2022
AACR offers monthly "Editors' Picks" from our journals. We highlight one article from each issue that has been determined a "must read" by the Editors. Be sure to bookmark this page, as it will be updated on a monthly basis.
Sign up for an email alert for new monthly picks.
:: 2022 Picks :: 2021 Picks :: 2020 Picks
January | February | March | April | May | June | July
August
Blood Cancer Discovery
Perspectives on the Risk-Stratified Treatment of Multiple Myeloma
Blood Cancer Discovery August 2022
Cancer Discovery
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer
Cancer Discov August 2022
Cancer Epidemiology, Biomarkers & Prevention
Association of Abdominal Visceral Adiposity and Total Fat Mass with Cancer Incidence and Mortality in White and Black Adults
Cancer Epidemiol Bio Prev August 2022
Cancer Immunology Research
Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor–Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors
Cancer Immunol Res August 2022
Cancer Prevention Research
Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer
Cancer Prev Res August 2022
Cancer Research
Intratumoral Resolution of Driver Gene Mutation Heterogeneity in Renal Cancer Using Deep Learning
Cancer Res August 2022
Genomic Profiling of Bronchoalveolar Lavage Fluid in Lung Cancer
Cancer Res August 2022
Clinical Cancer Research
Phase II Clinical Trial of Eribulin–Gemcitabine Combination Therapy in Previously Treated Patients With Advanced Liposarcoma or Leiomyosarcoma
Clin Cancer Res August 2022
First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clin Cancer Res August 2022
Molecular Cancer Research
Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner
Mol Cancer Res August 2022
Molecular Cancer Therapeutics
Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Mol Cancer Ther August 2022
Cancer Research Communications
Tumor Purity in Preclinical Mouse Tumor Models
Cancer Res Commun August 2022
July
Blood Cancer Discovery
The Cell Type–Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia
Blood Cancer Discovery July 2022
Cancer Discovery
Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer
Cancer Discov July 2022
Cancer Epidemiology, Biomarkers & Prevention
Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
Cancer Epidemiol Bio Prev July 2022
Cancer Immunology Research
Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies
Cancer Immunol Res July 2022
Cancer Prevention Research
Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals
Cancer Prev Res July 2022
Cancer Research
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
Cancer Res July 2022
Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment
Cancer Res July 2022
Clinical Cancer Research
Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia
Clin Cancer Res July 2022
Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma
Clin Cancer Res July 2022
Molecular Cancer Research
Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma
Mol Cancer Res July 2022
Molecular Cancer Therapeutics
HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations
Mol Cancer Ther July 2022
Cancer Research Communications
Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase Inhibitors
Cancer Res Commun July 2022
June
Blood Cancer Discovery
Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma
Blood Cancer Discovery May 2022
Cancer Discovery
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
Cancer Discov June 2022
Cancer Epidemiology, Biomarkers & Prevention
Mapping the Lay of the Land: Using Interactive Network Analytic Tools for Collaboration in Rural Cancer Prevention and Control
Cancer Epidemiol Bio Prev June 2022
Cancer Immunology Research
T Cell–Mediated Targeted Delivery of Anti–PD-L1 Nanobody Overcomes Poor Antibody Penetration and Improves PD-L1 Blocking at the Tumor Site
Cancer Immunol Res June 2022
Cancer Prevention Research
Strategies to Identify and Recruit Women at High Risk for Breast Cancer to a Randomized Controlled Trial of Web-based Decision Support Tools
Cancer Prev Res June 2022
Cancer Research
Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor–Induced Synthetic Lethality
Cancer Res June 2022
The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Cancer Res June 2022
Clinical Cancer Research
A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors
Clin Cancer Res June 2022
ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients with ALK-Positive Non–Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges
Clin Cancer Res June 2022
Molecular Cancer Research
Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity
Mol Cancer Res June 2022
Molecular Cancer Therapeutics
A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Mol Cancer Ther June 2022
Cancer Research Communications
Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma
Cancer Res Commun June 2022
May
Blood Cancer Discovery
Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree
Blood Cancer Discovery May 2022
Cancer Discovery
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors
Cancer Discov May 2022
Cancer Epidemiology, Biomarkers & Prevention
Neighborhood Obesogenic Environment and Risk of Prostate Cancer: The Multiethnic Cohort
Cancer Epidemiol Bio Prev May 2022
Cancer Immunology Research
Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self
Cancer Immunol Res May 2022
Cancer Prevention Research
Implementing Strategies at the Workplace Level to Increase Colorectal Cancer Screening Uptake in Argentina: A Controlled Interrupted Time-series Study
Cancer Prev Res May 2022
Cancer Research
Secretion of IL1 by Dedifferentiated Melanoma Cells Inhibits JAK1-STAT3–Driven Actomyosin Contractility of Lymph Node Fibroblastic Reticular Cells
Cancer Res May 2022
Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
Cancer Res May 2022
Clinical Cancer Research
Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors
Clin Cancer Res May 2022
IL15 and Anti–PD-1 Augment the Efficacy of Agonistic Intratumoral Anti-CD40 in a Mouse Model with Multiple TRAMP-C2 Tumors
Clin Cancer Res May 2022
Molecular Cancer Research
Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications
Mol Cancer Res May 2022
Molecular Cancer Therapeutics
Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer–Targeted Therapies
Mol Cancer Ther May 2022
Cancer Research Communications
Race-associated Molecular Changes in Gynecologic Malignancies
Cancer Res Commun May 2022
April
Blood Cancer Discovery
Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Blood Cancer Discovery April 2022
Cancer Discovery
Cancer-Causative Mutations Occurring in Early Embryogenesis
Cancer Discov April 2022
Cancer Epidemiology, Biomarkers & Prevention
Estimation of the Exposure–Response Relation between Benzene and Acute Myeloid Leukemia by Combining Epidemiologic, Human Biomarker, and Animal Data
Cancer Epidemiol Bio Prev April 2022
Cancer Immunology Research
Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival
Cancer Immunol Res April 2022
Cancer Prevention Research
Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study
Cancer Prev Res April 2022
Cancer Research
Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Cancer Res April 2022
Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer
Cancer Res April 2022
Clinical Cancer Research
The Phase II MutHER Study of Neratinib Alone and in Combination with Fulvestrant in HER2-Mutated, Non-amplified Metastatic Breast Cancer
Clin Cancer Res April 2022
Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant
Clin Cancer Res April 2022
Molecular Cancer Research
MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling
Mol Cancer Res April 2022
Molecular Cancer Therapeutics
(+)-JJ-74–138 is a Novel Noncompetitive Androgen Receptor Antagonist
Mol Cancer Ther April 2022
March
Blood Cancer Discovery
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies
Blood Cancer Discovery March 2022
Cancer Discovery
Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma
Cancer Discov March 2022
Cancer Epidemiology, Biomarkers & Prevention
Racial/Ethnic Differences in Cancer Diagnosed after Metastasis: Absolute Burden and Deaths Potentially Avoidable through Earlier Detection
Cancer Epidemiol Bio Prev March 2022
Cancer Immunology Research
Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia
Cancer Immunol Res March 2022
Cancer Prevention Research
Preparation of a Beverage Containing Freeze-Dried Watercress for a Clinical Trial of Carcinogen and Toxicant Detoxification
Cancer Prev Res March 2022
Cancer Research
Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
Cancer Res March 2022
Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells
Cancer Res March 2022
Clinical Cancer Research
Safety, Activity, and Long-term Outcomes of Pomalidomide in the Treatment of Kaposi Sarcoma among Individuals with or without HIV Infection
Clin Cancer Res March 2022
Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study
Clin Cancer Res March 2022
Molecular Cancer Research
Disruption of β-Catenin–Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion
Mol Cancer Res March 2022
Molecular Cancer Therapeutics
Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Mol Cancer Ther March 2022
February
Blood Cancer Discovery
Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia
Blood Cancer Discovery February 2022
Cancer Discovery
Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer
Cancer Discov February 2022
Cancer Epidemiology, Biomarkers & Prevention
Comparison of Fecal Sample Collection Methods for Microbial Analysis Embedded within Colorectal Cancer Screening Programs
Cancer Epidemiol Bio Prev February 2022
Cancer Immunology Research
NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy
Cancer Immunol Res February 2022
Cancer Prevention Research
Progestin Significantly Inhibits Carcinogenesis in the Mogp-TAg Transgenic Mouse Model of Fallopian Tube Cancer
Cancer Prev Res February 2022
Cancer Research
Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression
Cancer Res February 2022
An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Cancer Res February 2022
Clinical Cancer Research
A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma
Clin Cancer Res February 2022
First-in-human HER2-targeted Bispecific Antibody KN026 for the Treatment of Patients with HER2-positive Metastatic Breast Cancer: Results from a Phase I Study
Clin Cancer Res February 2022
Molecular Cancer Research
Glioblastoma–Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Mol Cancer Res February 2022
Molecular Cancer Therapeutics
RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors
Mol Cancer Ther February 2022
January
Blood Cancer Discovery
NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity
Blood Cancer Discovery January 2022
Cancer Discovery
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Cancer Discov January 2022
Cancer Epidemiology, Biomarkers & Prevention
Work-Related Stress Was Not Associated with Increased Cancer Risk in a Population-Based Cohort Setting
Cancer Epidemiol Bio Prev January 2022
Cancer Immunology Research
Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Cancer Immunol Res January 2022
Cancer Prevention Research
Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon
Cancer Prev Res January 2022
Cancer Research
EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd
Cancer Res January 2022
T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy
Cancer Res January 2022
Clinical Cancer Research
Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study
Clin Cancer Res January 2022
Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas
Clin Cancer Res January 2022
Molecular Cancer Research
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
Mol Cancer Res January 2022
Molecular Cancer Therapeutics
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance
Mol Cancer Ther January 2022
