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Yves Pommier
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Journal Articles

The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs

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Ukhyun Jo, Yasuhiro Arakawa, Astrid Zimmermann, Daiki Taniyama, Makito Mizunuma, Lisa M. Jenkins, Tapan K. Maity, Suresh Kumar, Frank T. Zenke, Naoko Takebe, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (7): 911–923.
https://doi.org/10.1158/1535-7163.MCT-23-0402
Published: 02 July 2024
View articletitled, The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs
Open the PDF for The Novel ATR Inhibitor Tuvusertib (M1774) Induces Replication Protein Overexpression and Broad Synergy with DNA-targeted Anticancer Drugs in another window
Includes: Supplementary data
Journal Articles

Abstract LB_A10: Efficacy of ATR inhibitor berzosertib plus topotecan or topotecan alone in patients with relapsed small cell lung cancer: A randomized clinical trial

Free
Nobuyuki Takahashi, Zhonglin Hao, Liza C Villaruz, Jun Zhang, Jimmy Ruiz, W. Jeffrey Petty, Hirva Mamdani, Jonathan W Riess, Jorge Nieva, Jose M Pachecho, Alexander D Fuld, Elaine Shum, Aman Chauhan, Samantha Nichols, Hirity Shimellis, Jessie McGlone, Linda Sciuto, Danielle Pinkiert, Chante Graham, Meenakshi Shelat, Robbie Kattappuram, Melissa Abel, Brett Schroeder, Deep Upadhyay, Manan Krishnamurthy, Ajit Kumar Sharma, Rajesh Kumar, Justin Malin, Christopher W Schultz, Shubhank Goyal, Christophe E Redon, Yves Pommier, Mirit I Aladjem, Steven D Gore, Seth M Steinberg, Rasa Vilimas, Parth Desai, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): LB_A10.
https://doi.org/10.1158/1535-7163.TARG-23-LB_A10
Published: 01 December 2023
View articletitled, Abstract LB_A10: Efficacy of ATR inhibitor berzosertib plus topotecan or topotecan alone in patients with relapsed small cell lung cancer: A randomized clinical trial
Journal Articles

Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication

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Junko Murai, Michele Ceribelli, Haiqing Fu, Christophe E. Redon, Ukhyun Jo, Yasuhisa Murai, Mirit I. Aladjem, Craig J. Thomas, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (8): 985–995.
https://doi.org/10.1158/1535-7163.MCT-22-0552
Published: 01 August 2023
View articletitled, Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication
Open the PDF for Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication in another window
Includes: Supplementary data
Journal Articles

PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors

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Anish Thomas, Shaun D. Fontaine, Morgan E. Diolaiti, Parth Desai, Rajesh Kumar, Nobuyuki Takahashi, Linda Sciuto, Samantha Nichols, Alan Ashworth, Felix Y. Feng, Gary W. Ashley, Minh Nguyen, Yves Pommier, Daniel V. Santi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (11): 1722–1728.
https://doi.org/10.1158/1535-7163.MCT-22-0217
Published: 03 November 2022
View articletitled, PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors
Open the PDF for PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II

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Yilun Sun, Yang Zhang, Christopher W. Schultz, Yves Pommier, Anish Thomas
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (9): 1430–1438.
https://doi.org/10.1158/1535-7163.MCT-21-0891
Published: 06 September 2022
View articletitled, CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II
Open the PDF for CDK7 Inhibition Synergizes with Topoisomerase I Inhibition in Small Cell Lung Cancer Cells by Inducing Ubiquitin-Mediated Proteolysis of RNA Polymerase II in another window
Includes: Supplementary data
Journal Articles

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

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Ukhyun Jo, Yasuhisa Murai, Keli K. Agama, Yilun Sun, Liton Kumar Saha, Xi Yang, Yasuhiro Arakawa, Sophia Gayle, Kelli Jones, Vishwas Paralkar, Ranjini K. Sundaram, Jinny Van Doorn, Juan C. Vasquez, Ranjit S. Bindra, Woo Suk Choi, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (7): 1090–1102.
https://doi.org/10.1158/1535-7163.MCT-21-1000
Published: 05 July 2022
View articletitled, TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor
Open the PDF for TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor in another window
Includes: Supplementary data
Journal Articles

Abstract P057: The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

Free
Dragomir Krastev, Shudong Li, Yilun Sun, Yves Pommier, Kristijan Ramadan, Christopher J. Lord
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P057.
https://doi.org/10.1158/1535-7163.TARG-21-P057
Published: 01 December 2021
View articletitled, Abstract P057: The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Journal Articles

The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria

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Christopher W. Schultz, Grace A. McCarthy, Teena Nerwal, Avinoam Nevler, James B. DuHadaway, Matthew D. McCoy, Wei Jiang, Samantha Z. Brown, Austin Goetz, Aditi Jain, Valerie S. Calvert, Vikalp Vishwakarma, Dezhen Wang, Ranjan Preet, Joel Cassel, Ross Summer, Hoora Shaghaghi, Yves Pommier, Simone A. Baechler, Michael J. Pishvaian, Talia Golan, Charles J. Yeo, Emanuel F. Petricoin, George C. Prendergast, Joseph Salvino, Pankaj K. Singh, Dan A. Dixon, Jonathan R. Brody
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (11): 2166–2176.
https://doi.org/10.1158/1535-7163.MCT-20-0652
Published: 01 November 2021
View articletitled, The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria
Open the PDF for The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria in another window
Includes: Supplementary data
Journal Articles

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Open Access
Ukhyun Jo, Ilya S. Senatorov, Astrid Zimmermann, Liton Kumar Saha, Yasuhisa Murai, Se Hyun Kim, Vinodh N. Rajapakse, Fathi Elloumi, Nobuyuki Takahashi, Christopher W. Schultz, Anish Thomas, Frank T. Zenke, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (8): 1431–1441.
https://doi.org/10.1158/1535-7163.MCT-20-1026
Published: 01 August 2021
View articletitled, Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents
Open the PDF for Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents in another window
Journal Articles

The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2

Available to Purchase
Laetitia Marzi, Yilun Sun, Shar-yin N. Huang, Amy James, Simone Difilippantonio, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (8): 1589–1597.
https://doi.org/10.1158/1535-7163.MCT-19-1064
Published: 04 August 2020
View articletitled, The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2
Open the PDF for The Indenoisoquinoline LMP517: A Novel Antitumor Agent Targeting both TOP1 and TOP2 in another window
Includes: Supplementary data
Journal Articles

Abstract B013: Associations of epigenome-wide DNA methylation patterns with chemosensitivity and chemoresistance of small cell lung cancer cell lines

Free
Julia Krushkal, Thomas Silvers, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, William C. Reinhold, Annamaria Rapisarda, David Evans, Yves Pommier, Beverly A. Teicher
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): B013.
https://doi.org/10.1158/1535-7163.TARG-19-B013
Published: 01 December 2019
View articletitled, Abstract B013: Associations of epigenome-wide DNA methylation patterns with chemosensitivity and chemoresistance of small cell lung cancer cell lines
Journal Articles

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors

Free
Laetitia Marzi, Keli Agama, Junko Murai, Simone Difilippantonio, Amy James, Cody J. Peer, William D. Figg, Daniel Beck, Mohamed S.A. Elsayed, Mark Cushman, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (8): 1694–1704.
https://doi.org/10.1158/1535-7163.MCT-18-0028
Published: 31 July 2018
View articletitled, Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract B188: DNA topoisomerase-mediated transcription-replication conflicts cause DNA damage by a transient increase of R loops and proteasome activity

Free
Jessica Marinello, Maria Delcuratolo, Yves Pommier, Monica Binaschi, Andrea Pellacani, Giovanni Capranico
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B188.
https://doi.org/10.1158/1535-7163.TARG-17-B188
Published: 01 January 2018
View articletitled, Abstract B188: DNA topoisomerase-mediated transcription-replication conflicts cause DNA damage by a transient increase of R loops and proteasome activity
Journal Articles

Abstract B023: ONC201 kills breast cancer cells by targeting mitochondria

Free
Yoshimi Endo Greer, Samuel Gilbert, Celia Islam, Ashley Ubaldini, Christina Stuelten, Natalie Porat-Shliom, Roberto Weigert, Yun Ji, Luca Gattinoni, Ferri Soheilian, Kunio Nagashima, Xiantao Wang, Markus Hafner, Jyoti Shetty, Bao Tran, Vishal Koparde, Parthav Jailwala, Maggie Cam, Dan Crooks, W. Marston Linehan, Donna Voeller, William Reinhold, Vinodh Rajapakse, Yves Pommier, Stanley Lipkowitz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B023.
https://doi.org/10.1158/1535-7163.TARG-17-B023
Published: 01 January 2018
View articletitled, Abstract B023: ONC201 kills breast cancer cells by targeting mitochondria
Journal Articles

TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors

Free
Muthana Al Abo, Hiroyuki Sasanuma, Xiaojun Liu, Vinodh N. Rajapakse, Shar-yin Huang, Evgeny Kiselev, Shunichi Takeda, William Plunkett, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (11): 2543–2551.
https://doi.org/10.1158/1535-7163.MCT-17-0110
Published: 01 November 2017
View articletitled, TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors
Open the PDF for TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors in another window
Includes: Supplementary data
Journal Articles

Chromatin Regulators as a Guide for Cancer Treatment Choice

Free
Zachary A. Gurard-Levin, Laurence O.W. Wilson, Vera Pancaldi, Sophie Postel-Vinay, Fabricio G. Sousa, Cecile Reyes, Elisabetta Marangoni, David Gentien, Alfonso Valencia, Yves Pommier, Paul Cottu, Geneviève Almouzni
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (7): 1768–1777.
https://doi.org/10.1158/1535-7163.MCT-15-1008
Published: 05 July 2016
View articletitled, Chromatin Regulators as a Guide for Cancer Treatment Choice
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Includes: Supplementary data
Journal Articles

Abstract C56: Platinum containing anti-cancer agents as targeted therapeutics

Free
Peter M. Bruno, Ga Young Park, Junko Murai, Yunpeng Liu, Justin Pritchard, Yves Pommier, Stephen J. Lippard, Michael T. Hemann
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C56.
https://doi.org/10.1158/1535-7163.TARG-15-C56
Published: 01 December 2015
View articletitled, Abstract C56: Platinum containing anti-cancer agents as targeted therapeutics
Journal Articles

Abstract B64: Schlafen 11 (SLFN11) irreversibly blocks cell cycle recovery independently of ATR following replicative damage by poly(ADPribose) polymerase inhibitors

Free
Junko Murai, Yves Pommier
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B64.
https://doi.org/10.1158/1535-7163.TARG-15-B64
Published: 01 December 2015
View articletitled, Abstract B64: Schlafen 11 (SLFN11) irreversibly blocks cell cycle recovery independently of ATR following replicative damage by poly(ADPribose) polymerase inhibitors
Journal Articles

Abstract A182: Targeting the topoisomerase I enzyme in cancer cells with acquired resistance to SN-38

Free
Jan Stenvang, Niels Frank Jensen, Haatisha Jandu, Steen Knudsen, Keli Agama, Thomas Jensen, Anker Hansen, Peter Buhl Jensen, Yves Pommier, Mark Cushman, Nils Brünner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A182.
https://doi.org/10.1158/1535-7163.TARG-15-A182
Published: 01 December 2015
View articletitled, Abstract A182: Targeting the topoisomerase I enzyme in cancer cells with acquired resistance to SN-38
Journal Articles

Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors

Free
Yeonee Seol, Hongliang Zhang, Keli Agama, Nicholas Lorence, Yves Pommier, Keir C. Neuman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (11): 2552–2559.
https://doi.org/10.1158/1535-7163.MCT-15-0454
Published: 03 November 2015
View articletitled, Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors
Open the PDF for Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors in another window
Includes: Supplementary data