2023
AACR offers monthly "Editors' Picks" from our journals. We highlight one article from each issue that has been determined a "must read" by the Editors. Be sure to bookmark this page, as it will be updated on a monthly basis.
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October
Blood Cancer Discovery
A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Blood Cancer Discovery October 2023
Cancer Discovery
GABA Regulates Electrical Activity and Tumor Initiation in Melanoma
Cancer Discov October 2023
Cancer Epidemiology, Biomarkers & Prevention
Changes in Geographic Variation and Socioeconomic Inequalities in Esophageal Cancer Mortality in China, 1973–2017
Cancer Epidemiol Bio Prev October 2023
Cancer Immunology Research
Glioblastoma Vascular Plasticity Limits Effector T-cell Infiltration and Is Blocked by cAMP Activation
Cancer Immunol Res October 2023
Cancer Prevention Research
Examining the Barriers and Opportunities for Human Papillomavirus Vaccine Delivery in Cancer Care Settings: A Mixed-Methods Study
Cancer Prev Res October 2023
Cancer Research
Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer
Cancer Res October 2023
Fatty Acids Support the Fitness and Functionality of Tumor-Resident CD8+ T Cells by Maintaining SCML4 Expression
Cancer Res October 2023
Clinical Cancer Research
A Phase II Study of Optimized Individualized Adaptive Radiotherapy for Hepatocellular Carcinoma
Clin Cancer Res October 2023
Efficacy and Safety of Stereotactic Body Radiotherapy Combined with Camrelizumab and Apatinib in Patients with Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
Clin Cancer Res October 2023
Molecular Cancer Research
Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha–Mutant Endometrial Cancer
Mol Cancer Res October 2023
Molecular Cancer Therapeutics
Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis
Mol Cancer Ther October 2023
Cancer Research Communications
A Druggable FOXA1-Glucocorticoid Receptor Transcriptional Axis Drives Tumor Growth in a Subset of Non-Small Cell Lung Cancer
Cancer Res Commun October 2023
September
Blood Cancer Discovery
Time-Dependent Prognostic Value of Serological and Measurable Residual Disease Assessments after Idecabtagene Vicleucel
Blood Cancer Discovery September 2023
Cancer Discovery
A Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development
Cancer Discov September 2023
Cancer Epidemiology, Biomarkers & Prevention
Elevated EVL Methylation Level in the Normal Colon Mucosa Is a Potential Risk Biomarker for Developing Recurrent Adenomas
Cancer Epidemiol Bio Prev September 2023
Cancer Immunology Research
Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation
Cancer Immunol Res September 2023
Cancer Prevention Research
Risk Factors for Early-onset Sporadic Colorectal Cancer in Male Veterans
Cancer Prev Res September 2023
Cancer Research
Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis
Cancer Res September 2023
Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma
Cancer Res September 2023
Clinical Cancer Research
Efficacy and Quality-of-Life Following Involved Nodal Radiotherapy for Head and Neck Squamous Cell Carcinoma: The INRT-AIR Phase II Clinical Trial
Clin Cancer Res September 2023
CD49d Expression Identifies a Biologically Distinct Subtype of Chronic Lymphocytic Leukemia with Inferior Progression-Free Survival on BTK Inhibitor Therapy
Clin Cancer Res September 2023
Molecular Cancer Research
Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
Mol Cancer Res September 2023
Molecular Cancer Therapeutics
Discovery and Preclinical Characterization of XMT-1660, an Optimized B7-H4-Targeted Antibody–Drug Conjugate for the Treatment of Cancer
Mol Cancer Ther September 2023
Cancer Research Communications
Targeted Single-cell Isolation of Spontaneously Escaping Live Melanoma Cells for Comparative Transcriptomics
Cancer Res Commun September 2023
August
Blood Cancer Discovery
A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies
Blood Cancer Discovery July 2023
Cancer Discovery
SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy
Cancer Discov August 2023
Cancer Epidemiology, Biomarkers & Prevention
Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012–2016
Cancer Epidemiol Bio Prev August 2023
Cancer Immunology Research
Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer
Cancer Immunol Res August 2023
Cancer Prevention Research
Progressive Spreading of DNA Methylation in the GSTP1 Promoter CpG Island across Transitions from Precursors to Invasive Prostate Cancer
Cancer Prev Res August 2023
Cancer Research
BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Cancer Res August 2023
Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors
Cancer Res August 2023
Clinical Cancer Research
Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Clin Cancer Res August 2023
Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers
Clin Cancer Res August 2023
Molecular Cancer Research
Dynamic Intestinal Stem Cell Plasticity and Lineage Remodeling by a Nutritional Environment Relevant to Human Risk for Tumorigenesis
Mol Cancer Res August 2023
Molecular Cancer Therapeutics
ABBV-184: A Novel Survivin-specific TCR/CD3 Bispecific T-cell Engager is Active against Both Solid Tumor and Hematologic Malignancies
Mol Cancer Ther August 2023
Cancer Research Communications
The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition
Cancer Res Commun July 2023
July
Blood Cancer Discovery
The Polyamine–Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma
Blood Cancer Discovery July 2023
Cancer Discovery
Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer
Cancer Discov July 2023
Cancer Epidemiology, Biomarkers & Prevention
Circadian Disruption and Colorectal Cancer Incidence in Black Women
Cancer Epidemiol Bio Prev July 2023
Cancer Immunology Research
High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects
Cancer Immunol Res July 2023
Cancer Prevention Research
Associations between Physical Activity and Incidence of Cancer among Overweight Adults in Korea: Results from the Health Examinees-G Study
Cancer Prev Res July 2023
Cancer Research
Periostin+ Stromal Cells Guide Lymphovascular Invasion by Cancer Cells
Cancer Res July 2023
ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma
Cancer Res July 2023
Clinical Cancer Research
Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04)
Clin Cancer Res July 2023
Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Clin Cancer Res July 2023
Molecular Cancer Research
Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Mol Cancer Res July 2023
Molecular Cancer Therapeutics
Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy
Mol Cancer Ther July 2023
Cancer Research Communications
Multi-institutional Prognostic Modeling in Head and Neck Cancer: Evaluating Impact and Generalizability of Deep Learning and Radiomics
Cancer Res Commun June 2023
June
Blood Cancer Discovery
Molecular Evolution of Classic Hodgkin Lymphoma Revealed Through Whole-Genome Sequencing of Hodgkin and Reed Sternberg Cells
Blood Cancer Discovery June 2023
Cancer Discovery
Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways
Cancer Discov June 2023
Cancer Epidemiology, Biomarkers & Prevention
Efficacy of the Outsmart HPV Intervention: A Randomized Controlled Trial to Increase HPV Vaccination among Young Gay, Bisexual, and Other Men Who Have Sex with Men
Cancer Epidemiol Bio Prev June 2023
Cancer Immunology Research
Regional Variation in the Tumor Microenvironment, Immune Escape and Prognostic Factors in Breast Cancer in Sub-Saharan Africa
Cancer Immunol Res June 2023
Cancer Prevention Research
Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells
Cancer Prev Res June 2023
Cancer Research
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis
Cancer Res June 2023
Angiopoietin-2–Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits Immunotherapy in Melanoma
Cancer Res June 2023
Clinical Cancer Research
Multicenter Phase I Trial of Ivosidenib as Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplantation for IDH1-Mutated Acute Myeloid Leukemia
Clin Cancer Res June 2023
Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
Clin Cancer Res June 2023
Molecular Cancer Research
Interdependence of SS18-SSX–driven YAP1 and β-Catenin Activation in Synovial Sarcoma
Mol Cancer Res June 2023
Molecular Cancer Therapeutics
Targeting Glutamine Metabolism with a Novel Na+/K+-ATPase Inhibitor RX108 in Hepatocellular Carcinoma
Mol Cancer Ther June 2023
Cancer Research Communications
Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome
Cancer Res Commun May 2023
May
Blood Cancer Discovery
METTL3-Mediated m6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL
Blood Cancer Discovery May 2023
Cancer Discovery
Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047
Cancer Discov May 2023
Cancer Epidemiology, Biomarkers & Prevention
Risk and Protective Factors for Cancer Mortality among United States Service Members and Veterans (2001–2018)
Cancer Epidemiol Bio Prev May 2023
Cancer Immunology Research
Low TCR Binding Strength Results in Increased Progenitor-like CD8+ Tumor-Infiltrating Lymphocytes
Cancer Immunol Res May 2023
Cancer Prevention Research
Stressful Life Events, Social Support, and Incident Breast Cancer by Estrogen Receptor Status
Cancer Prev Res May 2023
Cancer Research
Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Cancer Res May 2023
Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell–Derived Cytokines
Cancer Res May 2023
Clinical Cancer Research
Genomic Complexity Predicts Resistance to Endocrine Therapy and CDK4/6 Inhibition in Hormone Receptor–Positive (HR+)/HER2-Negative Metastatic Breast Cancer
Clin Cancer Res May 2023
Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis
Clin Cancer Res May 2023
Molecular Cancer Research
The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma
Mol Cancer Res May 2023
Molecular Cancer Therapeutics
Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic
Mol Cancer Ther May 2023
Cancer Research Communications
IOA-244 is a Non–ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance
Cancer Res Commun April 2023
April
Blood Cancer Discovery
Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy
Blood Cancer Discovery April 2023
Cancer Discovery
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma
Cancer Discov April 2023
Cancer Epidemiology, Biomarkers & Prevention
The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study
Cancer Epidemiol Bio Prev April 2023
Cancer Immunology Research
IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model
Cancer Immunol Res April 2023
Cancer Prevention Research
Safety Run-in of Intramuscular pNGVL4a-Sig/E7(detox)/HSP70 DNA and TA-CIN Protein Vaccination as Treatment for HPV16+ ASC-US, ASC-H, or LSIL/CIN1
Cancer Prev Res April 2023
Cancer Research
CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer
Cancer Res April 2023
Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization
Cancer Res April 2023
Clinical Cancer Research
Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma
Clin Cancer Res April 2023
The Oral PI3Kδ Inhibitor Linperlisib for the Treatment of Relapsed and/or Refractory Follicular Lymphoma: A Phase II, Single-Arm, Open-Label Clinical Trial
Clin Cancer Res April 2023
Molecular Cancer Research
Multi-substrate Metabolic Tracing Reveals Marked Heterogeneity and Dependency on Fatty Acid Metabolism in Human Prostate Cancer
Mol Cancer Res April 2023
Molecular Cancer Therapeutics
SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
Mol Cancer Ther April 2023
Cancer Research Communications
Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men
Cancer Res Commun March 2023
March
Blood Cancer Discovery
Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis
Blood Cancer Discovery March 2023
Cancer Discovery
Racial/Ethnic and Sex Differences in Somatic Cancer Gene Mutations among Patients with Early-Onset Colorectal Cancer
Cancer Discov March 2023
Cancer Epidemiology, Biomarkers & Prevention
Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study
Cancer Epidemiol Bio Prev March 2023
Cancer Immunology Research
Syntaphilin Regulates Neutrophil Migration in Cancer
Cancer Immunol Res March 2023
Cancer Prevention Research
Benign Breast Disease, NSAIDs, and Postmenopausal Breast Cancer Risk in the CPS-II Cohort
Cancer Prev Res March 2023
Cancer Research
Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors
Cancer Res March 2023
Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss–Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities
Cancer Res March 2023
Clinical Cancer Research
Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial
Clin Cancer Res March 2023
A Phase Ib/II Trial of Combined BRAF and EGFR Inhibition in BRAF V600E Positive Metastatic Colorectal Cancer and Other Cancers: The EVICT (Erlotinib and Vemurafenib In Combination Trial) Study
Clin Cancer Res March 2023
Molecular Cancer Research
ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Mol Cancer Res March 2023
Molecular Cancer Therapeutics
Interplay Between Extracellular Matrix Remodeling and Angiogenesis in Tumor Ecosystem
Mol Cancer Ther March 2023
Cancer Research Communications
Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer
Cancer Res Commun February 2023
February
Blood Cancer Discovery
Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies
Blood Cancer Discovery January 2023
Cancer Discovery
Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer
Cancer Discov February 2023
Cancer Epidemiology, Biomarkers & Prevention
Race Differences in Patient-Reported Symptoms during Chemotherapy among Women with Early-Stage Hormone Receptor–Positive Breast Cancer
Cancer Epidemiol Bio Prev February 2023
Cancer Immunology Research
Rational Protein Design Yields a CD20 CAR with Superior Antitumor Efficacy Compared with CD19 CAR
Cancer Immunol Res February 2023
Cancer Prevention Research
Plasma Concentrations of Gut Hormones Acyl Ghrelin and Peptide YY and Subsequent Risk of Colorectal Cancer and Molecular Tumor Subtypes
Cancer Prev Res February 2023
Cancer Research
Single-Cell Analysis in Lung Adenocarcinoma Implicates RNA Editing in Cancer Innate Immunity and Patient Prognosis
Cancer Res February 2023
The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer
Cancer Res February 2023
Clinical Cancer Research
Clinical Features Associated with Outcomes and Biomarker Analysis of Dabrafenib plus Trametinib Treatment in Patients with BRAF-Mutant Melanoma Brain Metastases
Clin Cancer Res February 2023
Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non–Small Cell Lung Cancer
Clin Cancer Res February 2023
Molecular Cancer Research
BET Inhibitors Target the SCLC-N Subtype of Small-Cell Lung Cancer by Blocking NEUROD1 Transactivation
Mol Cancer Res February 2023
Molecular Cancer Therapeutics
Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers
Mol Cancer Ther February 2023
Cancer Research Communications
Incorporating RNA-based Risk Scores for Genomic Instability to Predict Breast Cancer Recurrence and Immunogenicity in a Diverse Population
Cancer Res Commun January 2023
January
Blood Cancer Discovery
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses
Blood Cancer Discovery January 2023
Cancer Discovery
Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy
Cancer Discov January 2023
Cancer Epidemiology, Biomarkers & Prevention
Impact and Recovery from COVID-19–Related Disruptions in Colorectal Cancer Screening and Care in the US: A Scenario Analysis
Cancer Epidemiol Bio Prev January 2023
Cancer Immunology Research
The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain
Cancer Immunol Res January 2023
Cancer Prevention Research
Phase I Dose Escalation Study of Topical Bexarotene in Women at High Risk for Breast Cancer
Cancer Prev Res January 2023
Cancer Research
Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast Cancer
Cancer Res January 2023
Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma
Cancer Res January 2023
Clinical Cancer Research
Pilot Study of ONCOS-102 and Pembrolizumab: Remodeling of the Tumor Microenvironment and Clinical Outcomes in Anti–PD-1–Resistant Advanced Melanoma
Clin Cancer Res January 2023
Intraperitoneal Monocytes plus IFNs as a Novel Cellular Immunotherapy for Ovarian Cancer: Mechanistic Characterization and Results from a Phase I Clinical Trial
Clin Cancer Res January 2023
Molecular Cancer Research
Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
Mol Cancer Res January 2023
Molecular Cancer Therapeutics
Antibody–Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release
Mol Cancer Ther January 2023
Cancer Research Communications
Complex Patterns of Genomic Heterogeneity Identified in 42 Tumor Samples and ctDNA of a Pulmonary Atypical Carcinoid Patient
Cancer Res Commun January 2023
