1-20 of 20
Shaomeng Wang
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer

Free
Jianfeng Lu, Donna McEachern, Shunqiang Li, Matthew J. Ellis, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (12): 2887–2893.
https://doi.org/10.1158/1535-7163.MCT-16-0028
Published: 01 December 2016
View articletitled, Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer
Open the PDF for Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C250: Concurrent targeting Bcl-2/Bcl-xL and MDM2 as a new therapeutic strategy for acute leukemia.

Free
C. Gianna Hoffman-Luca, Donna McEachern, Daniel Ziazadeh, Yu-Jun Zhao, Wei Sun, Laurent Debussche, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): C250.
https://doi.org/10.1158/1535-7163.TARG-13-C250
Published: 01 November 2013
View articletitled, Abstract C250: Concurrent targeting Bcl-2/Bcl-xL and MDM2 as a new therapeutic strategy for acute leukemia.
Journal Articles

Abstract A16: A drug combination screen identifies taxanes as synergistic agents with the oral IAP inhibitor Debio 1143 in non-small cell lung cancer cells.

Free
Casey G. Langdon, Norbert Wiedemann, Mathew A. Held, James T. Platt, Frédéric Lévy, Claudio Zanna, Grégoire Vuagniaux, Mel Sorensen, Shaomeng Wang, Marcus W. Bosenberg, David F. Stern
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (11_Supplement): A16.
https://doi.org/10.1158/1535-7163.TARG-13-A16
Published: 01 November 2013
View articletitled, Abstract A16: A drug combination screen identifies taxanes as synergistic agents with the oral IAP inhibitor Debio 1143 in non-small cell lung cancer cells.
Journal Articles

Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment

Free
Jianfeng Lu, Donna McEachern, Haiying Sun, Longchuan Bai, Yuefeng Peng, Su Qiu, Rebecca Miller, Jinhui Liao, Han Yi, Meilan Liu, Anita Bellail, Chunhai Hao, Shi-Yong Sun, Adrian T. Ting, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (5): 902–914.
https://doi.org/10.1158/1535-7163.MCT-10-0864
Published: 08 May 2011
View articletitled, Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment
Open the PDF for Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment in another window
Includes: Supplementary data
Journal Articles

Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases

Free
Jie Yang, Donna McEachern, Wenyan Li, Mary A. Davis, Hua Li, Meredith A. Morgan, Longchuan Bai, Jonathan T. Sebolt, Haiying Sun, Theodore S. Lawrence, Shaomeng Wang, Yi Sun
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2011) 10 (4): 658–669.
https://doi.org/10.1158/1535-7163.MCT-10-0643
Published: 06 April 2011
View articletitled, Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases
Open the PDF for Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases in another window
Includes: Supplementary data
Journal Articles

TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis

Free
Naoki Ashimori, Benjamin D. Zeitlin, Zhaocheng Zhang, Kristy Warner, Ilan M. Turkienicz, Aaron C. Spalding, Theodoros N. Teknos, Shaomeng Wang, Jacques E. Nör
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (4): 893–903.
https://doi.org/10.1158/1535-7163.MCT-08-1078
Published: 16 April 2009
View articletitled, TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis
Open the PDF for TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis in another window
Includes: Supplementary data
Journal Articles

Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis

Free
Asfar Sohail Azmi, Zhiwei Wang, Ravshan Burikhanov, Vivek M. Rangnekar, Guoping Wang, Jianyong Chen, Shaomeng Wang, Fazlul H. Sarkar, Ramzi M. Mohammad
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (9): 2884–2893.
https://doi.org/10.1158/1535-7163.MCT-08-0438
Published: 11 September 2008
View articletitled, Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis
Open the PDF for Critical role of prostate apoptosis response-4 in determining the sensitivity of pancreatic cancer cells to small-molecule inhibitor-induced apoptosis in another window
Journal Articles

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

Free
Mahmoud Toulany, Rainer Kehlbach, Urszula Florczak, Ali Sak, Shaomeng Wang, Jianyong Chen, Markus Lobrich, H. Peter Rodemann
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (7): 1772–1781.
https://doi.org/10.1158/1535-7163.MCT-07-2200
Published: 21 July 2008
View articletitled, Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
Open the PDF for Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair in another window
Journal Articles

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

Free
Sanjeev Shangary, Ke Ding, Su Qiu, Zaneta Nikolovska-Coleska, Joshua A. Bauer, Meilan Liu, Guoping Wang, Yipin Lu, Donna McEachern, Denzil Bernard, Carol R. Bradford, Thomas E. Carey, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2008) 7 (6): 1533–1542.
https://doi.org/10.1158/1535-7163.MCT-08-0140
Published: 19 June 2008
View articletitled, Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
Open the PDF for Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer in another window
Includes: Supplementary data
Journal Articles

BI-33, a novel and potent pan-Bcl-2 inhibitor, induces apoptosis in cancer cells and shows combinational effect with chemo drugs

Free
Feng Jiang, Jianting Long, Sanjeev Shangary, Su Qiu, Meilan Liu, Guozhi Tang, ke Ding, Zaneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C229.
Published: 01 November 2007
View articletitled, BI-33, a novel and potent pan-Bcl-2 inhibitor, induces apoptosis in cancer cells and shows combinational effect with chemo drugs
Journal Articles

In vivo tumor regression achieved by a potent bivalent Smac mimetic (SM-164) in combination with TRAIL

Free
jianfeng lu, Haiying Sun, Donna McEachern, Rebecca Miller, Su Qiu, Han Yi, Zeneta Nikolovska-Coleska, Dajun Yang, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): C228.
Published: 01 November 2007
View articletitled, In vivo tumor regression achieved by a potent bivalent Smac mimetic (SM-164) in combination with TRAIL
Journal Articles

A novel orally active MDM2 inhibitor (MI-219) activates the p53 pathway and is selectively toxic to tumor cells

Free
Sanjeev Shangary, Dongguang Qin, Donna McEachern, Rebecca Miller, Zaneta Nikolovska-Coleska, Meilan Liu, Su Qiu, Ke Ding, Guoping Wang, Jianyong Chen, Yipin Lu, Denzil Bernard, Qingyang Gu, Yi Sun, Rajal Shah, Kenneth Pienta, Xiaolan Lin, Sanmao Kang, Shuguang Zhu, Ming Guo, Dajun Yang, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B271.
Published: 01 November 2007
View articletitled, A novel orally active MDM2 inhibitor (MI-219) activates the p53 pathway and is selectively toxic to tumor cells
Journal Articles

Design, synthesis, and evaluation of bivalent conformationally constrained Smac mimetics that concurrently targeting both BIR2 and BIR3 domain of XIAP

Free
Haiying Sun, Zaneta Nikolovska-Coleska, Jianfeng Lu, Jennifer Meagher, Chao-Yie Yang, Su Qiu, Krzysztof Krajewski, Peter Roller, Jeanne Stuckey, Han Yi, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): PR-2.
Published: 01 November 2007
View articletitled, Design, synthesis, and evaluation of bivalent conformationally constrained Smac mimetics that concurrently targeting both BIR2 and BIR3 domain of XIAP
Journal Articles

Design of cyclic Smac mimetic peptide and in vitro characterization of its complex with X-linked inhibitor of apoptosis protein (XIAP)

Free
Zaneta Nikolovska-Coleska, Jennifer Meagher, Chao-Yie Yang, Sheng Jiang, Su Qiu, Jeanne Stuckey, Peter Roller, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): B288.
Published: 01 November 2007
View articletitled, Design of cyclic Smac mimetic peptide and in vitro characterization of its complex with X-linked inhibitor of apoptosis protein (XIAP)
Journal Articles

Development and validation of mitochondria-based functional assays to investigate the mechanism of small-molecule inhibitors of Bcl-2/Bcl-xL/Mcl-1 (BH3 mimetics) in cell-free systems

Free
Jianting Long, Zaneta Nikolovska-Coleska, Feng Jiang, Sanjeev Shangary, Peter Roller, Shaomeng Wang
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2007) 6 (11_Supplement): A214.
Published: 01 November 2007
View articletitled, Development and validation of mitochondria-based functional assays to investigate the mechanism of small-molecule inhibitors of Bcl-2/Bcl-xL/Mcl-1 (BH3 mimetics) in cell-free systems
Journal Articles

Reversal of cisplatin resistance with a BH3 mimetic, (−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL

Free
Joshua A. Bauer, Douglas K. Trask, Bhavna Kumar, Gerrit Los, Jason Castro, Julia Shin-Jung Lee, Jianyong Chen, Shaomeng Wang, Carol R. Bradford, Thomas E. Carey
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (7): 1096–1104.
https://doi.org/10.1158/1535-7163.MCT-05-0081
Published: 14 July 2005
View articletitled, Reversal of cisplatin resistance with a BH3 mimetic, (−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL
Open the PDF for Reversal of cisplatin resistance with a BH3 mimetic, (−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL in another window
Journal Articles

(−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer

Free
Liang Xu, Dajun Yang, Shaomeng Wang, Wenhua Tang, Meilan Liu, Mary Davis, Jianyong Chen, James M. Rae, Theodore Lawrence, Marc E. Lippman
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (2): 197–205.
https://doi.org/10.1158/1535-7163.197.4.2
Published: 15 February 2005
View articletitled, (−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer
Open the PDF for (−)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer in another window
Journal Articles

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(−)-gossypol] against diffuse large cell lymphoma

Free
Ramzi M. Mohammad, Shaomeng Wang, Amro Aboukameel, Ben Chen, Xihan Wu, Jianyong Chen, Ayad Al-Katib
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (1): 13–21.
https://doi.org/10.1158/1535-7163.13.4.1
Published: 18 January 2005
View articletitled, Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(−)-gossypol] against diffuse large cell lymphoma
Open the PDF for Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(−)-gossypol] against diffuse large cell lymphoma in another window
Journal Articles

Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: Real-time analysis using fluorescent ligands and proteins

Free
Derek C. Braun, Yeyu Cao, Shaomeng Wang, Susan H. Garfield, Gang Min Hur, Peter M. Blumberg
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (1): 141–150.
https://doi.org/10.1158/1535-7163.141.4.1
Published: 18 January 2005
View articletitled, Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: Real-time analysis using fluorescent ligands and proteins
Open the PDF for Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: Real-time analysis using fluorescent ligands and proteins in another window
Journal Articles

(−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance

Free
Christopher L. Oliver, Michelle B. Miranda, Sanjeev Shangary, Stephanie Land, Shaomeng Wang, Daniel E. Johnson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2005) 4 (1): 23–31.
https://doi.org/10.1158/1535-7163.23.4.1
Published: 18 January 2005
View articletitled, (−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance
Open the PDF for (−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance in another window