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Sharon Gowan
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Journal Articles

Abstract PR02: Identification of a potent and selective chemical probe for exploring the role of CDK8/19 in cancer biology

Free
Paul A. Clarke, Trevor Dale, Christina Esdar, Dennis Waalboer, Olajumoke Adeniji-Popoola, Maria-Jesus Ortiz-Ruiz, Aurelie Mallinger, Ken Ewan, Robert te Poele, Sharon Gowan, Paul Workman, Kai Schiemann, Suzanne A. Eccles, Dirk Wienke, Julian Blagg
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (12_Supplement_2): PR02.
https://doi.org/10.1158/1535-7163.TARG-15-PR02
Published: 01 December 2015
View articletitled, Abstract PR02: Identification of a potent and selective chemical probe for exploring the role of CDK8/19 in cancer biology
Journal Articles

Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β

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Aleksandra Bielen, Lara Perryman, Gary M. Box, Melanie Valenti, Alexis de Haven Brandon, Vanessa Martins, Alexa Jury, Sergey Popov, Sharon Gowan, Sebastien Jeay, Florence I. Raynaud, Francesco Hofmann, Darren Hargrave, Suzanne A. Eccles, Chris Jones
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (8): 1407–1418.
https://doi.org/10.1158/1535-7163.MCT-11-0205
Published: 08 August 2011
View articletitled, Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Open the PDF for Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β in another window
Includes: Supplementary data
Journal Articles

Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma

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Nathalie Gaspar, Swee Y. Sharp, Suzanne A. Eccles, Sharon Gowan, Sergey Popov, Chris Jones, Andrew Pearson, Gilles Vassal, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2010) 9 (5): 1219–1233.
https://doi.org/10.1158/1535-7163.MCT-09-0683
Published: 09 May 2010
View articletitled, Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma
Open the PDF for Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

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Florence I. Raynaud, Suzanne A. Eccles, Sonal Patel, Sonia Alix, Gary Box, Irina Chuckowree, Adrian Folkes, Sharon Gowan, Alexis De Haven Brandon, Francesca Di Stefano, Angela Hayes, Alan T. Henley, Letitia Lensun, Giles Pergl-Wilson, Anthony Robson, Nahid Saghir, Alexander Zhyvoloup, Edward McDonald, Peter Sheldrake, Stephen Shuttleworth, Melanie Valenti, Nan Chi Wan, Paul A. Clarke, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (7): 1725–1738.
https://doi.org/10.1158/1535-7163.MCT-08-1200
Published: 14 July 2009
View articletitled, Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941
Open the PDF for Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941 in another window
Includes: Supplementary data
Journal Articles

NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts

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Suzanne Eccles, Swee Sharp, Florence Raynaud, Melanie Valenti, Lisa Patterson, Sharon Gowan, Kathy Boxall, Wynne Aherne, Martin Rowlands, Angela Hayes, Vanessa Martins, Federique Urban, Chrisostomos Prodromou, Laurence Pearl, Karen James, Thomas Matthews, Kwai-Ming Cheung, Andrew Kalusa, Keith Jones, Edward McDonald, Paul Brough, Andrew Massey, Brian Dymock, Martin Drysdale, Paul Workman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B284.
Published: 01 November 2007
View articletitled, NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts
Journal Articles

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

Free
Sharon Sanderson, Melanie Valenti, Sharon Gowan, Lisa Patterson, Zahida Ahmad, Paul Workman, Suzanne A. Eccles
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2006) 5 (3): 522–532.
https://doi.org/10.1158/1535-7163.MCT-05-0439
Published: 16 March 2006
View articletitled, Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis
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