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Journal Articles

The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair

Yun Dai, Shuang Chen, Maciej Kmieciak, Liang Zhou, Hui Lin, Xin-Yan Pei, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (6): 878–889.
https://doi.org/10.1158/1535-7163.MCT-12-0902
Published: 09 June 2013
View article titled, The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair
Open the PDF for The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair in another window
Includes: Supplementary data
Journal Articles

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

Hossein Hamed, William Hawkins, Clint Mitchell, Donna Gilfor, Guo Zhang, Xin-Yan Pei, Yun Dai, Michael P. Hagan, John D. Roberts, Adly Yacoub, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (3): 616–629.
https://doi.org/10.1158/1535-7163.MCT-07-2376
Published: 17 March 2008
View article titled, Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death <em>in vitro</em> and <em>in vivo</em>
Open the PDF for Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death <em>in vitro</em> and <em>in vivo</em> in another window
Journal Articles

Ras-dependent activation of ERK1/2 regulates the lethality of Chk1 inhibitors in multiple myeloma cells

Yun Dai, Shuang Chen, Xin-Yan Pei, Jorge Almenara, Lora Kramer, Charis Venditti, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C180.
Published: 01 November 2007
View article titled, Ras-dependent activation of ERK1/2 regulates the lethality of Chk1 inhibitors in multiple myeloma cells
Journal Articles

The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical–dependent and Jun NH2-terminal kinase–dependent mechanism

Xin-Yan Pei, Yun Dai, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2004) 3 (12): 1513–1524.
https://doi.org/10.1158/1535-7163.1513.3.12
Published: 04 January 2005
View article titled, The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical–dependent and Jun NH<sub>2</sub>-terminal kinase–dependent mechanism
Open the PDF for The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical–dependent and Jun NH<sub>2</sub>-terminal kinase–dependent mechanism in another window