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Shanhu Hu
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Journal Articles

Abstract C091: Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clinical development in multiple solid tumor indications

Liv H Johannessen, Shanhu Hu, Nan Ke, Anthony D'Ippolito, Nisha Rajagopal, Jason Marineau, Anneli Savinainen, William Zamboni, Graeme Hodgson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2019) 18 (12_Supplement): C091.
https://doi.org/10.1158/1535-7163.TARG-19-C091
Published: 01 December 2019
View articletitled, Abstract C091: Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clinical development in multiple solid tumor indications
Journal Articles

Abstract B171: PK/PD modeling of the first-in-class, potent and selective covalent CDK7 inhibitor, SY-1365, provides mechanistic basis for intermittent dosing regimens in preclinical efficacy models of hematologic and solid tumors

Nigel J. Waters, Shanhu Hu, Brett Matzuka, Graeme Hodgson, Yixuan Ren, Yoon Choi, Kevin Dykstra, Christopher Roberts, Kevin Sprott, Emmanuelle di Tomaso, Christian Fritz
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (1_Supplement): B171.
https://doi.org/10.1158/1535-7163.TARG-17-B171
Published: 01 January 2018
View articletitled, Abstract B171: PK/PD modeling of the first-in-class, potent and selective covalent CDK7 inhibitor, SY-1365, provides mechanistic basis for intermittent dosing regimens in preclinical efficacy models of hematologic and solid tumors
Journal Articles

Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2

Alexey V. Danilov, Shanhu Hu, Bernardo Orr, Kristina Godek, Lisa Maria Mustachio, David Sekula, Xi Liu, Masanori Kawakami, Faye M. Johnson, Duane A. Compton, Sarah J. Freemantle, Ethan Dmitrovsky
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2016) 15 (11): 2758–2766.
https://doi.org/10.1158/1535-7163.MCT-16-0127
Published: 01 November 2016
View articletitled, Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2
Open the PDF for Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2 in another window
Includes: Multimedia, Supplementary data
Journal Articles

Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown

Shanhu Hu, Yun Lu, Bernardo Orr, Kristina Godek, Lisa Maria Mustachio, Masanori Kawakami, David Sekula, Duane A. Compton, Sarah Freemantle, Ethan Dmitrovsky
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2015) 14 (11): 2576–2585.
https://doi.org/10.1158/1535-7163.MCT-15-0443
Published: 03 November 2015
View articletitled, Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown
Open the PDF for Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown in another window
Includes: Supplementary data