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Takahiko Seki
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Journal Articles

Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma

Kohei Takano, Yoichi Munehira, Mana Hatanaka, Ryo Murakami, Yoshihiro Shibata, Takeshi Shida, Kosuke Takeuchi, Sho Takechi, Toshiki Tabata, Takashi Shimada, Shuhei Kishikawa, Yumi Matsui, Osamu Ubukata, Takahiko Seki, Yasuyuki Kaneta
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (3): 317–332.
DOI: https://doi.org/10.1158/1535-7163.MCT-22-0306
Published: 02 March 2023
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Includes: Supplementary data
Journal Articles

A Potent Blood–Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model

Yukino Machida, Makoto Nakagawa, Hironori Matsunaga, Masayuki Yamaguchi, Yoko Ogawara, Yutaka Shima, Kazutsune Yamagata, Takuo Katsumoto, Ayuna Hattori, Masato Itoh, Takahiko Seki, Yumi Nishiya, Koichi Nakamura, Kanae Suzuki, Tomoki Imaoka, Daichi Baba, Makoto Suzuki, Oltea Sampetrean, Hideyuki Saya, Koichi Ichimura, Issay Kitabayashi
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (2): 375–383.
DOI: https://doi.org/10.1158/1535-7163.MCT-18-1349
Published: 06 February 2020
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Includes: Supplementary data
Journal Articles

Abstract B5: Preclinical characterization of a novel orally-available MDM2 inhibitor DS-3032b: Anti-tumor profile and predictive biomarkers for sensitivity

Kenji Nakamaru, Takahiko Seki, Koichi Tazaki, Archie Tse
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B5.
DOI: https://doi.org/10.1158/1535-7163.TARG-15-B5
Published: 01 December 2015
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Journal Articles

Abstract B1: Gene expression and TP53 mutation analysis predict sensitivity of leukemia cells to MDM2 inhibition by DS-3032b

Jo Ishizawa, Kenji Nakamaru, Takahiko Seki, Koichi Tazaki, Kensuke Kojima, Dhruv Chachad, Archie Tse, Arvind Rao, Michael Andreeff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): B1.
DOI: https://doi.org/10.1158/1535-7163.TARG-15-B1
Published: 01 December 2015
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