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Journal Articles

Abstract C045: Combinations of PI3K inhibitors with targeted oncology agents in multicellular spheroid models

Thomas S Dexheimer, Thomas Silvers, Nathan P Coussens, Rabih Said, Beverly A Teicher, James H Doroshow

Mol Cancer Ther (2023) 22 (12_Supplement): C045.

https://doi.org/10.1158/1535-7163.TARG-23-C045

Published: 01 December 2023

View article titled, Abstract C045: Combinations of PI3K inhibitors with targeted oncology agents in multicellular spheroid models

Journal Articles

Abstract LB_A21: NCI60 HTS384: The next phase of the NCI60 screen

Beverly A Teicher, Mark W Kunkel, Joel Morris, Ronald C Taylor, Thomas S Dexheimer, Nathan P Coussens, James H Doroshow

Mol Cancer Ther (2023) 22 (12_Supplement): LB_A21.

https://doi.org/10.1158/1535-7163.TARG-23-LB_A21

Published: 01 December 2023

View article titled, Abstract LB_A21: NCI60 HTS384: The next phase of the NCI60 screen

Journal Articles

Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource

Mol Cancer Ther (2023) 22 (11): 1270–1279.

https://doi.org/10.1158/1535-7163.MCT-23-0267

Published: 01 November 2023

View article titled, Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource

Includes: Supplementary data

Journal Articles

Abstract P222: Combinations of receptor tyrosine kinase inhibitors targeting the tumor and stromal cells of complex spheroids from the National Cancer Institute’s Patient-Derived Models Repository (PDMR; https://pdmr.cancer.gov/)

Thomas S. Dexheimer, Julie Laudeman, Thomas Silvers, Rene Delosh, Russell Reinhart, Chad Ogle, Eric Jones, Nathan P. Coussens, Beverly A. Teicher, Naoko Takebe, Alice Chen, James H. Doroshow

Mol Cancer Ther (2021) 20 (12_Supplement): P222.

https://doi.org/10.1158/1535-7163.TARG-21-P222

Published: 01 December 2021

View article titled, Abstract P222: Combinations of receptor tyrosine kinase inhibitors targeting the tumor and stromal cells of complex spheroids from the National Cancer Institute’s Patient-Derived Models Repository (PDMR; https://pdmr.cancer.gov/)

Journal Articles

Biochemical Assays for the Discovery of TDP1 Inhibitors

Christophe Marchand, Shar-yin N. Huang, Thomas S. Dexheimer, Wendy A. Lea, Bryan T. Mott, Adel Chergui, Alena Naumova, Andrew G. Stephen, Andrew S. Rosenthal, Ganesha Rai, Junko Murai, Rui Gao, David J. Maloney, Ajit Jadhav, William L. Jorgensen, Anton Simeonov, Yves Pommier

Mol Cancer Ther (2014) 13 (8): 2116–2126.

https://doi.org/10.1158/1535-7163.MCT-13-0952

Published: 05 August 2014

View article titled, Biochemical Assays for the Discovery of TDP1 Inhibitors

Includes: Supplementary data

Journal Articles

Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

Shar-Yin N. Huang, Junko Murai, Ilaria Dalla Rosa, Thomas S. Dexheimer, William H. Gmeiner, Yves Pommier

Mol Cancer Ther (2013) 12 (11_Supplement): C79.

https://doi.org/10.1158/1535-7163.TARG-13-C79

Published: 01 November 2013

View article titled, Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

Journal Articles

Molecular and Cellular Pharmacology of the Novel Noncamptothecin Topoisomerase I Inhibitor Genz-644282

Dhriti Sooryakumar, Thomas S. Dexheimer, Beverly A. Teicher, Yves Pommier

Mol Cancer Ther (2011) 10 (8): 1490–1499.

https://doi.org/10.1158/1535-7163.MCT-10-1043

Published: 08 August 2011

View article titled, Molecular and Cellular Pharmacology of the Novel Noncamptothecin Topoisomerase I Inhibitor Genz-644282

Includes: Supplementary data

Journal Articles

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III₁

Thomas S. Dexheimer, Steven S. Carey, Song Zuohe, Vijay M. Gokhale, Xiaohui Hu, Lauren B. Murata, Estelle M. Maes, Andrzej Weichsel, Daekyu Sun, Emmanuelle J. Meuillet, William R. Montfort, Laurence H. Hurley

Mol Cancer Ther (2009) 8 (5): 1363–1377.

https://doi.org/10.1158/1535-7163.MCT-08-1093

Published: 13 May 2009

View article titled, NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

Journal Articles

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

Christophe Marchand, Wendy A. Lea, Ajit Jadhav, Thomas S. Dexheimer, Christopher P. Austin, James Inglese, Yves Pommier, Anton Simeonov

Mol Cancer Ther (2009) 8 (1): 240–248.

https://doi.org/10.1158/1535-7163.MCT-08-0878

Published: 12 January 2009

View article titled, Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

Includes: Supplementary data

Journal Articles

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

Kazutaka Takagi, Thomas S. Dexheimer, Christophe Redon, Olivier Sordet, Keli Agama, Gilbert Lavielle, Alain Pierré, Susan E. Bates, Yves Pommier

Mol Cancer Ther (2007) 6 (12): 3229–3238.

https://doi.org/10.1158/1535-7163.MCT-07-0441

Published: 18 December 2007

View article titled, Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

Journal Articles

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity

Ingrid M. Fellows, Michael Schwaebe, Thomas S. Dexheimer, Hariprasad Vankayalapati, Mary Gleason-Guzman, Jeffrey P. Whitten, Laurence H. Hurley

Mol Cancer Ther (2005) 4 (11): 1729–1739.

https://doi.org/10.1158/1535-7163.MCT-05-0183

Published: 07 November 2005

View article titled, Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity

NARROW

Abstract C045: Combinations of PI3K inhibitors with targeted oncology agents in multicellular spheroid models

Abstract LB_A21: NCI60 HTS384: The next phase of the NCI60 screen

Targeted Investigational Oncology Agents in the NCI-60: A Phenotypic Systems–based Resource

Abstract P222: Combinations of receptor tyrosine kinase inhibitors targeting the tumor and stromal cells of complex spheroids from the National Cancer Institute’s Patient-Derived Models Repository (PDMR; https://pdmr.cancer.gov/)

Biochemical Assays for the Discovery of TDP1 Inhibitors

Abstract C79: TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.

Molecular and Cellular Pharmacology of the Novel Noncamptothecin Topoisomerase I Inhibitor Genz-644282

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III₁

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity

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