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Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Lichao Guo, Wen Zhang, Yanqi Xie, Xi Chen, Emma E. Olmstead, Mengqiang Lian, Baochen Zhang, Yekaterina Y. Zaytseva, B. Mark Evers, H. Peter Spielmann, Xifu Liu, David S. Watt, Chunming Liu

Mol Cancer Ther (2022) 21 (5): 740–750.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0925

Published: 04 May 2022

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Includes: Supplementary data

Journal Articles

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Brion W. Murray, Evan Rogers, Dayong Zhai, Wei Deng, Xi Chen, Paul A. Sprengeler, Xin Zhang, Armin Graber, Siegfried H. Reich, Shanna Stopatschinskaja, Benjamin Solomon, Benjamin Besse, Alexander Drilon

Mol Cancer Ther (2021) 20 (12): 2446–2456.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0632

Published: 03 December 2021

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Includes: Supplementary data

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Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer

Austin R. Dosch, Samara Singh, Xizi Dai, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi, Supriya Srinivasan, Zhen Gao, Yuguang Ban, Xi Chen, Sulagna Banerjee, Nagaraj S. Nagathihalli, Jashodeep Datta, Nipun B. Merchant

Mol Cancer Ther (2021) 20 (11): 2280–2290.

DOI: https://doi.org/10.1158/1535-7163.MCT-21-0083

Published: 01 November 2021

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Includes: Supplementary data

Journal Articles

Potent Synergistic Effect on C-Myc–Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor

Yanqi Xie, Wen Zhang, Lichao Guo, Liliia M. Kril, Kristin L. Begley, Vitaliy M. Sviripa, Xi Chen, Xifu Liu, Eun Y. Lee, Daheng He, Chi Wang, Tianyan Gao, Xiaoqi Liu, B. Mark Evers, David S. Watt, Chunming Liu

Mol Cancer Ther (2021) 20 (10): 1893–1903.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-1017

Published: 01 October 2021

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Includes: Supplementary data

Journal Articles

Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

Tulasigeri M. Totiger, Supriya Srinivasan, Venkatakrishna R. Jala, Purushottam Lamichhane, Austin R. Dosch, Alexander A. Gaidarski, III, Chandrashekhar Joshi, Shobith Rangappa, Jason Castellanos, Praveen Kumar Vemula, Xi Chen, Deukwoo Kwon, Nilesh Kashikar, Michael VanSaun, Nipun B. Merchant, Nagaraj S. Nagathihalli

Mol Cancer Ther (2019) 18 (2): 301–311.

DOI: https://doi.org/10.1158/1535-7163.MCT-18-0464

Published: 04 February 2019

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Includes: Supplementary data

Journal Articles

PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature

Evgeni Efimenko, Utpal P. Davé, Irina V. Lebedeva, Yao Shen, Maria J. Sanchez-Quintero, Daniel Diolaiti, Andrew Kung, Brian J. Lannutti, Jianchung Chen, Ronald Realubit, Zoya Niatsetskaya, Vadim Ten, Charles Karan, Xi Chen, Andrea Califano, Thomas G. Diacovo

Mol Cancer Ther (2017) 16 (10): 2069–2082.

DOI: https://doi.org/10.1158/1535-7163.MCT-17-0141

Published: 02 October 2017

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Includes: Supplementary data

Journal Articles

Abstract LB-A24: Molecular alteration of SMAD4 in hindgut-derived colorectal tumors identifies a distinct subset of patients and is associated with worse recurrence-free survival

Jesse Joshua Smith, Lik Hang Lee, Xi Chen, Chao Wu, Raphael Pelossof, Garrett M. Nash, Larissa R. Temple, Jose G. Guillem, Martin R. Weiser, Philip B. Paty, Jinru Shia, Julio Garcia-Aguilar, Charles L. Sawyers

Mol Cancer Ther (2015) 14 (12_Supplement_2): LB-A24.

DOI: https://doi.org/10.1158/1535-7163.TARG-15-LB-A24

Published: 01 December 2015

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Journal Articles

Abstract A140: Novel drug development candidate potently and selectively inhibits growth of tumor cells harboring activated Ras

Gary A. Piazza, Bing Zhu, Kevin Lee, Joshua Canzoneri, Sara Sigler, Ashley Lindsey, Veronica Ramirez-Alcantara, Luciana Madeira da Silva, Haddon Mullins, Alisa Trinh, Kristy Berry, Jacob Valiyaveettil, Adam B. Keeton, Xi Chen, Michael R. Boyd

Mol Cancer Ther (2015) 14 (12_Supplement_2): A140.

DOI: https://doi.org/10.1158/1535-7163.TARG-15-A140

Published: 01 December 2015

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Journal Articles

Optimizing the Sequence of Anti-EGFR–Targeted Therapy in EGFR-Mutant Lung Cancer

Catherine B. Meador, Hailing Jin, Elisa de Stanchina, Caroline A. Nebhan, Valentina Pirazzoli, Lu Wang, Pengcheng Lu, Huy Vuong, Katherine E. Hutchinson, Peilin Jia, Xi Chen, Rosana Eisenberg, Marc Ladanyi, Katerina Politi, Zhongming Zhao, Christine M. Lovly, Darren A.E. Cross, William Pao

Mol Cancer Ther (2015) 14 (2): 542–552.

DOI: https://doi.org/10.1158/1535-7163.MCT-14-0723

Published: 09 February 2015

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Includes: Supplementary data

Journal Articles

Genetic and Pharmacologic Evidence That mTOR Targeting Outweighs mTORC1 Inhibition as an Antimyeloma Strategy

Xi Chen, Elena Díaz-Rodríguez, Enrique M. Ocio, Bruno Paiva, Deborah S. Mortensen, Antonia Lopez-Girona, Rajesh Chopra, Jesús San Miguel, Atanasio Pandiella

Mol Cancer Ther (2014) 13 (2): 504–516.

DOI: https://doi.org/10.1158/1535-7163.MCT-13-0022

Published: 09 February 2014

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Includes: Supplementary data

Journal Articles

Abstract C182: Phosphodiesterase 10: A novel cancer target.

Mol Cancer Ther (2013) 12 (11_Supplement): C182.

DOI: https://doi.org/10.1158/1535-7163.TARG-13-C182

Published: 01 November 2013

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Journal Articles

Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/β-Catenin Signaling

Nan Li, Yaguang Xi, Heather N. Tinsley, Evrim Gurpinar, Bernard D. Gary, Bing Zhu, Yonghe Li, Xi Chen, Adam B. Keeton, Ashraf H. Abadi, Mary P. Moyer, William E. Grizzle, Wen-Chi Chang, Margie L. Clapper, Gary A. Piazza

Mol Cancer Ther (2013) 12 (9): 1848–1859.

DOI: https://doi.org/10.1158/1535-7163.MCT-13-0048

Published: 05 September 2013

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Journal Articles

Predominance of mTORC1 over mTORC2 in the Regulation of Proliferation of Ovarian Cancer Cells: Therapeutic Implications

Juan Carlos Montero, Xi Chen, Alberto Ocaña, Atanasio Pandiella

Mol Cancer Ther (2012) 11 (6): 1342–1352.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0723

Published: 10 June 2012

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Includes: Supplementary data

Journal Articles

Abstract C66: Role of mTORC1 and mTORC2 in multiple myeloma and their targeting with CC214.

Atanasio Pandiella, Xi Chen, Enrique M. Ocio, Elena Diaz-Rodriguez, Antonia Lopez-Girona, Rajesh Chopra, Jesus San Miguel

Mol Cancer Ther (2011) 10 (11_Supplement): C66.

DOI: https://doi.org/10.1158/1535-7163.TARG-11-C66

Published: 12 November 2011

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NARROW

Diaminobutoxy-substituted Isoflavonoid (DBI-1) Enhances the Therapeutic Efficacy of GLUT1 Inhibitor BAY-876 by Modulating Metabolic Pathways in Colon Cancer Cells

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer

Potent Synergistic Effect on C-Myc–Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor

Urolithin A, a Novel Natural Compound to Target PI3K/AKT/mTOR Pathway in Pancreatic Cancer

PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature

Abstract LB-A24: Molecular alteration of SMAD4 in hindgut-derived colorectal tumors identifies a distinct subset of patients and is associated with worse recurrence-free survival

Abstract A140: Novel drug development candidate potently and selectively inhibits growth of tumor cells harboring activated Ras

Optimizing the Sequence of Anti-EGFR–Targeted Therapy in EGFR-Mutant Lung Cancer

Genetic and Pharmacologic Evidence That mTOR Targeting Outweighs mTORC1 Inhibition as an Antimyeloma Strategy

Abstract C182: Phosphodiesterase 10: A novel cancer target.

Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/β-Catenin Signaling

Predominance of mTORC1 over mTORC2 in the Regulation of Proliferation of Ovarian Cancer Cells: Therapeutic Implications

Abstract C66: Role of mTORC1 and mTORC2 in multiple myeloma and their targeting with CC214.

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