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Susan E. Critchlow
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Journal Articles

Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition

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Larissa S. Carnevalli, Molly A. Taylor, Matthew King, Anna M.L. Coenen-Stass, Adina M. Hughes, Sigourney Bell, Theresa A. Proia, Yanjun Wang, Antonio Ramos-Montoya, Neha Wali, Danielle Carroll, Maneesh Singh, Michele Moschetta, Pablo Morentin Gutierrez, Cristina Gardelli, Susan E. Critchlow, Teresa Klinowska, Stephen E. Fawell, Simon T. Barry
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 1080–1091.
https://doi.org/10.1158/1535-7163.MCT-20-0961
Published: 01 June 2021
View articletitled, Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition
Open the PDF for Macrophage Activation Status Rather than Repolarization Is Associated with Enhanced Checkpoint Activity in Combination with PI3Kγ Inhibition in another window
Includes: Supplementary data
Journal Articles

3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

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Dylan T. Jones, Alessandro Valli, Syed Haider, Qifeng Zhang, Elizabeth A. Smethurst, Zachary T. Schug, Barrie Peck, Eric O. Aboagye, Susan E. Critchlow, Almut Schulze, Eyal Gottlieb, Michael J.O. Wakelam, Adrian L. Harris
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2019) 18 (2): 376–388.
https://doi.org/10.1158/1535-7163.MCT-17-0857
Published: 04 February 2019
View articletitled, 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Open the PDF for 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers in another window
Includes: Supplementary data
Journal Articles

Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors

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James T. Lynch, Urszula M. Polanska, Ursula Hancox, Oona Delpuech, Juliana Maynard, Catherine Trigwell, Catherine Eberlein, Carol Lenaghan, Radoslaw Polanski, Alvaro Avivar-Valderas, Marie Cumberbatch, Teresa Klinowska, Susan E. Critchlow, Francisco Cruzalegui, Simon T. Barry
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2018) 17 (11): 2309–2319.
https://doi.org/10.1158/1535-7163.MCT-18-0183
Published: 02 November 2018
View articletitled, Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors
Open the PDF for Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors in another window
Includes: Supplementary data
Journal Articles

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

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Becky M. Bola, Amy L. Chadwick, Filippos Michopoulos, Kathryn G. Blount, Brian A. Telfer, Kaye J. Williams, Paul D. Smith, Susan E. Critchlow, Ian J. Stratford
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (12): 2805–2816.
https://doi.org/10.1158/1535-7163.MCT-13-1091
Published: 04 December 2014
View articletitled, Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport
Open the PDF for Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport in another window
Includes: Supplementary data
Journal Articles

AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

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Sarah A. Loddick, Sarah J. Ross, Andrew G. Thomason, David M. Robinson, Graeme E. Walker, Tom P.J. Dunkley, Sandra R. Brave, Nicola Broadbent, Natalie C. Stratton, Dawn Trueman, Elizabeth Mouchet, Fadhel S. Shaheen, Vivien N. Jacobs, Marie Cumberbatch, Joanne Wilson, Rhys D.O. Jones, Robert H. Bradbury, Alfred Rabow, Luke Gaughan, Chris Womack, Simon T. Barry, Craig N. Robson, Susan E. Critchlow, Stephen R. Wedge, A. Nigel Brooks
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (9): 1715–1727.
https://doi.org/10.1158/1535-7163.MCT-12-1174
Published: 05 September 2013
View articletitled, AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
Open the PDF for AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo in another window
Includes: Supplementary data