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Somesh Sharma
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Journal Articles

P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity

Archana Jalota-Badhwar, Dimple R. Bhatia, Srinivas Boreddy, Asavari Joshi, Magesh Venkatraman, Nikesh Desai, Sarika Chaudhari, Julie Bose, Lakshmi S. Kolla, Vijaykumar Deore, Nilambari Yewalkar, Sanjay Kumar, Rajiv Sharma, Anagha Damre, Avinash More, Somesh Sharma, Veena R. Agarwal
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (5): 1095–1106.
https://doi.org/10.1158/1535-7163.MCT-14-0486
Published: 05 May 2015
View article titled, P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity
Open the PDF for P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity in another window
Includes: Supplementary data
Journal Articles

CDK-4 Inhibitor P276 Sensitizes Pancreatic Cancer Cells to Gemcitabine-Induced Apoptosis

Dharmalingam Subramaniam, Giridharan Periyasamy, Sivapriya Ponnurangam, Debarshi Chakrabarti, Aravind Sugumar, Muralidhara Padigaru, Scott J. Weir, Arun Balakrishnan, Somesh Sharma, Shrikant Anant
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (7): 1598–1608.
https://doi.org/10.1158/1535-7163.MCT-12-0102
Published: 05 July 2012
View article titled, CDK-4 Inhibitor P276 Sensitizes Pancreatic Cancer Cells to Gemcitabine-Induced Apoptosis
Open the PDF for CDK-4 Inhibitor P276 Sensitizes Pancreatic Cancer Cells to Gemcitabine-Induced Apoptosis in another window
Includes: Supplementary data
Journal Articles

Abstract A67: Molecular evidence of increased antitumor activity of gemcitabine in combination with a Cdk inhibitor, P276 in pancreatic cancer

Kalpana S. Joshi, Maggie J. Rathos, Kavita Joshi, Harshal Khanwalkar, Somesh Sharma
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): A67.
https://doi.org/10.1158/1535-7163.TARG-09-A67
Published: 10 December 2009
View article titled, Abstract A67: Molecular evidence of increased antitumor activity of gemcitabine in combination with a Cdk inhibitor, P276 in pancreatic cancer
Journal Articles

In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00

Kalpana S. Joshi, Maggie J. Rathos, Rajendra D. Joshi, Meenakshi Sivakumar, Malcolm Mascarenhas, Shrikant Kamble, Bansi Lal, Somesh Sharma
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (3): 918–925.
https://doi.org/10.1158/1535-7163.MCT-06-0613
Published: 15 March 2007
View article titled, <em>In vitro</em> antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00
Open the PDF for <em>In vitro</em> antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00 in another window
Journal Articles

P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models

Kalpana S. Joshi, Maggie J. Rathos, Pravin Mahajan, Vilas Wagh, Satyendra Shenoy, Dimple Bhatia, Shailaja Chile, Meenakshi Sivakumar, Armin Maier, Heinz-Herbert Fiebig, Somesh Sharma
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (3): 926–934.
https://doi.org/10.1158/1535-7163.MCT-06-0614
Published: 15 March 2007
View article titled, P276-00, a novel cyclin-dependent inhibitor induces G<sub>1</sub>-G<sub>2</sub> arrest, shows antitumor activity on cisplatin-resistant cells and significant <em>in vivo</em> efficacy in tumor models
Open the PDF for P276-00, a novel cyclin-dependent inhibitor induces G<sub>1</sub>-G<sub>2</sub> arrest, shows antitumor activity on cisplatin-resistant cells and significant <em>in vivo</em> efficacy in tumor models in another window