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Shiv K. Gupta
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Journal Articles

DNA-PK Inhibition Shows Differential Radiosensitization in Orthotopic GBM PDX Models Based on DDR Pathway Deficits

Sonja Dragojevic, Emily J. Smith, Michael S. Regan, Sylwia A. Stopka, Gerard Baquer, Zhiyi Xue, Wenjuan Zhang, Margaret A. Connors, Jake A. Kloeber, Zeng Hu, Katrina K. Bakken, Lauren L. Ott, Brett L. Carlson, Danielle M. Burgenske, Paul A. Decker, Shulan Tian, Shiv K. Gupta, Daniel J. Laverty, Jeanette E. Eckel-Passow, William F. Elmquist, Nathalie Y.R. Agar, Zachary D. Nagel, Jann N. Sarkaria, Cameron M. Callaghan
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther OF1–OF11.
https://doi.org/10.1158/1535-7163.MCT-24-0003
Published: 08 November 2024
View article titled, DNA-PK Inhibition Shows Differential Radiosensitization in Orthotopic GBM PDX Models Based on DDR Pathway Deficits
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Includes: Supplementary data
Journal Articles

Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts

Jianxiong Ji, Sonja Dragojevic, Cameron M. Callaghan, Emily J. Smith, Surabhi Talele, Wenjuan Zhang, Margaret A. Connors, Ann C. Mladek, Zeng Hu, Katrina K. Bakken, Paige P. Sarkaria, Brett L. Carlson, Danielle M. Burgenske, Paul A. Decker, Mohammad Abdur Rashid, Mi-hyeon Jang, Shiv K. Gupta, Jeanette E. Eckel-Passow, William F. Elmquist, Jann N. Sarkaria
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2024) 23 (5): 662–671.
https://doi.org/10.1158/1535-7163.MCT-23-0552
Published: 02 May 2024
View article titled, Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts
Open the PDF for Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts in another window
Includes: Supplementary data
Journal Articles

Abstract A148: The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenografts

Zhiyi Xue, Ann C. Mladek, Sneha Rathi, Danielle M. Burgenske, Shiv K. Gupta, Brett L. Carlson, Zeng Hu, Lauren L Ott, Katrina K. Bakken, Rachael A. Vaubel, William F Elmquist, Wei Zhong, Jann N Sarkaria
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2023) 22 (12_Supplement): A148.
https://doi.org/10.1158/1535-7163.TARG-23-A148
Published: 01 December 2023
View article titled, Abstract A148: The radiosensitizing effects of the novel brain penetrant and potent ATM inhibitor WSD0628 in glioblastoma and melanoma patient derived xenografts
Journal Articles

In Vivo Efficacy of Tesevatinib in EGFR-Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory Signaling

Sani H. Kizilbash, Shiv K. Gupta, Karen E. Parrish, Janice K. Laramy, Minjee Kim, Gautham Gampa, Brett L. Carlson, Katrina K. Bakken, Ann C. Mladek, Mark A. Schroeder, Paul A. Decker, William F. Elmquist, Jann N. Sarkaria
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 1009–1018.
https://doi.org/10.1158/1535-7163.MCT-20-0640
Published: 01 June 2021
View article titled, <em>In Vivo</em> Efficacy of Tesevatinib in <em>EGFR</em>-Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory Signaling
Open the PDF for <em>In Vivo</em> Efficacy of Tesevatinib in <em>EGFR</em>-Amplified Patient-Derived Xenograft Glioblastoma Models May Be Limited by Tissue Binding and Compensatory Signaling in another window
Includes: Supplementary data
Journal Articles

Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma

Sani H. Kizilbash, Shiv K. Gupta, Kenneth Chang, Ryo Kawashima, Karen E. Parrish, Brett L. Carlson, Katrina K. Bakken, Ann C. Mladek, Mark A. Schroeder, Paul A. Decker, Gaspar J. Kitange, Yuqiao Shen, Ying Feng, Andrew A. Protter, William F. Elmquist, Jann N. Sarkaria
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (12): 2735–2746.
https://doi.org/10.1158/1535-7163.MCT-17-0365
Published: 03 December 2017
View article titled, Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma
Open the PDF for Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma in another window
Includes: Supplementary data