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Journal Articles

HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors

Free
David A. Proia, Donald L. Smith, Junyi Zhang, John-Paul Jimenez, Jim Sang, Luisa Shin Ogawa, Manuel Sequeira, Jaime Acquaviva, Suqin He, Chaohua Zhang, Vladimir Khazak, Igor Astsaturov, Takayo Inoue, Noriaki Tatsuta, Sami Osman, Richard C. Bates, Dinesh Chimmanamada, Weiwen Ying
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2015) 14 (11): 2422–2432.
https://doi.org/10.1158/1535-7163.MCT-15-0455
Published: 03 November 2015
View articletitled, HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors
Open the PDF for HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors in another window
Includes: Supplementary data
Journal Articles

Overcoming Acquired BRAF Inhibitor Resistance in Melanoma via Targeted Inhibition of Hsp90 with Ganetespib

Free
Jaime Acquaviva, Donald L. Smith, John-Paul Jimenez, Chaohua Zhang, Manuel Sequeira, Suqin He, Jim Sang, Richard C. Bates, David A. Proia
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2014) 13 (2): 353–363.
https://doi.org/10.1158/1535-7163.MCT-13-0481
Published: 09 February 2014
View articletitled, Overcoming Acquired BRAF Inhibitor Resistance in Melanoma via Targeted Inhibition of Hsp90 with Ganetespib
Open the PDF for Overcoming Acquired BRAF Inhibitor Resistance in Melanoma via Targeted Inhibition of Hsp90 with Ganetespib in another window
Includes: Supplementary data
Journal Articles

Abstract C130: The Hsp90 inhibitor ganetespib promotes the degradation of FGFR3 in bladder cancer models and induces regression in tumors harboring oncogenic FGFR3 fusions.

Free
Jaime L. Acquaviva, Chaohua Zhang, Suqin He, John-Paul Jimenez, Masa Nagai, Jim Sang, Manuel Sequeira, Donald L. Smith, Margaret A. Knowles, David A. Proia
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C130.
https://doi.org/10.1158/1535-7163.TARG-13-C130
Published: 01 November 2013
View articletitled, Abstract C130: The Hsp90 inhibitor ganetespib promotes the degradation of FGFR3 in bladder cancer models and induces regression in tumors harboring oncogenic FGFR3 fusions.
Journal Articles

Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib

Free
Jaime Acquaviva, Donald L. Smith, Jim Sang, Julie C. Friedland, Suqin He, Manuel Sequeira, Chaohua Zhang, Yumiko Wada, David A. Proia
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (12): 2633–2643.
https://doi.org/10.1158/1535-7163.MCT-12-0615
Published: 09 December 2012
View articletitled, Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib
Open the PDF for Targeting KRAS-Mutant Non–Small Cell Lung Cancer with the Hsp90 Inhibitor Ganetespib in another window
Includes: Supplementary data
Journal Articles

Abstract B199: In vitro and in vivo efficacy of the novel Hsp90 inhibitor STA‐9090 and its synergy with paclitaxel

Free
Weiwen Ying, Ronald K. Blackman, Dinesh Chimmanamada, Zhenjian Du, Kevin P. Foley, Suqin He, Takayo Inoue, David James, Jane Kepros, Tim Korbut, Luisa Shin Ogawa, Cong Peng, Teresa Przewloka, David Proia, Jim Sang, Donald Smith, Noriaki Tatsuta, Chin‐Yu Yang, Chaohua Zhang, Haili Zhang, Shijie Zhang, Shaoguang Li, James Barsoum
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B199.
https://doi.org/10.1158/1535-7163.TARG-09-B199
Published: 10 December 2009
View articletitled, Abstract B199: In vitro and in vivo efficacy of the novel Hsp90 inhibitor STA‐9090 and its synergy with paclitaxel
Journal Articles

Abstract C11: The oxidative stress inducer elesclomol requires copper chelation for its anticancer activity

Free
Masazumi Nagai, Nha Vho, Elena Kostik, Suqin He, Jane Kepros, Luisa S. Ogawa, Takayo Inoue, Ronald K. Blackman, Yumiko Wada, James Barsoum
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): C11.
https://doi.org/10.1158/1535-7163.TARG-09-C11
Published: 10 December 2009
View articletitled, Abstract C11: The oxidative stress inducer elesclomol requires copper chelation for its anticancer activity
Journal Articles

Elesclomol induces cancer cell apoptosis through oxidative stress

Free
Jessica R. Kirshner, Suqin He, Vishwasenani Balasubramanyam, Jane Kepros, Chin-Yu Yang, Mei Zhang, Zhenjian Du, James Barsoum, John Bertin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (8): 2319–2327.
https://doi.org/10.1158/1535-7163.MCT-08-0298
Published: 21 August 2008
View articletitled, Elesclomol induces cancer cell apoptosis through oxidative stress
Open the PDF for Elesclomol induces cancer cell apoptosis through oxidative stress in another window
Includes: Supplementary data
Journal Articles

STA-4783 induces apoptosis and enhances the anticancer activity of paclitaxel through induction of oxidative stress

Free
Jessica Kirshner, Zhenjian Du, Jane Kepros, Vish Balasubramanyam, Suqin He, Mei Zhang, Chin-Yu Yang, Kevin Foley, James Barsoum, John Bertin
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B274.
Published: 01 November 2007
View articletitled, STA-4783 induces apoptosis and enhances the anticancer activity of paclitaxel through induction of oxidative stress