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William R. Wilson
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Journal Articles

Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer

Francis W. Hunter, Huai-Ling Hsu, Jiechuang Su, Susan M. Pullen, William R. Wilson, Jingli Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (11): 2501–2514.
https://doi.org/10.1158/1535-7163.MCT-14-0476
Published: 03 November 2014
View article titled, Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer
Open the PDF for Dual Targeting of Hypoxia and Homologous Recombination Repair Dysfunction in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C21: A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumor patients.

Mark McKeage, Yongchuan Gu, William R. Wilson, Andrew Hill, Karen Amies, Teresa Melink, Michael B. Jameson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C21.
https://doi.org/10.1158/1535-7163.TARG-11-C21
Published: 12 November 2011
View article titled, Abstract C21: A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumor patients.
Journal Articles

Abstract A247: Mechanism of action of the hypoxia-activated irreversible pan-HER inhibitor SN29966.

Jeff B. Smaill, Jagdish Jaiswal, Maria Abbattista, Guo-Liang Lu, Robert F. Anderson, Amir Ashoorzadeh, William A. Denny, Fernando Donate, Huai-Ling Hsu, Ho H. Lee, Andrej Maroz, Sunali Mehta, Alison Pruijn, Michelle Puryer, Sophie P. Syddall, Aaron Thompson, Wouter van Leeuwen, William R. Wilson, Stephen Jamieson, Adam V. Patterson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): A247.
https://doi.org/10.1158/1535-7163.TARG-11-A247
Published: 12 November 2011
View article titled, Abstract A247: Mechanism of action of the hypoxia-activated irreversible pan-HER inhibitor SN29966.
Journal Articles

Abstract B76: Cellular metabolism, murine pharmacokinetics and preclinical antitumor activity of SN29966, a novel hypoxia‐activated irreversible pan‐HER inhibitor

Adam V. Patterson, Jagdish Jaswail, Sophie P. Syddall, Maria Abbattista, Wouter van Leeuwen, Michelle Puryer, Aaron Thompson, Annie Hsu, Sunali Mehta, Alison Pruijn, G. Leon Lu, Fernando Doñate, William A. Denny, William R. Wilson, Jeffrey B. Smaill
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B76.
https://doi.org/10.1158/1535-7163.TARG-09-B76
Published: 10 December 2009
View article titled, Abstract B76: Cellular metabolism, murine pharmacokinetics and preclinical antitumor activity of SN29966, a novel hypoxia‐activated irreversible pan‐HER inhibitor
Journal Articles

Abstract C46: Design and identification of the novel hypoxia‐activated irreversible pan‐HER inhibitor SN29966

Jeff B. Smaill, Guo‐Liang Lu, Wouter van Leeuwen, Maria Abbattista, Robert F. Anderson, William A. Denny, Fernando Doñate, Jagdish Jaswail, Andrej Maroz, Michelle Puryer, Sophie P. Syddall, William R. Wilson, Adam V. Patterson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C46.
https://doi.org/10.1158/1535-7163.TARG-09-C46
Published: 10 December 2009
View article titled, Abstract C46: Design and identification of the novel hypoxia‐activated irreversible pan‐HER inhibitor SN29966
Journal Articles

Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators

William R. Wilson, Stephen M. Stribbling, Frederik B. Pruijn, Sophie P. Syddall, Adam V. Patterson, H.D. Sarath Liyanage, Eileen Smith, K. Jane Botting, Moana Tercel
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2903–2913.
https://doi.org/10.1158/1535-7163.MCT-09-0571
Published: 12 October 2009
View article titled, Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine <em>N</em>3 DNA minor groove alkylators
Open the PDF for Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine <em>N</em>3 DNA minor groove alkylators in another window
Includes: Supplementary data
Journal Articles

Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A

Yongchuan Gu, Adam V. Patterson, Graham J. Atwell, Sophia B. Chernikova, J. Martin Brown, Larry H. Thompson, William R. Wilson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (6): 1714–1723.
https://doi.org/10.1158/1535-7163.MCT-08-1209
Published: 10 June 2009
View article titled, Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A
Open the PDF for Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A in another window
Includes: Supplementary data