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Journal Articles

Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47

Matthew R. Levengood, Christopher M. Carosino, Xinqun Zhang, Sasha Lucas, David J. Ortiz, Lori Westendorf, Alice P. Chin, Arlan D. Martin, Abbie Wong, Shawna M. Hengel, Hao Sun, Weiping Zeng, Roma Yumul, Melissa M.C. Dominguez, Yufei Chen, Janet H. Zheng, Courtney A.B. Karlsson, Vivian H. Trang, Peter D. Senter, Shyra J. Gardai
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther OF1–OF14.
https://doi.org/10.1158/1535-7163.MCT-24-0371
Published: 22 November 2024
View article titled, Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47
Open the PDF for Preclinical Development of SGN-CD47M: Protease-Activated Antibody Technology Enables Selective Tumor Targeting of the Innate Immune Checkpoint Receptor CD47 in another window
Includes: Supplementary data
Journal Articles

Abstract C113: Discovery of a novel auristatin antibody drug conjugate drug linker with equal efficacy and reduced bone marrow toxicity compared to vedotin

Noah A Bindman, Roma Yumul, Erica E McKinney, Scott Blackburn, Nicole Blesie, Xinqun Zhang, Brendan Drouhard, Sarah Anderson, Calvin Neace, David Ortiz, KC Crowder, Nancy Everds, Chris Carosino, Forgivemore Magunda, Django Sussman, Esther Trueblood, Nicole M. Okeley, Peter Senter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C113.
https://doi.org/10.1158/1535-7163.TARG-23-C113
Published: 01 December 2023
View article titled, Abstract C113: Discovery of a novel auristatin antibody drug conjugate drug linker with equal efficacy and reduced bone marrow toxicity compared to vedotin
Journal Articles

Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates

Fu Li, Michelle Ulrich, Mechthild Jonas, Ivan J. Stone, Germein Linares, Xinqun Zhang, Lori Westendorf, Dennis R. Benjamin, Che-Leung Law
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (7): 1347–1354.
https://doi.org/10.1158/1535-7163.MCT-17-0019
Published: 04 July 2017
View article titled, Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates
Open the PDF for Tumor-Associated Macrophages Can Contribute to Antitumor Activity through FcγR-Mediated Processing of Antibody–Drug Conjugates in another window
Includes: Supplementary data
Journal Articles

Abstract B204: Engineered cysteine antibodies: Improved antibody-drug conjugate vehicles.

Django Sussman, Lindsay Torrey, Lori Westendorf, Xinqun Zhang, Nicole M. Okeley, Stephen C. Alley, Robert Lyon, David Meyer, Jamie B. Miyamoto, Dennis R. Benjamin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B204.
https://doi.org/10.1158/1535-7163.TARG-11-B204
Published: 12 November 2011
View article titled, Abstract B204: Engineered cysteine antibodies: Improved antibody-drug conjugate vehicles.
Journal Articles

Abstract C52: Enhancing the activities of endogenous antibodies.

Stephen Alley, Dennis Benjamin, Kim Emmerton, Xinqun Zhang, Che-Leung Law, Nicole Okeley, Peter Senter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C52.
https://doi.org/10.1158/1535-7163.TARG-11-C52
Published: 12 November 2011
View article titled, Abstract C52: Enhancing the activities of endogenous antibodies.
Journal Articles

Anti-CD30 diabody-drug conjugates with potent antitumor activity

Kristine M. Kim, Charlotte F. McDonagh, Lori Westendorf, Lindsay L. Brown, Django Sussman, Tiffany Feist, Robert Lyon, Stephen C. Alley, Nicole M. Okeley, Xinqun Zhang, Melissa C. Thompson, Ivan Stone, Hans-Peter Gerber, Paul J. Carter
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (8): 2486–2497.
https://doi.org/10.1158/1535-7163.MCT-08-0388
Published: 21 August 2008
View article titled, Anti-CD30 diabody-drug conjugates with potent antitumor activity
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Includes: Supplementary data