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Timothy R. Donahue
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Journal Articles

Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody–Drug Conjugate for Treatment of CLDN18.2-Positive Cancers

Neil A. O'Brien, Martina S.J. McDermott, Jun Zhang, Ke Wei Gong, Ming Lu, Benjamin Hoffstrom, Tong Luo, Raul Ayala, Kevin Chau, Min Liang, Athena M. Madrid, Timothy R. Donahue, John A. Glaspy, Leonard Presta, Dennis J. Slamon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12): 1365–1375.
https://doi.org/10.1158/1535-7163.MCT-23-0353
Published: 01 December 2023
View article titled, Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody–Drug Conjugate for Treatment of CLDN18.2-Positive Cancers
Open the PDF for Development of a Novel CLDN18.2-directed Monoclonal Antibody and Antibody–Drug Conjugate for Treatment of CLDN18.2-Positive Cancers in another window
Includes: Supplementary data
Journal Articles

Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer

Kristina Y. Aguilera, Thuc Le, Rana Riahi, Anna R. Lay, Stefan Hinz, Edris A. Saadat, Ajay A. Vashisht, James Wohlschlegel, Timothy R. Donahue, Caius G. Radu, David W. Dawson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (6): 936–947.
https://doi.org/10.1158/1535-7163.MCT-21-0623
Published: 01 June 2022
View article titled, Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer
Open the PDF for Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand–Addicted Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma

Jenifer B. Gifford, Wei Huang, Ann E. Zeleniak, Antreas Hindoyan, Hong Wu, Timothy R. Donahue, Reginald Hill
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (5): 1043–1052.
https://doi.org/10.1158/1535-7163.MCT-15-0774
Published: 05 May 2016
View article titled, Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma
Open the PDF for Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth

Michael D. Arensman, Donatello Telesca, Anna R. Lay, Kathleen M. Kershaw, Nanping Wu, Timothy R. Donahue, David W. Dawson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (10): 2303–2314.
https://doi.org/10.1158/1535-7163.MCT-13-1005
Published: 02 October 2014
View article titled, The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth
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Includes: Supplementary data
Journal Articles

Cell Intrinsic Role of COX-2 in Pancreatic Cancer Development

Reginald Hill, Yunfeng Li, Linh M. Tran, Sarah Dry, Joseph Hargan Calvopina, Alejandro Garcia, Christine Kim, Ying Wang, Timothy R. Donahue, Harvey R. Herschman, Hong Wu
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (10): 2127–2137.
https://doi.org/10.1158/1535-7163.MCT-12-0342
Published: 09 October 2012
View article titled, Cell Intrinsic Role of COX-2 in Pancreatic Cancer Development
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Includes: Supplementary data