Cancer Hallmarks
Presented by the AACR Journals
The Cancer Hallmarks define a set of fundamental functional properties that are acquired in the process of tumor progression and that enable cancer cells to adopt these capabilities. Since the first description of the Hallmarks by Douglas Hanahan and Robert Weinberg in 2000, this model has been expanded to include other core features of malignant tumors. In 2022, the most recent update to the Hallmarks provided yet further dimensionality, adding four more defining characteristics of tumors: nonmutational epigenetic reprogramming, polymorphic microbiomes, senescent cells, and unlocking phenotypic plasticity. The AACR Journals proudly present this collection of Cancer Hallmarks–related content, including new Reviews related to the Hallmarks from key thought leaders and recent Research Articles from across our journal portfolio.
Featured Reviews:
Hallmarks of Cancer: New Dimensions
Doi: 10.1158/2159-8290.CD-21-1059
Cancer Hallmarks: Piecing the Puzzle Together
Doi: 10.1158/2159-8290.CD-24-0097
Doi: 10.1158/2159-8290.CD-23-1550
Metabolic Signaling in Cancer Metastasis
Doi: 10.1158/2159-8290.CD-24-0174
The DNA Damage Response and Inflammation in Cancer
Doi: 10.1158/2159-8290.CD-22-1220
Doi: 10.1158/2159-8290.CD-23-1073
Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells
Doi: 10.1158/0008-5472.CAN-23-0230
Lineage Plasticity: The New Cancer Hallmark on the Block
Doi: 10.1158/0008-5472.CAN-23-1067
Chromatin Remodelers Are Regulators of the Tumor Immune Microenvironment
Doi: 10.1158/0008-5472.CAN-23-2244
Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities
Doi: 10.1158/0008-5472.CAN-23-4042
The Role of the Gut Microbiome in Hematological Cancers
Doi: 10.1158/1541-7786.MCR-23-0080
A Metabolic Axis of Immune Intractability
Doi: 10.1158/2326-6066.CIR-23-0433
The Past and Future of Inflammation as a Target to Cancer Prevention
Doi: 10.1158/1940-6207.CAPR-23-0423
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