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AACR Journals Editors' Picks

2021

AACR offers monthly "Editors' Picks" from our journals. We highlight one article from each issue that has been determined a "must read" by the Editors. Be sure to bookmark this page, as it will be updated on a monthly basis.
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January  |  February  |  March  |  April  |  May  |  June  |  July  |  August  |  September  |  October  |  November 


December

Blood Cancer Discovery

Overcoming Acquired Epigenetic Resistance to BTK Inhibitors
Arthur L. Shaffer III et al.
Blood Cancer Discovery December 2021

Cancer Epidemiology, Biomarkers & Prevention

Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures
Verena A. Katzke et al.
Cancer Epidemiol Bio Prev December 2021

Cancer Immunology Research

PD-1/PD-L1–Associated Immunoarchitectural Patterns Stratify Pancreatic Cancer Patients into Prognostic/Predictive Subgroups
Eva Karamitopoulou et al.
Cancer Immunol Res December 2021

Cancer Prevention Research

Transcriptome-wide In Vitro Effects of Aspirin on Patient-derived Normal Colon Organoids
Matthew A.M. Devall et al.
Cancer Prev Res December 2021

Molecular Cancer Research

Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine Subtype
Ellen Voigt et al.
Mol Cancer Res December 2021

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November

Blood Cancer Discovery

Phase II Trial of Pembrolizumab after High-Dose Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia
Joshua F. Zeidner et al.
Blood Cancer Discovery November 2021

Cancer Epidemiology, Biomarkers & Prevention

Characterizing Trends in Cancer Patients' Survival Using the JPSurv Software
Angela B. Mariotto et al.
Cancer Epidemiol Bio Prev November 2021

Cancer Immunology Research

Spatial UMAP and Image Cytometry for Topographic Immuno-oncology Biomarker Discovery
Nicolas A. Giraldo et al.
Cancer Immunol Res November 2021

Cancer Prevention Research

EUS-based Pancreatic Cancer Surveillance in BRCA1/BRCA2/PALB2/ATM Carriers Without a Family History of Pancreatic Cancer
Bryson W. Katona et al.
Cancer Prev Res November 2021

Molecular Cancer Research

SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation
Christelle Adolphe et al.
Mol Cancer Res November 2021

Molecular Cancer Therapeutics

Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages
Bryan D. Smith et al.
Mol Cancer Ther November 2021

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October

Blood Cancer Discovery

A Method for Overcoming Plasma Protein Inhibition of Tyrosine Kinase Inhibitors
David J. Young et al.
Blood Cancer Discovery October 2021

Cancer Discovery

Discovery and Features of an Alkylating Signature in Colorectal Cancer
Carino Gurjao et al.
Cancer Discov October 2021

Cancer Epidemiology, Biomarkers & Prevention

Hereditary and Inflammatory Bowel Disease-Related Early Onset Colorectal Cancer Have Unique Characteristics and Clinical Course Compared with Sporadic Disease
Arif A. Arif et al.
Cancer Epidemiol Bio Prev October 2021

Cancer Immunology Research

The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Momeneh Foroutan et al.
Cancer Immunol Res October 2021

Cancer Prevention Research

Vaccination with Polyclonal Antibody Stimulator (PAS) Prevents Pancreatic Carcinogenesis in the KRAS Mouse Model
Jill P. Smith et al.
Cancer Prev Res October 2021

Molecular Cancer Research

Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow
Brian S. Canter et al.
Mol Cancer Res October 2021

Molecular Cancer Therapeutics

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK
Joanne M. Munck et al.
Mol Cancer Ther October 2021

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September

Blood Cancer Discovery

Predictors of Humoral Response to SARS-CoV-2 Vaccination after Hematopoietic Cell Transplantation and CAR T Cell Therapy
Roni Tamari et al.
Blood Cancer Discovery September 2021

Cancer Discovery

Discovery of Candidate DNA Methylation Cancer Driver Genes
Heng Pan et al.
Cancer Discov September 2021

Cancer Epidemiology, Biomarkers & Prevention

Updated Methodology for Projecting U.S.- and State-Level Cancer Counts for the Current Calendar Year: Part I: Spatio-temporal Modeling for Cancer Incidence
Benmei Liu et al.
Cancer Epidemiol Bio Prev September 2021

Cancer Prevention Research

Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology
Kristin Wallace et al.
Cancer Prev Res September 2021

Molecular Cancer Therapeutics

TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations
Brion W. Murray et al.
Mol Cancer Ther September 2021

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August

Blood Cancer Discovery

Personalized Single-Cell Proteogenomics to Distinguish Acute Myeloid Leukemia from Nonmalignant Clonal Hematopoiesis
Laura W. Dillon et al.
Blood Cancer Discovery August 2021

Cancer Immunology Research

Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming
Mark S. Diamond et al.
Cancer Immunol Res August 2021

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July

Blood Cancer Discovery

Lysine Demethylase 5A Is Required for MYC-Driven Transcription in Multiple Myeloma
Hiroto Ohguchi et al.
Blood Cancer Discovery July 2021

Cancer Epidemiology, Biomarkers & Prevention

Solid Organ Transplantation and Survival among Individuals with a History of Cancer
Eric A. Engels et al.
Cancer Epidemiol Bio Prev July 2021

Cancer Research

TIMP1 Triggers Neutrophil Extracellular Trap Formation in Pancreatic Cancer
Benjamin Schoeps et al.
Cancer Res July 2021

Hypothermia Effectively Treats Tumors with Temperature-Sensitive p53 Mutations
Junhao Lu et al.
Cancer Res July 2021

Molecular Cancer Research

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma
Jennifer A. Jiménez et al.
Mol Cancer Res July 2021

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June

Blood Cancer Discovery

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia
Dongqing Yan et al.
Blood Cancer Discovery June 2021

Cancer Discovery

Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
Shengqing Stan Gu et al.
Cancer Discov June 2021

Cancer Epidemiology, Biomarkers & Prevention

Long-term Patterns of Excess Mortality among Endometrial Cancer Survivors
Chelsea Anderson et al.
Cancer Epidemiol Bio Prev June 2021

Cancer Immunology Research

Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer
Owen Heath et al.
Cancer Immunol Res June 2021

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May

Blood Cancer Discovery

Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers
Julie E. Feusier et al.
Blood Cancer Discovery May 2021

Cancer Epidemiology, Biomarkers & Prevention

Cancer Progress and Priorities: Breast Cancer
Serena C. Houghton and Susan E. Hankinson et al.
Cancer Epidemiol Bio Prev May 2021

Molecular Cancer Therapeutics

Robust Antitumor Activity and Low Cytokine Production by Novel Humanized Anti-CD19 CAR T Cells
Alka Dwivedi et al.
Mol Cancer Ther May 2021

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April

Cancer Discovery

Special April Issue!
Cancer Discov April 2021

Cancer Epidemiology, Biomarkers & Prevention

Simplified Breast Risk Tool Integrating Questionnaire Risk Factors, Mammographic Density, and Polygenic Risk Score: Development and Validation
Bernard Rosner et al.
Cancer Epidemiol Bio Prev April 2021

Cancer Immunology Research

Gut Microbiota and Antitumor Immunity: Potential Mechanisms for Clinical Effect
Erez N. Baruch et al.
Cancer Immunol Res April 2021

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March

Cancer Epidemiology, Biomarkers & Prevention

Modeled Reductions in Late-stage Cancer with a Multi-Cancer Early Detection Test
Earl Hubbell et al.
Cancer Epidemiol Bio Prev March 2021

Cancer Immunology Research

Antitumor Effects of CAR T Cells Redirected to the EDB Splice Variant of Fibronectin
Jessica Wagner et al.
Cancer Immunol Res March 2021

Cancer Prevention Research

An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia
Lori D. Dwyer-Nield et al.
Cancer Prev Res March 2021

Cancer Research

Replication Gaps Underlie BRCA Deficiency and Therapy Response
Nicholas J. Panzarino et al.
Cancer Res March 2021

EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers
Mélanie K. Prodhomme et al.
Cancer Res March 2021

Molecular Cancer Research

Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules
Yasuyo Sano et al.
Mol Cancer Res March 2021

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February

Blood Cancer Discovery

Preneoplastic Alterations Define CLL DNA Methylome and Persist through Disease Progression and Therapy
Helene Kretzmer et al.
Cancer Discov February 2021

Cancer Discovery

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site
Joanna C. Fowler et al.
Cancer Discov February 2021

Cancer Epidemiology, Biomarkers & Prevention

Could HPV Testing on Self-collected Samples Be Routinely Used in an Organized Cervical Screening Program? A Modeled Analysis
Megan A. Smith et al.
Cancer Epidemiol Bio Prev February 2021

Cancer Immunology Research

Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma
Emily J. Lelliott et al.
Cancer Immunol Res February 2021

Cancer Prevention Research

The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital
Denise Peixoto Guimarães et al.
Cancer Prev Res February 2021

Molecular Cancer Research

Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages
Elisenda Alsina-Sanchis et al.
Mol Cancer Res February 2021

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January

Cancer Discovery

Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death
Stephen Sakuma et al.
Cancer Discov January 2021

Cancer Epidemiology, Biomarkers & Prevention

Assessing Impact of HPV Vaccination on Cervical Cancer Incidence among Women Aged 15–29 Years in the United States, 1999–2017: An Ecologic Study
Jacqueline M. Mix et al.
Cancer Epidemiol Bio Prev January 2021

Cancer Immunology Research

The Prognostic Role of Macrophage Polarization in the Colorectal Cancer Microenvironment
Juha P. Väyrynen et al.
Cancer Immunol Res January 2021

Cancer Prevention Research

Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians
Courtney Macdonald et al.
Cancer Prev Res January 2021

Molecular Cancer Research

Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Yuri Park et al.
Mol Cancer Res January 2021

Molecular Cancer Therapeutics

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis–Addicted Breast Tumor Growth
Shauni Lien Geeraerts et al.
Mol Cancer Ther January 2021

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