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Journal Articles

CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors

Available to Purchase
Katherine Lazarides, Justin L. Engel, Michele Meseonznik, Tianshu Feng, Ashley H. Choi, Yi Yu, Shangtao Liu, Samuel R. Meier, Hongxiang Zhang, Binzhang Shen, Robert Tjin Tham Sjin, Douglas A. Whittington, Brian J. McMillan, Brian Doyon, Xuewen Pan, Erik Wilker, Alan Huang, Jannik N. Andersen, William D. Mallender, Madhavi Bandi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther OF1–OF14.
https://doi.org/10.1158/1535-7163.MCT-24-0822
Published: 21 May 2025
View articletitled, CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors
Open the PDF for CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors in another window
Includes: Supplementary data
Journal Articles

Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency

Open Access
Antoine Simoneau, Charlotte B. Pratt, Hsin-Jung Wu, Shreya S. Rajeswaran, Charlotte Grace Comer, Sirimas Sudsakorn, Wenhai Zhang, Shangtao Liu, Samuel R. Meier, Ashley H. Choi, Tenzing Khendu, Hannah Stowe, Binzhang Shen, Douglas A. Whittington, Yingnan Chen, Yi Yu, William D. Mallender, Tianshu Feng, Jannik N. Andersen, John P. Maxwell, Scott Throner
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2025) 24 (5): 678–691.
https://doi.org/10.1158/1535-7163.MCT-24-0515
Published: 02 May 2025
View articletitled, Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency
Open the PDF for Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency in another window
Includes: Supplementary data
Journal Articles

LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers

Open Access
Lauren Catherine M. Martires, Leanne G. Ahronian, Charlotte B. Pratt, Nikitha M. Das, Xiaobin Zhang, Douglas A. Whittington, Hongxiang Zhang, Binzhang Shen, Jon Come, Patrick McCarren, Mu-Sen Liu, Chengyin Min, Tianshu Feng, Haris Jahic, Janid A. Ali, Daniel R. Aird, Fang Li, Jannik N. Andersen, Alan Huang, William D. Mallender, Hilary E. Nicholson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2025) 24 (4): 618–627.
https://doi.org/10.1158/1535-7163.MCT-24-0598
Published: 02 April 2025
View articletitled, LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers
Open the PDF for LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers in another window
Includes: Supplementary data
Journal Articles

Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

Open Access
Antoine Simoneau, Justin L. Engel, Madhavi Bandi, Katherine Lazarides, Shangtao Liu, Samuel R. Meier, Ashley H. Choi, Hongxiang Zhang, Binzhang Shen, Lauren Martires, Deepali Gotur, Truc V. Pham, Fang Li, Lina Gu, Shanzhong Gong, Minjie Zhang, Erik Wilker, Xuewen Pan, Douglas A. Whittington, Scott Throner, John P. Maxwell, Yingnan Chen, Yi Yu, Alan Huang, Jannik N. Andersen, Tianshu Feng
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (2): 215–226.
https://doi.org/10.1158/1535-7163.MCT-22-0409
Published: 01 February 2023
View articletitled, Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer
Open the PDF for Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer in another window
Includes: Supplementary data
Journal Articles

Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAFV600-Mutant Melanoma Patient-Derived Xenografts

Free
Tianshu Feng, Javad Golji, Ailing Li, Xiamei Zhang, David A. Ruddy, Daniel P. Rakiec, Felipe C. Geyer, Jane Gu, Hui Gao, Juliet A. Williams, Darrin D. Stuart, Matthew J. Meyer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12): 2421–2432.
https://doi.org/10.1158/1535-7163.MCT-19-0028
Published: 02 December 2019
View articletitled, Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAFV600-Mutant Melanoma Patient-Derived Xenografts
Open the PDF for Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAFV600-Mutant Melanoma Patient-Derived Xenografts in another window
Includes: Supplementary data