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Journal Articles

Abstract B081: Aurora kinase A inhibition overcomes adaptive resistance to KRAS G12C inhibitor by G1-checkpoint induced apoptosis in KRAS non-small cell lung cancer

Free
Chendi Li, Jeremy Chang, Christopher J Graser, Usman M Syed, Anahita Nimbalkar, Yi Shen, Steve Altschuler, Lani Wu, Franziska Michor, Xueqian Gong, Aaron N Hata
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): B081.
https://doi.org/10.1158/1535-7163.TARG-23-B081
Published: 01 December 2023
View articletitled, Abstract B081: Aurora kinase A inhibition overcomes adaptive resistance to KRAS G12C inhibitor by G1-checkpoint induced apoptosis in KRAS non-small cell lung cancer
Journal Articles

AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors

Open Access
Weining Weng, Tao Meng, Junyi Pu, Linjie Ma, Yi Shen, Zhaohui Wang, Rong Pan, Mingqiao Wang, Caiwei Chen, Lijun Wang, Jianjian Zhang, Biao Zhou, Siyuan Shao, Yu Qian, Shuhui Liu, Wenhao Hu, Xun Meng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (9): 1013–1027.
https://doi.org/10.1158/1535-7163.MCT-23-0198
Published: 05 September 2023
View articletitled, AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors
Open the PDF for AMT-562, a Novel HER3-targeting Antibody–Drug Conjugate, Demonstrates a Potential to Broaden Therapeutic Opportunities for HER3-expressing Tumors in another window
Includes: Supplementary data
Journal Articles

Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes

Free
Nishant Mohan, Yi Shen, Yukinori Endo, M. Khair ElZarrad, Wen Jin Wu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (6): 1321–1331.
https://doi.org/10.1158/1535-7163.MCT-15-0741
Published: 02 June 2016
View articletitled, Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes
Open the PDF for Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes in another window
Journal Articles

Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity

Free
Haoheng Yan, Yukinori Endo, Yi Shen, David Rotstein, Milos Dokmanovic, Nishant Mohan, Partha Mukhopadhyay, Bin Gao, Pal Pacher, Wen Jin Wu
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2016) 15 (3): 480–490.
https://doi.org/10.1158/1535-7163.MCT-15-0580
Published: 06 March 2016
View articletitled, Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity
Open the PDF for Ado-Trastuzumab Emtansine Targets Hepatocytes Via Human Epidermal Growth Factor Receptor 2 to Induce Hepatotoxicity in another window
Journal Articles

Trastuzumab Regulates IGFBP-2 and IGFBP-3 to Mediate Growth Inhibition: Implications for the Development of Predictive Biomarkers for Trastuzumab Resistance

Free
Milos Dokmanovic, Yi Shen, Tabetha M. Bonacci, Dianne S. Hirsch, Wen Jin Wu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (6): 917–928.
https://doi.org/10.1158/1535-7163.MCT-10-0980
Published: 08 June 2011
View articletitled, Trastuzumab Regulates IGFBP-2 and IGFBP-3 to Mediate Growth Inhibition: Implications for the Development of Predictive Biomarkers for Trastuzumab Resistance
Open the PDF for Trastuzumab Regulates IGFBP-2 and IGFBP-3 to Mediate Growth Inhibition: Implications for the Development of Predictive Biomarkers for Trastuzumab Resistance in another window
Journal Articles

Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

Free
Milos Dokmanovic, Dianne S. Hirsch, Yi Shen, Wen Jin Wu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (6): 1557–1569.
https://doi.org/10.1158/1535-7163.MCT-09-0140
Published: 10 June 2009
View articletitled, Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer
Open the PDF for Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer in another window