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Journal Articles

Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase

Gabrielle McDonald, Victor Chubukov, John Coco, Kevin Truskowski, Rohini Narayanaswamy, Sung Choe, Mya Steadman, Erin Artin, Anil K. Padyana, Lei Jin, Sebastien Ronseaux, Charles Locuson, Zi-Peng Fan, Tabea Erdmann, Alan Mann, Sebastian Hayes, Mark Fletcher, Kavitha Nellore, Siva Sanjeeva Rao, Hosahalli Subramanya, K. Satish Reddy, Sunil K. Panigrahi, Thomas Antony, Sreevalsam Gopinath, Zhihua Sui, Nelamangala Nagaraja, Lenny Dang, Georg Lenz, Jonathan Hurov, Scott A. Biller, Josh Murtie, Kevin M. Marks, Danielle B. Ulanet
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2020) 19 (12): 2502–2515.
https://doi.org/10.1158/1535-7163.MCT-20-0550
Published: 02 December 2020
View article titled, Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase
Open the PDF for Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase in another window
Includes: Supplementary data
Journal Articles

Abstract A071: AG-120 (ivosidenib), a first-in-class mutant IDH1 inhibitor, promotes morphologic changes and upregulates liver-specific genes in IDH1 mutant cholangiocarcinoma

Yuko Ishii, Carlie Sigel, Maeve A. Lowery, Lipika Goyal, Camelia Gliser, Liewen Jiang, Susan Pandya, Bin Wu, Sung Choe, Vikram Deshpande
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): A071.
https://doi.org/10.1158/1535-7163.TARG-17-A071
Published: 01 January 2018
View article titled, Abstract A071: AG-120 (ivosidenib), a first-in-class mutant IDH1 inhibitor, promotes morphologic changes and upregulates liver-specific genes in IDH1 mutant cholangiocarcinoma
Journal Articles

Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a small molecule inhibitor of Src/Abl, in human pancreatic tumor xenografts

N.V Rajeshkumar, Antonio Jimeno, XiaoFei Wang, Anna Solomon, Elena Garcia-Garcia, Fernando Lopez-Rios, Veronica Diesel, Sung Choe, Max Follettie, Christina Coughlin, Frank Boschelli, Wells Messersmith, Manuel Hidalgo
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A250.
Published: 01 November 2007
View article titled, Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a small molecule inhibitor of Src/Abl, in human pancreatic tumor xenografts