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Thomas Helleday
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Journal Articles

Abstract B109: MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window

Petra Martilla, Alanna C Green, Nicole Kiweler, Christina Chalkiadaki, Elisée Wiita, Victoria Cookson, Antoine Lesur, Kim Eiden, François Bernhardin, Maeve Long, Ann-Sofie Jemth, Oliver Mortusewicz, Evert Homan, Nadilly Bonagas, Louise Ramos, Kumar Sanjiv, Emilio Guillén Mancina, Therese Pham, Ana Slipicevic, Martin Henriksson, Johannes Meiser, Thomas Helleday
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): B109.
https://doi.org/10.1158/1535-7163.TARG-23-B109
Published: 01 December 2023
View article titled, Abstract B109: MTHFD1/2 inhibitor TH9619 targets the DNA damage response and causes cancer-specific folate trapping with an unprecedented therapeutic window
Journal Articles

Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML

Anders Centio, Montserrat Estruch, Kristian Reckzeh, Kumar Sanjiv, Camilla Vittori, Sophia Engelhard, Ulrika Warpman Berglund, Thomas Helleday, Kim Theilgaard-Mönch
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2022) 21 (5): 703–714.
https://doi.org/10.1158/1535-7163.MCT-21-0185
Published: 04 May 2022
View article titled, Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Open the PDF for Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML in another window
Includes: Supplementary data
Journal Articles

Abstract CN05-04: Novel DNA repair targets for anticancer treatments.

Thomas Helleday
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): CN05-04.
https://doi.org/10.1158/1535-7163.TARG-13-CN05-04
Published: 01 November 2013
View article titled, Abstract CN05-04: Novel DNA repair targets for anticancer treatments.
Journal Articles

Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival

Deborah Wilsker, Jon H. Chung, Ivan Pradilla, Eva Petermann, Thomas Helleday, Fred Bunz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (1): 98–107.
https://doi.org/10.1158/1535-7163.MCT-11-0675
Published: 09 January 2012
View article titled, Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival
Open the PDF for Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival in another window
Includes: Supplementary data
Journal Articles

Abstract A115: Contextual synthetic lethality: Repair‐deficient hypoxic tumor cells are sensitized to poly(ADP‐ribose) polymerase (PARP) inhibition

Norman Chan, Isabel M. Pires, Zuzana Bencokova, Carla Coackley, Nirmal Bhogal, Minalini Lakshman, Ponnari Gottipati, F Javier Oliver, Thomas Helleday, Ester M. Hammond, Robert G. Bristow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A115.
https://doi.org/10.1158/1535-7163.TARG-09-A115
Published: 10 December 2009
View article titled, Abstract A115: Contextual synthetic lethality: Repair‐deficient hypoxic tumor cells are sensitized to poly(ADP‐ribose) polymerase (PARP) inhibition