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Journal Articles

Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers

Wei Zhou, Peng Fang, Dongan Yu, Hongyuan Ren, Meng You, Long Yin, Fei Mei, Huikai Zhu, Zhenzhen Wang, Hui Xu, Yuxia Cao, Xiaowei Sun, Xiaohong Xu, Jianjun Bi, Jin Wang, Lanping Ma, Xin Wang, Lin Chen, Yongliang Zhang, Xiaowei Cen, Xi Zhu, Liguang Lou, Datao Liu, Xiaoding Tan, Jinliang Yang, Tao Meng, Jingkang Shen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (8): 913–925.
https://doi.org/10.1158/1535-7163.MCT-22-0743
Published: 01 August 2023
View article titled, Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers
Open the PDF for Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers in another window
Includes: Supplementary data
Journal Articles

Leflunomide Suppresses the Growth of LKB1-Inactivated Tumors in the Immune-Competent Host and Attenuates Distant Cancer Metastasis

Rui Jin, Boxuan Liu, Xiuju Liu, Yijian Fan, Wei Peng, Chunzi Huang, Adam Marcus, Gabriel Sica, Melissa Gilbert-Ross, Yuan Liu, Wei Zhou
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (2): 274–283.
https://doi.org/10.1158/1535-7163.MCT-20-0567
Published: 05 February 2021
View article titled, Leflunomide Suppresses the Growth of LKB1-Inactivated Tumors in the Immune-Competent Host and Attenuates Distant Cancer Metastasis
Open the PDF for Leflunomide Suppresses the Growth of LKB1-Inactivated Tumors in the Immune-Competent Host and Attenuates Distant Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models

Heather M. Moore, Heidi M. Savage, Carol O'Brien, Wei Zhou, Ethan S. Sokol, Michael E. Goldberg, Ciara Metcalfe, Lori S. Friedman, Mark R. Lackner, Timothy R. Wilson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (1): 292–303.
https://doi.org/10.1158/1535-7163.MCT-19-0284
Published: 03 January 2020
View article titled, Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models
Open the PDF for Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3-Kinase Inhibitor Taselisib in Breast Cancer Preclinical Models in another window
Includes: Supplementary data
Journal Articles

Abstract B222: Dicer substrate siRNAs to MYC, B-catenin, and other target genes effectively induce in vivo target gene knockdown and tumor inhibition.

Hank Dudek, Kathleen Wortham, Rokhand Arvan, Anee Shah, Bo Ying, Wendy Cyr, Hailin Yang, Wei Zhou, Utsav Saxena, Yi Zhou, Rohan Diwanji, Ben Holmes, Ruchir Farkiwala, Aalok Shah, Bob Brown
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B222.
https://doi.org/10.1158/1535-7163.TARG-13-B222
Published: 01 November 2013
View article titled, Abstract B222: Dicer substrate siRNAs to MYC, B-catenin, and other target genes effectively induce in vivo target gene knockdown and tumor inhibition.
Journal Articles

ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors

Georgia Hatzivassiliou, Bonnie Liu, Carol O'Brien, Jill M. Spoerke, Klaus P. Hoeflich, Peter M. Haverty, Robert Soriano, William F. Forrest, Sherry Heldens, Huifen Chen, Karen Toy, Connie Ha, Wei Zhou, Kyung Song, Lori S. Friedman, Lukas C. Amler, Garret M. Hampton, John Moffat, Marcia Belvin, Mark R. Lackner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (5): 1143–1154.
https://doi.org/10.1158/1535-7163.MCT-11-1010
Published: 08 May 2012
View article titled, ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract C178: Synergistic activity of SR16388 with microtubule inhibitors against multiple cancer cell lines.

Wei Zhou, Joy Calaogan, Barbara Sato, Lidia Sambucetti
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): C178.
https://doi.org/10.1158/1535-7163.TARG-11-C178
Published: 12 November 2011
View article titled, Abstract C178: Synergistic activity of SR16388 with microtubule inhibitors against multiple cancer cell lines.
Journal Articles

2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition

Diansheng Zhong, Xiuju Liu, Katherine Schafer-Hales, Adam I. Marcus, Fadlo R. Khuri, Shi-Yong Sun, Wei Zhou
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (4): 809–817.
https://doi.org/10.1158/1535-7163.MCT-07-0559
Published: 15 April 2008
View article titled, 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition
Open the PDF for 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition in another window