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Journal Articles

Abstract LB_A05: Coadministration of AZD 4573 and gilteritinib exhibits a potent activity in FLT3 inhibitor-sensitive and -resistant AML cells

Free
Mohamed Rahmani, Baraa Khalid Salah, Burcu Yener, Bassam Mahboub, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): LB_A05.
https://doi.org/10.1158/1535-7163.TARG-23-LB_A05
Published: 01 December 2023
View articletitled, Abstract LB_A05: Coadministration of AZD 4573 and gilteritinib exhibits a potent activity in FLT3 inhibitor-sensitive and -resistant AML cells
Journal Articles

Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Free
Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (9): 1669.
https://doi.org/10.1158/1535-7163.MCT-19-0666
Published: 03 September 2019
View articletitled, Editor's Note: Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
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Journal Articles

Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

Free
Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Hiral Patel, Derick Peterson, Elisa Attkisson, Richard I. Fisher, Jonathan W. Friedberg, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (6): 1180.
https://doi.org/10.1158/1535-7163.MCT-19-0470
Published: 03 June 2019
View articletitled, Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo
Open the PDF for Retraction: Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo in another window
Journal Articles

Retraction: In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells

Free
Girija Dasmahapatra, Hiral Patel, Johnathan Friedberg, Steven N. Quayle, Simon S. Jones, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (6): 1181.
https://doi.org/10.1158/1535-7163.MCT-19-0471
Published: 03 June 2019
View articletitled, Retraction: In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells
Open the PDF for Retraction: In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells in another window
Journal Articles

Retraction: Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo

Free
Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Elisa Attkisson, Paul Dent, Richard I. Fisher, Jonathan W. Friedberg, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (6): 1179.
https://doi.org/10.1158/1535-7163.MCT-19-0469
Published: 03 June 2019
View articletitled, Retraction: Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
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Journal Articles

In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells

Free
Girija Dasmahapatra, Hiral Patel, Johnathan Friedberg, Steven N. Quayle, Simon S. Jones, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (12): 2886–2897.
https://doi.org/10.1158/1535-7163.MCT-14-0220
Published: 04 December 2014
View articletitled, In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells
Open the PDF for In Vitro and In Vivo Interactions between the HDAC6 Inhibitor Ricolinostat (ACY1215) and the Irreversible Proteasome Inhibitor Carfilzomib in Non-Hodgkin Lymphoma Cells in another window
Includes: Supplementary data
Journal Articles

Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs

Free
Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (10): 2384–2398.
https://doi.org/10.1158/1535-7163.MCT-14-0172
Published: 02 October 2014
View articletitled, Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
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Journal Articles

Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism

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Tri K. Nguyen, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (3): 662–674.
https://doi.org/10.1158/1535-7163.MCT-13-0714
Published: 09 March 2014
View articletitled, Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism
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Includes: Supplementary data
Journal Articles

The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair

Free
Yun Dai, Shuang Chen, Maciej Kmieciak, Liang Zhou, Hui Lin, Xin-Yan Pei, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (6): 878–889.
https://doi.org/10.1158/1535-7163.MCT-12-0902
Published: 09 June 2013
View articletitled, The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair
Open the PDF for The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair in another window
Includes: Supplementary data
Journal Articles

Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo

Free
Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Hiral Patel, Derick Peterson, Elisa Attkisson, Richard I. Fisher, Jonathan W. Friedberg, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (5): 1122–1132.
https://doi.org/10.1158/1535-7163.MCT-12-0021
Published: 08 May 2012
View articletitled, Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo
Open the PDF for Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo in another window
Includes: Supplementary data
Journal Articles

Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo

Free
Girija Dasmahapatra, Dmitry Lembersky, Minkyeong P. Son, Elisa Attkisson, Paul Dent, Richard I. Fisher, Jonathan W. Friedberg, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (9): 1686–1697.
https://doi.org/10.1158/1535-7163.MCT-10-1108
Published: 07 September 2011
View articletitled, Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo
Open the PDF for Carfilzomib Interacts Synergistically with Histone Deacetylase Inhibitors in Mantle Cell Lymphoma Cells In Vitro and In Vivo in another window
Includes: Supplementary data
Journal Articles

Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells

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Margaret A. Park, Roland Reinehr, Dieter Häussinger, Christina Voelkel-Johnson, Besim Ogretmen, Adly Yacoub, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (8): 2220–2231.
https://doi.org/10.1158/1535-7163.MCT-10-0274
Published: 09 August 2010
View articletitled, Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells
Open the PDF for Sorafenib Activates CD95 and Promotes Autophagy and Cell Death via Src Family Kinases in Gastrointestinal Tumor Cells in another window
Includes: Supplementary data
Journal Articles

17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species

Free
Teneille Walker, Clint Mitchell, Margaret A. Park, Adly Yacoub, Mohamed Rahmani, Dieter Häussinger, Roland Reinehr, Christina Voelkel-Johnson, Paul B. Fisher, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1378–1395.
https://doi.org/10.1158/1535-7163.MCT-09-1131
Published: 09 May 2010
View articletitled, 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species
Open the PDF for 17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species in another window
Includes: Supplementary data
Journal Articles

MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism

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Margaret A. Park, Teneille Walker, Aditi Pandya Martin, Jeremy Allegood, Nicollaq Vozhilla, Luni Emdad, Devanand Sarkar, Mohammed Rahmani, Martin Graf, Adly Yacoub, Costas Koumenis, Sarah Spiegel, David T. Curiel, Christina Voelkel-Johnson, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (5): 1280–1291.
https://doi.org/10.1158/1535-7163.MCT-09-0073
Published: 13 May 2009
View articletitled, MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism
Open the PDF for MDA-7/IL-24–induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK–dependent mechanism in another window
Includes: Supplementary data
Journal Articles

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

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Roberto R. Rosato, Jorge A. Almenara, Sonia C. Maggio, Stefanie Coe, Peter Atadja, Paul Dent, Steven Grant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (10): 3285–3297.
https://doi.org/10.1158/1535-7163.MCT-08-0385
Published: 13 October 2008
View articletitled, Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions
Open the PDF for Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions in another window
Includes: Supplementary data
Journal Articles

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

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Margaret A. Park, Guo Zhang, Clint Mitchell, Mohamed Rahmani, Hossein Hamed, Michael P. Hagan, Adly Yacoub, David T. Curiel, Paul B. Fisher, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2633–2648.
https://doi.org/10.1158/1535-7163.MCT-08-0400
Published: 11 September 2008
View articletitled, Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95
Open the PDF for Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95 in another window
Includes: Supplementary data
Journal Articles

Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo

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Hossein Hamed, William Hawkins, Clint Mitchell, Donna Gilfor, Guo Zhang, Xin-Yan Pei, Yun Dai, Michael P. Hagan, John D. Roberts, Adly Yacoub, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (3): 616–629.
https://doi.org/10.1158/1535-7163.MCT-07-2376
Published: 17 March 2008
View articletitled, Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo
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Journal Articles

Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling

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Adly Yacoub, Pankaj Gupta, Margaret A. Park, Mohammed Rhamani, Hossein Hamed, David Hanna, Guo Zhang, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Costas Koumenis, David T. Curiel, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (2): 314–329.
https://doi.org/10.1158/1535-7163.MCT-07-2150
Published: 15 February 2008
View articletitled, Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling
Open the PDF for Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signaling in another window
Journal Articles

Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells

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Adly Yacoub, Margaret A. Park, Pankaj Gupta, Mohammed Rahmani, Guo Zhang, Hossein Hamed, David Hanna, Devanand Sarkar, Irina V. Lebedeva, Luni Emdad, Moira Sauane, Nicollaq Vozhilla, Sarah Spiegel, Costas Koumenis, Martin Graf, David T. Curiel, Steven Grant, Paul B. Fisher, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (2): 297–313.
https://doi.org/10.1158/1535-7163.MCT-07-2166
Published: 15 February 2008
View articletitled, Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells
Open the PDF for Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells in another window
Journal Articles

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells

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Clint Mitchell, Maragret A. Park, Guo Zhang, Adly Yacoub, David T. Curiel, Paul B. Fisher, John D. Roberts, Steven Grant, Paul Dent
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (12): 3101–3112.
https://doi.org/10.1158/1535-7163.MCT-07-0561
Published: 18 December 2007
View articletitled, Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells
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