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Toshihiko Doi
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Journal Articles

Abstract PR006: Initial results from first-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in biomarker-selected solid tumors

Jordi Rodon, Noboru Yamamoto, Toshihiko Doi, François Ghiringhelli, Maria-Elisabeth Goebeler, Yutaka Fujuwara, Miguel Villalona-Calero, Nicolas Penel, Amita Patnaik, Jean-Pascal Machiels, Alfredo Addeo, James Abbruzzese, Sophie Postel-Vinay, Sylvie Rottey, Chunxu Liu, Chen-Hua Chuang, William Kormany, Paul Hughes, Kiana Keyvanjah, Bert O'Neil
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): PR006.
https://doi.org/10.1158/1535-7163.TARG-23-PR006
Published: 01 December 2023
View article titled, Abstract PR006: Initial results from first-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in biomarker-selected solid tumors
Journal Articles

Abstract C113: Multiple modalities of single cell analyses to evaluate the tumor microenvironment in clinical specimens

Yukie Kashima, Shota Fukuoka, Yosuke Togashi, Takahiro Kamada, Ayako Suzuki, Yoshiaki Nakamura, Kohei Shitara, Akihiro Ohashi, Taku Yoshida, Naofumi Taoka, Tatsuya Kawase, Teiji Wada, Kocihiro Inaki, Masataka Chihara, Yutaka Suzuki, Katsuya Tsuchihara, Susumu S Kobayashi, Hiroyoshi Nishikawa, Toshihiko Doi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C113.
https://doi.org/10.1158/1535-7163.TARG-19-C113
Published: 01 December 2019
View article titled, Abstract C113: Multiple modalities of single cell analyses to evaluate the tumor microenvironment in clinical specimens
Journal Articles

U3-1402, a Novel HER3-Targeting Antibody–Drug Conjugate, for the Treatment of Colorectal Cancer

Shigehiro Koganemaru, Yasutoshi Kuboki, Yoshikatsu Koga, Takashi Kojima, Mayumi Yamauchi, Naoyuki Maeda, Takashi Kagari, Kenji Hirotani, Masahiro Yasunaga, Yasuhiro Matsumura, Toshihiko Doi
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (11): 2043–2050.
https://doi.org/10.1158/1535-7163.MCT-19-0452
Published: 01 November 2019
View article titled, U3-1402, a Novel HER3-Targeting Antibody–Drug Conjugate, for the Treatment of Colorectal Cancer
Open the PDF for U3-1402, a Novel HER3-Targeting Antibody–Drug Conjugate, for the Treatment of Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors

Akihiko Shimomura, Noboru Yamamoto, Shunsuke Kondo, Yutaka Fujiwara, Shigenobu Suzuki, Noriko Yanagitani, Atsushi Horiike, Satoru Kitazono, Fumiyoshi Ohyanagi, Toshihiko Doi, Yasutoshi Kuboki, Akihito Kawazoe, Kohei Shitara, Izumi Ohno, Udai Banerji, Raghav Sundar, Shuichi Ohkubo, Elizabeth M. Calleja, Makoto Nishio
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (3): 531–540.
https://doi.org/10.1158/1535-7163.MCT-18-0831
Published: 01 March 2019
View article titled, First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors
Open the PDF for First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors in another window
Journal Articles

Abstract A204: INCB024360 (Epacadostat) monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: primary results from first-in-Japanese phase I study (KEYNOTE-434)

Yutaka Fujiwara, Kohei Shitara, Toshio Shimizu, Kan Yonemori, Nobuaki Matsubara, Izumi Ohno, Takahiro Kogawa, Yoichi Naito, Lance Leopold, Kahori Sasahara, Naoyoshi Yatsuzuka, Tomoko Takami, Takashi Shimamoto, Noboru Yamamoto, Toshihiko Doi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A204.
https://doi.org/10.1158/1535-7163.TARG-17-A204
Published: 01 January 2018
View article titled, Abstract A204: INCB024360 (Epacadostat) monotherapy and in combination with pembrolizumab in patients with advanced solid tumors: primary results from first-in-Japanese phase I study (KEYNOTE-434)
Journal Articles

Abstract A165: Result of a phase 1 (dose-escalation stage), first-in-human study of ASP5878, an oral FGFR inhibitor, in patients with advanced solid tumors

Toshio Shimizu, Toshihiko Doi, Noboru Yamamoto, Haruyasu Murakami, Junji Furuse, Koji Kawai, Hiroyuki Nishiyama, Satoshi Morita, Shunji Takahashi, Erkut Bahceci, Joyce Steinberg, Howard A. Ball, Futoshi Kunieda, Kentaro Takeda, Aya Kita, Shigeru Takeshita
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A165.
https://doi.org/10.1158/1535-7163.TARG-15-A165
Published: 01 December 2015
View article titled, Abstract A165: Result of a phase 1 (dose-escalation stage), first-in-human study of ASP5878, an oral FGFR inhibitor, in patients with advanced solid tumors
Journal Articles

Abstract A167: A phase I study of MET TKI SAR125844 in Asian patients (pts) with advanced solid tumors

Kohei Shitara, Do-Youn Oh, Tomoya Yokota, Tae Won Kim, Toshihiko Doi, Satoshi Hamauchi, Jin-Hee Ahn, Corinne Gomez, Marzia Harnois, Yung Jue Bang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): A167.
https://doi.org/10.1158/1535-7163.TARG-15-A167
Published: 01 December 2015
View article titled, Abstract A167: A phase I study of MET TKI SAR125844 in Asian patients (pts) with advanced solid tumors
Journal Articles

Abstract C121: A non-randomized, open-label, single-arm, phase 2 study of LY2875358 in Asian patients with MET diagnostic positive, advanced gastric cancer

Hyun Cheol Chung, Taroh Satoh, Do-Youn Oh, Se Hoon Park, Shigenori Kadowaki, Volker Wacheck, Ayuko Yamamura, Kazunori Uenaka, Xuejing Aimee Wang, Sameera R. Wijayawardana, Toshihiko Doi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): C121.
https://doi.org/10.1158/1535-7163.TARG-15-C121
Published: 01 December 2015
View article titled, Abstract C121: A non-randomized, open-label, single-arm, phase 2 study of LY2875358 in Asian patients with MET diagnostic positive, advanced gastric cancer
Journal Articles

Abstract B31: A Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors

Yasuhide Yamada, Norifumi Ishikawa, Tomoyuki Kakizume, Takeshi Tajima, Becker Hewes, Toshihiko Doi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B31.
https://doi.org/10.1158/1535-7163.TARG-15-B31
Published: 01 December 2015
View article titled, Abstract B31: A Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors
Journal Articles

Abstract B159: Phase I dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors.

Toshihiko Doi, Yuichi Ando, Hideaki Bando, Takayuki Yoshino, Megumi Inada, Ayako Mitsuma, Cornelia Quadt, Matthew Robson, Atsushi Ohtsu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B159.
https://doi.org/10.1158/1535-7163.TARG-11-B159
Published: 12 November 2011
View article titled, Abstract B159: Phase I dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in Japanese patients with advanced solid tumors.
Journal Articles

Abstract B98: AUY922, a novel HSP90 inhibitor: Final results of a phase I dose escalation study in Japanese patients with advanced solid malignancies.

Yusuke Onozawa, Toshihiko Doi, Kentaro Yamazaki, Junichiro Watanabe, Nozomu Fuse, Takayuki Yoshino, Mikhail Akimov, Matthew Robson, Narikazu Boku, Atsushi Ohtsu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (11_Supplement): B98.
https://doi.org/10.1158/1535-7163.TARG-11-B98
Published: 12 November 2011
View article titled, Abstract B98: AUY922, a novel HSP90 inhibitor: Final results of a phase I dose escalation study in Japanese patients with advanced solid malignancies.
Journal Articles

Abstract A260: A phase 1 study of sorafenib (BAY 43‐9006) in combination with S‐1 plus cisplatin in patients with advanced gastric cancer

Yasuhide Yamada, Hironobu Minami, Nozomu Fuse, Atsushi Ohtsu, Ken Kato, Naomi Kiyota, Yasushiro Shimada, Toshihiko Doi, Takako Nakajima, Tetsuya Hamaguchi, Yutaka Fujiwara, Yuichiro Ito, Kiyomi Mera
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A260.
https://doi.org/10.1158/1535-7163.TARG-09-A260
Published: 10 December 2009
View article titled, Abstract A260: A phase 1 study of sorafenib (BAY 43‐9006) in combination with S‐1 plus cisplatin in patients with advanced gastric cancer