Cancer HallmarksPresented by the AACR Journals
The Cancer Hallmarks define a set of fundamental functional properties that are acquired in the process of tumor progression and that enable cancer cells to adopt these capabilities. Since the first description of the Hallmarks by Douglas Hanahan and Robert Weinberg in 2000, this model has been expanded to include other core features of malignant tumors. In 2022, the most recent update to the Hallmarks provided yet further dimensionality, adding four more defining characteristics of tumors: nonmutational epigenetic reprogramming, polymorphic microbiomes, senescent cells, and unlocking phenotypic plasticity. The AACR Journals proudly present this collection of Cancer Hallmarks–related content, including new Reviews related to the Hallmarks from key thought leaders and recent Research Articles from across our journal portfolio.
Hallmarks of Cancer: New Dimensions
Significance of RB Loss in Unlocking Phenotypic Plasticity in Advanced Cancers
Varadha Balaji Venkadakrishnan; Yasutaka Yamada; Kenny Weng; Osasenaga Idahor; Himisha Beltran
Senescence and Immunotherapy: Redundant Immunomodulatory Pathways Promote Resistance
Steffi Oesterreich; Katherine M. Aird
Targeting Senescence as a Therapeutic Opportunity for Triple-negative Breast Cancer
Bruno de Paula; Rosalind Kieran; Samantha Shui Yuan. Koh; Susanne Crocamo; Eliana Abdelhay; Daniel Muñoz-Espín
Small non-coding RNAs in Soft Tissue Sarcomas: State of the Art and Future Directions
Alessandro La Ferlita; Nipin Sp, Marina Goryunova; Giovanni Nigita; Raphael E. Pollock; Carlo M. Croce; Joal D. Beane
Microbiota Influences on Hematopoiesis and Blood Cancers: New Horizons?
Jessica R. Galloway-Pena; Christian Jobin
The Role of Inflammation in the Initiation and Progression of Myeloid Neoplasms
Juan Balandran; Audrey Lasry; Iannis Aifantis