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Toshiyoshi Fujiwara
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Journal Articles

Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody

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Teruki Kobayashi, Kazuhiro Noma, Seitaro Nishimura, Takuya Kato, Noriyuki Nishiwaki, Toshiaki Ohara, Tomoyoshi Kunitomo, Kento Kawasaki, Masaaki Akai, Satoshi Komoto, Hajime Kashima, Satoru Kikuchi, Hiroshi Tazawa, Yasuhiro Shirakawa, Peter L. Choyke, Hisataka Kobayashi, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (7): 1031–1042.
https://doi.org/10.1158/1535-7163.MCT-23-0527
Published: 02 July 2024
View articletitled, Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody
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Includes: Supplementary data
Journal Articles

CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment

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Tomohiro Fujiwara, Mohamed A. Yakoub, Andrew Chandler, Alexander B. Christ, Guangli Yang, Ouathek Ouerfelli, Vinagolu K. Rajasekhar, Aki Yoshida, Hiroya Kondo, Toshiaki Hata, Hiroshi Tazawa, Yildirim Dogan, Malcolm A.S. Moore, Toshiyoshi Fujiwara, Toshifumi Ozaki, Ed Purdue, John H. Healey
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (8): 1388–1399.
https://doi.org/10.1158/1535-7163.MCT-20-0591
Published: 01 August 2021
View articletitled, CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment
Open the PDF for CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment in another window
Includes: Supplementary data
Journal Articles

Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer

Free
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (1): 251–259.
https://doi.org/10.1158/1535-7163.MCT-16-0383
Published: 05 January 2017
View articletitled, Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer
Open the PDF for Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer in another window
Includes: Supplementary data
Journal Articles

Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer

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Michihiro Ishida, Shunsuke Kagawa, Kyoko Shimoyama, Kiyoto Takehara, Kazuhiro Noma, Shunsuke Tanabe, Yasuhiro Shirakawa, Hiroshi Tazawa, Hisataka Kobayashi, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (3): 402–411.
https://doi.org/10.1158/1535-7163.MCT-15-0644
Published: 06 March 2016
View articletitled, Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer
Open the PDF for Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer

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Kiyoto Takehara, Hiroshi Tazawa, Naohiro Okada, Yuuri Hashimoto, Satoru Kikuchi, Shinji Kuroda, Hiroyuki Kishimoto, Yasuhiro Shirakawa, Nobuhiro Narii, Hiroyuki Mizuguchi, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (1): 199–208.
https://doi.org/10.1158/1535-7163.MCT-15-0344
Published: 07 January 2016
View articletitled, Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract B60: FUCCI cell cycle imaging identifies drug-resistant quiescent cancer cells within tumors.

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Shuya Yano, Yasunori Tome, Yong Zhang, Shinji Miwa, Atsushi Suetsugu, Hiroyuki Kishimoto, Hiroshi Tazawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M. Hoffman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): B60.
https://doi.org/10.1158/1535-7163.TARG-13-B60
Published: 01 November 2013
View articletitled, Abstract B60: FUCCI cell cycle imaging identifies drug-resistant quiescent cancer cells within tumors.
Journal Articles

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

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Joe Hasei, Tsuyoshi Sasaki, Hiroshi Tazawa, Shuhei Osaki, Yasuaki Yamakawa, Toshiyuki Kunisada, Aki Yoshida, Yuuri Hashimoto, Teppei Onishi, Futoshi Uno, Shunsuke Kagawa, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (3): 314–325.
https://doi.org/10.1158/1535-7163.MCT-12-0869
Published: 10 March 2013
View articletitled, Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Open the PDF for Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer

Free
Ryo Sakai, Shunsuke Kagawa, Yasumoto Yamasaki, Toru Kojima, Futoshi Uno, Yuuri Hashimoto, Yuichi Watanabe, Yasuo Urata, Noriaki Tanaka, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (6): 1884–1893.
https://doi.org/10.1158/1535-7163.MCT-10-0205
Published: 09 June 2010
View articletitled, Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer
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Includes: Supplementary data
Journal Articles

Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses

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Hiroyuki Kishimoto, Yasuo Urata, Noriaki Tanaka, Toshiyoshi Fujiwara, Robert M. Hoffman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (11): 3001–3008.
https://doi.org/10.1158/1535-7163.MCT-09-0556
Published: 10 November 2009
View articletitled, Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses
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Journal Articles

Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer

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Dong Liu, Toru Kojima, Masaaki Ouchi, Shinji Kuroda, Yuichi Watanabe, Yuuri Hashimoto, Hideki Onimatsu, Yasuo Urata, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (4): 980–987.
https://doi.org/10.1158/1535-7163.MCT-08-0901
Published: 16 April 2009
View articletitled, Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer
Open the PDF for Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer in another window
Includes: Supplementary data
Journal Articles

Telomerase-specific virotherapy in an animal model of human head and neck cancer

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Oumi Nakajima, Atsuko Matsunaga, Daiju Ichimaru, Yasuo Urata, Toshiyoshi Fujiwara, Koji Kawakami
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (1): 171–177.
https://doi.org/10.1158/1535-7163.MCT-08-0620
Published: 12 January 2009
View articletitled, Telomerase-specific virotherapy in an animal model of human head and neck cancer
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Journal Articles

Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo

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Shoichiro Ohtani, Shunsuke Kagawa, Yasuhisa Tango, Tatsuo Umeoka, Naoyuki Tokunaga, Yousuke Tsunemitsu, Jack A. Roth, Yoichi Taya, Noriaki Tanaka, Toshiyoshi Fujiwara
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2004) 3 (1): 93–100.
https://doi.org/10.1158/1535-7163.93.3.1
Published: 28 January 2004
View articletitled, Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo
Open the PDF for Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo in another window