Childhood Cancer Subtypes
Cancer Epidemiol Bio Prev March 2024
Cancer Immunology Research
Immune-Related Colitis Is Associated with Fecal Microbial Dysbiosis and Can Be Mitigated by Fecal Microbiota Transplantation
Cancer Immunol Res March 2024
Cancer Prevention Research
Next-generation Multi-target Stool DNA Panel Accurately Detects Colorectal Cancer and Advanced Precancerous Lesions
Cancer Prev Res March 2024
Cancer Research
Chronic Stress Dampens Lactobacillus Johnsonii–Mediated Tumor Suppression to Enhance Colorectal Cancer Progression
Cancer Res March 2024
AKT1 interacts with DHX9 to Mitigate R Loop–Induced Replication Stress in Ovarian Cancer
Cancer Res March 2024
Clinical Cancer Research
Phase I Trial of First-line Bintrafusp Alfa in Patients with Locally Advanced or Persistent/Recurrent/Metastatic Cervical Cancer
Clin Cancer Res March 2024
Phase II Study of Durvalumab Immediately after Completion of Chemoradiotherapy in Unresectable Stage III Non–small Cell Lung Cancer: TORG1937 (DATE Study)
Clin Cancer Res March 2024
Molecular Cancer Research
FGFR1 Signaling Facilitates Obesity-Driven Pulmonary Outgrowth in Metastatic Breast Cancer
Mol Cancer Res March 2024
Molecular Cancer Therapeutics
Raludotatug Deruxtecan, a CDH6-Targeting Antibody–Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models
Mol Cancer Ther March 2024
Cancer Research Communications
Estrogen Receptor Mutations as Novel Targets for Immunotherapy in Metastatic Estrogen Receptor–positive Breast Cancer
Cancer Res Commun March 2024
February
Blood Cancer Discovery
ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma
Blood Cancer Discovery January 2024
Cancer Discovery
Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma
Cancer Discov February 2024
Cancer Epidemiology, Biomarkers & Prevention
Racial Disparities in Accessing Care along the Continuum of Cancer Genetic Service Delivery
Cancer Epidemiol Bio Prev February 2024
Cancer Immunology Research
RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma
Cancer Immunol Res February 2024
Cancer Prevention Research
High-Fat Diet Promotes Acute Promyelocytic Leukemia through PPARδ-Enhanced Self-renewal of Preleukemic Progenitors
Cancer Prev Res February 2024
Cancer Research
Osteoclast Cancer Cell Metabolic Cross-talk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
Cancer Res February 2024
Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis
Cancer Res February 2024
Clinical Cancer Research
Absence of BTK, BCL2, and PLCG2 Mutations in Chronic Lymphocytic Leukemia Relapsing after First-Line Treatment with Fixed-Duration Ibrutinib plus Venetoclax
Clin Cancer Res February 2024
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
Clin Cancer Res February 2024
Molecular Cancer Research
Spatial Transcriptomics Suggests That Alterations Occur in the Preneoplastic Breast Microenvironment of BRCA1/2 Mutation Carriers
Mol Cancer Res February 2024
Molecular Cancer Therapeutics
CD38 x ICAM-1 Bispecific Antibody Is a Novel Approach for Treating Multiple Myeloma and Lymphoma
Mol Cancer Ther February 2024
Cancer Research Communications
The Oncolytic Activity of Zika Viral Therapy in Human Neuroblastoma In Vivo Models Confers a Major Survival Advantage in a CD24-dependent Manner
Cancer Res Commun February 2024
January
Blood Cancer Discovery
Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma
Blood Cancer Discovery January 2024
Cancer Discovery
GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress
Cancer Discov January 2024
Cancer Epidemiology, Biomarkers & Prevention
Racial Disparities in Accessing Care along the Continuum of Cancer Genetic Service Delivery
Cancer Epidemiol Bio Prev January 2024
Cancer Immunology Research
Intracellular K+ Limits T-cell Exhaustion and Preserves Antitumor Function
Cancer Immunol Res January 2024
Cancer Prevention Research
Early-onset Colon Cancer Shows a Distinct Intestinal Microbiome and a Host–Microbe Interaction
Cancer Prev Res January 2024
Cancer Research
XPO1 Enables Adaptive Regulation of mRNA Export Required for Genotoxic Stress Tolerance in Cancer Cells
Cancer Res January 2024
Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts
Cancer Res January 2024
Clinical Cancer Research
Overall Survival and Exploratory Biomarker Analyses of Abemaciclib plus Trastuzumab with or without Fulvestrant versus Trastuzumab plus Chemotherapy in HR+, HER2+ Metastatic Breast Cancer Patients
Clin Cancer Res January 2024
Targeted Radiation Delivery before Haploidentical HCT for High-risk Leukemia or MDS Patients Yields Long-term Survivors
Clin Cancer Res January 2024
Molecular Cancer Research
Metabolic Hallmarks for Purine Nucleotide Biosynthesis in Small Cell Lung Carcinoma
Mol Cancer Res January 2024
Molecular Cancer Therapeutics
A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models
Mol Cancer Ther January 2024
Cancer Research Communications
Sustained Disease Control in Immune Checkpoint Blockade Responders with Microsatellite Instability-high Colorectal Cancer after Treatment Termination
Cancer Res Commun December 2023
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