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Journal Articles

Abstract P167: Site-specific Dolasynthen ADCs demonstrate consistent exposure across a wide range of drug-to-antibody ratios

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Kalli C. Catcott, Susan Clardy, Jack Sadowsky, Rebecca K. Rowntree, Naniye Malli Centibas, Ling Xu, Andy Polson, Kenneth Avocetien, Tyler Carter, Mark Nazzaro, Dokyong "DK" Kim, Thomas H. Pillow, Neelie Zacharias, Cong Wu, Jeffrey Zurita, Elizabeth Ditty, Stephen Bradley, Alex Uttard, Bingfan Du, William S. Sawyer, Doug Leipold, Gail Lewis Phillips, LiuLiang Qin, Kelly Slocum, Geoffrey Del Rosario, Ginny Li, Shang-Fan Yu, David Lee, Radha Iyengar, Marc Damelin, Dorin Toader, Timothy B. Lowinger
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (12_Supplement): P167.
https://doi.org/10.1158/1535-7163.TARG-21-P167
Published: 01 December 2021
View articletitled, Abstract P167: Site-specific Dolasynthen ADCs demonstrate consistent exposure across a wide range of drug-to-antibody ratios
Journal Articles

Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration

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Madeleine K. Ramos, Danielle Mandikian, Lauren N. Sermeño, Anna King, Alecia T. Dent, Jason Ho, Sheila Ulufatu, T. Noelle Lombana, Christoph Spiess, Mary Ann T. Go, Shang-Fan Yu, Amrita V. Kamath, Gregory Z. Ferl, C. Andrew Boswell
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (10): 1956–1965.
https://doi.org/10.1158/1535-7163.MCT-20-1097
Published: 01 October 2021
View articletitled, Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and Penetration
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Includes: Supplementary data
Journal Articles

Calicheamicin Antibody–Drug Conjugates with Improved Properties

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Breanna S. Vollmar, Chris Frantz, Melissa M. Schutten, Fiona Zhong, Geoffrey del Rosario, Mary Ann T. Go, Shang-Fan Yu, Douglas D. Leipold, Amrita V. Kamath, Carl Ng, Keyang Xu, Josefa dela Cruz-Chuh, Katherine R. Kozak, Jinhua Chen, Zijin Xu, John Wai, Pragya Adhikari, Hans K. Erickson, Peter S. Dragovich, Andrew G. Polson, Thomas H. Pillow
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (6): 1112–1120.
https://doi.org/10.1158/1535-7163.MCT-20-0035
Published: 01 June 2021
View articletitled, Calicheamicin Antibody–Drug Conjugates with Improved Properties
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Includes: Supplementary data
Journal Articles

An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models

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Shang-Fan Yu, Donna W. Lee, Bing Zheng, Geoffrey del Rosario, Douglas Leipold, Helen Booler, Fiona Zhong, Montserrat Carrasco-Triguero, Kyu Hong, Peter Yan, Rebecca K. Rowntree, Melissa M. Schutten, Thomas Pillow, Jack D. Sadowsky, Peter S. Dragovich, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2021) 20 (2): 340–346.
https://doi.org/10.1158/1535-7163.MCT-20-0046
Published: 05 February 2021
View articletitled, An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
Open the PDF for An Anti–CD22-seco-CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models in another window
Includes: Supplementary data
Journal Articles

Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies

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Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z. Ferl, James T. Koerber, Christopher W. Davies, Sheila Ulufatu, Jason Ho, Jeffrey Lau, Shang-Fan Yu, James Ernst, Jack D. Sadowsky, C. Andrew Boswell
Journal: Molecular Cancer Therapeutics
Series: Author Choice
Mol Cancer Ther (2020) 19 (4): 1052–1058.
https://doi.org/10.1158/1535-7163.MCT-19-1015
Published: 02 April 2020
View articletitled, Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies
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Includes: Supplementary data
Journal Articles

Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates

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Donglu Zhang, Shang-Fan Yu, S. Cyrus Khojasteh, Yong Ma, Thomas H. Pillow, Jack D. Sadowsky, Dian Su, Katherine R. Kozak, Keyang Xu, Andrew G. Polson, Peter S. Dragovich, Cornelis E.C.A. Hop
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2018) 17 (3): 677–685.
https://doi.org/10.1158/1535-7163.MCT-17-0697
Published: 28 February 2018
View articletitled, Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates
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Includes: Supplementary data
Journal Articles

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

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Thomas H. Pillow, Melissa Schutten, Shang-Fan Yu, Rachana Ohri, Jack Sadowsky, Kirsten Achilles Poon, Willy Solis, Fiona Zhong, Geoffrey Del Rosario, Mary Ann T. Go, Jeffrey Lau, Sharon Yee, Jintang He, Luna Liu, Carl Ng, Keyang Xu, Douglas D. Leipold, Amrita V. Kamath, Donglu Zhang, Luke Masterson, Stephen J. Gregson, Philip W. Howard, Fan Fang, Jinhua Chen, Janet Gunzner-Toste, Katherine K. Kozak, Susan Spencer, Paul Polakis, Andrew G. Polson, John A. Flygare, Jagath R. Junutula
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2017) 16 (5): 871–878.
https://doi.org/10.1158/1535-7163.MCT-16-0641
Published: 02 May 2017
View articletitled, Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers
Open the PDF for Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers in another window
Includes: Supplementary data
Journal Articles

DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma

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Dongwei Li, Kirsten Achilles Poon, Shang-Fan Yu, Randall Dere, MaryAnn Go, Jeffrey Lau, Bing Zheng, Kristi Elkins, Dimitry Danilenko, Katherine R. Kozak, Pamela Chan, Josefa Chuh, Xiaoyan Shi, Denise Nazzal, Franklin Fuh, Jacqueline McBride, Vanitha Ramakrishnan, Ruth de Tute, Andy Rawstron, Andrew S. Jack, Rong Deng, Yu-Waye Chu, David Dornan, Marna Williams, William Ho, Allen Ebens, Saileta Prabhu, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2013) 12 (7): 1255–1265.
https://doi.org/10.1158/1535-7163.MCT-12-1173
Published: 07 July 2013
View articletitled, DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma
Open the PDF for DCDT2980S, an Anti-CD22-Monomethyl Auristatin E Antibody–Drug Conjugate, Is a Potential Treatment for Non-Hodgkin Lymphoma in another window
Includes: Supplementary data
Journal Articles

FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma

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Kristi Elkins, Bing Zheng, MaryAnn Go, Dionysos Slaga, Changchun Du, Suzie J. Scales, Shang-Fan Yu, Jacqueline McBride, Ruth de Tute, Andy Rawstron, Andrew S. Jack, Allen Ebens, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2012) 11 (10): 2222–2232.
https://doi.org/10.1158/1535-7163.MCT-12-0087
Published: 09 October 2012
View articletitled, FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Abstract B205: Evaluation of circulating CD34+ cells following treatment with anti‐EGFL7 in preclinical models of efficacy

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Mahrukh Huseni, Edward Kadel, III, Rupal Desai, David Kan, Jason Cheng, Shang‐Fan Yu, Mallika Singh, Rajiv Raja, Weilan Ye, Priti Hegde
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (12_Supplement): B205.
https://doi.org/10.1158/1535-7163.TARG-09-B205
Published: 10 December 2009
View articletitled, Abstract B205: Evaluation of circulating CD34+ cells following treatment with anti‐EGFL7 in preclinical models of efficacy
Journal Articles

In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates

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Bing Zheng, Reina N. Fuji, Kristi Elkins, Shang-Fan Yu, Franklin K. Fuh, Josefa Chuh, Christine Tan, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Marna Williams, Elena McDorman, Dan Eaton, Allen Ebens, Andrew G. Polson
Journal: Molecular Cancer Therapeutics
Mol Cancer Ther (2009) 8 (10): 2937–2946.
https://doi.org/10.1158/1535-7163.MCT-09-0369
Published: 12 October 2009
View articletitled, In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates
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