Search Results | Molecular Cancer Therapeutics | American Association for Cancer Research

1-11 of 11

Sort by

Sort Order Select

Journal Articles

DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models

Yanyan Jiang, Elaine Willmore, Stephen R. Wedge, Anderson J. Ryan

Mol Cancer Ther (2021) 20 (9): 1663–1671.

DOI: https://doi.org/10.1158/1535-7163.MCT-20-0857

Published: 01 September 2021

View article

Includes: Supplementary data

Journal Articles

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

Mol Cancer Ther (2015) 14 (1): 48–58.

DOI: https://doi.org/10.1158/1535-7163.MCT-14-0406

Published: 13 January 2015

View article

Includes: Supplementary data

Journal Articles

AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Mol Cancer Ther (2013) 12 (9): 1715–1727.

DOI: https://doi.org/10.1158/1535-7163.MCT-12-1174

Published: 05 September 2013

View article

Includes: Supplementary data

Journal Articles

Abstract C2: Selection for combinational studies through biomarker stratification in colorectal patient-derived explant models.

Denis G. Alferez, Jonathan R. Dry, Sarah V. Holt, Susie L. Weston, Gael McWalter, Garry J. Beran, Mitch Revill, Paul D. Smith, Sylvie Guichard, Stephen R. Wedge, Phillip Hedge, Robert W. Wilkinson

Mol Cancer Ther (2011) 10 (11_Supplement): C2.

DOI: https://doi.org/10.1158/1535-7163.TARG-11-C2

Published: 12 November 2011

View article

Journal Articles

Abstract A13: Characterization of CRC primary explant models in comparison to standard human tumor cell-line-derived CRC xenografts.

Denis G. Alferez, Helen Brown, Jonathan R. Dry, Sarah Runswick, Neil James, Gael McWalter, Jessica Whiteley, Mitch Revill, Garry Beran, Matthew Farren, Neil R. Smith, Phillip Hedge, Simon Barry, Stephen R. Wedge, Robert W. Wilkinson

Mol Cancer Ther (2011) 10 (11_Supplement): A13.

DOI: https://doi.org/10.1158/1535-7163.TARG-11-A13

Published: 12 November 2011

View article

Journal Articles

Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft

Joana M. Senra, Brian A. Telfer, Kim E. Cherry, Cian M. McCrudden, David G. Hirst, Mark J. O'Connor, Stephen R. Wedge, Ian J. Stratford

Mol Cancer Ther (2011) 10 (10): 1949–1958.

DOI: https://doi.org/10.1158/1535-7163.MCT-11-0278

Published: 09 October 2011

View article

Includes: Supplementary data

Journal Articles

Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family

Mol Cancer Ther (2011) 10 (5): 861–873.

DOI: https://doi.org/10.1158/1535-7163.MCT-10-0976

Published: 08 May 2011

View article

Includes: Supplementary data

Journal Articles

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding

Jane Kendrew, Cath Eberlein, Brad Hedberg, Karen McDaid, Neil R. Smith, Hazel M. Weir, Stephen R. Wedge, David C. Blakey, Ian Foltz, Joe Zhou, Jaspal S. Kang, Simon T. Barry

Mol Cancer Ther (2011) 10 (5): 770–783.

DOI: https://doi.org/10.1158/1535-7163.MCT-10-0876

Published: 08 May 2011

View article

Journal Articles

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc^Min/+ mice

Denis Alferez, Robert W. Wilkinson, Jim Watkins, Richard Poulsom, Nikki Mandir, Stephen R. Wedge, Ian T. Pyrah, Neil R. Smith, Lynsay Jackson, Anderson J. Ryan, Robert A. Goodlad

Mol Cancer Ther (2008) 7 (3): 590–598.

DOI: https://doi.org/10.1158/1535-7163.MCT-07-0433

Published: 17 March 2008

View article

Journal Articles

Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts

Neil R. Smith, Neil H. James, Ian Oakley, Anna Wainwright, Clive Copley, Jane Kendrew, Lynsey M. Womersley, Juliane M. Jürgensmeier, Stephen R. Wedge, Simon T. Barry

Mol Cancer Ther (2007) 6 (8): 2198–2208.

DOI: https://doi.org/10.1158/1535-7163.MCT-07-0142

Published: 15 August 2007

View article

Journal Articles

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

Kaye J. Williams, Brian A. Telfer, Aoife M. Shannon, Muhammad Babur, Ian J. Stratford, Stephen R. Wedge

Mol Cancer Ther (2007) 6 (2): 599–606.

DOI: https://doi.org/10.1158/1535-7163.MCT-06-0508

Published: 16 February 2007

View article

NARROW

DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

Abstract C2: Selection for combinational studies through biomarker stratification in colorectal patient-derived explant models.

Abstract A13: Characterization of CRC primary explant models in comparison to standard human tumor cell-line-derived CRC xenografts.

Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft

Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against VEGFR-1 and Members of the Structurally Related PDGFR Family

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2–Dependent Angiogenesis without Affecting Ligand Binding

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc^Min/+ mice

Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts

Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only