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Vahe Bedian
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Journal Articles

Abstract B170: Discovery of tubulysin payloads for antibody drug conjugates with potent in vitro activity and in vivo efficacy in solid tumor models

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Dorin Toader, Jay Harper, Chris Lloyd, Rose Marwood, David Bannister, Shenlan Mao, Cui (Tracy) Chen, Haihon (Helen) Zhong, Vahe Bedian, Fengjiang Wang, Lakshmaiah Gingipalli, Melisa Vasbinder, Pamela Thompson, Ryan Fleming, Byniam Bezabeh, Nazzareno Dimasi, Changshou Gao, Adeela Kamal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B170.
https://doi.org/10.1158/1535-7163.TARG-15-B170
Published: 01 December 2015
View articletitled, Abstract B170: Discovery of tubulysin payloads for antibody drug conjugates with potent in vitro activity and in vivo efficacy in solid tumor models
Journal Articles

Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling

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Neil R. Michaud, Youzhen Wang, Kristen A. McEachern, Jerold J. Jordan, Anne Marie Mazzola, Axel Hernandez, Sanjoo Jalla, Jon W. Chesebrough, Mark J. Hynes, Matthew A. Belmonte, Lidong Wang, Jaspal S. Kang, Jelena Jovanović, Naomi Laing, David W. Jenkins, Elaine Hurt, Meina Liang, Christopher Frantz, Robert E. Hollingsworth, Diane M. Simeone, David C. Blakey, Vahe Bedian
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (2): 386–398.
https://doi.org/10.1158/1535-7163.MCT-13-0420
Published: 09 February 2014
View articletitled, Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling
Open the PDF for Novel Neutralizing Hedgehog Antibody MEDI-5304 Exhibits Antitumor Activity by Inhibiting Paracrine Hedgehog Signaling in another window
Includes: Supplementary data
Journal Articles

MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo

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David W. Jenkins, Sarah Ross, Margaret Veldman-Jones, Ian N. Foltz, Brandon C. Clavette, Kathy Manchulenko, Cath Eberlein, Jane Kendrew, Philip Petteruti, Song Cho, Melissa Damschroder, Li Peng, Dawn Baker, Neil R. Smith, Hazel M. Weir, David C. Blakey, Vahe Bedian, Simon T. Barry
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (8): 1650–1660.
https://doi.org/10.1158/1535-7163.MCT-11-1027
Published: 08 August 2012
View articletitled, MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
Open the PDF for MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo in another window
Includes: Supplementary data
Journal Articles

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

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Jeffrey L. Brown, Z. Alexander Cao, Maria Pinzon-Ortiz, Jane Kendrew, Corinne Reimer, Shenghua Wen, Joe Q. Zhou, Mohammad Tabrizi, Steve Emery, Brenda McDermott, Lourdes Pablo, Patricia McCoon, Vahe Bedian, David C. Blakey
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (1): 145–156.
https://doi.org/10.1158/1535-7163.MCT-09-0554
Published: 12 January 2010
View articletitled, A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models
Open the PDF for A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models in another window
Includes: Supplementary data