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Simon Planken
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Journal Articles

Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer

Catherine Lee, Ziyue Karen Jiang, Simon Planken, Lisa K. Manzuk, Roberto Ortiz, Michael Hall, Kavon Noorbehesht, Sripad Ram, Timothy Affolter, Gabriel E. Troche, Nathan T. Ihle, Theodore Johnson, Youngwook Ahn, Manfred Kraus, Anand Giddabasappa
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (7): 891–900.
https://doi.org/10.1158/1535-7163.MCT-22-0810
Published: 05 July 2023
View article titled, Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer
Open the PDF for Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer in another window
Includes: Supplementary data
Journal Articles

Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier

Allison Rohner, Mary E. Spilker, Justine L. Lam, Bernadette Pascual, Darian Bartkowski, Qing John Li, Amy H. Yang, Greg Stevens, Meirong Xu, Peter A. Wells, Simon Planken, Sajiv Nair, Shaoxian Sun
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (1): 57–65.
https://doi.org/10.1158/1535-7163.MCT-11-0691
Published: 09 January 2012
View article titled, Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier
Open the PDF for Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood–Brain Barrier in another window
Includes: Supplementary data