Cancer Hallmarks

Presented by the AACR Journals

The Cancer Hallmarks define a set of fundamental functional properties that are acquired in the process of tumor progression and that enable cancer cells to adopt these capabilities. Since the first description of the Hallmarks by Douglas Hanahan and Robert Weinberg in 2000, this model has been expanded to include other core features of malignant tumors. In 2022, the most recent update to the Hallmarks provided yet further dimensionality, adding four more defining characteristics of tumors: nonmutational epigenetic reprogramming, polymorphic microbiomes, senescent cells, and unlocking phenotypic plasticity. The AACR Journals proudly present this collection of Cancer Hallmarks–related content, including new Reviews related to the Hallmarks from key thought leaders and recent Research Articles from across our journal portfolio.

Featured Reviews:

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Doi: 10.1158/2159-8290.CD-21-1059

Cancer Hallmarks: Piecing the Puzzle Together

Maria P. Alcolea; Direna Alonso-Curbelo; Chiara Ambrogio; Susan Bullman; Ana Luísa Correia; Aurélie Ernst; Christopher J. Halbrook; Gemma L. Kelly; Amanda W. Lund; Daniela F. Quail; Marcus Ruscetti; Efrat Shema; Ingunn M. Stromnes; Wai Leong Tam

Doi: 10.1158/2159-8290.CD-24-0097

The Epigenetic Hallmarks of Cancer

Manel Esteller; Mark A. Dawson; Cigall Kadoch; Feyruz V. Rassool; Peter A. Jones; Stephen B. Baylin

Doi: 10.1158/2159-8290.CD-24-0296

A View of Myeloid Transformation through the Hallmarks of Cancer

Inés Fernández-Maestre; Sheng F. Cai; Ross L. Levine

Doi: 10.1158/2643-3230.BCD-24-0009

Inflammation and Immunity in Liver Neoplasms: Implications for Future Therapeutic Strategies

Jieun Kim; Ekihiro Seki

Doi: 10.1158/1535-7163.MCT-23-0726

AKT and the Hallmarks of Cancer

Eleonora Sementino; Dalal Hassan; Alfonso Bellacosa; Joseph R. Testa

Doi: 10.1158/0008-5472.CAN-24-1846

Oncogenic Enhancers in Leukemia

Roger Mulet-Lazaro; Ruud Delwel

Doi: 10.1158/2643-3230.BCD-23-0211

Patterns of Aneuploidy and Signaling Consequences in Cancer

Nadja Zhakula-Kostadinova; Alison M. Taylor

Doi: 10.1158/0008-5472.CAN-24-0169

The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention

Adriana Albini; Douglas M. Noonan; Paola Corradino; Francesca Magnoni; Giovanni Corso

Doi: 10.1158/1940-6207.CAPR-24-0085

The Hallmarks of Precancer

Mary M. Stangis; Zhengyi Chen; Jimin Min; Sarah E. Glass; Jordan O. Jackson; Megan D. Radyk; Xen Ping Hoi; W. Nathaniel Brennen; Ming Yu; Huy Q. Dinh; Robert J. Coffey; Martha J. Shrubsole; Keith S. Chan; William M. Grady; Srinivasan Yegnasubramanian; Costas A. Lyssiotis; Anirban Maitra; Richard B. Halberg; Neelendu Dey; Ken S. Lau

Doi: 10.1158/2159-8290.CD-23-1550

Metabolic Signaling in Cancer Metastasis

Sarah Krieg; Sara Isabel Fernandes; Constantinos Kolliopoulos; Ming Liu; Sarah-Maria Fendt

Doi: 10.1158/2159-8290.CD-24-0174

The DNA Damage Response and Inflammation in Cancer

Vanessa Klapp; Beatriz Álvarez-Abril; Giuseppe Leuzzi; Guido Kroemer; Alberto Ciccia; Lorenzo Galluzzi

Doi: 10.1158/2159-8290.CD-22-1220

Micronuclei and Cancer

Melody Di Bona; Samuel F. Bakhoum

Doi: 10.1158/2159-8290.CD-23-1073

Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells

Linheng Li; Roy A. Jensen