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Weiwen Ying
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Journal Articles

Abstract B093: Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent

Ines Pulido, Qiyue Luan, Chenghao Yin, Zimo Yang, Jinhua Lin, Yaya Wang, Yuetong Sun, Chuche Liu, Haoxin Zhou, Marek Massad, Ian Papautsky, Thomas L. Prince, Guoqiang Wang, Kevin P. Foley, Weiwen Ying, Takeshi Shimamura
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): B093.
https://doi.org/10.1158/1535-7163.TARG-23-B093
Published: 01 December 2023
View article titled, Abstract B093: Treating KRAS(G12D) inhibitor resistance using a KRAS- and HSP90 chaperone-targeted hetero-bispecific small molecule agent
Journal Articles

Abstract C137: Tumor-selective, chaperone-mediated targeting of ERK5 (MAPK7)

Kevin P Foley, Xiangcai Yang, Wei Yin, Mengmeng Xu, Mingkai Wang, Qinglin Ding, Yan Dai, Haoxin Zhou, Ignazia Tusa, Alessio Menconi, Zoe Lombardi, Alessandro Tubita, Thomas L Prince, Guoqiang Wang, Elisabetta Rovida, Weiwen Ying
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C137.
https://doi.org/10.1158/1535-7163.TARG-23-C137
Published: 01 December 2023
View article titled, Abstract C137: Tumor-selective, chaperone-mediated targeting of ERK5 (MAPK7)
Journal Articles

HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors

David A. Proia, Donald L. Smith, Junyi Zhang, John-Paul Jimenez, Jim Sang, Luisa Shin Ogawa, Manuel Sequeira, Jaime Acquaviva, Suqin He, Chaohua Zhang, Vladimir Khazak, Igor Astsaturov, Takayo Inoue, Noriaki Tatsuta, Sami Osman, Richard C. Bates, Dinesh Chimmanamada, Weiwen Ying
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2015) 14 (11): 2422–2432.
https://doi.org/10.1158/1535-7163.MCT-15-0455
Published: 03 November 2015
View article titled, HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Open the PDF for HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors in another window
Includes: Supplementary data
Journal Articles

Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy

Weiwen Ying, Zhenjian Du, Lijun Sun, Kevin P. Foley, David A. Proia, Ronald K. Blackman, Dan Zhou, Takayo Inoue, Noriaki Tatsuta, Jim Sang, Shuxia Ye, Jamie Acquaviva, Luisa Shin Ogawa, Yumiko Wada, James Barsoum, Keizo Koya
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (2): 475–484.
https://doi.org/10.1158/1535-7163.MCT-11-0755
Published: 08 February 2012
View article titled, Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy
Open the PDF for Ganetespib, a Unique Triazolone-Containing Hsp90 Inhibitor, Exhibits Potent Antitumor Activity and a Superior Safety Profile for Cancer Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract C212: A critical role for the tissue distribution profile in heat shock protein (Hsp) 90 inhibitor-induced ocular toxicity in rats.

Dan Zhou, Yuan Liu, Josephine Ye, Weiwen Ying, Shijie Zhang, Luisa Shin Ogawa, Takayo Inoue, Noriaki Tatsuta, Yumiko Wada, Andrew Sonderfan, Keizo Koya
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C212.
https://doi.org/10.1158/1535-7163.TARG-11-C212
Published: 12 November 2011
View article titled, Abstract C212: A critical role for the tissue distribution profile in heat shock protein (Hsp) 90 inhibitor-induced ocular toxicity in rats.
Journal Articles

Abstract B105: Ganetespib, a unique resorcinolic Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile in preclinical models.

Weiwen Ying, David A. Proia, Dan Zhou, Takayo Inoue, Noriaki Tatsuta, Jim Sang, Shuxia Ye, Jaime Acquaviva, Luisa Shin Ogawa, Yumiko Wada, Dinesh Chimmanamada, Shijie Zhang, Keizo Koya
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B105.
https://doi.org/10.1158/1535-7163.TARG-11-B105
Published: 12 November 2011
View article titled, Abstract B105: Ganetespib, a unique resorcinolic Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile in preclinical models.
Journal Articles

Abstract C91: Pharmacodynamic analysis of the Hsp90 inhibitor STA‐9090 in a lung cancer xenograft model supports an infrequent dosing schedule in the clinic

Kevin P. Foley, Takeshi Shimamura, Ron K. Blackman, Christa L. Borgman, Takayo Inoue, Tim Korbut, David Proia, Jim Sang, Luisa Shin Ogawa, Don Smith, Noriaki Tatsuta, Chaohua Zhang, Haili Zhang, Weiwen Ying, Geoffrey I. Shapiro, James Barsoum
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C91.
https://doi.org/10.1158/1535-7163.TARG-09-C91
Published: 10 December 2009
View article titled, Abstract C91: Pharmacodynamic analysis of the Hsp90 inhibitor STA‐9090 in a lung cancer xenograft model supports an infrequent dosing schedule in the clinic
Journal Articles

Abstract B199: In vitro and in vivo efficacy of the novel Hsp90 inhibitor STA‐9090 and its synergy with paclitaxel

Weiwen Ying, Ronald K. Blackman, Dinesh Chimmanamada, Zhenjian Du, Kevin P. Foley, Suqin He, Takayo Inoue, David James, Jane Kepros, Tim Korbut, Luisa Shin Ogawa, Cong Peng, Teresa Przewloka, David Proia, Jim Sang, Donald Smith, Noriaki Tatsuta, Chin‐Yu Yang, Chaohua Zhang, Haili Zhang, Shijie Zhang, Shaoguang Li, James Barsoum
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B199.
https://doi.org/10.1158/1535-7163.TARG-09-B199
Published: 10 December 2009
View article titled, Abstract B199: <em>In vitro</em> and <em>in vivo</em> efficacy of the novel Hsp90 inhibitor STA‐9090 and its synergy with paclitaxel