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Sonya Zabludoff
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Journal Articles

A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-Driven Non–small Cell Lung Cancer

Cima Cina, Bharat Majeti, Zhihong O’Brien, Li Wang, Jean Pierre Clamme, Roger Adami, Kwok Yin Tsang, Jens Harborth, Wenbin Ying, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2025) 24 (1): 7–17.
https://doi.org/10.1158/1535-7163.MCT-23-0915
Published: 02 January 2025
View article titled, A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-Driven Non–small Cell Lung Cancer
Open the PDF for A Novel Lipid Nanoparticle NBF-006 Encapsulating Glutathione S-Transferase P siRNA for the Treatment of KRAS-Driven Non–small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C108: Enhanced growth inhibition in lung cancer cells through NBF-006 combination therapy with chemotherapy or KRAS inhibitors

Cima Cina, Akinori Sugiyama, Murali Kuracha, Nazia Abbasi, Dominic Medina, Hiroyuki Tanaka, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C108.
https://doi.org/10.1158/1535-7163.TARG-23-C108
Published: 01 December 2023
View article titled, Abstract C108: Enhanced growth inhibition in lung cancer cells through NBF-006 combination therapy with chemotherapy or KRAS inhibitors
Journal Articles

Abstract PR013: First-in-human dose-expansion study of NBF-006, a novel investigational siRNA targeting GSTP, in patients with KRAS-mutated non-small cell lung cancer

Hirva Mamdani, Alberto Chiappori, Lyudmila Bazhenova, Alexander Spira, Wade Iams, Minal Barve, Anthony W Tolcher, Eli Gabayan, Andrae Vandross, Annie Huynh, Yael Cohen-Arazi, Zachary Albaugh, Joachim Gullbo, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): PR013.
https://doi.org/10.1158/1535-7163.TARG-23-PR013
Published: 01 December 2023
View article titled, Abstract PR013: First-in-human dose-expansion study of NBF-006, a novel investigational siRNA targeting GSTP, in patients with KRAS-mutated non-small cell lung cancer
Journal Articles

Abstract C103: Preclinical and clinical safety and tolerability evaluation of NBF-006, a novel siRNA inhibitor of glutathione-s-transferase P (GSTP) encapsulated in a lipid nanoparticle (LNP) for treatment of advanced non-small cell lung cancer (NSCLC)

Jian Liu, Cima Cina, Douglas Kornbrust, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C103.
https://doi.org/10.1158/1535-7163.TARG-23-C103
Published: 01 December 2023
View article titled, Abstract C103: Preclinical and clinical safety and tolerability evaluation of NBF-006, a novel siRNA inhibitor of glutathione-s-transferase P (GSTP) encapsulated in a lipid nanoparticle (LNP) for treatment of advanced non-small cell lung cancer (NSCLC)
Journal Articles

Abstract C101: Preclinical and clinical pharmacokinetics (PK) of NBF-006, a novel siRNA inhibitor of glutathione-s-transferase P (GSTP) encapsulated in a lipid nanoparticle (LNP), for treatment of advanced non-small cell lung cancer (NSCLC)

Michael Hall, Zhihong O'Brien, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): C101.
https://doi.org/10.1158/1535-7163.TARG-23-C101
Published: 01 December 2023
View article titled, Abstract C101: Preclinical and clinical pharmacokinetics (PK) of NBF-006, a novel siRNA inhibitor of glutathione-s-transferase P (GSTP) encapsulated in a lipid nanoparticle (LNP), for treatment of advanced non-small cell lung cancer (NSCLC)
Journal Articles

Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth

Xinqiang Huang, Jill Magnus, Vivek Kaimal, Priya Karmali, Jian Li, Marlena Walls, Rene Prudente, Eric Sung, Mehran Sorourian, Robin Lee, Scott Davis, Xia Yang, Heather Estrella, Edmund C. Lee, B. Nelson Chau, Adam Pavlicek, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (5): 905–913.
https://doi.org/10.1158/1535-7163.MCT-16-0613
Published: 02 May 2017
View article titled, Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth
Open the PDF for Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth in another window
Includes: Supplementary data
Journal Articles

Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice

Xiaofei Xu, Bushra Ayub, Zhaojian Liu, Vanida Ann Serna, Wenan Qiang, Yugang Liu, Eva Hernando, Sonya Zabludoff, Takeshi Kurita, Beihua Kong, Jian-Jun Wei
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2014) 13 (7): 1729–1739.
https://doi.org/10.1158/1535-7163.MCT-13-0982
Published: 06 July 2014
View article titled, Anti-<em>miR182</em> Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An <em>In Vivo</em> Study in Orthotopic Xenografts of Nude Mice
Open the PDF for Anti-<em>miR182</em> Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An <em>In Vivo</em> Study in Orthotopic Xenografts of Nude Mice in another window
Includes: Supplementary data
Journal Articles

Structure activity and structure property relationships of a novel series of potent inhibitors of Checkpoint kinases

Lynsie Almeida, Susan Ashwell, David Ayres, Patrick Brassil, Kevin Daly, Chun Deng, Thomas Gero, Roberta Glynn, Candice Horn, Stephanos Ioannidis, James Janetka, Paul Lyne, Vibha Oza, Stephanie Springer, Mei Su, Dorin Toader, Melissa Vasbinder, Dingwei Yu, Yan Yu, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A233.
Published: 01 November 2007
View article titled, Structure activity and structure property relationships of a novel series of potent inhibitors of Checkpoint kinases
Journal Articles

Preclinical identification of AZD7762, a novel, potent and selective inhibitor of Checkpoint kinases

Susan Ashwell, Benjamin Caleb, Chun Deng, Stephen Green, Michael Grondine, Heather Haye, Candice Horn, James Janetka, Dongfang Liu, Elizabeth Mouchet, Shannon Ready, Judith Rosenthal, Christophe Queva, Karen Taylor, Adam Sheehy, Graeme Walker, Anne White, Sonya Zabludoff
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A232.
Published: 01 November 2007
View article titled, Preclinical identification of AZD7762, a novel, potent and selective inhibitor of Checkpoint kinases