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The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells

Rupesh Shrestha, Kumaravel Mohankumar, Un-ho Jin, Gregory Martin, Stephen Safe

Mol Cancer Ther (2021) 20 (3): 612–622.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-0474

Published: 02 March 2021

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Includes: Supplementary data

Journal Articles

Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma

Alexandra Lacey, Erik Hedrick, Yating Cheng, Kumaravel Mohankumar, Melanie Warren, Stephen Safe

Mol Cancer Ther (2018) 17 (12): 2756–2766.

DOI: https://doi.org/10.1158/1535-7163.MCT-18-0118

Published: 03 December 2018

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Includes: Supplementary data

Journal Articles

Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors

Erik Hedrick, Xi Li, Stephen Safe

Mol Cancer Ther (2017) 16 (1): 205–216.

DOI: https://doi.org/10.1158/1535-7163.MCT-16-0451

Published: 05 January 2017

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Includes: Supplementary data

Journal Articles

Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species–Dependent Targeting of Specificity Protein Transcription Factors

Erik Hedrick, Lisa Crose, Corinne M. Linardic, Stephen Safe

Mol Cancer Ther (2015) 14 (9): 2143–2153.

DOI: https://doi.org/10.1158/1535-7163.MCT-15-0148

Published: 02 September 2015

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Includes: Supplementary data

Journal Articles

MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 Expression

Zichao Zhang, KyoungHyun Kim, Xiao Li, Myriam Moreno, Thad Sharp, Michael J. Goodheart, Stephen Safe, Adam J. Dupuy, Brad A. Amendt

Mol Cancer Ther (2014) 13 (7): 1942–1951.

DOI: https://doi.org/10.1158/1535-7163.MCT-13-1000

Published: 06 July 2014

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Journal Articles

The Cannabinoid WIN 55,212-2 Decreases Specificity Protein Transcription Factors and the Oncogenic Cap Protein eIF4E in Colon Cancer Cells

Sandeep Sreevalsan, Stephen Safe

Mol Cancer Ther (2013) 12 (11): 2483–2493.

DOI: https://doi.org/10.1158/1535-7163.MCT-13-0486

Published: 06 November 2013

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Includes: Supplementary data

Journal Articles

Induction of the Transcriptional Repressor ZBTB4 in Prostate Cancer Cells by Drug-Induced Targeting of MicroRNA-17-92/106b-25 Clusters

KyoungHyun Kim, Gayathri Chadalapaka, Satya S. Pathi, Un-Ho Jin, Ju-Seog Lee, Yun-Yong Park, Sung-Gook Cho, Sudhakar Chintharlapalli, Stephen Safe

Mol Cancer Ther (2012) 11 (9): 1852–1862.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0181

Published: 06 September 2012

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Includes: Supplementary data

Journal Articles

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

Xinyi Liu, Indira Jutooru, Ping Lei, KyoungHyun Kim, Syng-ook Lee, Lisa K. Brents, Paul L. Prather, Stephen Safe

Mol Cancer Ther (2012) 11 (7): 1421–1431.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-0026

Published: 05 July 2012

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Includes: Supplementary data

Journal Articles

Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells

Shu Zhang, KyoungHyun Kim, Un Ho Jin, Catherine Pfent, Huojun Cao, Brad Amendt, Xinyi Liu, Heather Wilson-Robles, Stephen Safe

Mol Cancer Ther (2012) 11 (1): 108–118.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0548

Published: 09 January 2012

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Includes: Supplementary data

Journal Articles

Inhalation Delivery of a Novel Diindolylmethane Derivative for the Treatment of Lung Cancer

Nkechi Ichite, Mahavir Chougule, Apurva R. Patel, Tanise Jackson, Stephen Safe, Mandip Singh

Mol Cancer Ther (2010) 9 (11): 3003–3014.

DOI: https://doi.org/10.1158/1535-7163.MCT-09-1104

Published: 09 November 2010

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Journal Articles

The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression

Xinyi Liu, Maen Abdelrahim, Ala Abudayyeh, Ping Lei, Stephen Safe

Mol Cancer Ther (2009) 8 (5): 1207–1217.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-1097

Published: 13 May 2009

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Includes: Supplementary data

Journal Articles

Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression

Santhi Konduri, Jimmie Colon, Cheryl H. Baker, Stephen Safe, James L. Abbruzzese, Ala Abudayyeh, Md. Riyaz Basha, Maen Abdelrahim

Mol Cancer Ther (2009) 8 (3): 533–542.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0405

Published: 13 March 2009

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Includes: Supplementary data

Journal Articles

1,1-Bis(3′-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

Teruo Inamoto, Sabitha Papineni, Sudhakar Chintharlapalli, Sung-Dae Cho, Stephen Safe, Ashish M. Kamat

Mol Cancer Ther (2008) 7 (12): 3825–3833.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0730

Published: 15 December 2008

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Includes: Supplementary data

Journal Articles

ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells

Seong-Ho Lee, Jae Hoon Bahn, Chang Kyoung Choi, Nichelle C. Whitlock, Anthony E. English, Stephen Safe, Seung Joon Baek

Mol Cancer Ther (2008) 7 (12): 3739–3750.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0548

Published: 15 December 2008

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Journal Articles

Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3′-indoly)-1-(p-substituted phenyl)methanes

Ping Lei, Maen Abdelrahim, Sung Dae Cho, Xingi Liu, Stephen Safe

Mol Cancer Ther (2008) 7 (10): 3363–3372.

DOI: https://doi.org/10.1158/1535-7163.MCT-08-0439

Published: 13 October 2008

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Journal Articles

5,5′-Dibromo-bis(3′-indolyl)methane induces Krüppel-like factor 4 and p21 in colon cancer cells

Sung Dae Cho, Sudhakar Chintharlapalli, Maen Abdelrahim, Sabitha Papineni, Shengxi Liu, Jingjing Guo, Ping Lei, Ala Abudayyeh, Stephen Safe

Mol Cancer Ther (2008) 7 (7): 2109–2120.

DOI: https://doi.org/10.1158/1535-7163.MCT-07-2311

Published: 21 July 2008

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Journal Articles

Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator–activated receptor γ agonists in colon cancer cells

Sudhakar Chintharlapalli, Sabitha Papineni, Indira Jutooru, Alan McAlees, Stephen Safe

Mol Cancer Ther (2007) 6 (5): 1588–1598.

DOI: https://doi.org/10.1158/1535-7163.MCT-07-0022

Published: 18 May 2007

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Journal Articles

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator–activated receptor–dependent and independent pathways

Ping Lei, Maen Abdelrahim, Stephen Safe

Mol Cancer Ther (2006) 5 (9): 2324–2336.

DOI: https://doi.org/10.1158/1535-7163.MCT-06-0184

Published: 19 September 2006

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Journal Articles

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARγ-dependent and PPARγ-independent pathways

Sudhakar Chintharlapalli, Sabitha Papineni, Stephen Safe

Mol Cancer Ther (2006) 5 (5): 1362–1370.

DOI: https://doi.org/10.1158/1535-7163.MCT-06-0002

Published: 26 May 2006

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Journal Articles

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

Ismael Samudio, Marina Konopleva, Stephen Safe, Teresa McQueen, Michael Andreeff

Mol Cancer Ther (2005) 4 (12): 1982–1992.

DOI: https://doi.org/10.1158/1535-7163.MCT-05-0247

Published: 22 December 2005

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NARROW

The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells

Interleukin-24 (IL24) Is Suppressed by PAX3-FOXO1 and Is a Novel Therapy for Rhabdomyosarcoma

Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors

Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species–Dependent Targeting of Specificity Protein Transcription Factors

MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 Expression

The Cannabinoid WIN 55,212-2 Decreases Specificity Protein Transcription Factors and the Oncogenic Cap Protein eIF4E in Colon Cancer Cells

Induction of the Transcriptional Repressor ZBTB4 in Prostate Cancer Cells by Drug-Induced Targeting of MicroRNA-17-92/106b-25 Clusters

Betulinic Acid Targets YY1 and ErbB2 through Cannabinoid Receptor-Dependent Disruption of MicroRNA-27a:ZBTB10 in Breast Cancer

Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells

Inhalation Delivery of a Novel Diindolylmethane Derivative for the Treatment of Lung Cancer

The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression

Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression

1,1-Bis(3′-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth

ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells

Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3′-indoly)-1-(p-substituted phenyl)methanes

5,5′-Dibromo-bis(3′-indolyl)methane induces Krüppel-like factor 4 and p21 in colon cancer cells

Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator–activated receptor γ agonists in colon cancer cells

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit ovarian cancer cell growth through peroxisome proliferator–activated receptor–dependent and independent pathways

1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARγ-dependent and PPARγ-independent pathways

Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure

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