Blood Cancer Discovery

Progenitor Hierarchy of Chronic Myelomonocytic Leukemia Identifies Inflammatory Monocytic-Biased Trajectory Linked to Worse Outcomes
Meghan C. Ferrall-Fairbanks, et al.
Blood Cancer Discovery November 2022

Cancer Discovery

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade
Varintra E. Lander, et al.
Cancer Discov November 2022

Cancer Epidemiology, Biomarkers & Prevention

Associations of Individual and Combined Physical Activity and Body Mass Index Groups with Proinflammatory Biomarkers among Colorectal Cancer Patients
Caroline Himbert, et al.
Cancer Epidemiol Bio Prev November 2022

Cancer Immunology Research

Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors
Jeroen Slaats, et al.
Cancer Immunol Res November 2022

Cancer Prevention Research

Endoscopic Screening and Risk of Colorectal Cancer according to Type 2 Diabetes Status
Kai Wang, et al.
Cancer Prev Res November 2022

Cancer Research

Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer
Khoosheh Khayati, et al.
Cancer Res November 2022

Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer
Laura M. Chambers, et al.
Cancer Res November 2022

Clinical Cancer Research

A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412
Kara L. Davis, et al.
Clin Cancer Res November 2022

A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer
Kathy Han, et al.
Clin Cancer Res November 2022

Molecular Cancer Research

A Recurrent ADPRHL1 Germline Mutation Activates PARP1 and Confers Prostate Cancer Risk in African American Families
Guanyi Zhang, et al.
Mol Cancer Res November 2022

Molecular Cancer Therapeutics

BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
Michael Rigby, et al.
Mol Cancer Ther November 2022

Cancer Research Communications

A Preclinical and Phase Ib Study of Palbociclib plus Nab-Paclitaxel in Patients with Metastatic Adenocarcinoma of the Pancreas
Manuel Hidalgo, et al.
Cancer Res Commun November 2022

Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis
Laura E. Kane, et al.
Cancer Res Commun October 2022

Blood Cancer Discovery

Changes in Bone Marrow Tumor and Immune Cells Correlate with Durability of Remissions Following BCMA CAR T Therapy in Myeloma
Kavita M. Dhodapkar, et al.
Blood Cancer Discovery November 2022

Cancer Discovery

African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent
Rachel Martini, et al.
Cancer Discov November 2022

Cancer Epidemiology, Biomarkers & Prevention

The Current Burden of Oropharyngeal Cancer: A Global Assessment Based on GLOBOCAN 2020
Valentina Lorenzoni, et al.
Cancer Epidemiol Bio Prev November 2022

Cancer Immunology Research

A Population of TIM4⁺FOLR2⁺ Macrophages Localized in Tertiary Lymphoid Structures Correlates to an Active Immune Infiltrate Across Several Cancer Types
Mattia Bugatti, et al.
Cancer Immunol Res November 2022

Cancer Prevention Research

Vulvar Cancer Incidence in the United States and its Relationship to Human Papillomavirus Vaccinations, 2001–2018
Abbey B. Berenson, et al.
Cancer Prev Res November 2022

Cancer Research

Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Robert B. Scharpf, et al.
Cancer Res November 2022

An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
Danna Sheinboim, et al.
Cancer Res November 2022

Clinical Cancer Research

A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer
Susana Banerjee, et al.
Clin Cancer Res November 2022

PD-1^T TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC
Karlijn Hummelink, et al.
Clin Cancer Res November 2022

Molecular Cancer Research

Proliferation and Self-Renewal Are Differentially Sensitive to NRAS^G12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line
Morito Kurata, et al.
Mol Cancer Res November 2022

Molecular Cancer Therapeutics

Anticancer Activity of ST101, A Novel Antagonist of CCAAT/Enhancer Binding Protein β
Emad Darvishi, et al.
Mol Cancer Ther November 2022

Cancer Research Communications

NetrinG1⁺ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress
Kristopher S. Raghavan, et al.
Cancer Res Commun November 2022

Blood Cancer Discovery

Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II Expression
Guangchun Han, et al.
Blood Cancer Discovery October 2022

Cancer Discovery

Reprogrammed Schwann Cells Organize into Dynamic Tracks that Promote Pancreatic Cancer Invasion
Sylvie Deborde, et al.
Cancer Discov October 2022

Cancer Epidemiology, Biomarkers & Prevention

New-Onset Cancer Cases in FDA's Sentinel System: A Large Distributed System of US Electronic Healthcare Data
Nicole R. Haug, et al.
Cancer Epidemiol Bio Prev October 2022

Cancer Immunology Research

Checkpoint Blockade–Induced Dermatitis and Colitis Are Dominated by Tissue-Resident Memory T Cells and Th1/Tc1 Cytokines
Robin Reschke, et al.
Cancer Immunol Res October 2022

Cancer Prevention Research

Leukotriene Receptor Antagonist Therapy for the Chemoprevention of Human Rectal Aberrant Crypt Foci: Nonrandomized, Open-Label, Controlled Trial
Takuma Higurashi, et al.
Cancer Prev Res October 2022

Cancer Research

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
Owen J. Chen, et al.
Cancer Res October 2022

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer
Agostina Nardone, et al.
Cancer Res October 2022

Clinical Cancer Research

OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma
Zhenhua Xu, et al.
Clin Cancer Res October 2022

EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma
April A. Apfelbaum, et al.
Clin Cancer Res October 2022

Molecular Cancer Research

EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
Aishwarya Krishnan, et al.
Mol Cancer Res October 2022

Molecular Cancer Therapeutics

A Novel EGFRvIII T-Cell Bispecific Antibody for the Treatment of Glioblastoma
Raffaella Iurlaro, et al.
Mol Cancer Ther October 2022

Cancer Research Communications

Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry
Jason A. White, et al.
Cancer Res Commun October 2022

Blood Cancer Discovery

Transcriptional Plasticity Drives Leukemia Immune Escape
Kenneth Eagle, et al.
Blood Cancer Discovery September 2022

Cancer Discovery

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron–Sulfur Cluster Proteins
Naiara Santana-Codina, et al.
Cancer Discov September 2022

Cancer Discovery

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS–MAPK Pathway Inhibition in Pancreatic Cancer
Mirunalini Ravichandran, et al.
Cancer Discov September 2022

Cancer Epidemiology, Biomarkers & Prevention

Postdiagnostic Inflammatory, Hyperinsulinemic, and Insulin-Resistant Diets and Lifestyles and the Risk of Prostate Cancer Progression and Mortality
Crystal S. Langlais, et al.
Cancer Epidemiol Bio Prev September 2022

Cancer Immunology Research

Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy
Nam Gyu Im, et al.
Cancer Immunol Res September 2022

Cancer Prevention Research

Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up
John C. Mathers, et al.
Cancer Prev Res September 2022

Cancer Research

Retinoic Acid Receptor Activation Reduces Metastatic Prostate Cancer Bone Lesions by Blocking the Endothelial-to-Osteoblast Transition
Guoyu Yu, et al.
Cancer Res September 2022

Mapping the Immune Landscape in Metastatic Melanoma Reveals Localized Cell–Cell Interactions That Predict Immunotherapy Response
Asier Antoranz, et al.
Cancer Res September 2022

Clinical Cancer Research

Lenalidomide plus R-GDP (R2-GDP) in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Final Results of the R2-GDP-GOTEL Trial and Immune Biomarker Subanalysis
Natalia Palazón-Carrión, et al.
Clin Cancer Res September 2022

A Phase I Trial of TB-403 in Relapsed Medulloblastoma, Neuroblastoma, Ewing Sarcoma, and Alveolar Rhabdomyosarcoma
Giselle Saulnier-Sholler, et al.
Clin Cancer Res September 2022

Molecular Cancer Research

Ceramide Kinase Inhibition Drives Ferroptosis and Sensitivity to Cisplatin in Mutant KRAS Lung Cancer by Dysregulating VDAC-Mediated Mitochondria Function
Ngoc T. Vu, et al.
Mol Cancer Res September 2022

Molecular Cancer Therapeutics

An Enzymatically Cleavable Tripeptide Linker for Maximizing the Therapeutic Index of Antibody–Drug Conjugates
Summer Y.Y. Ha, et al.
Mol Cancer Ther September 2022

Cancer Research Communications

Persistent Ethnicity-Associated Disparity in Antitumor Effectiveness of Immune Checkpoint Inhibitors Despite Equal Access
Marcus A. Florez, et al.
Cancer Res Commun September 2022

Cancer Research Communications

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles
Yitian Xu, et al.
Cancer Res Commun September 2022

Blood Cancer Discovery

Perspectives on the Risk-Stratified Treatment of Multiple Myeloma
Faith E. Davies, et al.
Blood Cancer Discovery August 2022

Cancer Discovery

Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer
Guillaume Fonteneau, et al.
Cancer Discov August 2022

Cancer Epidemiology, Biomarkers & Prevention

Association of Abdominal Visceral Adiposity and Total Fat Mass with Cancer Incidence and Mortality in White and Black Adults
Peter T. Katzmarzyk, et al.
Cancer Epidemiol Bio Prev August 2022

Cancer Immunology Research

Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor–Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors
Sanghyun P. Kim, et al.
Cancer Immunol Res August 2022

Cancer Prevention Research

Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer
Laura W. Bowers, et al.
Cancer Prev Res August 2022

Cancer Research

Intratumoral Resolution of Driver Gene Mutation Heterogeneity in Renal Cancer Using Deep Learning
Paul H. Acosta, et al.
Cancer Res August 2022

Genomic Profiling of Bronchoalveolar Lavage Fluid in Lung Cancer
Viswam S. Nair, et al.
Cancer Res August 2022

Clinical Cancer Research

Phase II Clinical Trial of Eribulin–Gemcitabine Combination Therapy in Previously Treated Patients With Advanced Liposarcoma or Leiomyosarcoma
Chang Gon Kim, et al.
Clin Cancer Res August 2022

First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Tae Won Kim, et al.
Clin Cancer Res August 2022

Molecular Cancer Research

Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner
Jinghai Wu, et al.
Mol Cancer Res August 2022

Molecular Cancer Therapeutics

Discovery and Characterization of a Novel Aryl Hydrocarbon Receptor Inhibitor, IK-175, and Its Inhibitory Activity on Tumor Immune Suppression
Karen McGovern, et al.
Mol Cancer Ther August 2022

Cancer Research Communications

Tumor Purity in Preclinical Mouse Tumor Models
Wubin Qian, et al.
Cancer Res Commun August 2022

Blood Cancer Discovery

The Cell Type–Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia
Yusuke Nakauchi, et al.
Blood Cancer Discovery July 2022

Cancer Discovery

Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer
Rumi Lee, et al.
Cancer Discov July 2022

Cancer Epidemiology, Biomarkers & Prevention

Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening
Coral Arnau-Collell, et al.
Cancer Epidemiol Bio Prev July 2022

Cancer Immunology Research

Comprehensive Characterizations of Immune Receptor Repertoire in Tumors and Cancer Immunotherapy Studies
Li Song, et al.
Cancer Immunol Res July 2022

Cancer Prevention Research

Aspirin and the Risk of Colorectal Cancer According to Genetic Susceptibility among Older Individuals
Andrew Bakshi, et al.
Cancer Prev Res July 2022

Cancer Research

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
Bo Zhang, et al.
Cancer Res July 2022

Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment
Hee-Jin Jang, et al.
Cancer Res July 2022

Clinical Cancer Research

Impact of FLT3 Mutation on Outcomes after Venetoclax and Azacitidine for Patients with Treatment-Naïve Acute Myeloid Leukemia
Marina Konopleva, et al.
Clin Cancer Res July 2022

Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma
Martin Schuler, et al.
Clin Cancer Res July 2022

Molecular Cancer Research

Mitochondrial Dysfunction Is a Driver of SP-2509 Drug Resistance in Ewing Sarcoma
E. John Tokarsky, et al.
Mol Cancer Res July 2022

Molecular Cancer Therapeutics

HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations
Yong Du, et al.
Mol Cancer Ther July 2022

Cancer Research Communications

Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase Inhibitors
Ana M. Metelo, et al.
Cancer Res Commun July 2022

Blood Cancer Discovery

Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma
Koichi Takahashi, et al.
Blood Cancer Discovery May 2022

Cancer Discovery

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS^G12C
Saskia M. Brachmann, et al.
Cancer Discov June 2022

Cancer Epidemiology, Biomarkers & Prevention

Mapping the Lay of the Land: Using Interactive Network Analytic Tools for Collaboration in Rural Cancer Prevention and Control
Ross C. Brownson, et al.
Cancer Epidemiol Bio Prev June 2022

Cancer Immunology Research

T Cell–Mediated Targeted Delivery of Anti–PD-L1 Nanobody Overcomes Poor Antibody Penetration and Improves PD-L1 Blocking at the Tumor Site
Jingjing Zhu, et al.
Cancer Immunol Res June 2022

Cancer Prevention Research

Strategies to Identify and Recruit Women at High Risk for Breast Cancer to a Randomized Controlled Trial of Web-based Decision Support Tools
Katherine D. Crew, et al.
Cancer Prev Res June 2022

Cancer Research

Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor–Induced Synthetic Lethality
Tyler J. Curiel, et al.
Cancer Res June 2022

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Eneda Toska, et al.
Cancer Res June 2022

Clinical Cancer Research

A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors
Aaron R. Hansen, et al.
Clin Cancer Res June 2022

ASCEND-7: Efficacy and Safety of Ceritinib Treatment in Patients with ALK-Positive Non–Small Cell Lung Cancer Metastatic to the Brain and/or Leptomeninges
Dong-Wan Kim, et al.
Clin Cancer Res June 2022

Molecular Cancer Research

Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity
Christopher G. Twitty, et al.
Mol Cancer Res June 2022

Molecular Cancer Therapeutics

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
Andree Blaukat, et al.
Mol Cancer Ther June 2022

Cancer Research Communications

Phase I Study of High-Dose l-Methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH Wild-Type High-Grade Glioma
Stephen W. Clark, et al.
Cancer Res Commun June 2022

Blood Cancer Discovery

Reconstructing Complex Cancer Evolutionary Histories from Multiple Bulk DNA Samples Using Pairtree
Quaid Morris, et al.
Blood Cancer Discovery May 2022

Cancer Discovery

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors
Ignacio Melero, et al.
Cancer Discov May 2022

Cancer Epidemiology, Biomarkers & Prevention

Neighborhood Obesogenic Environment and Risk of Prostate Cancer: The Multiethnic Cohort
Iona Cheng, et al.
Cancer Epidemiol Bio Prev May 2022

Cancer Immunology Research

Phosphoantigen-Stimulated γδ T Cells Suppress Natural Killer–Cell Responses to Missing-Self
Zakia Djaoud, et al.
Cancer Immunol Res May 2022

Cancer Prevention Research

Implementing Strategies at the Workplace Level to Increase Colorectal Cancer Screening Uptake in Argentina: A Controlled Interrupted Time-series Study
Lucas Angel González, et al.
Cancer Prev Res May 2022

Cancer Research

Secretion of IL1 by Dedifferentiated Melanoma Cells Inhibits JAK1-STAT3–Driven Actomyosin Contractility of Lymph Node Fibroblastic Reticular Cells
Virginie Prod'homme, et al.
Cancer Res May 2022

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage
Hugo J.G. Snippert, et al.
Cancer Res May 2022

Clinical Cancer Research

Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors
Noboru Yamamoto, et al.
Clin Cancer Res May 2022

IL15 and Anti–PD-1 Augment the Efficacy of Agonistic Intratumoral Anti-CD40 in a Mouse Model with Multiple TRAMP-C2 Tumors
Thomas A. Waldmann, et al.
Clin Cancer Res May 2022

Molecular Cancer Research

Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications
Yuzhuo Wang, et al.
Mol Cancer Res May 2022

Molecular Cancer Therapeutics

Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer–Targeted Therapies
Dennis J. Slamon, et al.
Mol Cancer Ther May 2022

Cancer Research Communications

Race-associated Molecular Changes in Gynecologic Malignancies
Anil K. Sood, et al.
Cancer Res Commun May 2022

Blood Cancer Discovery

Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies
Stefanie R. Bailey, et al.
Blood Cancer Discovery April 2022

Cancer Discovery

Cancer-Causative Mutations Occurring in Early Embryogenesis
Fresia Pareja, et al.
Cancer Discov April 2022

Cancer Epidemiology, Biomarkers & Prevention

Estimation of the Exposure–Response Relation between Benzene and Acute Myeloid Leukemia by Combining Epidemiologic, Human Biomarker, and Animal Data
Bernice Scholten, et al.
Cancer Epidemiol Bio Prev April 2022

Cancer Immunology Research

Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival
Junko Sawada, et al.
Cancer Immunol Res April 2022

Cancer Prevention Research

Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study
Sohee Kwon, et al.
Cancer Prev Res April 2022

Cancer Research

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
Mario R. Fernandez, et al.
Cancer Res April 2022

Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer
Ruozheng Wei, et al.
Cancer Res April 2022

Clinical Cancer Research

The Phase II MutHER Study of Neratinib Alone and in Combination with Fulvestrant in HER2-Mutated, Non-amplified Metastatic Breast Cancer
Cynthia X. Ma, et al.
Clin Cancer Res April 2022

Clinical Significance of PIK3CA and ESR1 Mutations in Circulating Tumor DNA: Analysis from the MONARCH 2 Study of Abemaciclib plus Fulvestrant
Sara M. Tolaney, et al.
Clin Cancer Res April 2022

Molecular Cancer Research

MIRO2 Regulates Prostate Cancer Cell Growth via GCN1-Dependent Stress Signaling
Madison Furnish, et al.
Mol Cancer Res April 2022

Molecular Cancer Therapeutics

(+)-JJ-74–138 is a Novel Noncompetitive Androgen Receptor Antagonist
Ryan N. Cole, et al.
Mol Cancer Ther April 2022

Blood Cancer Discovery

Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies
Sisi Zheng, et al.
Blood Cancer Discovery March 2022

Cancer Discovery

Mutant IDH Inhibits IFNγ–TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma
Meng-Ju Wu, et al.
Cancer Discov March 2022

Cancer Epidemiology, Biomarkers & Prevention

Racial/Ethnic Differences in Cancer Diagnosed after Metastasis: Absolute Burden and Deaths Potentially Avoidable through Earlier Detection
Christina A. Clarke, et al.
Cancer Epidemiol Bio Prev March 2022

Cancer Immunology Research

Exploiting Natural Killer Cell Engagers to Control Pediatric B-cell Precursor Acute Lymphoblastic Leukemia
Natalia Colomar-Carando, et al.
Cancer Immunol Res March 2022

Cancer Prevention Research

Preparation of a Beverage Containing Freeze-Dried Watercress for a Clinical Trial of Carcinogen and Toxicant Detoxification
Melissa J.L. Bonorden, et al.
Cancer Prev Res March 2022

Cancer Research

Quantification of T- and B-cell Immune Receptor Distribution Diversity Characterizes Immune Cell Infiltration and Lymphocyte Heterogeneity in Clear Cell Renal Cell Carcinoma
Meghan C. Ferrall-Fairbanks, et al.
Cancer Res March 2022

Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells
Zhe Sun, et al.
Cancer Res March 2022

Clinical Cancer Research

Safety, Activity, and Long-term Outcomes of Pomalidomide in the Treatment of Kaposi Sarcoma among Individuals with or without HIV Infection
Ramya Ramaswami, et al.
Clin Cancer Res March 2022

Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study
Albiruni R. Abdul Razak, et al.
Clin Cancer Res March 2022

Molecular Cancer Research

Disruption of β-Catenin–Dependent Wnt Signaling in Colon Cancer Cells Remodels the Microenvironment to Promote Tumor Invasion
George T. Chen, et al.
Mol Cancer Res March 2022

Molecular Cancer Therapeutics

Preclinical Development of the Class-I–Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors
Jennifer R. Diamond, et al.
Mol Cancer Ther March 2022

Blood Cancer Discovery

Next-Generation Sequencing of Minimal Residual Disease for Predicting Relapse after Tisagenlecleucel in Children and Young Adults with Acute Lymphoblastic Leukemia
Michael A. Pulsipher, et al.
Blood Cancer Discovery February 2022

Cancer Discovery

Live-Cell Imaging Shows Uneven Segregation of Extrachromosomal DNA Elements and Transcriptionally Active Extrachromosomal DNA Hubs in Cancer
Eunhee Yi, et al.
Cancer Discov February 2022

Cancer Epidemiology, Biomarkers & Prevention

Comparison of Fecal Sample Collection Methods for Microbial Analysis Embedded within Colorectal Cancer Screening Programs
Semi Zouiouich, et al.
Cancer Epidemiol Bio Prev February 2022

Cancer Immunology Research

NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy
Ti Wen, et al.
Cancer Immunol Res February 2022

Cancer Prevention Research

Progestin Significantly Inhibits Carcinogenesis in the Mogp-TAg Transgenic Mouse Model of Fallopian Tube Cancer
Omar L. Nelson, et al.
Cancer Prev Res February 2022

Cancer Research

Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression
Patrizia Porazzi, et al.
Cancer Res February 2022

An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression
Manuel C. Scheidmann, et al.
Cancer Res February 2022

Clinical Cancer Research

A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma
Andrew B. Lassman, et al.
Clin Cancer Res February 2022

First-in-human HER2-targeted Bispecific Antibody KN026 for the Treatment of Patients with HER2-positive Metastatic Breast Cancer: Results from a Phase I Study
Jian Zhang, et al.
Clin Cancer Res February 2022

Molecular Cancer Research

Glioblastoma–Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Sean McCutcheon, et al.
Mol Cancer Res February 2022

Molecular Cancer Therapeutics

RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors
Nicole Gormley, et al.
Mol Cancer Ther February 2022

Blood Cancer Discovery

NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity
Rebecca M. Richards, et al.
Blood Cancer Discovery January 2022

Cancer Discovery

Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Claudio Vernieri, et al.
Cancer Discov January 2022

Cancer Epidemiology, Biomarkers & Prevention

Work-Related Stress Was Not Associated with Increased Cancer Risk in a Population-Based Cohort Setting
Jenny Hadrévi, et al.
Cancer Epidemiol Bio Prev January 2022

Cancer Immunology Research

Imaging α-GalCer–Activated iNKT Cells in a Hepatic Metastatic Environment
Liane Babes, et al.
Cancer Immunol Res January 2022

Cancer Prevention Research

Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon
Yongjian Yang, et al.
Cancer Prev Res January 2022

Cancer Research

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd
Heidi M. Haikala, et al.
Cancer Res January 2022

T Cells Promote Metastasis by Regulating Extracellular Matrix Remodeling following Chemotherapy
Jozafina Haj-Shomaly, et al.
Cancer Res January 2022

Clinical Cancer Research

Adavosertib with Chemotherapy in Patients with Primary Platinum-Resistant Ovarian, Fallopian Tube, or Peritoneal Cancer: An Open-Label, Four-Arm, Phase II Study
Kathleen N. Moore, et al.
Clin Cancer Res January 2022

Clinical Activity of Single-Agent Cabozantinib (XL184), a Multi-receptor Tyrosine Kinase Inhibitor, in Patients with Refractory Soft-Tissue Sarcomas
Geraldine O'Sullivan Coyne, et al.
Clin Cancer Res January 2022

Molecular Cancer Research

A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
Aditya Wirawan, et al.
Mol Cancer Res January 2022

Molecular Cancer Therapeutics

SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance
Kristen Jensen-Pergakes, et al.
Mol Cancer Ther January 2022