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Suresh V. Ambudkar
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Journal Articles

The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors

Hui Zhang, Atish Patel, Yi-Jun Wang, Yun-Kai Zhang, Rishil J. Kathawala, Long-Hui Qiu, Bhargav A. Patel, Li-Hua Huang, Suneet Shukla, Dong-Hua Yang, Suresh V. Ambudkar, Li-Wu Fu, Zhe-Sheng Chen
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (6): 1021–1030.
https://doi.org/10.1158/1535-7163.MCT-16-0511
Published: 01 June 2017
View article titled, The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Open the PDF for The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors in another window
Includes: Supplementary data
Journal Articles

The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2

Rupashree Sen, Karthika Natarajan, Jasjeet Bhullar, Suneet Shukla, Hong-Bin Fang, Ling Cai, Zhe-Sheng Chen, Suresh V. Ambudkar, Maria R. Baer
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (9): 2033–2044.
https://doi.org/10.1158/1535-7163.MCT-12-0302
Published: 06 September 2012
View article titled, The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2
Open the PDF for The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2 in another window
Journal Articles

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

Josiah N. Orina, Anna Maria Calcagno, Chung-Pu Wu, Sudhir Varma, Joanna Shih, Min Lin, Gabriel Eichler, John N. Weinstein, Yves Pommier, Suresh V. Ambudkar, Michael M. Gottesman, Jean-Pierre Gillet
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (7): 2057–2066.
https://doi.org/10.1158/1535-7163.MCT-09-0256
Published: 14 July 2009
View article titled, Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database
Open the PDF for Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database in another window
Includes: Supplementary data
Journal Articles

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2

Suneet Shukla, Chung-Pu Wu, Krishnamachary Nandigama, Suresh V. Ambudkar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3279–3286.
https://doi.org/10.1158/1535-7163.MCT-07-0564
Published: 18 December 2007
View article titled, The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2
Open the PDF for The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2 in another window
Journal Articles

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Chung-Pu Wu, Suneet Shukla, Anna Maria Calcagno, Matthew D. Hall, Michael M. Gottesman, Suresh V. Ambudkar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3287–3296.
https://doi.org/10.1158/1535-7163.MCT-07-2005
Published: 18 December 2007
View article titled, Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter
Open the PDF for Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter in another window
Journal Articles

New inhibitors of ABCG2 identified by high-throughput screening

Curtis J. Henrich, Robert W. Robey, Heidi R. Bokesch, Susan E. Bates, Suneet Shukla, Suresh V. Ambudkar, Michael Dean, James B. McMahon
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3271–3278.
https://doi.org/10.1158/1535-7163.MCT-07-0352
Published: 18 December 2007
View article titled, New inhibitors of ABCG2 identified by high-throughput screening
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Journal Articles

Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure

Robert W. Robey, Suneet Shukla, Kenneth Steadman, Tomasz Obrzut, Elizabeth M. Finley, Suresh V. Ambudkar, Susan E. Bates
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (6): 1877–1885.
https://doi.org/10.1158/1535-7163.MCT-06-0811
Published: 15 June 2007
View article titled, Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure
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Journal Articles

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

Zuben E. Sauna, Suresh V. Ambudkar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (1): 13–23.
https://doi.org/10.1158/1535-7163.MCT-06-0155
Published: 19 January 2007
View article titled, About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work
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Journal Articles

Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor

Jennifer A. Seamon, Catherine A. Rugg, Stuart Emanuel, Anna Maria Calcagno, Suresh V. Ambudkar, Steven A. Middleton, Jeannene Butler, Virna Borowski, Lee M. Greenberger
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (10): 2459–2467.
https://doi.org/10.1158/1535-7163.MCT-06-0339
Published: 13 October 2006
View article titled, Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor
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Journal Articles

Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin

Wanida Chearwae, Suneet Shukla, Pornngarm Limtrakul, Suresh V. Ambudkar
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (8): 1995–2006.
https://doi.org/10.1158/1535-7163.MCT-06-0087
Published: 23 August 2006
View article titled, Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin
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