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Journal Articles

Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells

Liyuan Yin, Yi Zhang, Lijuan Yin, Yan Ou, Michael S. Lewis, Ruoxiang Wang, Haiyen E. Zhau, Qinghua Zhou, Leland W.K. Chung
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12): 2527–2538.
https://doi.org/10.1158/1535-7163.MCT-20-1095
Published: 03 December 2021
View article titled, Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells
Open the PDF for Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract P108: In vivo CRISPR screens identify E3 ligase COP1 as a modulator of macrophage infiltration and cancer immunotherapy target

Xiaoqing Wang, Collin Tokheim, Shengqing S. Gu, Binbin Wang, Qin Tang, Yihao Li, Nicole Traugh, Zexian Zeng, Yi Zhang, Boning Zhang, Jingxin Fu, Tengfei Xiao, Wei Li, Clifford Meyer, Peng Jiang, Paloma Cejas, Klothilda Lim, Henry Long, Myles Brown, X. Shirley Liu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P108.
https://doi.org/10.1158/1535-7163.TARG-21-P108
Published: 01 December 2021
View article titled, Abstract P108: In vivo CRISPR screens identify E3 ligase COP1 as a modulator of macrophage infiltration and cancer immunotherapy target
Journal Articles

Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Siler H. Panowski, Tracy C. Kuo, Yi Zhang, Amy Chen, Tao Geng, Laura Aschenbrenner, Cris Kamperschroer, Edward Pascua, Wei Chen, Kathy Delaria, Santiago Farias, Marjorie Bateman, Russell G. Dushin, Sherman M. Chin, Thomas J. Van Blarcom, Yik Andy Yeung, Kevin C. Lindquist, Allison G. Chunyk, Bing Kuang, Bora Han, Michael Mirsky, Ingrid Pardo, Bernard Buetow, Thomas G. Martin, Jeffrey L. Wolf, David Shelton, Arvind Rajpal, Pavel Strop, Javier Chaparro-Riggers, Barbra J. Sasu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (11): 2008–2020.
https://doi.org/10.1158/1535-7163.MCT-19-0007
Published: 01 November 2019
View article titled, Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma
Open the PDF for Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma

Haiyang Yu, Yuling Qiu, Xu Pang, Jian Li, Song Wu, Shuangshuang Yin, Lifeng Han, Yi Zhang, Chengyun Jin, Xiumei Gao, Wenwei Hu, Tao Wang
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2017) 16 (12): 2711–2723.
https://doi.org/10.1158/1535-7163.MCT-17-0498
Published: 03 December 2017
View article titled, Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma
Open the PDF for Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Angiotensin-(1-7) Decreases Cell Growth and Angiogenesis of Human Nasopharyngeal Carcinoma Xenografts

Nana Pei, Renqiang Wan, Xinglu Chen, Andrew Li, Yanling Zhang, Jinlong Li, Hongyan Du, Baihong Chen, Wenjin Wei, Yanfei Qi, Yi Zhang, Michael J. Katovich, Colin Sumners, Haifa Zheng, Hongwei Li
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (1): 37–47.
https://doi.org/10.1158/1535-7163.MCT-14-0981
Published: 07 January 2016
View article titled, Angiotensin-(1-7) Decreases Cell Growth and Angiogenesis of Human Nasopharyngeal Carcinoma Xenografts
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Includes: Supplementary data
Journal Articles

Abstract C63: Effects of rolapitant on the pharmacokinetics of digoxin and sulfasalazine in healthy subjects

Xiaodong Wang, Zhi-Yi Zhang, Sujata Arora, Lorraine Hughes, Jing Wang, Sharon Lu, Jennifer Christensen, Vikram Kansra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C63.
https://doi.org/10.1158/1535-7163.TARG-15-C63
Published: 01 December 2015
View article titled, Abstract C63: Effects of rolapitant on the pharmacokinetics of digoxin and sulfasalazine in healthy subjects
Journal Articles

Abstract C62: Effects of rolapitant on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects

Xiaodong Wang, Zhi-Yi Zhang, Jing Wang, Sharon Lu, Sujata Arora, Lorraine Hughes, Jennifer Christensen, Vikram Kansra
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C62.
https://doi.org/10.1158/1535-7163.TARG-15-C62
Published: 01 December 2015
View article titled, Abstract C62: Effects of rolapitant on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects
Journal Articles

BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers

Zhiyu Tang, Xi Yuan, Rong Du, Shing-Hu Cheung, Guoliang Zhang, Jing Wei, Yuan Zhao, Yingcai Feng, Hao Peng, Yi Zhang, Yunguang Du, Xiaoxia Hu, Wenfeng Gong, Yong Liu, Yajuan Gao, Ye Liu, Rui Hao, Shengjian Li, Shaohui Wang, Jiafu Ji, Lianhai Zhang, Shuangxi Li, David Sutton, Min Wei, Changyou Zhou, Lai Wang, Lusong Luo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (10): 2187–2197.
https://doi.org/10.1158/1535-7163.MCT-15-0262
Published: 05 October 2015
View article titled, BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in <em>BRAF</em>-Mutated Colorectal Cancers
Open the PDF for BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in <em>BRAF</em>-Mutated Colorectal Cancers in another window
Includes: Supplementary data
Journal Articles

MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis

Yan Cheng, Yi Zhang, Li Zhang, Xingcong Ren, Kathryn J. Huber-Keener, Xiaoyuan Liu, Lei Zhou, Jason Liao, Heike Keihack, Li Yan, Eric Rubin, Jin-Ming Yang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (1): 154–164.
https://doi.org/10.1158/1535-7163.MCT-11-0606
Published: 09 January 2012
View article titled, MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis
Open the PDF for MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis in another window
Includes: Supplementary data